Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
10,508
result(s) for
"Dan Yu"
Sort by:
Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina
In an analysis involving more than 10 million North Carolina residents, Covid-19 vaccines were highly effective in preventing hospitalization and death up to 9 months after vaccination. Waning protection against infection over time was due to both declining immunity and the emergence of the delta variant.
Journal Article
Inhumans vs. X-Men
\"The Terrigen that grants the Inhumans their powers has been released into Earth's atmosphere! But while the Terrigen Mists circling the planet are creating ever more new Inhumans, mutants are dying from exposure to the substance. Both groups have sought a solution to the problem, and a fragile truce has held, until now! Brilliant scientist and longtime X-Man Hank McCoy -- the Beast -- has discovered the terrible truth: Soon, there will be nowhere left to hide from the poisonous gas. Mutantkind's days are numbered, unless the Terrigen can be destroyed. And if that happens, the Inhumans' legacy will come to an end. There are no options left. This means war!\"--Back cover.
BOOK
Durability of Bivalent Boosters against Omicron Subvariants
In a trial of two bivalent Covid-19 boosters, effectiveness against severe infection resulting in hospitalization or death reached a level of 67.4% after 2 weeks and decreased to 38.4% after 20 weeks.
Journal Article
Effectiveness of Bivalent Boosters against Severe Omicron Infection
Effectiveness of Bivalent Covid-19 BoostersIn this study, effectiveness against hospitalization or death was 24.9% after a monovalent booster and 61.8% after a bivalent booster. Protection has waned over time.
Journal Article
Exosomes in development, metastasis and drug resistance of breast cancer
Transport through the cell membrane can be divided into active, passive and vesicular types (exosomes). Exosomes are nano‐sized vesicles released by a variety of cells. Emerging evidence shows that exosomes play a critical role in cancers. Exosomes mediate communication between stroma and cancer cells through the transfer of nucleic acid and proteins. It is demonstrated that the contents and the quantity of exosomes will change after occurrence of cancers. Over the last decade, growing attention has been paid to the role of exosomes in the development of breast cancer, the most life‐threatening cancer in women. Breast cancer could induce salivary glands to secret specific exosomes, which could be used as biomarkers in the diagnosis of early breast cancer. Exosome‐delivered nucleic acid and proteins partly facilitate the tumorigenesis, metastasis and resistance of breast cancer. Exosomes could also transmit anti‐cancer drugs outside breast cancer cells, therefore leading to drug resistance. However, exosomes are effective tools for transportation of anti‐cancer drugs with lower immunogenicity and toxicity. This is a promising way to establish a drug delivery system. Exosomes are nano‐sized vesicles released by a variety of cells. Exosomes function as versatile promoters in the tumorigenesis, metastasis and drug resistance of breast cancer. In this review, we summarize the current knowledge about the functions of exosomes in the diagnosis, tumorigenesis, metastasis, microenvironment, drug resistance and therapy of breast cancer.
Journal Article
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death. However, the origin of excessive damages caused by SARS-CoV-2 remains largely unknown. Here we show that the SARS-CoV-2 envelope (2-E) protein alone is able to cause acute respiratory distress syndrome (ARDS)-like damages in vitro and in vivo. 2-E proteins were found to form a type of pH-sensitive cation channels in bilayer lipid membranes. As observed in SARS-CoV-2-infected cells, heterologous expression of 2-E channels induced rapid cell death in various susceptible cell types and robust secretion of cytokines and chemokines in macrophages. Intravenous administration of purified 2-E protein into mice caused ARDS-like pathological damages in lung and spleen. A dominant negative mutation lowering 2-E channel activity attenuated cell death and SARS-CoV-2 production. Newly identified channel inhibitors exhibited potent anti-SARS-CoV-2 activity and excellent cell protective activity in vitro and these activities were positively correlated with inhibition of 2-E channel. Importantly, prophylactic and therapeutic administration of the channel inhibitor effectively reduced both the viral load and secretion of inflammation cytokines in lungs of SARS-CoV-2-infected transgenic mice expressing human angiotensin-converting enzyme 2 (hACE-2). Our study supports that 2-E is a promising drug target against SARS-CoV-2.
Journal Article
Durability of XBB.1.5 Vaccines against Omicron Subvariants
A data survey of 1.8 million people in Nebraska showed that XBB.1.5 vaccine effectiveness was 52% against infection and 67% against hospitalization, despite a decline in circulating XBB.1.5 during data collection.
Journal Article
Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior
Major depressive disorder is a devastating psychiatric disease that afflicts up to 17% of the world’s population. Postmortem brain analyses and imaging studies of patients with depression have implicated basal lateral amygdala (BLA) dysfunction in the pathophysiology of depression. However, the circuit and molecular mechanisms through which BLA neurons modulate depressive behavior are largely uncharacterized. Here, in mice, we identified that BLA cholecystokinin (CCK) glutamatergic neurons mediated negative reinforcement via D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) and that chronic social defeat selectively potentiated excitatory transmission of the CCK
BLA
–D2
NAc
circuit in susceptible mice via reduction of presynaptic cannabinoid type-1 receptor (CB
1
R). Knockdown of CB
1
R in the CCK
BLA
–D2
NAc
circuit elevated synaptic activity and promoted stress susceptibility. Notably, selective inhibition of the CCK
BLA
–D2
NAc
circuit or administration of synthetic cannabinoids in the NAc was sufficient to produce antidepressant-like effects. Overall, our studies reveal the circuit and molecular mechanisms of depression.
Activating cannabinoid receptors in a newly identified neural circuit ameliorates depressive-like behaviors in mice.
Journal Article
New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle
Fifteen new diterpenoids, namely xishaklyanes A-O (1–15), along with three known related ones (16–18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher’s method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 μg/mL against Lactococcus garvieae.
Journal Article