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Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their circular shape limits their annotation and a complete functional elucidation is lacking. This makes their detection and biomedical application still challenging. Herein, we review the current knowledge of circRNA biogenesis and function, and of their involvement in tumorigenesis and potential utility in cancer-targeted therapy.
Journal Article
Critical theory and the digital
\"This Critical Theory and Contemporary Society volume offers an original analysis of the role of the digital in today's society. It rearticulates critical theory by engaging it with the challenges of the digital revolution to show how the digital is changing the ways in which we lead our politics, societies, economies, media, and even private lives. In particular, the work examines how the enlightenment values embedded within the culture and materiality of digital technology can be used to explain the changes that are occurring across society.Critical Theory and the Digital draws from the critical concepts developed by critical theorists to demonstrate how the digital needs to be understood within a dialectic of potentially democratizing and totalizing technical power. By relating critical theory to aspects of a code-based digital world and the political economy that it leads to, the book introduces the importance of the digital code in the contemporary world to researchers in the field of politics, sociology, globalization and media studies\"-- Provided by publisher.
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THE PERILS OF LAUNDERING CONTROL THROUGH CUSTOMERS
Customer abuse of frontline service workers is widespread. Yet despite growing recognition of this problem, we know very little about the role that service companies play in potentially enabling customers’ abusive behaviors. This phenomenon deserves attention because one of the recent trends in service management is giving customers a direct role in managing and evaluating workers’ performance. In this article, the author explores how granting customers direct access to organizational power over workers, what the author develops conceptually as ‘‘laundering control through customers,’’ explains how customer abuse emerges. Drawing on a sample of 486 Uber and Lyft drivers, the author examines how the companies’ use of the ‘‘five-star’’ evaluation system enables customers to engage in a range of different forms of abuse and how workers resist this configuration of control. This study contributes to the customer triangle literature by bringing in evidence from the gig economy and uncovers new implications for the ‘‘dark side’’ of customer service work.
Journal Article
Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis
Despite recent progress in recognizing the importance of mesenchymal cells for the homeostasis of the intestinal system, the current picture of how these cells communicate with the associated epithelial layer remains unclear. To describe the relevant cell populations in an unbiased manner, we carried out a single-cell transcriptome analysis of the adult murine colon, producing a high-quality atlas of matched colonic epithelium and mesenchyme. We identify two crypt-associated colonic fibroblast populations that are demarcated by different strengths of platelet-derived growth factor receptor A (Pdgfra) expression. Crypt-bottom fibroblasts (CBFs), close to the intestinal stem cells, express low levels of Pdgfra and secrete canonical Wnt ligands, Wnt potentiators, and bone morphogenetic protein (Bmp) inhibitors. Crypt-top fibroblasts (CTFs) exhibit high Pdgfra levels and secrete noncanonical Wnts and Bmp ligands. While the Pdgfra low cells maintain intestinal stem cell proliferation, the Pdgfra high cells induce differentiation of the epithelial cells. Our findings enhance our understanding of the crosstalk between various colonic epithelial cells and their associated mesenchymal signaling hubs along the crypt axis—placing differential Pdgfra expression levels in the spotlight of intestinal fibroblast identity.
Journal Article
Staphylococcus aureus Genomic Analysis and Outcomes in Patients with Bone and Joint Infections: A Systematic Review
Many studies have been published assessing the association between the presence of S. aureus genes and outcomes in patients with bone and joint infections (BJI), but it is not known if they have had similar findings. A systematic literature review was performed. All available data on studies in Pubmed between January 2000 to October 2022 reporting the genetic characteristics of S. aureus and the outcomes of BJIs were analyzed. BJI included prosthetic joint infection (PJI), osteomyelitis (OM), diabetic foot infection (DFI), and septic arthritis. Because of the heterogeneity of studies and outcomes, no meta-analysis was performed. With the search strategy, 34 articles were included: 15 articles on children and 19 articles on adults. In children, most BJI studied were OM (n = 13) and septic arthritis (n = 9). Panton Valentine leucocidin (PVL) genes were associated with higher biological inflammatory markers at presentation (n = 4 studies), more febrile days (n = 3), and more complicated/severe infection (n = 4). Other genes were reported anecdotally associated with poor outcomes. In adults, six studies reported outcomes in patients with PJI, 2 with DFI, 3 with OM, and 3 with various BJI. Several genes were associated with a variety of poor outcomes in adults, but studies found contradictory results. Whereas PVL genes were associated with poor outcomes in children, no specific genes were reported similarly in adults. Additional studies with homogenous BJI and larger sample sizes are needed.
Journal Article