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Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.

This review examines the transformation of educational practices to online and distance learning during the COVID-19 pandemic. It specifically focuses on the challenges, innovative approaches, and successes of this transition, emphasizing the integration of educational technology, student well-being, and teacher development. The COVID-19 pandemic has significantly transformed the educational landscape, necessitating a rapid shift to online and distance learning. This review has highlighted key strategies and innovations in online teaching, emphasizing the importance of engaging, adaptable, and inclusive educational practices. It underscores the need for continuous professional development for educators, the integration of advanced technological tools, and the importance of prioritizing student well-being and academic success in digital environments. As we move forward, the insights gathered from this experience will be invaluable in shaping a resilient and dynamic educational framework that is well suited for the post-pandemic era, focusing on inclusivity, engagement, and the effective use of technology to enhance learning experiences.

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global health crisis. The present study discusses the main finding in nutrition sciences associated with COVID-19 in the literature. We conducted a consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, and web pages. The method was a narrative literature review of the available literature regarding nutrition interventions and nutrition-related factors during the COVID-19 pandemic. The main search engines used in the present research were PubMed, SciELO, and Google Scholar. We found how the COVID-19 lockdown promoted unhealthy dietary changes and increases in body weight of the population, showing obesity and low physical activity levels as increased risk factors of COVID-19 affection and physiopathology. In addition, hospitalized COVID-19 patients presented malnutrition and deficiencies in vitamin C, D, B12 selenium, iron, omega-3, and medium and long-chain fatty acids highlighting the potential health effect of vitamin C and D interventions. Further investigations are needed to show the complete role and implications of nutrition both in the prevention and in the treatment of patients with COVID-19.

The purpose of this study was to examine the effects of different dryland warm-up protocols on knee isokinetic strength, vertical jumping, and sprint performance in competitive swimmers. Twenty-four male swimmers were randomly assigned to the FIFA 11 + group ( n  = 12) or the post-activation performance enhancement (PAPE) group ( n  = 12). The FIFA 11 + group performed the FIFA 11 + warm-up program three times per week for 6 weeks, whereas the PAPE group consisted of performing general activities and three sets of five drop jumps. Performance test included concentric (con) and eccentric (ecc) isokinetic strength of the quadriceps (Q) and hamstrings (H) of the dominant (DL) and non-dominant (NDL) limbs at three angular velocities, countermovement jump (CMJ), squat jump (SJ) and a 50-m time trial. The conventional (Hcon: Qcon) and functional (Hecc: Qcon) ratios were calculated pre- and post- intervention. The FIFA 11 + group showed a significant increase in DL-Hcon ( p  < 0.05, ES = 1.0-1.8), and NDL-Hcon ( p  < 0.05, ES = 1.0-1.6) in all angular velocities, and DL-Qcon ( p  < 0.05, ES = 0.9) at 60°·s − 1 . The PAPE group significantly improved DL-Qcon at 180°·s − 1 , 240°·s − 1 (both p  < 0.05, ES = 1.0), and NDL-Qcon at 240°·s − 1 ( p  < 0.05, ES = 0.9). Additionally, FIFA 11 + showed significant improvement in DL-Hcon and NDL-Hcon (both p  < 0.05, ES = 0.9–1.8) compared with PAPE. FIFA 11 + increased DL-Hcon: Qcon 60 ( p  < 0.05, ES = 1.1) and NDL- Hcom: Qcon 60,240 (both p  < 0.05, ES = 1.2) compared with PAPE. Both groups significantly improved CMJ (FIFA 11 +  p  < 0.01, ES = 0.4 and PAPE p  < 0.01, ES = 0.3), SJ (both p  < 0.01, ES = 0.6) and 50-m swimming performance (FIFA 11 +  p  < 0.05, ES = -0.8 and PAPE p  < 0.05, ES = -0.6). Both warm-up protocols showed similar improvements in jumping ability and sprint swimming performance. The FIFA 11 + seemed more efficient in improving lower limb isokinetic strength and conventional strength ratios in male competitive swimmers.

Stress is regulated by the autonomous nervous system, increasing the sympathetic modulation when a threat is perceived. A multifactorial response usually leads to significant behavioural modifications and alterations on homeostasis and physical and psychological status. Moreover, stress is an emotional response that can lead to psychosocial and psychophysiological adversity. Regarding military population, military operations and combat exposure are important stressors that influence acute and chronic stress response in soldiers, affecting their performance and health. A bibliographic search was carried out between April and May 2019, focusing on recent studies (2013–2019) that analysed psychophysiological response, stress, stress regulation, heart rate, heart rate variability, and posttraumatic stress disorder in military population. Autonomic and cardiovascular chronic stress seems to be modulated by experience and previous specific training of each military unit. Physical exercise, music embedded with binaural beat technology, bidirectional sensory motor rhythm training, heart rate variability biofeedback, and transcutaneous vagal nerve stimulation are the main techniques applied to balance stress and to recover body homeostasis. Since military population are usually exposed to multiple stressors, knowing previous training and experience, together with developing techniques to balance stress, is the main practical application in this field of study to balance autonomic and cardiovascular systems.

Background: Myofascial trigger points (MTrPs) are hyperirritable spots in skeletal muscle associated with pain and dysfunction, often impacting individuals’ quality of life. Various interventions, such as dry needling and manual therapy, have shown limited effects in addressing these conditions. This study aimed to assess the effectiveness of a functional neurology intervention in reducing pain and improving muscle function in patients with MTrPs in the upper trapezius muscle. We hypothesized that a single session of functional neurology intervention would significantly increase the pressure pain threshold (PPT) and improve peripheral vascular response in individuals with myofascial trigger points compared to a control group. Methods: A randomized controlled trial (RCT) was conducted with 63 participants randomly assigned to an experimental (receiving functional neurology treatment) or control group. Pre- and post-treatment assessments were conducted, and both intra- and inter-group comparisons were performed using algometry to measure the PPT and infrared thermography to analyze peripheral vascular response. Data were analyzed using dependent and independent t-tests with statistical significance set at p < 0.05. Results: The experimental group demonstrated a significant 46.4% increase in PPT, while the control group showed negligible changes. Thermographic analysis indicated improved peripheral blood flow in the experimental group, reflected by increased skin temperatures and reduced thermal anomalies. No significant differences were observed between the groups at baseline. Conclusions: A single session of functional neurology intervention significantly reduced pain and improved muscle function in patients with MTrPs. These findings suggest that functional neurology offers a promising non-invasive alternative to traditional treatments, with potential implications for more rapid and sustained therapeutic outcomes.

A single session of functional neurology led to the integration of multiple retained primitive reflexes in a child, resulting in improved motor coordination and cognitive function. This case highlights functional neurology as a promising treatment for neurodevelopmental challenges.

Objectives: This study aimed to investigate the effects of external (EXT) versus internal (INT) focus of attention on acquiring and transferring simple and complex motor skills in novice female volleyball players. Methods: Fifty-seven participants were assigned to one of the three groups: The external focus (EXT), the internal focus (INT), and the control group (CON). Over a 6-week intervention, participants practiced a simple skill (volleyball passing) and a complex skill (overhead tennis serve). Pre-tests, post-tests, and transfer tests (conducted two weeks later) assessed movement form and accuracy. Results: The results showed a statistically significant interaction among focus methods, skill complexity, and testing periods for movement form and performance outcome. The EXT group showed higher movement form and performance outcome improvements during the simple skill (passing) compared to the INT and CON groups. For the complex skill (serving), the EXT group outperformed the INT and CON groups regarding movement outcome; however, no differences in movement form were observed between the EXT and INT groups. Post hoc Tukey tests indicated that the EXT group scored higher than the INT and CON groups in the post-test and transfer test for the simple skill, with movement form improving from 1.68 ± 0.48 to 2.32 ± 0.58. In the complex skill, the EXT group’s movement outcome improved from 11.32 ± 6.83 to 44.47 ± 16.57. Conclusions: External focus significantly enhances movement form and outcome in simple tasks and performance outcomes in more complex skills among novice athletes.

Background/Objectives: The global aging population faces rising rates of cognitive decline and neurodegenerative disorders. This review explores how physical exercise influences brain health in aging, focusing on mechanisms, moderators, and personalized strategies to enhance cognitive resilience. Methods: A narrative review methodology was applied. Literature published between 2015 and 2025 was retrieved from PubMed, Scopus, and Web of Science using keywords and MeSH terms related to exercise, cognition, neuroplasticity, aging, and dementia. Inclusion criteria targeted peer-reviewed original studies in humans aged ≥60 years or aged animal models, examining exercise-induced cognitive or neurobiological outcomes. Results: Evidence shows that regular physical activity improves executive function, memory, and processing speed in older adults, including those with mild impairment or genetic risk (e.g., APOE ε4). Exercise promotes neuroplasticity through increased levels of BDNF, IGF-1, and irisin, and enhances brain structure and functional connectivity. It also improves glymphatic clearance and modulates inflammation and circadian rhythms. Myokines act as messengers between muscle and brain, mediating many of these effects. Cognitive benefits vary with exercise type, intensity, and individual factors such as age, sex, chronotype, and baseline fitness. Combined interventions—physical, cognitive, nutritional—show synergistic outcomes. Digital tools (e.g., tele-exercise, gamification) offer scalable ways to sustain engagement and cognitive function. Conclusions: Physical exercise is a key non-pharmacological strategy to support cognitive health in aging. It acts through diverse systemic, molecular, and neurofunctional pathways. Tailored exercise programs, informed by individual profiles and emerging technologies, hold promise for delaying or preventing cognitive decline.

In recent years, the interest of female dominance in long-distance swimming has grown where several newspaper articles have been published speculating about female performance and dominance—especially in open-water ultra-distance swimming. The aim of this narrative review is to review the scientific literature regarding the difference between the sexes for all swimming strokes (i.e., butterfly, backstroke, breaststroke, freestyle and individual medley), different distances (i.e., from sprint to ultra-distances), extreme conditions (i.e., cold water), different ages and swimming integrated in multi-sports disciplines, such as triathlon, in various age groups and over calendar years. The influence of various physiological, psychological, anthropometrical and biomechanical aspects to potentially explain the female dominance was also discussed. The data bases Scopus and PUBMED were searched by April 2020 for the terms ’sex–difference–swimming’. Long-distance open-water swimmers and pool swimmers of different ages and performance levels were mainly investigated. In open-water long-distance swimming events of the ’Triple Crown of Open Water Swimming’ with the ’Catalina Channel Swim’, the ’English Channel Swim’ and the ’Manhattan Island Marathon Swim’, women were about 0.06 km/h faster than men. In master swimmers (i.e., age groups 25–29 to 90–94 years) competing in the FINA (Fédération Internationale de Natation) World Championships in pool swimming in freestyle, backstroke, butterfly, breaststroke, individual medley and in 3000-m open-water swimming, women master swimmers appeared able to achieve similar performances as men in the oldest age groups (i.e., older than 75–80 years). In boys and girls aged 5–18 years—and listed in the all-time top 100 U.S. freestyle swimming performances from 50 m to 1500 m—the five fastest girls were faster than the five fastest boys until the age of ~10 years. After the age of 10 years, and until the age of 17 years, however, boys were increasingly faster than girls. Therefore, women tended to decrease the existing sex differences in specific age groups (i.e., younger than 10 years and older than 75–80 years) and swimming strokes in pool-swimming or even to overperform men in long-distance open-water swimming (distance of ~30 km), especially under extreme weather conditions (water colder than ~20 °C). Two main variables may explain why women can swim faster than men in open-water swimming events: (i) the long distance of around 30 km, (ii) and water colder than ~20 °C. Future studies may investigate more detailed (e.g., anthropometry) the very young (<10 years) and very old (>75–80 years) age groups in swimming