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A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure–activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer’s agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects.

Hundreds of billions of commensal microorganisms live in and on our bodies, most of which colonize the gut shortly after birth and stay there for the rest of our lives. In animal models, bidirectional communications between the central nervous system and gut microbiota (Gut–Brain Axis) have been extensively studied, and it is clear that changes in microbiota composition play a vital role in the pathogenesis of various neurodevelopmental and neurodegenerative disorders, such as Autism Spectrum Disorder, Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, anxiety, stress, and so on. The makeup of the microbiome is impacted by a variety of factors, such as genetics, health status, method of delivery, environment, nutrition, and exercise, and the present understanding of the role of gut microbiota and its metabolites in the preservation of brain functioning and the development of the aforementioned neurological illnesses is summarized in this review article. Furthermore, we discuss current breakthroughs in the use of probiotics, prebiotics, and synbiotics to address neurological illnesses. Moreover, we also discussed the role of boron-based diet in memory, boron and microbiome relation, boron as anti-inflammatory agents, and boron in neurodegenerative diseases. In addition, in the coming years, boron reagents will play a significant role to improve dysbiosis and will open new areas for researchers.

In this paper, we consider the second-order three point boundary value problem on time scales with integral boundary conditions on a half-line. We will use the upper and lower solution method along with the Schauder’s fixed point theorem to establish the existence of at least one solution which lies between pairs of unbounded upper and lower solutions. Further, by assuming two pairs of unbounded upper and lower solutions, the Nagumo condition on the nonlinear term involved in the first-order derivative, we will establish the existence of multiple unbounded solutions on an infinite interval by using the topological degree theory. The results of this paper extend the results of Akcan and Çetin (2018), Akcan and Hamal (2014), Eloe, Kaufmann and Tisdell (2006), and generalize the results of Lian and Geng (2011). Examples are included to illustrate the validation of the results.

Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthesize boron-containing oxacycles. In this report, the borylation of coumarins, chromones, and chromenes comprising functional groups, such as esters, nitriles, carbonyls, and amides, has been achieved. In addition, the method generates different classes of potential boron-based retinoids, including the ones with oxadiazole and anthocyanin motifs. The borylated oxacycles can serve as suitable intermediates to generate a library of compounds.

Background Maternal and child health among tribal populations in Odisha, India, is significantly influenced by socio-economic, cultural, and infrastructural factors. Cultural practices, reliance on traditional medicine, and limited awareness of modern healthcare benefits shape health-seeking behavior. This scoping review synthesises evidence on health-seeking behaviour, healthcare utilisation, awareness of healthcare services, government policies, and barriers in tribal communities in Odisha, India. Methods This scoping review was conducted following the Joanna Briggs Institute guidelines. We followed the Arksey and O’Malley methodological framework and applied the PAGER framework (Patterns, Advances, Gaps, Evidence for Practice, Research Recommendations) for quality of reporting. Studies were identified through systematic searches of international and Indian databases, Indian journal websites, organisational websites, repositories, and registries, focusing on health-seeking behaviour and healthcare utilisation among Odisha’s tribal communities. Only English-language articles published between January 2011 and July 2024 were included. The methodological quality of the selected studies was independently assessed by two reviewers using the JBI Quality Assessment Checklist. Results A total of 39 studies, encompassing 36,613 participants, were included in the review. The findings highlight significant barriers to healthcare access among tribal communities, including poverty, illiteracy, cultural practices, geographic isolation, distance to healthcare centres, transportation availability and mistrust of government services. While some tribes have shown progress in adopting modern healthcare services, many continue to rely on traditional medicine and indigenous practices. Socio-cultural factors, such as patriarchal norms and religious rituals, further influence healthcare-seeking behavior. Government initiatives like the National Rural Health Mission and the Integrated Child Development Services have had some success in improving healthcare utilisation among tribal populations. However, strengthening community support, conducting village-level awareness campaigns, and implementing targeted educational interventions can play a transformative role in enhancing healthcare access and overall well-being. Conclusion Improving maternal and child health in Odisha’s tribal populations requires culturally sensitive approaches integrated with modern healthcare strategies. Enhancing awareness, infrastructure, and community health workers’ roles can bridge access gaps while respecting tribal traditions.

Objective Non-communicable diseases (NCDs) remain the leading cause of mortality in India, imposing a significant healthcare and economic burden. This study evaluates the health-seeking behaviour, healthcare utilization, and financial impact of major NCDs hypertension, diabetes, ischemic heart disease, and chronic kidney disease (CKD). Methods A systematic search was conducted across global health databases, including PubMed, EMBASE, CINAHL, Scopus, Web of Science, ProQuest, and J-Gate. Simultaneously, searches were performed on Indian databases, journal websites, and Google Scholar for studies published between January 2014 and December 2024. A total of 1,462 studies were identified and exported to Rayyan software for screening. Two independent reviewers screened the studies based on predefined eligibility criteria. The quality of included studies was assessed using the Joanna Briggs Institute checklist, while data extraction was performed using Cochrane data collection forms. Meta-analysis was not conducted due to heterogeneity in the included studies. This review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results A total of 44 observational survey-based studies were included in this review. Financial constraints, geographical barriers, and awareness gaps influenced healthcare utilization for NCDs. While 60.5% relied on government services for affordability, 39.4% preferred private care for faster access. Out-of-pocket expenses, particularly for hemodialysis and cardiac interventions, posed a major financial burden. Treatment adherence varied by 70.1% among diabetic patients but only 32.4% among hypertensive women. Stockouts of essential medications in public hospitals and high costs of branded drugs in private facilities further restricted access. Emergency care utilisation was high for ischemic heart disease, while CKD patients faced long-term financial strain due to dialysis and frequent hospitalisations. Despite an increase in telemedicine use during COVID-19, accessibility challenges persisted. Systemic inefficiencies, cultural beliefs, and transportation issues further delayed timely care. Conclusion This review highlights critical gaps in NCD care in India, particularly in treatment adherence, financial accessibility, and healthcare infrastructure. Strengthening public healthcare services, expanding insurance coverage for long-term NCD management, and integrating community-based interventions are key policy directions. Additionally, targeted strategies to improve health literacy and promote early disease detection are essential to improving health outcomes and reducing inequities in NCD care in India. Trial registration PROSPERO registration number CRD42024576994.

Methionine aminopeptidase 2 (MetAP2) plays an important role in the regulation of protein synthesis and post-translational processing. Preclinical/clinical applications of MetAP2 inhibitors for the treatment of various diseases have been explored because of their antiangiogenic, anticancer, antiobesity, antidiabetic, and immunosuppressive properties. However, the effects of MetAP2 inhibitors on CNS diseases are rarely examined despite the abundant presence of MetAP2 in the brain. Previously, we synthesized a novel boron-containing MetAP2 inhibitor, BL6, and found that it suppressed angiogenesis and adipogenesis yet improved glucose uptake. Here, we studied the anti-inflammatory effects of BL6 in SIM-A9 microglia and in a mouse model of Alzheimer’s disease generated by the intracerebroventricular (icv) injection of streptozotocin (STZ). We found that BL6 reduced proinflammatory molecules, such as nitric oxide, iNOS, IL-1β, and IL-6, together with phospho-Akt and phospho-NF-κB p65, which were elevated in lipopolysaccharide (LPS)-activated microglial SIM-A9 cells. However, the LPS-induced reduction in Arg-1 and CD206 was attenuated by BL6, suggesting that BL6 promotes microglial M1 to M2 polarization. BL6 also decreased glial activation along with a reduction in phospho-tau and an elevation in synaptophysin in the icv-STZ mouse model. Thus, our experiments demonstrate an anti-neuroinflammatory action of BL6, suggesting possible clinical applications of MetAP2 inhibitors for brain disorders in which neuroinflammation is involved.

Objectives: The COVID-19 pandemic containment necessitated the diversion of substantial health care resources thus affecting the routine essential care, and posing barriers to achieving the Sustainable Development Goals (SDGs). We explored the experiences of vulnerable communities—urban-slum-dwelling women regarding maternal and child health services during COVID-19.Methods: We conducted 48 in-depth interviews in four Indian states—12 in each state among urban-slum antenatal, intra-natal, and postnatal women. We used framework analysis.Results: Amidst the implementation of the mandatory stay-at-home, many women acknowledged that routine immunization services and antenatal check-ups remained uninterrupted, and were mostly provided at the community level. To prevent transmission, the family members and relatives had restricted visits to the health facility during labor or post-delivery. Women preferred to have a shorter hospital stay post-delivery and reduced routine postnatal check-ups for fear of infection.Conclusion: India has a variety of national and state-level programs focused on improving MCH indicators to achieve the SDGs. COVID-19 inadvertently interrupted some components of health services, insinuating the need for a disaster or pandemic-resilient MCH services delivery system.

Background/Objectives: Metastatic prostate cancer (PCa) is the leading cause of cancer-related deaths and a major contributor to cancer mortality in men. Most patients with metastatic PCa eventually develop metastatic castration-resistant prostate cancer (mCRPC), characterized by resistance to treatment with androgen-deprivation therapy, and often later the development of resistance to other types of agents. MAGMAS, a 13.8 kDa mitochondrial-associated protein, facilitates the import of nuclear-encoded proteins into the mitochondrial matrix. Overexpression of MAGMAS has been observed in several aggressive cancers, including breast, glioblastoma, and prostate cancer. When overexpressed, MAGMAS acts as a cytoprotective protein by scavenging reactive oxygen species (ROS), maintaining ROS levels that support cell proliferation while avoiding the induction of apoptosis. This study investigates the role of MAGMAS in therapy resistance in PCa cells. Methods/Results: Quantitative immunoblotting revealed that MAGMAS is endogenously upregulated in docetaxel-resistant (DR) PCa cell lines compared to their docetaxel-sensitive parental counterparts. While MAGMAS depletion alone did not affect the survival of DR cells, it significantly sensitized them to docetaxel (DTX), as indicated by a marked reduction in clonogenic potential. Additionally, transient knockdown of MAGMAS in these resistant cells significantly decreased the levels of ABCB1 protein. Consistent with these findings, sub-therapeutic inhibition of MAGMAS using the novel BT#9 inhibitor, in combination with increasing concentrations of DTX, enhanced the sensitivity of DR cells to DTX, as demonstrated by proliferation and clonogenic assays. Lastly, RNA tumor expression predicts overall survival (OS). Conclusions: These results implicate MAGMAS in PCa chemoresistance and suggest that targeting this protein could provide a novel therapeutic strategy for treating DR tumors.

Benzo[c][1,2,5]oxadiazoles and benzo[c][1,2,5]thiadiazoles are recognized to possess potent pharmacological activities including anticancer potential. In continuation of our research endeavors in the development of boron-based heterocycles as potential therapeutic agents, herein we report the design and synthesis of new series of boron-based benzo[c][1,2,5]oxadiazoles and benzo[c][1,2,5]thiadiazoles as anticancer agents targeting tumor hypoxia. A series of seventeen compounds were synthesized in two steps in an efficient manner via substitution reactions followed by subsequent hydrolysis of aryltrifluoroboronate salts into corresponding boronic acid derivatives in the presence of silica. This is the first example to develop boron-based hypoxia agents. The synthesized hybrids were characterized by suitable spectroscopic techniques. The biological studies are currently underway.