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"Davis, Emma"
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The joy of yoga : fifty sequences for your home and studio practice
The Joy of Yoga offers short sequences that readers can perform while seated on airplanes, in taxi cabs, standing at the bus stop, or even while waiting for water to boil. In addition, it also includes sequences to help with daily aches, pains, and annoyances, such as tired feet, sensitive wrists, neck and shoulder tension, lower back pain, anxiety, and even heartbreak. Weekend gardeners, cyclists, runners, musicians, and waiters/waitresses will also find exercises that will help ease the tension in their muscles after long hours of work or play. The Joy of Yoga will also provide step-by-step instructions on asana (postures) and pranayama (breathing techniques) for fifty sequences List the benefits of each sequence and include helpful information about modifications for poses encourage readers to create sequences on their own, using the sequences in the book as starting points.
Book
An analytically tractable, age-structured model of the impact of vector control on mosquito-transmitted infections
Vector control is a vital tool utilised by malaria control and elimination programmes worldwide, and as such it is important that we can accurately quantify the expected public health impact of these methods. There are very few previous models that consider vector-control-induced changes in the age-structure of the vector population and the resulting impact on transmission. We analytically derive the steady-state solution of a novel age-structured deterministic compartmental model describing the mosquito feeding cycle, with mosquito age represented discretely by parity—the number of cycles (or successful bloodmeals) completed. Our key model output comprises an explicit, analytically tractable solution that can be used to directly quantify key transmission statistics, such as the effective reproductive ratio under control, R c , and investigate the age-structured impact of vector control. Application of this model reinforces current knowledge that adult-acting interventions, such as indoor residual spraying of insecticides (IRS) or long-lasting insecticidal nets (LLINs), can be highly effective at reducing transmission, due to the dual effects of repelling and killing mosquitoes. We also demonstrate how larval measures can be implemented in addition to adult-acting measures to reduce R c and mitigate the impact of waning insecticidal efficacy, as well as how mid-ranges of LLIN coverage are likely to experience the largest effect of reduced net integrity on transmission. We conclude that whilst well-maintained adult-acting vector control measures are substantially more effective than larval-based interventions, incorporating larval control in existing LLIN or IRS programmes could substantially reduce transmission and help mitigate any waning effects of adult-acting measures.
Journal Article
Yoga twists and turns : 50 sequences to take your practice to the next level
\"A series of warm-ups, yoga postures, and stretches to lead to specific intermediate and advanced yoga postures\"--Page 4 of cover.
Book
Conservation of Earth’s biodiversity is embedded in Indigenous fire stewardship
Increasingly, severe wildfires have led to declines in biodiversity across all of Earth’s vegetated biomes [D. B. McWethy et al., Nat. Sustain. 2, 797–804 (2019)]. Unfortunately, the displacement of Indigenous peoples and place-based societies that rely on and routinely practice fire stewardship has resulted in significant declines in biodiversity and the functional roles of people in shaping pyrodiverse systems [R. Bliege Bird et al., Proc. Natl. Acad. Sci. U.S.A. 117, 12904–12914 (2020)]. With the aim of assessing the impacts of Indigenous fire stewardship on biodiversity and species function across Earth’s major terrestrial biomes, we conducted a review of relevant primary data papers published from 1900 to present. We examined how the frequency, seasonality, and severity of humanignited fires can improve or reduce reported metrics of biodiversity and habitat heterogeneity as well as changes to species composition across a range of taxa and spatial and temporal scales. A total of 79% of applicable studies reported increases in biodiversity as a result of fire stewardship, and 63% concluded that habitat heterogeneity was increased by the use of fire. All studies reported that fire stewardship occurred outside of the window of uncontrollable fire activity, and plants (woody and nonwoody vegetation) were the most intensively studied life forms. Three studies reported declines in biodiversity associated with increases in the use of high-severity fire as a result of the disruption of Indigenous-controlled fire regimes with the onset of colonization. Supporting Indigenous-led fire stewardship can assist with reviving important cultural practices while protecting human communities from increasingly severe wildfires, enhancing biodiversity, and increasing ecosystem heterogeneity.
Journal Article
Beautiful creatures : dark secrets will come to light
\"Lena has just moved to the small, Southern town of Gatlin, where the only person who seems to understand her, or dream of bigger places or ideas, is a cute guy named Ethan Wate, who recognizes her instantly from the cryptic dreams he's been having every night. Lena is an orphan, and she's come to stay with her mysterious uncle, Macon Ravenwood, the patriarch of her powerful family. Powerful, because The Ravenwood clan are Casters, born with powers that ordinary mortals don't have, like the ability to move objects, control the elements, and even step out of normal space and time to communicate only with each other. But just as Lena feels ready to open up to Ethan, she discovers that their love is in imminent danger, because when female Casters turn 16, their destiny as either good or evil is revealed. Unwilling to let her nature be dictated by forces outside her control, Lena and Ethan set out together to uncover the strange, secret lore of their families' intertwined histories dating back to the Civil War, and figure out how to grant Lena the power to choose her own destiny\"--Allmovie.com, September 28, 2018.
DVD
Regional variability in the response of alpine treelines to climate change
The distributions of many high-elevation tree species have shifted as a result of recent climate change; however, there is substantial variability in the movement of alpine treelines at local to regional scales. In this study, we derive records of tree growth and establishment from nine alpine treeline ecotones in the Canadian Rocky Mountains, characterise the influence of seasonal climate variables on four tree species (Abies lasiocarpa, Larix lyallii, Picea engelmannii, Pinus albicaulis) and estimate the degree to which treeline movement in the twentieth century has lagged or exceeded the rate predicted by recent temperature warming. The growth and establishment records revealed a widespread increase in radial growth, establishment frequency and stand density beginning in the mid-twentieth century. Coinciding with a period of warming summer temperatures and favourable moisture availability, these changes appear to have supported upslope treeline advance at all sites (range, 0.23–2.00 m/year; mean, 0.83 + 0.67 m/year). However, relationships with seasonal climate variables varied between species, and the rates of treeline movement lagged those of temperature warming in most cases. These results indicate that future climate change impacts on treelines in the region are likely to be moderated by species composition and to occur more slowly than anticipated based on temperature warming alone.
Journal Article
The proteomic landscape of microglia in health and disease
Microglia are the resident immune cells of the central nervous system (CNS) and as such play crucial roles in regulating brain homeostasis. Their presence in neurodegenerative diseases is known, with neurodegeneration-associated risk genes heavily expressed in microglia, highlighting their importance in contributing to disease pathogenesis. Transcriptomics studies have uncovered the heterogeneous landscape of microglia in health and disease, identifying important disease-associated signatures such as DAM, and insight into both the regional and temporal diversity of microglia phenotypes. Quantitative mass spectrometry methods are ever increasing in the field of neurodegeneration, utilised as ways to identify disease biomarkers and to gain deeper understanding of disease pathology. Proteins are the main mechanistic indicators of cellular function, yet discordance between transcript and proteomic findings has highlighted the need for in-depth proteomic phenotypic and functional analysis to fully understand disease kinetics at the cellular and molecular level. This review details the current progress of using proteomics to define microglia biology, the relationship between gene and protein expression in microglia, and the future of proteomics and emerging methods aiming to resolve heterogeneous cell landscapes.
Journal Article
Beta oscillations reflect changes in motor cortex inhibition in healthy ageing
Beta oscillations are involved in movement and have previously been linked to levels of the inhibitory neurotransmitter GABA. We examined changes in beta oscillations during rest and movement in primary motor cortex (M1). Amplitude and frequency of beta power at rest and movement-related beta desynchronization (MRBD) were measured during a simple unimanual grip task and their relationship with age was explored in a group of healthy participants. We were able to show that at rest, increasing age was associated with greater baseline beta power in M1 contralateral to the active hand, with a similar (non-significant) trend in ipsilateral M1. During movement, increasing age was associated with increased MRBD amplitude in ipsilateral M1 and reduced frequency (in contralateral and ipsilateral M1). These findings would be consistent with greater GABAergic inhibitory activity within motor cortices of older subjects. These oscillatory parameters have the potential to reveal changes in the excitatory–inhibitory balance in M1 which in turn may be a useful marker of plasticity in the brain, both in healthy ageing and disease.
•Changes in motor cortex beta oscillations are linked with changes in GABA.•Changes in GABA-related cortical inhibition are linked with plasticity.•Older subjects had higher resting beta power and greater beta decrease during grip.•Beta oscillations are useful markers of cortical inhibition and plasticity.
Journal Article
Preclinical In Vivo Evaluation and Screening of Zinc-Based Degradable Metals for Endovascular Stents
Zinc alloy development and characterization for vascular stent application have been facilitated by many standardized and inexpensive methods. In contrast, overly simplistic in vitro approaches dominate the preliminary biological testing of materials. In 2012, our group introduced a metal wire implantation model in rats as a cost-effective and realistic approach to evaluate the biocompatibility of degradable materials in the vascular environment. In this work, we adapted metrics routinely used for evaluating stents to quantitatively characterize the long-term progression of the neointima that forms around zinc-based wire implants. Histological cross-sections were used to measure the length of neointimal protrusion from the wire into the lumen (denoted wire to lumen thickness), the base neointimal length (describing the breadth of neointimal activation), and the neointimal area. These metrics were used to provide in-depth characterization details for neointimal responses to Zn-Mg and Zn-Li alloys and may be used to compare different materials.
Journal Article
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa translocator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinflammation and a new drug target in neurological diseases ranging from Alzheimer’s disease to anxiety. Here we show that global C57BL/6-
Tspo
tm1GuWu(GuwiyangWurra)
-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour. However, while the activation of microglia after neuronal injury appears to be unimpaired, microglia from
GuwiyangWurra
TSPO knockouts produce significantly less ATP, suggesting reduced metabolic activity. Using the isoquinoline PK11195, the ligand originally used for the pharmacological and structural characterization of the PBR/TSPO, and the imidazopyridines CLINDE and PBR111, we demonstrate the utility of
GuwiyangWurra
TSPO knockouts to provide robust data on drug specificity and selectivity, both
in vitro
and
in vivo
, as well as the mechanism of action of putative TSPO-targeting drugs.
The 18-kDa translocator protein (TSPO) has been implicated in steroid biogenesis and neuroinflammation. Here, the authors create viable and fertile global TSPO knockout mice, challenging the assumption that TSPO is essential for mouse development but suggesting that it may have a role under certain disease conditions.
Journal Article