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Urban agriculture can contribute to food security, food system resilience and sustainability at the city level. Whilst studies have examined urban agricultural productivity, we lack systemic knowledge of how agricultural productivity of urban systems compares to conventional agriculture and how productivity varies for different urban spaces (e.g., allotments vs. rooftops vs. indoor farming) and growing systems (e.g., hydroponics vs. soil-based agriculture). Here, we present a global meta-analysis that seeks to quantify crop yields of urban agriculture for a broad range of crops and explore differences in yields for distinct urban spaces and growing systems. We found 200 studies reporting urban crop yields, from which 2,062 observations were extracted. ‘Lettuces and chicories’ were the most studied urban grown crops. We observed high agronomic suitability of urban areas, with urban agricultural yields on par with or greater than global average conventional agricultural yields. ‘Cucumbers and gherkins’ were the category of crops for which differences in yields between urban and conventional agriculture were the greatest (17 kg m-2 cycle-1 vs. 3.8 kg m-2 cycle-1). Some urban spaces and growing systems also had a significant effect on specific crop yields (e.g., tomato yields in hydroponic systems were significantly greater than tomato yields in soil-based systems). This analysis provides a more robust, globally-relevant evidence base on the productivity of urban agriculture that can be used in future research and practice relating to urban agriculture, especially in scaling-up studies aiming to estimate the self-sufficiency of cities and towns and their potential to meet local food demand.

Ecosystems limited in phosphorous (P) are widespread, yet there is limited understanding of how these ecosystems may respond to anthropogenic deposition of nitrogen (N) and the interconnected effects on the biogeochemical cycling of carbon (C), N, and P. Here, we investigate the consequences of enhanced N addition for the C–N–P pools of two P-limited grasslands, one acidic and one limestone, occurring on contrasting soils, and we explore their responses to a long-term nutrient-manipulation experiment. We do this by combining data with an integrated C–N–P cycling model (N14CP). We explore the role of P-access mechanisms by allowing these to vary in the modelling framework and comparing model plant–soil C–N–P outputs to empirical data. Combinations of organic P access and inorganic P availability most closely representing empirical data were used to simulate the grasslands and quantify their temporal response to nutrient manipulation. The model suggested that access to organic P is a key determinant of grassland nutrient limitation and responses to experimental N and P manipulation. A high rate of organic P access allowed the acidic grassland to overcome N-induced P limitation, increasing biomass C input to soil and promoting soil organic carbon (SOC) sequestration in response to N addition. Conversely, poor accessibility of organic P for the limestone grassland meant N provision exacerbated P limitation and reduced biomass input to the soil, reducing soil carbon storage. Plant acquisition of organic P may therefore play an important role in reducing P limitation and determining responses to anthropogenic changes in nutrient availability. We conclude that grasslands differing in their access to organic P may respond to N deposition in contrasting ways, and where access is limited, soil organic carbon stocks could decline.

The association between lymphopenia and autoimmunity is recognized, but the underlying mechanisms are poorly understood and have not been studied systematically in humans. People with multiple sclerosis treated with the lymphocyte-depleting monoclonal antibody alemtuzumab offer a unique opportunity to study this phenomenon; one in three people develops clinical autoimmunity, and one in three people develops asymptomatic autoantibodies after treatment. Here, we show that T-cell recovery after alemtuzumab is driven by homeostatic proliferation, leading to the generation of chronically activated (CD28 ⁻CD57 ⁺), highly proliferative (Ki67 ⁺), oligoclonal, memory-like CD4 and CD8 T cells (CCR7 ⁻CD45RA ⁻ or CCR7 ⁻CD45RA ⁺) capable of producing proinflammatory cytokines. Individuals who develop autoimmunity after treatment are no more lymphopenic than their nonautoimmune counterparts, but they show reduced thymopoiesis and generate a more restricted T-cell repertoire. Taken together, these findings demonstrate that homeostatic proliferation drives lymphopenia-associated autoimmunity in humans.

The need to combat widespread degradation of grassland ecosystem services makes grassland restoration a global sustainability priority. However, simultaneously enhancing multiple ecosystem services (i.e. ecosystem service multifunctionality) is a major challenge for grassland restoration due to trade-offs among services. We use a long-term multifactor grassland restoration experiment established in 1989 on agriculturally improved, species-poor grassland in northern England, to assess how increasing the number of restoration treatments, including addition of manure, inorganic fertiliser, a seed mixture, and promotion of a nitrogen-fixing legume ( Trifolium pratense ), affects ecosystem service multifunctionality, based on 26 ecosystem service indicators measured between 2011 and 2014. We find that single interventions usually lead to trade-offs among services and thus have few positive effects on ecosystem service multifunctionality. However, ecosystem service multifunctionality increases with the number of restoration interventions, as trade-offs are reduced. Our findings highlight the significant potential for combined use of multiple targeted interventions to aid the restoration of ecosystem service multifunctionality in degraded grasslands, and potentially, other ecosystems. Widespread grassland degradation poses major societal and environmental challenges. Here, the authors propose multiple targeted interventions as a crucial strategy for simultaneously enhancing grassland ecosystem services and improving their equitability.

Most patients with advanced non-small cell lung cancer (NSCLC) have a poor prognosis and receive limited benefit from conventional treatments, especially in later lines of therapy. In recent years, several novel therapies have been approved for second- and third-line treatment of advanced NSCLC. In light of these approvals, it is valuable to understand the uptake of these new treatments in routine clinical practice and their impact on patient care. A systematic literature search was conducted in multiple scientific databases to identify observational cohort studies published between January 2010 and March 2017 that described second- or third-line treatment patterns and clinical outcomes in patients with advanced NSCLC. A qualitative data synthesis was performed because a meta-analysis was not possible due to the heterogeneity of the study populations. A total of 12 different study cohorts in 15 articles were identified. In these cohorts, single-agent chemotherapy was the most commonly administered treatment in both the second- and third-line settings. In the 5 studies that described survival from the time of second-line treatment initiation, median overall survival ranged from 4.6 months (95% CI, 3.8-5.7) to 12.8 months (95% CI, 10.7-14.5). There was limited information on the use of biomarker-directed therapy in these patient populations. This systematic literature review offers insights into the adoption of novel therapies into routine clinical practice for second- and third-line treatment of patients with advanced NSCLC. This information provides a valuable real-world context for the impact of recently approved treatments for advanced NSCLC.

The global demand for providing nutritious, sustainable, and safe diets for a 10 billion population by 2050 while preserving affordability, reducing environmental impacts, and adapting to climate change will require accelerating the transition to sustainable agri‐food systems. A plausible way to help tackle these challenges is by developing new plant varieties that have improved crop yield, plant nutritional quality, and sustainability (or resilience) traits. However, stakeholders, consumers, and citizens' concerns and appreciation of future‐proofing crops and the acceptability of new plant breeding strategies are not well‐established. These groups are actors in the agri‐food systems, and their views, values, needs, and expectations are crucial in helping to co‐design fair, ethical, acceptable, sustainable, and socially desirable policies on new plant breeding techniques (NPBTs) and the transition to sustainable agri‐food systems. In this study, we engaged with consumer experts and societal stakeholders to consider their perceptions, expectations, and acceptability of improving crops and NPBTs for future‐proofing the agri‐food systems. Our analysis points to a need for governments to take a proactive role in regulating NPBTs, ensure openness and transparency in breeding new crop varieties, and inform consumers about the effects of these breeding programmes and the risks and benefits of the new crop varieties developed. Consumer experts and societal stakeholders considered these strategies necessary to instil confidence in society about NPBTs and accelerate the transition to sustainable agri‐food systems. Stakeholders, consumers and citizens’ concerns and appreciation of future‐proofing crops and the acceptability of new plant breeding strategies are not well‐established. These groups are actors in the agri‐food systems, and their views, values, needs, and expectations are crucial for co‐designing fair, ethical, acceptable, sustainable, and socially desirable policies on New Plant Breeding Techniques (NPBTs) and transitioning to sustainable agri‐food systems. In this study, we engaged with consumer experts and societal stakeholders to consider their perceptions, expectations, and acceptability of improving crops and NPBTs for future‐proofing the agri‐food systems.

Background Climate change is one of the greatest threats to public health in this century. The UK is one of six countries that has enshrined in law a commitment to become net zero by 2050. However, there is a lack of guidance and structure for local government in the UK, which has responsibility for public health, to reach this goal and help their communities mitigate and adapt to the health and health inequality impacts of climate change. This study aimed to identify common barriers and facilitators related to addressing the health and health inequality impacts of climate change in local governments. Methods Using Normalisation Process Theory, we developed a two-round survey for people working in local authorities to identify the barriers and facilitators to including the health and health inequality impact of climate change in their climate action plans. The survey was delivered online via Qualtrics software. In the first-round respondents were able to express their views on barriers and facilitators and in the second round they ranked common themes identified from the first round. Two hundred and fifty people working in local government were invited to take part and n  = 28 (11.2%) completed the first round of the survey and n  = 14 completed the second round. Thematic analysis was used in Round 1 to identify common themes and weighted rankings were used to assess key barriers and facilitators in Round 2. Results Key facilitators were the need to save money on energy, and successful partnership working already in place including across local government, with local communities and external stakeholders. Key barriers were insufficient staff, resources and lack of support from management/leaders, and lack of local evidence. Conclusion To mitigate and adapt to the health impacts of climate change, local government must nurture a culture of innovation and collaboration to ensure that different departments work together This means not just working with external partners, but also collaborating and co-producing with communities to achieve health equity and mitigate the debilitating effect of climate change on public health.

Advances and the growing deployment of in-situ soil sensing has the potential to deliver new insights into soil system dynamics. However, it also calls for the development of efficient data analysis methods that can extract interpretable information from continuous data. This study utilises an automated, changepoint-based method for analysing soil moisture time series data. The method is used to autonomously detect wetting events and dynamically estimate parameters describing the drydown characteristics of the soil moisture following the event. Information can then be extracted from the output of the changepoint analysis. This provides an indication of how soils are responding to wetting events, and here we explore if this information corresponds with soil characteristics. In an illustration using soil moisture data from nine different field sites in the United States, different drydown characteristics were observed from the distributions of the estimated parameters. We find that these features can be associated to the climatic regimes and the soil texture of the sites. The potential for identifying changes in soil properties and processes based on shifts in drydown characteristics over time is discussed.

Hospitals are the largest greenhouse gas producers within the Australian healthcare sector due to the large amounts of energy, resource utilization, equipment and pharmaceuticals required to deliver care. In order to reduce healthcare emissions, healthcare services must take multiple actions to address the broad range of emissions produced when delivering patient care. The goal of this study was to seek consensus on the priority actions needed to reduce the environmental impact of a tertiary Australian hospital. A nominal group technique was utilized within a multidisciplinary, executive-led environmental sustainability committee to find consensus on the 62 proposed actions to reduce the environmental impact of a tertiary Australian hospital. Thirteen participants joined an online workshop during which an educational presentation was delivered, 62 potential actions were privately ranked according to two domains of ‘amenability to change’ and ‘scale of climate impact’ and a moderated group discussion ensued. The group achieved verbal consensus on 16 actions that span staff education, procurement, pharmaceuticals, waste, transport and advocacy on all-electric capital works upgrades. In addition, the individual ratings of potential actions according to each domain were ranked and shared with the group. Despite a large number of actions and varied perspectives within the group, the nominal group technique can be used to focus a hospital leadership group on priority actions to improve environmental sustainability.