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Management of Burns
The current goal in the care of patients with burns is to improve functional and cosmetic outcomes. Skin care and the toxic effects of smoke inhalation on the lungs are the two major clinical issues. Advances in fluid and metabolic support have improved survival.
Journal Article
Mornings on horseback
Examines the life of Theodore Roosevelt from age ten to twenty-seven, focusing on the influence of his family relationships and experiences on his growth to manhood.
Book
Plastics as a materials system in a circular economy
Plastics have transformed our modern world. With a range of outstanding properties, they are used in an ever-widening range of applications. However, the linear economy of their use means that a large volume of plastics is discarded after use. It is believed that approximately 80% of the estimated total 6.3 Bt of plastics ever produced have been discarded, representing not only a huge loss of valuable resources, but mismanaged waste is also the origin of an ever-increasing environmental disaster. Strategies to prevent loss of materials resources and damage to the environment are elements of a circular plastics economy that aims to maintain plastics at their highest value for the longest time possible and at the same time improve the economy and prevent detrimental environmental impact. The latter in particular is driving recent changes in policies and legislation across the world that are rapidly being introduced in order to solve these environmental issues. The achievement of a circular economy will require not only innovative technical developments, but also major economic investment and changes to business practice coupled with significant changes in social behaviour. This paper summarizes the complex and highly interrelated technical issues and provides an overview of the major challenges, potential solutions and opportunities required to achieve and operate a circular plastics economy. This article is part of a discussion meeting issue ‘Science to enable the circular economy’.
Journal Article
Macrophages as regulators of tumour immunity and immunotherapy
Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. As a result, tumour macrophages display an ability to suppress T cell recruitment and function as well as to regulate other aspects of tumour immunity. With the increasing impact of cancer immunotherapy, macrophage targeting is now being evaluated in this context. Here, we discuss the results of clinical trials and the future of combinatorial immunotherapy.In this Review, DeNardo and Ruffell describe how macrophages shape local immune responses in the tumour microenvironment to both suppress and promote immunity to tumours. The authors also discuss the potential of targeting tumour-associated macrophages to enhance antitumour immune responses.
Journal Article
Aging in world history
\"Contemporary concerns about aging societies have stimulated interest in past ways of growing old, and whilst historians have investigated the experience of the aged, cultural representations of old age, and the phenomenon of demographic ageing, however the literature has been overwhelmingly western. This study reviews the world-wide literature on aging and seeks to move beyond received wisdom about attitudes and experiences running from the ancient world to the present.Aging in World History will introduce students and general readers to historical ways of thinking about aging in two senses: the experience of individuals and the transformation of populations. The first section introduces theoretical concerns, understandings of \"natural\" or \"traditional\" ways of growing old, and diverse cultural prescriptions and representations. The second section covers key issues from the medieval to the early modern era. The third section looks at transitions to modernity, whilst the final part explores the contemporary world, before concluding with an overview of past, present and future\"-- Provided by publisher.
Book
collapse of the Kyoto Protocol and the struggle to slow global warming
Even as the evidence of global warming mounts, the international response to this serious threat is coming unraveled. The United States has formally withdrawn from the 1997 Kyoto Protocol; other key nations are facing difficulty in meeting their Kyoto commitments; and developing countries face no limit on their emissions of the gases that cause global warming. In this clear and cogent book-reissued in paperback with an afterword that comments on recent events--David Victor explains why the Kyoto Protocol was never likely to become an effective legal instrument. He explores how its collapse offers opportunities to establish a more realistic alternative.
Global warming continues to dominate environmental news as legislatures worldwide grapple with the process of ratification of the December 1997 Kyoto Protocol. The collapse of the November 2000 conference at the Hague showed clearly how difficult it will be to bring the Kyoto treaty into force. Yet most politicians, policymakers, and analysts hailed it as a vital first step in slowing greenhouse warming. David Victor was not among them.
Kyoto's fatal flaw, Victor argues, is that it can work only if emissions trading works. The Protocol requires industrialized nations to reduce their emissions of greenhouse gases to specific targets. Crucially, the Protocol also provides for so-called \"emissions trading,\" whereby nations could offset the need for rapid cuts in their own emissions by buying emissions credits from other countries. But starting this trading system would require creating emission permits worth two trillion dollars--the largest single invention of assets by voluntary international treaty in world history. Even if it were politically possible to distribute such astronomical sums, the Protocol does not provide for adequate monitoring and enforcement of these new property rights. Nor does it offer an achievable plan for allocating new permits, which would be essential if the system were expanded to include developing countries.
The collapse of the Kyoto Protocol--which Victor views as inevitable--will provide the political space to rethink strategy. Better alternatives would focus on policies that control emissions, such as emission taxes. Though economically sensible, however, a pure tax approach is impossible to monitor in practice. Thus, the author proposes a hybrid in which governments set targets for both emission quantities and tax levels. This offers the important advantages of both emission trading and taxes without the debilitating drawbacks of each.
Individuals at all levels of environmental science, economics, public policy, and politics-from students to professionals--and anyone else hoping to participate in the debate over how to slow global warming will want to read this book.
eBook
Cooperation, Fast and Slow: Meta-Analytic Evidence for a Theory of Social Heuristics and Self-Interested Deliberation
Does cooperating require the inhibition of selfish urges? Or does \"rational\" self-interest constrain cooperative impulses? I investigated the role of intuition and deliberation in cooperation by meta-analyzing 67 studies in which cognitive-processing manipulations were applied to economic cooperation games (total N = 17,647; no indication of publication bias using Egger's test, Begg's test, or p-curve). My meta-analysis was guided by the social heuristics hypothesis, which proposes that intuition favors behavior that typically maximizes payoffs, whereas deliberation favors behavior that maximizes one's payoff in the current situation. Therefore, this theory predicts that deliberation will undermine pure cooperation (i.e., cooperation in settings where there are few future consequences for one's actions, such that cooperating is not in one's self-interest) but not strategic cooperation (i.e., cooperation in settings where cooperating can maximize one's payoff). As predicted, the meta-analysis revealed 17.3% more pure cooperation when intuition was promoted over deliberation, but no significant difference in strategic cooperation between more intuitive and more deliberative conditions.
Journal Article