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The northeastern United States is a predominately-forested region that, like most of the eastern U.S., has undergone a 400-year history of intense logging, land clearance for agriculture, and natural reforestation. This setting affords the opportunity to address a major ecological question: How similar are today's forests to those existing prior to European colonization? Working throughout a nine-state region spanning Maine to Pennsylvania, we assembled a comprehensive database of archival land-survey records describing the forests at the time of European colonization. We compared these records to modern forest inventory data and described: (1) the magnitude and attributes of forest compositional change, (2) the geography of change, and (3) the relationships between change and environmental factors and historical land use. We found that with few exceptions, notably the American chestnut, the same taxa that made up the pre-colonial forest still comprise the forest today, despite ample opportunities for species invasion and loss. Nonetheless, there have been dramatic shifts in the relative abundance of forest taxa. The magnitude of change is spatially clustered at local scales (<125 km) but exhibits little evidence of regional-scale gradients. Compositional change is most strongly associated with the historical extent of agricultural clearing. Throughout the region, there has been a broad ecological shift away from late successional taxa, such as beech and hemlock, in favor of early- and mid-successional taxa, such as red maple and poplar. Additionally, the modern forest composition is more homogeneous and less coupled to local climatic controls.

\"Giant kelp (Macrocystis) is a remarkable plant, the largest seaweed and most rapidly growing and prolific of all plants found on earth. Growing from the seafloor and extending along the sea surface in lush canopies, giant kelp provides an extensive vertical habitat in a largely two-dimensional seascape. It is the foundation for one of the most species-rich, productive, and widely distributed ecological communities. Schiel and Foster's scholarly review and synthesis take the reader from the early observations by Darwin to the present day, providing a historical perspective for the modern understanding of giant kelp evolution, biogeography, biology, and physiology. This perspective is integrated into a thorough discussion of the species and forest ecology worldwide, with considerations of human uses and abuses, management and conservation, and the present effects of global change and likely future impacts. This volume promises to be the definitive treatise and reference on giant kelp and its forests for many years, and it will appeal to marine scientists and others who want a better appreciation and understanding of these wondrous forests of the sea\"-- Provided by publisher.

Nonrandom collecting practices may bias conclusions drawn from analyses of herbarium records. Recent efforts to fully digitize and mobilize regional floras online offer a timely opportunity to assess commonalities and differences in herbarium sampling biases. We determined spatial, temporal, trait, phylogenetic, and collector biases in c. 5 million herbarium records, representing three of the most complete digitized floras of the world: Australia (AU), South Africa (SA), and New England, USA (NE). We identified numerous shared and unique biases among these regions. Shared biases included specimens collected close to roads and herbaria; specimens collected more frequently during biological spring and summer; specimens of threatened species collected less frequently; and specimens of close relatives collected in similar numbers. Regional differences included overrepresentation of graminoids in SA and AU and of annuals in AU; and peak collection during the 1910s in NE, 1980s in SA, and 1990s in AU. Finally, in all regions, a disproportionately large percentage of specimens were collected by very few individuals. We hypothesize that these mega-collectors, with their associated preferences and idiosyncrasies, shaped patterns of collection bias via ‘founder effects’. Studies using herbarium collections should account for sampling biases, and future collecting efforts should avoid compounding these biases to the extent possible.

We review and synthesize information on invasions of nonnative forest insects and diseases in the United States, including their ecological and economic impacts, pathways of arrival, distribution within the United States, and policy options for reducing future invasions. Nonnative insects have accumulated in United States forests at a rate of

Changes in vegetation in North America indicate Holocene shifts in the latitudinal temperature gradient along the western margin of the North Atlantic. Tree taxa such as oak (Quercus) and birch (Betula) experienced opposing directions of change across different latitudes consistent with changes in temperature gradient steepness. Pollen‐inferred temperatures from 34 sites quantify the gradient changes and reconstruct a long‐term northward steepening in summer and southward steepening in winter. From 4.8 to 3.8 ka, an oscillation in tree distributions interrupted the long‐term trends as a steep temperature gradient developed north of 43.5°N. The shift likely limited cold outbreaks to the south, producing anomalously high summer temperatures at 42–43.5°N, and enabling a northward expansion of oak forests. The forest and temperature gradient changes appear consistent with orbital and ice sheet forcing as well as millennial variability in the North Atlantic pressure field analogous to the North Atlantic Oscillation on interannual time scales. Plain Language Summary In the Northern Hemisphere, average temperatures decline with latitude as climates cool toward the pole. Changes in this temperature pattern have significant consequences for weather systems and ecosystems. Past changes likely impacted the geographic extent of summer warmth and winter freezing that can determine where tree species can grow. In this study, fossil evidence of ancient tree distributions revealed how the poleward temperature gradient near the Atlantic coast of North America fluctuated over the past 11,700 years. Long‐term forest and temperature changes developed in response to the deglaciation of Canada and Earth's slow orbital changes. However, a particularly striking change 4,800–3,800 years ago briefly expanded oak‐hickory forests into mid‐latitude highlands otherwise dominated by cold‐tolerant northern tree species. The forest histories demonstrate the potential for ecosystems to change rapidly in the future, but also how fossil records can reveal poorly understood patterns and processes of millennial‐scale climate variability. Temperature patterns detected here may be analogous to patterns of climate variability in the North Atlantic region at monthly‐to‐annual scales. Key Points A major ecotone in eastern North America, which is linked to the latitudinal temperature gradient, shifted repeatedly during the Holocene Pollen‐inferred temperatures from different latitudes across the ecotone reveal gradient responses to deglaciation and orbital change Changes at 4.8–3.8 ka also indicate millennial‐scale variability with patterns analogous to the North Atlantic Oscillation

Purpose To establish an in vitro-in vivo correlation (IVIVC) model for Sporanox and SUBA-itraconazole formulations and to understand the impact of gastrointestinal (GI) pH and transit times on itraconazole dissolution and absorption. Methods IVIVC was developed based on fed/fasted pharmacokinetic data from randomized cross-over trials, in vitro dissolution studies, and prior information about typical and between subject variability of GI pH and transit times. Data were analysed using the population modelling approach as implemented in NONMEM. Results Dissolution kinetics were described using first order models. The in vivo pharmacokinetics of itraconazole was described with a 2-compartment model with 4-transit absorption compartments. Pharmacokinetic profiles for fasted itraconazole periods were described based on the in vitro dissolution model, in vivo disposition model, and the prior information on GI pH and transit times. The IVIVC model indicated that drug dissolution in the fed state required an additional pH-independent dissolution pathway. The IVIVC models were presented in a ‘Shiny’ application. Conclusion An IVIVC model was established and internally evaluated for the two itraconazole formulations. The IVIVC model provides more insight into the observed variability of itraconazole pharmacokinetics and indicated that GI pH and transit times influence in vivo dissolution and exposure.

In many forested ecosystems, the architecture and functional ecology of certain tree species define forest structure and their species-specific traits control ecosystem dynamics. Such foundation tree species are declining throughout the world due to introductions and outbreaks of pests and pathogens, selective removal of individual taxa, and over-harvesting. Through a series of case studies, we show that the loss of foundation tree species changes the local environment on which a variety of other species depend; how this disrupts fundamental ecosystem processes, including rates of decomposition, nutrient fluxes, carbon sequestration, and energy flow; and dramatically alters the dynamics of associated aquatic ecosystems. Forests in which dynamics are controlled by one or a few foundation species appear to be dominated by a small number of strong interactions and may be highly susceptible to alternating between stable states following even small perturbations. The ongoing decline of many foundation species provides a set of important, albeit unfortunate, opportunities to develop the research tools, models, and metrics needed to identify foundation species, anticipate the cascade of immediate, short- and long-term changes in ecosystem structure and function that will follow from their loss, and provide options for remedial conservation and management.

The development of old-growth forests in northeastern North America has largely been within the context of gap-scale disturbances given the rarity of stand-replacing disturbances. Using the 10-ha old-growth Harvard Tract and its associated 90-year history of measurements, including detailed surveys in 1989 and 2009, we document the long-term structural and biomass development of an old-growth Tsuga canadensis–Pinus strobus forest in southern New Hampshire, USA following a stand-replacing hurricane in 1938. Measurements of aboveground biomass pools were integrated with data from second- and old-growth T. canadensis forests to evaluate long-term patterns in biomass development following this disturbance. Ecosystem structure across the Tract prior to the hurricane exhibited a high degree of spatial heterogeneity with the greatest levels of live tree basal area (70–129 m2/ha) on upper west-facing slopes where P. strobus was dominant and intermixed with T. canadensis. Live-tree biomass estimates for these stratified mixtures ranged from 159 to 503 Mg/ha at the localized, plot scale (100 m2) and averaged 367 Mg/ha across these portions of the landscape approaching the upper bounds for eastern forests. Live-tree biomass 71 years after the hurricane is more uniform and lower in magnitude, with T. canadensis currently the dominant overstory tree species throughout much of the landscape. Despite only one living P. strobus stem in the 2009 plots (and fewer than five stems known across the entire 10-ha area), the detrital legacy of this species is pronounced with localized accumulations of coarse woody debris exceeding 237.7–404.2 m3/ha where this species once dominated the canopy. These patterns underscore the great sizes P. strobus attained in pre-European landscapes and its great decay resistance relative to its forest associates. Total aboveground biomass pools in this 71-year-old forest (255 Mg/ha) are comparable to those in modern old-growth ecosystems in the region that also lack abundant white pine. Results highlight the importance of disturbance legacies in affecting forest structural conditions over extended periods following stand-replacing events and underscore that post-disturbance salvage logging can alter ecosystem development for decades. Moreover, the dominant role of old-growth P. strobus in live and detrital biomass pools before and after the hurricane, respectively, demonstrate the disproportionate influence this species likely had on carbon storage at localized scales prior to the widespread, selective harvesting of large P. strobus across the region in the 18th and 19th centuries.