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Theatre of Nepal and the people who make it
\"Theatre of Nepal and the People Who Make It' is the first comprehensive look at Nepali theatre for readers outside of Nepal. Charting Nepali theatre from ancient times to the present and from the metropolis of Kathmandu to far-flung regions, this book highlights the history of formal theatre and connects it to shifting political and social conditions in the country. Sourcing extensive fieldwork, it takes us back stage to meet individual theatre makers and learn their unique attributes and stories. From these intimate glimpses and the intertwining of political history with theatrical expression, a portrait emerges that conveys the character of Nepalis who, in spite of adversities, continue to dramatize their hopes, fears, principles, and priorities through theatrical means\"-- Provided by publisher.
Book
Sestrins are evolutionarily conserved mediators of exercise benefits
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways mediating the metabolic benefits of exercise have remained elusive. Here, we show that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits. In both fly and mouse models, genetic ablation of Sestrins prevents organisms from acquiring metabolic benefits of exercise and improving their endurance through training. Conversely, Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it could be a major effector of exercise metabolism. Among the various targets modulated by Sestrin in response to exercise, AKT and PGC1α are critical for the Sestrin effects in extending endurance. These results indicate that Sestrin is a key integrating factor that drives the benefits of chronic exercise to metabolism and physical endurance.
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.
Journal Article
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss
The acute traumatic or surgical loss of skeletal muscle, known as volumetric muscle loss (VML), is a devastating type of injury that results in exacerbated and persistent inflammation followed by fibrosis. The mechanisms that mediate the magnitude and duration of the inflammatory response and ensuing fibrosis after VML remain understudied, and as such, the development of regenerative therapies has been limited. To address this need, we profiled how lipid mediators, which are potent regulators of the immune response after injury, varied with VML injuries that heal or result in fibrosis. We observed that non-healing VML injuries displayed increased pro-inflammatory eicosanoids and a lack of pro-resolving lipid mediators. Treatment of VML with a pro-resolving lipid mediator synthesized from docosahexaenoic acid, called Maresin 1, ameliorated fibrosis through reduction of neutrophils and macrophages and enhanced recovery of muscle strength. These results expand our knowledge of the dysregulated immune response that develops after VML and identify a novel immuno-regenerative therapeutic modality in Maresin 1.
Journal Article
Bart Simpson Blastoff
Countdown to laughter. . .Bart Simpson will send you over the moon with high-octane hilarity as he leads the Springfield Elementary team to the state eating competition, does his best not to embarrass Marge on Mother's Day, learns a Kwik-E life lesson from Apu, gets a little bedtime assistance from Maggie, bonds with Grampa over a junky jalopy, and foils Mr. Burns' plan to sidestep Springfield's child labor laws. Then, Lisa gets some surprising competition as she squares off against Bart in a contest to win a prized pony, teenagers Homer and Barney encounter zombies, and much, much more! It's a supersonic, supercharged, Bart Simpson shebang!
Book
The Effects of Physical Activity on Engagement in Young Children with Autism Spectrum Disorder
Physical activity (PA) is linked to multiple positive health outcomes for young children, with potential benefits in other domains as well. Engaging in higher intensity PA may produce positive gains for children with autism spectrum disorders (ASD), especially in academic engagement and on-task behavior. However, there is limited research documenting current levels of PA in young children with ASD and effective strategies for early childhood educators to increase PA. The aim of this study is to address these gaps by examining the extent to which embedded antecedent exercise (AE) increases and sustains engagement for children with ASD in early childhood settings. Three kindergarten students with ASD participated in this study, using a single-case withdrawal design to investigate the relationship between intensity of PA and student engagement during two unique classroom activities. Overall, results showed an increase in student engagement across classroom activities after participating in embedded AE.
Journal Article
School shootings and mental health outcomes: a scoping review
ObjectiveRecent data indicate a rising frequency of school shootings over the past two decades. Although these events are relatively rare within the broader context of firearm violence, more than 357 000 students have been exposed to firearm violence in primary and secondary schools since 1999. However, the psychological impacts remain poorly understood. This scoping review synthesises existing evidence and highlights gaps for further research.MethodsA systematic search was conducted across PubMed, PsycINFO, Web of Science and Criminal Justice Abstracts to identify empirical studies on school shootings and mental health outcomes. Inclusion criteria encompassed all publication dates, study designs and populations affected. Key attributes were extracted and analysed from included studies.ResultsOf 2798 studies identified, 84 met inclusion criteria, with 13% being qualitative. Despite covering 19 unique shootings, 40% of the articles focused on Virginia Tech and Northern Illinois University. Most studies were cross-sectional (42%), and students were the primary population studied (80%). Post-traumatic stress disorder (29%) and depression (11%) were the most commonly studied outcomes. Common predictors included age (13%) and trauma history (12%). Higher exposure levels to school shootings, prior trauma and existing mental health conditions were key predictors of adverse mental health outcomes. Social support from family or peers emerged as protective factors.ConclusionWhile findings of this review suggest that there is a substantial impact of school shootings on survivors’ mental health, additional research is needed to encompass impacted communities beyond students, integrate qualitative methods and incorporate longitudinal studies to track mental health outcomes over time.
Journal Article
Gene Expression and Silencing Studies in Phytophthora infestans Reveal Infection-Specific Nutrient Transporters and a Role for the Nitrate Reductase Pathway in Plant Pathogenesis
To help learn how phytopathogens feed from their hosts, genes for nutrient transporters from the hemibiotrophic potato and tomato pest Phytophthora infestans were annotated. This identified 453 genes from 19 families. Comparisons with a necrotrophic oomycete, Pythium ultimum var. ultimum, and a hemibiotrophic fungus, Magnaporthe oryzae, revealed diversity in the size of some families although a similar fraction of genes encoded transporters. RNA-seq of infected potato tubers, tomato leaves, and several artificial media revealed that 56 and 207 transporters from P. infestans were significantly up- or down-regulated, respectively, during early infection timepoints of leaves or tubers versus media. About 17 were up-regulated >4-fold in both leaves and tubers compared to media and expressed primarily in the biotrophic stage. The transcription pattern of many genes was host-organ specific. For example, the mRNA level of a nitrate transporter (NRT) was about 100-fold higher during mid-infection in leaves, which are nitrate-rich, than in tubers and three types of artificial media, which are nitrate-poor. The NRT gene is physically linked with genes encoding nitrate reductase (NR) and nitrite reductase (NiR), which mobilize nitrate into ammonium and amino acids. All three genes were coregulated. For example, the three genes were expressed primarily at mid-stage infection timepoints in both potato and tomato leaves, but showed little expression in potato tubers. Transformants down-regulated for all three genes were generated by DNA-directed RNAi, with silencing spreading from the NR target to the flanking NRT and NiR genes. The silenced strains were nonpathogenic on leaves but colonized tubers. We propose that the nitrate assimilation genes play roles both in obtaining nitrogen for amino acid biosynthesis and protecting P. infestans from natural or fertilization-induced nitrate and nitrite toxicity.
Journal Article
Stability of the fcc phase in shocked nickel up to 332 GPa
Despite making up 5-20 wt.% of Earth’s predominantly iron core, the melting properties of elemental nickel at core conditions remain poorly understood, due largely to a dearth of experimental data. We present here an in situ X-ray diffraction study performed on laser shock-compressed samples of bulk nickel, reaching pressures up to ~ 500 GPa. Hugoniot states of nickel were targeted using a flat-top laser drive, with in situ X-ray diffraction data collected using the Linac Coherent Light Source. Rietveld methods were used to determine the densities of the shocked states from the measured diffraction data, while peak pressures were determined using a combination of measured particle velocities, shock transit times, hydrodynamic simulations, and laser intensity calibrations. We observed solid compressed face-centered cubic (fcc) Ni up to at least 332 ± 30 GPa along the Hugoniot—significantly higher than expected from the majority of melt lines that have been proposed for nickel. We also bracket the partial melting onset to between 377 ± 38 GPa and 486 ± 35 GPa.
Shocked compression experiments support the melt line of nickel above that of iron, as recently theorised, which helps to constrain the behavior of nickel at conditions relevant to Earth’s core where it makes up 5-20 wt %
Journal Article
51 School Shootings and Mental Health in the United States
OBJECTIVES/GOALS: It is estimated that 357,000 children have experienced a school shooting since 1999, yet due to limitations in the firearm violence field broadly, the sequalae are not well understood. The objective of this work is to examine the mental health impacts of school shootings, providing insight into the lasting effects of firearm violence on our communities. METHODS/STUDY POPULATION: We will first conduct a quasi-experimental study using controlled interrupted time series with repeated cross-sectional data to assess school shootings’ impact on US mental health. School shooting data is from the K-12 School Shooting Database, and mental health data will be collected via the Behavioral Risk Factor Surveillance System. Second, we will conduct focus groups with community organizations, school administrators, and the public. Interview guides will be developed to explore the mental health impacts of school shootings, to guide the quantitative results interpretation, and assess educational materials’ usefulness. Qualitative analysis will occur in NVivo software with codebook refinement through thematic analysis. Results will be triangulated through convergence coding. RESULTS/ANTICIPATED RESULTS: This research is situated within the context of the pervasive mental health challenges in the US, where mental illness poses significant health, social, and economic burdens. Thus, we anticipate finding an association between school shootings and decreased self-reported mental well-being among US adults. Literature suggests that there may be a stronger association among specific subgroups, such as parents with school-aged children or individuals living in close proximity to such incidents. We expect to find heterogeneity in the effect estimate based on school shooting attributes, such as the number of casualties. Through focus groups, we anticipate furthering our comprehension of the broad-ranging effects of school shootings on less quantifiable outcomes and the unique trajectories of recovery. DISCUSSION/SIGNIFICANCE: This project will contribute needed information on the impact of school shootings and mental health and assist in reducing the frequency and impact of school shootings. Furthermore, we aim to extend our findings beyond the scientific community, translating them into educational resources advocating for policy and public health interventions.
Journal Article