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The effects of temperature, agitation and aeration on glycoprotein GP-1 production by Streptomyces kanasenisi ZX01 in bench-scale fermentors were systematically investigated. The maximum final GP-1 production was achieved at an agitation speed of 200 rpm, aeration rate of 2.0 vvm and temperature of 30 °C. By using a dynamic gassing out method, the effects of agitation and aeration on volumetric oxygen transfer coefficient (kLa) were also studied. The values of volumetric oxygen transfer coefficient in the logarithmic phase increased with increase of agitation speed (from 14.53 to 32.82 h−1) and aeration rate (from 13.21 to 22.43 h−1). In addition, a successful scale-up from bench-scale to pilot-scale was performed based on volumetric oxygen transfer coefficient, resulting in final GP-1 production of 3.92, 4.03, 3.82 and 4.20 mg/L in 5 L, 15 L, 70 L and 500 L fermentors, respectively. These results indicated that constant volumetric oxygen transfer coefficient was appropriate for the scale-up of batch fermentation of glycoprotein GP-1 by Streptomyces kanasenisi ZX01, and this scale-up strategy successfully achieved 100-fold scale-up from bench-scale to pilot-scale fermentor.

Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases, play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various xenobiotic substrates, which will eventually be responsible for most metabolism-based herb–herb or herb–drug interactions, usually involving competition with another drug for the same enzyme binding site. Compounds from herbal or natural products are involved in many scenarios in the context of such interactions. These interactions are decisive both in drug discovery regarding the synergistic effects, and drug application regarding unwanted side effects. Herein, this review was conducted as a comprehensive compilation of the effects of herbal ingredients on CYP450 enzymes. Nearly 500 publications reporting botanicals’ effects on CYP450s were collected and analyzed. The countries focusing on this topic were summarized, the identified herbal ingredients affecting enzyme activity of CYP450s, as well as methods identifying the inhibitory/inducing effects were reviewed. Inhibitory effects of botanicals on CYP450 enzymes may contribute to synergistic effects, such as herbal formulae/prescriptions, or lead to therapeutic failure, or even increase concentrations of conventional medicines causing serious adverse events. Conducting this review may help in metabolism-based drug combination discovery, and in the evaluation of the safety profile of natural products used therapeutically.

Background Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of major risk factors of cardiovascular diseases, insulin resistance and metabolism syndrome. However, there are fewer scientific dissertations about the correlation between TG/HDL-C and bapWV. This study was undertaken to investigate the relationship between Triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and brachial-ankle pulse wave velocity (baPWV) in Japanese. Methods The present study was a cross-sectional study. 912 Japanese men and women, aging 24−84 years old, received a health medical a health check-up program including the results from baPWV inspection and various standardized questionnaire in a health examination Center in Japan. Main outcome measures included TG/HDL-C ratio, baPWV, fatty liver, postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. Postmenopausal state was defined as beginning 1 year after the cessation of menses. It was noted that the entire study was completed by Fukuda et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis. Results After adjusting potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise status, fatty liver, alcohol consumption and ABI), non-linear relationship was detected between TG/HDL-C and baPWV, whose point was 5.6. The effect sizes and the confidence intervals on the left and right sides of inflection point were 12.7 (1.9 to 23.5) and − 16.7 (− 36.8 to 3.3), respectively. Subgroup analysis showed, in participants with excessive alcohol consumption (more than 280 g/week), that TG/HDL-C had a negative correlation with BAPWV (β = − 30.7, 95%CI (− 53.1, − 8.4)), and the P for interaction was less than 0.05, Conclusion The relationship between TG/HDL-C and baPWV is non-linear. TG/HDL-C was positively related with baPWV when TG/HDL-C is less than 5.6. In addition, while the trend is opposite in excessive alcoholic subjects.

A bstract NLO evolution of the Jalilian-Marian-Iancu-McLerran-Weigert-Leonidov-Kovner (JIMWLK) equation with massless quarks was derived a few years ago. We make a step further to compute the evolution kernels focusing on the effects due to finite quark masses. To this goal, the light-cone wave function of a fast moving dilute hadronic projectile is computed up to O ( g 3 ) in QCD coupling constant. Compared with the massless case, a new IR divergence emerges, which is eventually canceled by a mass dependent counter term. Our results extend the theoretical tools used in physics of gluon saturation and aim at improving precision in future phenomenological applications.

Lignin nanoparticles, the innovative achievements in the development and utilization of lignin, combine the structural characteristics of nanomaterials and lignin molecules and have a wide range of applications. In this review, we summarize the methods for preparing lignin nanoparticles by solvent exchange method, mechanical method, biological enzymatic method, interface polymerization/crosslinking method, and spray freezing method, and emphatically introduce the application prospects of lignin nanoparticles in ultraviolet protection, antibacterial, nano-filler, drug delivery, and adsorption, aiming to provide a certain reference direction for additional high-value applications of lignin nanoparticles.

A bstract In this paper, we study the fragmentation of a heavy quark into a jet near threshold, meaning that final state jet carries most of the energy of the fragmenting heavy quark. Using the heavy quark fragmentation function, we simultaneously resum large logarithms of the jet radius R and 1 − z , where z is the ratio of the jet energy to the initiating heavy quark energy. There are numerically significant corrections to the leading order rate due to this resummation. We also investigate the heavy quark fragmentation to a groomed jet, using the soft drop grooming algorithm as an example. In order to do so, we introduce a collinear-ultrasoft mode sensitive to the grooming region determined by the algorithm’s z cut parameter. This allows us to resum large logarithms of z cut / (1 − z ), again leading to large numerical corrections near the endpoint. A nice feature of the analysis of the heavy quark fragmenting to a groomed jet is the heavy quark mass m renders the algorithm infrared finite, allowing a perturbative calculation. We analyze this for E J R ∼ m and E J R » m , where E J is the jet energy. To do the latter case, we introduce an ultracollinear-soft mode, allowing us to resum large logarithms of E J R/m . Finally, as an application we calculate the rate for e + e − collisions to produce a heavy quark jet in the endpoint region, where we show that grooming effects have a sizable contribution near the endpoint.

Background Pretreatment is the key step for utilizing lignocellulosic biomass, which can extract cellulose from lignin and disrupt its recalcitrant crystalline structure to allow much more effective enzymatic hydrolysis; and organic acids pretreatment with dual benefic for generating xylooligosaccharides and boosting enzymatic hydrolysis has been widely used in adding values to lignocellulose materials. In this work, furoic acid, a novel recyclable organic acid as catalyst, was employed to pretreat sugarcane bagasse to recover the xylooligosaccharides fraction from hemicellulose and boost the subsequent cellulose saccharification. Results The FA-assisted hydrolysis of sugarcane bagasse using 3% furoic acid at 170 °C for 15 min resulted in the highest xylooligosaccharides yield of 45.6%; subsequently, 83.1 g/L of glucose was harvested by a fed-batch operation with a solid loading of 15%. Overall, a total of 120 g of xylooligosaccharides and 335 g glucose could be collected from 1000 g sugarcane bagasse starting from the furoic acid pretreatment. Furthermore, furoic acid can be easily recovered by cooling crystallization. Conclusion This work put forward a novel furoic acid pretreatment method to convert sugarcane bagasse into xylooligosaccharides and glucose, which provides a strategy that the sugar and nutraceutical industries can be used to reduce the production cost. The developed process showed that the yields of xylooligosaccharides and byproducts were controllable by shortening the reaction time; meanwhile, the recyclability of furoic acid also can potentially reduce the pretreatment cost and potentially replace the traditional mineral acids pretreatment.

Reinforced concrete structures are prone to the corrosion of steel bars when exposed to chloride-rich environments, which can severely impact their durability. To address this issue, a comprehensive understanding of the factors influencing chloride ion diffusion in concrete is essential. This paper provides a summary of recent domestic and foreign research on chloride ion transport in concrete, focusing on six key factors: water–binder ratio, additive content, crack width, ambient temperature, relative humidity, and dry–wet cycles. The findings show that the diffusion coefficient of chloride ions in concrete increases with a higher water–binder ratio and decreases with increased additive content. Additionally, wider cracks result in a greater diffusion of chloride ions. The permeability resistance of concrete to chloride ions decreases with rising temperature and humidity, and dry–wet cycles further accelerate the diffusion of chloride ions. The article concludes by discussing various anti-corrosion measures, such as the use of corrosion inhibitors, surface coatings, and electrochemical treatments, to ensure the longevity of the structure. Finally, directions for future research are proposed.

A bstract In this paper we study the fragmentation of a parton into a jet containing a heavy quark. When heavy quarks are involved in a jet, the quark mass can lead to a numerically significant correction to the jet cross section and its substructure. With this motivation, we calculated the heavy quark mass effects to next-to-leading order in α s on the fragmentation functions to a jet (FFJs) and the jet fragmentation functions (JFFs), where the former describes fragmentation of parton into a jet and the latter describes fragmenting processes inside a jet. The finite size of the heavy quark mass does not change the ultraviolet behaviors, but it can give significant corrections to the finite contributions. When we take the zero mass limit, we find that the FFJs and the JFFs reproduce established results for massless partons. If we define the heavy quark jet as one that include at least one heavy (anti-)quark, the tagged heavy quark jet production is sensitive to the heavy quark mass and produces large logarithms of the mass. Taking advantage of the FFJs and JFFs, we formulate a factorization theorem for heavy quark jet production in order to resum these large logarithms systematically. As an application, we study inclusive b -jet production and show phenomenological implications due to keeping a non-zero quark mass.

HighlightsHyperelastic and superlight multifunctional MXene/nanocellulose composite aerogels with high conductivity are designed by constructing biomimetic texture.The MXene/nanocellulose aerogels as flexible pressure sensors exhibit appealing linear sensitivity performance (817.3 kPa−1).The as-prepared compressible supercapacitor with MXene/nanocellulose electrodes reveals superior electrochemical performance (849.2 mF cm−2 at 0.8 mA cm−2).Multifunctional architecture with intriguing structural design is highly desired for realizing the promising performances in wearable sensors and flexible energy storage devices. Cellulose nanofiber (CNF) is employed for assisting in building conductive, hyperelastic, and ultralight Ti3C2Tx MXene hybrid aerogels with oriented tracheid-like texture. The biomimetic hybrid aerogels are constructed by a facile bidirectional freezing strategy with CNF, carbon nanotube (CNT), and MXene based on synergistic electrostatic interaction and hydrogen bonding. Entangled CNF and CNT “mortars” bonded with MXene “bricks” of the tracheid structure produce good interfacial binding, and superior mechanical strength (up to 80% compressibility and extraordinary fatigue resistance of 1000 cycles at 50% strain). Benefiting from the biomimetic texture, CNF/CNT/MXene aerogel shows ultralow density of 7.48 mg cm−3 and excellent electrical conductivity (~ 2400 S m−1). Used as pressure sensors, such aerogels exhibit appealing sensitivity performance with the linear sensitivity up to 817.3 kPa−1, which affords their application in monitoring body surface information and detecting human motion. Furthermore, the aerogels can also act as electrode materials of compressive solid-state supercapacitors that reveal satisfactory electrochemical performance (849.2 mF cm−2 at 0.8 mA cm−2) and superior long cycle compression performance (88% after 10,000 cycles at a compressive strain of 30%).