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The Pan-Andromeda Archaeological Survey is a survey of \\(>400\\) square degrees centered on the Andromeda (M31) and Triangulum (M33) galaxies that has provided the most extensive panorama of a \\(L_\\) galaxy group to large projected galactocentric radii. Here, we collate and summarise the current status of our knowledge of the substructures in the stellar halo of M31, and discuss connections between these features. We estimate that the 13 most distinctive substructures were produced by at least 5 different accretion events, all in the last 3 or 4 Gyrs. We suggest that a few of the substructures furthest from M31 may be shells from a single accretion event. We calculate the luminosities of some prominent substructures for which previous estimates were not available, and we estimate the stellar mass budget of the outer halo of M31. We revisit the problem of quantifying the properties of a highly structured dataset; specifically, we use the OPTICS clustering algorithm to quantify the hierarchical structure of M31's stellar halo, and identify three new faint structures. M31's halo, in projection, appears to be dominated by two `mega-structures', that can be considered as the two most significant branches of a merger tree produced by breaking M31's stellar halo into smaller and smaller structures based on the stellar spatial clustering. We conclude that OPTICS is a powerful algorithm that could be used in any astronomical application involving the hierarchical clustering of points. The publication of this article coincides with the public release of all PAndAS data products.

Sir: It is not surprising that when one goes to provincial Germany one should find it largely populated by provincial Germans.

Sir: I must say your article about the Archers signature tune (1 April) was the best spoof I've heard since the Guardian announced the existence of the island of San...

Sir: In your otherwise excellent feature on Vienna (Somewhere for the Weekend, 14 May) you state that the Emperor Franz...

The Gemini Infrared Multi-Object Spectrograph (GIRMOS) is a powerful new instrument being built to facility-class standards for the Gemini telescope. It takes advantage of the latest developments in adaptive optics and integral field spectrographs. GIRMOS will carry out simultaneous high-angular-resolution, spatially-resolved infrared (\\(1-2.4\\) \\(\\)m) spectroscopy of four objects within a two-arcminute field-of-regard by taking advantage of multi-object adaptive optics. This capability does not currently exist anywhere in the world and therefore offers significant scientific gains over a very broad range of topics in astronomical research. For example, current programs for high redshift galaxies are pushing the limits of what is possible with infrared spectroscopy at \\(8-10\\)-meter class facilities by requiring up to several nights of observing time per target. Therefore, the observation of multiple objects simultaneously with adaptive optics is absolutely necessary to make effective use of telescope time and obtain statistically significant samples for high redshift science. With an expected commissioning date of 2023, GIRMOS's capabilities will also make it a key followup instrument for the James Webb Space Telescope when it is launched in 2021, as well as a true scientific and technical pathfinder for future Thirty Meter Telescope (TMT) multi-object spectroscopic instrumentation. In this paper, we will present an overview of this instrument's capabilities and overall architecture. We also highlight how this instrument lays the ground work for a future TMT early-light instrument.

We have obtained limited photometric and spectroscopic data for Supernova (SN) 2008bk in NGC 7793, primarily at >~ 150 d after explosion. We find that it is a Type II-Plateau (II-P) SN which most closely resembles the low-luminosity SN 1999br in NGC 4900. Given the overall similarity between the observed light curves and colors of SNe 2008bk and 1999br, we infer that the total visual extinction to SN 2008bk (A_V=0.065 mag) must be almost entirely due to the Galactic foreground, similar to what has been assumed for SN 1999br. We confirm the identification of the putative red supergiant (RSG) progenitor star of the SN in high-quality g'r'i' images we had obtained in 2007 at the Gemini-South 8 m telescope. Little ambiguity exists in this progenitor identification, qualifying it as the best example to date, next to the identification of the star Sk -69 202 as the progenitor of SN 1987A. From a combination of photometry of the Gemini images with that of archival, pre-SN, Very Large Telescope JHK_s images, we derive an accurate observed spectral energy distribution (SED) for the progenitor. We find from nebular strong-intensity emission-line indices for several HII regions near the SN that the metallicity in the environment is likely subsolar (Z~0.6 Z_Sun). The observed SED of the star agrees quite well with synthetic SEDs obtained from model red supergiant atmospheres with effective temperature T_eff=3600+/-50 K. We find, therefore, that the star had a bolometric luminosity with respect to the Sun of log(L_bol/L_Sun)=4.57+/-0.06 and radius R_star=496+/-34 R_Sun at ~6 months prior to explosion. Comparing the progenitor's properties with theoretical massive-star evolutionary models, we conclude that the RSG progenitor had an initial mass in the range of 8--8.5 M_Sun. (Abridged.)

The synchronously rotating G stars in the detached, short-period (0.7 d), partially eclipsing binary, ER Vul, are the most chromospherically active solar-type stars known. We have monitored activity in the Ca II H & K reversals for almost an entire orbit. Rucinski's Broadening Function Formalism allows the photospheric contribution to be objectively subtracted from the highly blended spectra. The power of the BF technique is also demonstrated by the good agreement of radial velocities with those measured by others from less crowded spectral regions. In addition to strong Ca II emission from the primary and secondary, there appears to be a high-velocity stream flowing onto the secondary where it stimulates a large active region on the surface 30 - 40 degrees in advance of the sub-binary longitude. A model light curve with a spot centered on the same longitude also gives the best fit to the observed light curve. A flare with approximately 13% more power than at other phases was detected in one spectrum. We suggest ER Vul may offer a magnified view of the more subtle chromospheric effects synchronized to planetary revolution seen in certain `51 Peg'-type systems.

We discuss H and K observations of three fields in the bulge and disk of M31 obtained with the Altair adaptive optics system and NIRI instrument on Gemini North. These are the highest resolution and deepest near-infrared observations obtained to date of the inner regions of M31, and demonstrate the promise of ground-based adaptive optics for studying the crowded regions of nearby galaxies. We have combined our observations with previously published HST/NICMOS observations of nine M31 fields and have derived the coarse star formation histories of M31's bulge and inner disk. From fits to the M_K luminosity functions, we find the stellar population mix to be dominated by old, nearly solar-metallicity stars. The old populations, which we define as having age >~6 Gyr, indeed dominate the star formation histories at all radii independent of the relative contributions of bulge and disk stars. Although all of our fields contain some bulge contribution, our results suggest that there is no age difference between the bulge and disk to the limit of our precision.

AbstractObjectiveTo determine the efficacy of high dose folic acid supplementation for prevention of pre-eclampsia in women with at least one risk factor: pre-existing hypertension, prepregnancy diabetes (type 1 or 2), twin pregnancy, pre-eclampsia in a previous pregnancy, or body mass index ≥35.DesignRandomised, phase III, double blinded international, multicentre clinical trial.Setting70 obstetrical centres in five countries (Argentina, Australia, Canada, Jamaica, and UK).Participants2464 pregnant women with at least one high risk factor for pre-eclampsia were randomised between 2011 and 2015 (1144 to the folic acid group and 1157 to the placebo group); 2301 were included in the intention to treat analyses.InterventionEligible women were randomised to receive either daily high dose folic acid (four 1.0 mg oral tablets) or placebo from eight weeks of gestation to the end of week 16 of gestation until delivery. Clinicians, participants, adjudicators, and study staff were masked to study treatment allocation.Main outcome measureThe primary outcome was pre-eclampsia, defined as hypertension presenting after 20 weeks’ gestation with major proteinuria or HELLP syndrome (haemolysis, elevated liver enzymes, low platelets).ResultsPre-eclampsia occurred in 169/1144 (14.8%) women in the folic acid group and 156/1157 (13.5%) in the placebo group (relative risk 1.10, 95% confidence interval 0.90 to 1.34; P=0.37). There was no evidence of differences between the groups for any other adverse maternal or neonatal outcomes.ConclusionSupplementation with 4.0 mg/day folic acid beyond the first trimester does not prevent pre-eclampsia in women at high risk for this condition.Trial registrationCurrent Controlled Trials ISRCTN23781770 and ClinicalTrials.gov NCT01355159.

Doxorubicin‐induced cardiomyopathy is a clinically prevalent pathology, occurring as a sequelae following chemotherapy for cancer patients. In particular, the “first dose” effect has been particularly challenging, given the heterogeneous and multifactorial nature of this pathophysiology. Here, we describe the development of a physiologically relevant in vitro model for cardiotoxicity testing, using human cells. Primary cardiomyocytes, endothelial, and smooth muscle cells were tri‐cultured in 2D, or within nano‐fibrous scaffolds in a 3D environment, under dynamic nutrient flow, using the Quasi Vivo® system. State‐of‐the‐art sensor chips were used to detect troponin I levels, 2 h after acute exposure to doxorubicin. We demonstrate a significant improvement in cardiomyocyte viability when grown in a 3D tri‐culture environment over a 5‐day period and a 10‐fold reduction in doxorubicin‐induced toxicity. Our tri‐culture model can be used as a valuable tool for physiologically relevant assessment of drug‐induced cardiotoxicity in vitro. Here, we describe the development of a physiologically relevant in vitro model for cardiotoxicity testing, using a Quasi Vivo chamber (A). Primary cardiomyocytes, smooth muscle cells, and endothelial cells (B) were tri‐cultured in 2D, or within a nano‐fibrous scaffold, under dynamic nutrient flow conditions. We demonstrate a significant improvement in cardiomyocyte viability and reduced doxorubicin‐induced toxicity when grown in a 3D tri‐culture environment.