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The nature of emotion : fundamental questions
The editors of this unique volume asked some of the world's leading emotion researchers to address 14 fundamental questions about the nature and origins of emotion. Each chapter addresses one of these questions, with often divergent answers from the more than 100 experts represented here. At the end of each chapter, the editors highlight key areas of agreement and disagreement. In the final chapter, they outline the most important challenges facing the field and the most fruitful avenues for future research. Not a textbook offering a single viewpoint, 'The Nature of Emotion' reveals the central issues in emotion research and theory in the words of the leading scientists working in the field today, providing a unique and highly accessible guide for students, researchers, and clinicians.
BOOK
Completeness and complementarity for μ → eγ, μ → ee¯e and μA → eA
A
bstract
Lepton Flavour Violation (LFV) is New Physics that must occur, but is stringently constrained by experiments searching for
μ ↔ e
flavour change, such as
μ → eγ
,
μ →
e
e
¯
e
or
μ → e
conversion. However, in an Effective Field Theory(EFT) parametrisation, there are many more
μ ↔ e
operators than restrictive constraints, so determining operator coefficients from data is a remote dream. It is nonetheless interesting to learn about New Physics from data, so this manuscript introduces “observable-vectors” in the space of operator coefficients, which identify at any scale the combination of coefficients probed by the observable. These vectors have an overlap ≳ 10
−
3
with most of the coefficients, and are used to study whether
μ → eγ
,
μ →
e
e
¯
e
and
μ → e
conversion give complementary information about New Physics. The appendix gives updated sensitivities of these processes, (and a subset of
τ → ℓ
decays), to operator coefficients at the weak scale in the SMEFT and in the EFT below
m
W
.
Journal Article
Bioinspired underwater locomotion of light-driven liquid crystal gels
Soft-bodied aquatic invertebrates, such as sea slugs and snails, are capable of diverse locomotion modes under water. Recapitulation of such multimodal aquatic locomotion in small-scale soft robots is challenging, due to difficulties in precise spatiotemporal control of deformations and inefficient underwater actuation of existing stimuli-responsive materials. Solving this challenge and devising efficient untethered manipulation of soft stimuli-responsive materials in the aquatic environment would significantly broaden their application potential in biomedical devices. We mimic locomotion modes common to sea invertebrates using monolithic liquid crystal gels (LCGs) with inherent light responsiveness and molecular anisotropy. We elicit diverse underwater locomotion modes, such as crawling, walking, jumping, and swimming, by local deformations induced by selective spatiotemporal light illumination. Our results underpin the pivotal role of the physicomechanical properties of LCGs in the realization of diverse modes of light-driven robotic underwater locomotion. We envisage that our results will introduce a toolbox for designing efficient untethered soft robots for fluidic environments.
Journal Article
Renormalisation-group improved analysis of μ → e processes in a systematic effective-field-theory approach
A
bstract
In this article, a complete analysis of the three muonic lepton-flavour violating processes
μ
→
e
γ,
μ
→ 3
e
and coherent nuclear
μ
→
e
conversion is performed in the framework of an effective theory with dimension six operators defined below the electroweak symmetry breaking scale
m
W
. The renormalisation-group evolution of the Wilson coefficients between
m
W
and the experimental scale is fully taken into account at the leading order in QCD and QED, and explicit analytic and numerical evolution matrices are given. As a result, muonic decay and conversion rates are interpreted as functions of the Wilson coefficients at any scale up to
m
W
. Taking the experimental limits on these processes as input, the phenomenology of the mixing effects is investigated. It is found that a considerable set of Wilson coefficients unbounded in the simplistic tree-level approach are instead severely constrained. In addition, correlations among operators are studied both in the light of current data and future experimental prospects.
Journal Article
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar)
Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼ 480 individuals from the Cermaq Canada broodstock program and search for SNPs associated with growth and age at sexual maturation. Using a mixed model approach we identified markers showing a significant association with growth, grilsing (early sexual maturation) and late sexual maturation. The most significant associations were found for grilsing, with markers located in Ssa10, Ssa02, Ssa13, Ssa25 and Ssa12, and for late maturation with markers located in Ssa28, Ssa01 and Ssa21. A lower level of association was detected with growth on Ssa13. Candidate genes, which were linked to these genetic markers, were identified and some of them show a direct relationship with developmental processes, especially for those in association with sexual maturation. However, the relatively low power to detect genetic markers associated with growth (days to 5 kg) in this GWAS indicates the need to use a higher density SNP array in order to overcome the low levels of linkage disequilibrium observed in Atlantic salmon before the information can be incorporated into a selective breeding program.
Journal Article
Vaccine hesitancy educational tools for healthcare providers and trainees: A scoping review
In the era of vaccine hesitancy, highlighted by the current SARS-CoV2 pandemic, there is an acute need to develop an approach to reduce and address apprehension towards vaccinations. We sought to map and present an overview of existing educational interventions for healthcare providers (HCPs) on strategies to engage in effective vaccine discussion. We applied the Joanna Briggs Institute methodology framework in this scoping review. We searched five relevant databases (MEDLINE, CINAHL, EMBASE, PsycInfo, and SCOPUS) and grey literature through the Google search engine using keywords and subject headings that were systematically identified. We identified 3384 citations in peer-reviewed literature and 41 citations in grey literature. After screening for our inclusion criteria, we included 28 citations from peer reviewed literature and 16 citations from grey literature for analysis. We identified a total of 41 unique education interventions. Interventions were available from multiple disciplines, training levels, clinical settings, and diseases/vaccines. Interventions predominantly centered around two foci: knowledge sharing and communication training. Most interventions identified from peer-reviewed literature were facilitated and were applied with multiple modes of delivery. Interventions from grey literature were more topical and generally self-directed. We identified several gaps in knowledge. Firstly, accessibility and generalizability of interventions was limited. Secondly, distribution of interventions did not adequately address nursing and pharmacy disciplines, and did not cover the breadth of medical specialties for whom vaccine discussions apply. Thirdly, no interventions addressed self monitoring and the clinicians’ recognition and management of emotions during difficult conversations. There is a need to address this gap and provide available, credible and comprehensive educational interventions that will support our healthcare providers in effective communication with vaccine hesitant patients.
Journal Article
Combined impairments in vision, hearing and cognition are associated with greater levels of functional and communication difficulties than cognitive impairment alone: Analysis of interRAI data for home care and long-term care recipients in Ontario
The objective of the current study was to understand the added effects of having a sensory impairment (vision and/or hearing impairment) in combination with cognitive impairment with respect to health-related outcomes among older adults (65+ years old) receiving home care or residing in a long-term care (LTC) facility in Ontario, Canada.
Cross-sectional analyses were conducted using existing data collected with one of two interRAI assessments, one for home care (n = 291,824) and one for LTC (n = 110,578). Items in the assessments were used to identify clients with single sensory impairments (e.g., vision only [VI], hearing only [HI]), dual sensory impairment (DSI; i.e., vision and hearing) and those with cognitive impairment (CI). We defined seven mutually exclusive groups based on the presence of single or combined impairments.
The rate of people having all three impairments (i.e., CI+DSI) was 21.3% in home care and 29.2% in LTC. Across the seven groups, individuals with all three impairments were the most likely to report loneliness, to have a reduction in social engagement, and to experience reduced independence in their activities of daily living (ADLs) and instrumental ADLs (IADLs). Communication challenges were highly prevalent in this group, at 38.0% in home care and 49.2% in LTC. In both care settings, communication difficulties were more common in the CI+DSI group versus the CI-alone group.
The presence of combined sensory and cognitive impairments is high among older adults in these two care settings and having all three impairments is associated with higher rates of negative outcomes than the rates for those having CI alone. There is a rising imperative for all health care professionals to recognize the potential presence of hearing, vision and cognitive impairments in those for whom they provide care, to ensure that basic screening occurs and to use those results to inform care plans.
Journal Article
Wildfire and degradation accelerate northern peatland carbon release
The northern peatland carbon sink plays a vital role in climate regulation; however, the future of the carbon sink is uncertain, in part, due to the changing interactions of peatlands and wildfire. Here, we use empirical datasets from natural, degraded and restored peatlands in non-permafrost boreal and temperate regions to model net ecosystem exchange and methane fluxes, integrating peatland degradation status, wildfire combustion and post-fire dynamics. We find that wildfire processes reduced carbon uptake in pristine peatlands by 35% and further enhanced emissions from degraded peatlands by 10%. The current small net sink is vulnerable to the interactions of peatland degraded area, burn rate and peat burn severity. Climate change impacts accelerated carbon losses, where increased burn severity and burn rate reduced the carbon sink by 38% and 65%, respectively, by 2100. However, our study demonstrates the potential for active peatland restoration to buffer these impacts.Northern peatland carbon sink plays a vital role in climate regulation. Here, the authors show that wildfire reduced peatland carbon uptake and enhanced emissions from degraded peatlands; climate change impacts accelerated carbon losses where increased burn rate and severity reduced carbon sink.
Journal Article
Targeting myocardial ischaemic injury in the absence of reperfusion
Sudden myocardial ischaemia causes an acute coronary syndrome. In the case of ST-elevation myocardial infarction (STEMI), this is usually caused by the acute rupture of atherosclerotic plaque and obstruction of a coronary artery. Timely restoration of blood flow can reduce infarct size, but ischaemic regions of myocardium remain in up to two-thirds of patients due to microvascular obstruction (MVO). Experimentally, cardioprotective strategies can limit infarct size, but these are primarily intended to target reperfusion injury. Here, we address the question of whether it is possible to specifically prevent ischaemic injury, for example in models of chronic coronary artery occlusion. Two main types of intervention are identified: those that preserve ATP levels by reducing myocardial oxygen consumption, (e.g. hypothermia; cardiac unloading; a reduction in heart rate or contractility; or ischaemic preconditioning), and those that increase myocardial oxygen/blood supply (e.g. collateral vessel dilation). An important consideration in these studies is the method used to assess infarct size, which is not straightforward in the absence of reperfusion. After several hours, most of the ischaemic area is likely to become infarcted, unless it is supplied by pre-formed collateral vessels. Therefore, therapies that stimulate the formation of new collaterals can potentially limit injury during subsequent exposure to ischaemia. After a prolonged period of ischaemia, the heart undergoes a remodelling process. Interventions, such as those targeting inflammation, may prevent adverse remodelling. Finally, harnessing of the endogenous process of myocardial regeneration has the potential to restore cardiomyocytes lost during infarction.
Journal Article
Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop
The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2–ERIC–PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due to the disconnect between preclinical and clinical studies. Discussion points included how to adapt preclinical animal studies to mirror the patient presenting with an acute myocardial infarction, as well as how to refine patient selection in clinical studies to account for co-morbidities and ongoing therapy. These latter scenarios can modify cytoprotective signalling and need to be taken into account to allow for a more robust outcome when powered appropriately. The workshop also discussed the potential for RIC in other disease settings including ischaemic stroke, cardio-oncology and COVID-19. The workshop, therefore, put forward specific classifications which could help identify so-called responders vs. non-responders in both the preclinical and clinical settings.
Journal Article