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We here defined the impacts of γ-secretase inhibitors (GSIs) on T-cell-dependent BCMA-specific multiple myeloma (MM) cell lysis and immunomodulatory effects induced by bispecific antibodies (BisAbs). GSIs-induced membrane BCMA (mBCMA) accumulation reached near maximum within 4 h and sustained over 42h-study period on MM cell lines and patient MM cells. GSIs, i.e., 2 nM LY-411575 or 1 μM DAPT, robustly increased mBCMA densities on CD138+ but not CD3+ patient cells, concomitantly with minimum soluble/shed BCMA (sBCMA) in 1 day-culture supernatants. In ex vivo MM-T-cell co-cultures, GSIs overcame sBCMA-inhibited MM cell lysis and further enhanced autologous patient MM cell lysis induced by BCMAxCD3 BisAbs, accompanied by significantly enhanced cytolytic markers (CD107a, IFNγ, IL2, and TNFα) in patient T cells. In longer 7 day-co-cultures, LY-411575 minimally affected BCMAxCD3 BisAb (PL33)-induced transient expression of checkpoint (PD1, TIGIT, TIM3, LAG3) and co-stimulatory (41BB, CD28) proteins, as well as time-dependent increases in % effector memory/central memory subsets and CD8/CD4 ratios in patient T cells. Importantly, LY41157 rapidly cleared sBCMA from circulation of MM-bearing NSG mice reconstituted with human T cells and significantly enhanced anti-MM efficacy of PL33 with prolonged host survival. Taken together, these results further support ongoing combination BCMA-targeting immunotherapies with GSI clinical studies to improve patient outcome.

The rock critic Albert Goldman wrote an essay in 1969 called \"Why Do Whites Sing Black?\" This essay provides a classic framework of essentialism and selective representation in discussing white appropriations of the blues. The author uses Goldman's piece as a framework for a discussion of the 1960s blues revival. He argues that the blues revival depended on a stereotyped representation of black culture, and that this in turn was used to remedy a perceived lack of authenticity in white rock music. This colonization of black music involves a process of \"Othering,\" where the dominant culture renders the subordinate culture in terms of difference, and that difference allows the dominant culture to define itself. Endnotes and works cited are included.

In this article I hope to take on some questions of meaning in a rock vocal performance, examining Patti Smith's reworked version of Van Morrison's garage band standard ‘Gloria’. By looking particularly at Smith's textual accretions and timbral manipulation, I will demonstrate some of the ways that her performance can be thought of as an intertextual, critical recasting of Morrison's tale of male sexual conquest. Smith's ‘Gloria’ differs from Morrison's not only in its altered lyric text, but also in a number of musical details which include harmonic structure, melodic range and form. In this article, though, I devote the most attention to Smith's timbral manipulation, especially the ways that she alters her pronunciation of words for expressive ends. In order to examine this in detail, I have developed a system of notation that tracks Smith's sung vowel sounds alongside her use of pitch. Some of the sonic details so revealed will be used to construct a meta-narrative of Smith's ‘Gloria’ performance.

Daley examines Patti Smith's version of the song \"Gloria\" to take on some questions of meaning in a rock vocal performance. Smith's textual accretions and timbral manipulation are examined especially closely.

Displacement and separation may be as simple as wrapping the vehicles' suspension systems with chains and load/ratchet binders. Many rescue companies have opted to carry large flat load straps on their rigs. These straps can be deployed much easier than grade 80 chains can, and are not as bulky to work with. These straps will have hooks and connection points on them to be utilized on frame rails, rims, suspension parts, etc. (photos 5 and 6). Wrapping the suspension systems tight will result in 5 to 6 inches of displacement in passenger vehicles, and up to 12 inches when lifting larger vehicles off of passenger cars. When the suspensions are under compression, it may provide an adequate amount of displacement to separate the vehicles so that disentanglement procedures can begin. If not, then the larger vehicle will most likely need to be lifted or displaced from the smaller vehicle. If this is the case, you will need cribbing and associated strut supporting equipment that is strong enough to handle the working load limit of the vehicle. A combination of resources may have to be utilized in order to lift the larger vehicle. For example, a heavy duty wrecker may provide the strength to raise the larger vehicle high enough to separate the vehicles, but will benefit from cribbing and support from the underside of the vehicle, if possible (photo 7). Once the lift is done, it may be necessary to separate the vehicle(s) and begin the extrication. This may require dragging the passenger vehicle back from underneath the commercial vehicle. There will be numerous entanglements between the two vehicles, in the form of rear ICC bars, frame rails, body Beams and supports, and electrical wiring and pneumatic tubing. It might be necessary to cut the vehicles apart after the lift is completed (photos 8 and 9). While I understand that the \"move the victim and the vehicle\" approach is a bit controversial, and this may raise an eyebrow (or considerably more) on a few rescuers, let's consider two very critical points to this argument: Upon arrival, after scene safety has been secured, there is one critical question that has to be answered: Where is/are the victim(s)? The victim location will define what type of operation will be needed (Lift, move, swing, drag, etc...) and what additional resources are going to be required (photo 3). Secondly, stabilization needs will be difficult. Frame rails for commercial vehicles are much higher than what are found on passenger vehicles. Larger sized cribbing and raker struts may be needed, not only for an increase in weight support, but to provide for height gain in our crib stacks. Furthermore, when it comes to cribbing these vehicles, the cab of the truck will need additional cribbing from the frame rails to the underside of the cab. These vehicles not only have body-mount assemblies, but many of these are spring-loaded or pneumatically charged to adjust the ride for the operator. The cab \"load\" will also have to be directed to the ground through the frame rails as well.

Displacement and separation may be as simple as wrapping the vehicles' suspension systems with chains and load/ratchet binders. Many rescue companies have opted to carry large flat load straps on their rigs. These straps can be deployed much easier than grade 80 chains can, and are not as bulky to work with. These straps will have hooks and connection points on them to be utilized on frame rails, rims, suspension parts, etc. (photos 5 and 6). Wrapping the suspension systems tight will result in 5 to 6 inches of displacement in passenger vehicles, and up to 12 inches when lifting larger vehicles off of passenger cars. When the suspensions are under compression, it may provide an adequate amount of displacement to separate the vehicles so that disentanglement procedures can begin. If not, then the larger vehicle will most likely need to be lifted or displaced from the smaller vehicle. If this is the case, you will need cribbing and associated strut supporting equipment that is strong enough to handle the working load limit of the vehicle. A combination of resources may have to be utilized in order to lift the larger vehicle. For example, a heavy duty wrecker may provide the strength to raise the larger vehicle high enough to separate the vehicles, but will benefit from cribbing and support from the underside of the vehicle, if possible (photo 7). The victim location will define what type of operation will be needed (Lift, move, swing, drag, etc...) and what additional resources are going to be required (photo 3). Secondly, stabilization needs will be difficult. Frame rails for commercial vehicles are much higher than what are found on passenger vehicles. Larger sized cribbing and raker struts may be needed, not only for an increase in weight support, but to provide for height gain in our crib stacks. Furthermore, when it comes to cribbing these vehicles, the cab of the truck will need additional cribbing from the frame rails to the underside of the cab. These vehicles not only have body-mount assemblies, but many of these are spring-loaded or pneumatically charged to adjust the ride for the operator. The cab \"load\" will also have to be directed to the ground through the frame rails as well.

I have served as an evaluator for potential members when our task force held evaluations for potential new members. One constant in this process is that well over 90 percent of candidates try out for a spot as a \"knuckle-dragger\"-Jersey-speak for Rescue Specialist, a name given to us by New Jersey Task Force 1 (NJTFl) Task Force Leader James Riley and one we wear with pride-in the Rescue Component. Very few come to the evaluation looking for a spot in logistics.

The report states that the introduction of quality colostrum to a newborn calf will directly affect its health as an adult and, in turn, the amount of milk it is able to produce. [...]by giving dairy farmers a tool that they can easily use to predict the quality of colostrum and guarantee that the newborn calf is getting the essential nutrients they need, the farmers will be able to maximize production in the future.

Many of the first histories of rock were written in the late 1960s, at a time when rock journalism was in its first full flowering and the music itself was widely perceived as having entered a period of consolidation. But histories can never be innocent of the human need to mythologize, and these early accounts set in motion a process whereby the short history of this music would be understood in terms of a creation myth and a linear trajectory of style development in a tripartite model made up of primordial beginnings, classic flowering and a final period of decadence and decay. By the summer of 1969, the Jimi Hendrix Experience had completed what would be its last American tour. Bassist Noel Redding marked the occasion by resigning from the band and Hendrix began to formulate plans to put together a new band.