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"Davis, Jocelyn R"
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The greats on leadership : classic wisdom for modern managers
\"THE GREATS ON LEADERSHIP: 20 CLASSIC THINKERS TEACH US TO LEAD You don't need a big title or a business degree in order to lead with impact. What you need is practical wisdom: the insight, judgment, and strength of character that all great leaders have, but that most business schools and corporate workshops don't teach. The Greats on Leadership gets you there.Jocelyn Davis takes you on an in-depth tour of the best leadership ideas of the past twenty-five centuries-featuring classic authors from Plato to Winston Churchill, William Shakespeare to Jane Austen, Alexander Hamilton to Peter Drucker, and many more-combined with the best contemporary leadership concepts and plenty of real-life tools and examples. No matter where in the organization you sit, this remarkably readable and practical guide will set you on the road to becoming a great leader. THE GREATS ON LEADERSHIP features: Leaders vs. Misleaders (Moses) Leadership Traps (Shakespeare) Change (Machiavelli) Justice (Plato) Power (Sophocles) Authority (Shakespeare) Crises (Shakespeare) Competition (Hannibal) Dilemmas (Madison, Hamilton) Communication (Pericles, Lincoln) Motivation (Viktor Frankl) Personality (C.G. Jung) Decisions (Roald Dahl) Culture (Ruth Benedict) Relationships (Maupassant) Accountability (Melville) Talent (Austen) Vision (G.B. Shaw) Character (Churchill, Shelley, Plutarch, Joyce) Leadership Levels (Lao Tzu) \"-- Provided by publisher.
Book
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious
in vivo
, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.
Three tropical diseases targeted by new drug
Chagas disease, leishmaniasis, and sleeping sickness are caused by the kinetoplastid parasites
Trypanosoma cruzi
,
Leishmania
spp. and
Trypanosoma brucei
spp., respectively, and affect 20 million people worldwide. This study reports the results of a screen to find new conserved molecular targets and broad spectrum drugs that could be used to treat all three diseases. A selective inhibitor of the kinetoplastid proteasome (GNF6702) was identified as the most effective. It is highly efficacious
in vivo
, clearing parasites from mice in all three models of infection. GNF6702 is a non-competitive inhibitor, specific for kinetoplastid proteasome, and is well-tolerated in mice. These results highlight the possibility of developing a single class of drugs for these neglected diseases.
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually
1
. The diseases are caused by infection with the kinetoplastid parasites
Trypanosoma cruzi
,
Leishmania
spp. and
Trypanosoma brucei
spp., respectively. These parasites have similar biology and genomic sequence, suggesting that all three diseases could be cured with drugs that modulate the activity of a conserved parasite target
2
. However, no such molecular targets or broad spectrum drugs have been identified to date. Here we describe a selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented
in vivo
efficacy, which cleared parasites from mice in all three models of infection. GNF6702 inhibits the kinetoplastid proteasome through a non-competitive mechanism, does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice. Our data provide genetic and chemical validation of the parasite proteasome as a promising therapeutic target for treatment of kinetoplastid infections, and underscore the possibility of developing a single class of drugs for these neglected diseases.
Journal Article
Analysis of variants in GATA4 and FOG2/ZFPM2 demonstrates benign contribution to 46,XY disorders of sex development
Background GATA‐binding protein 4 (GATA4) and Friend of GATA 2 protein (FOG2, also known as ZFPM2) form a heterodimer complex that has been shown to influence transcription of genes in a number of developmental systems. Recent evidence has also shown these genes play a role in gonadal sexual differentiation in humans. Previously we identified four variants in GATA4 and an unexpectedly large number of variants in ZFPM2 in a cohort of individuals with 46,XY Differences/Disorders of Sex Development (DSD) (Eggers et al, Genome Biology, 2016; 17: 243). Method Here, we review variant curation and test the functional activity of GATA4 and ZFPM2 variants. We assess variant transcriptional activity on gonadal specific promoters (Sox9 and AMH) and variant protein–protein interactions. Results Our findings support that the majority of GATA4 and ZFPM2 variants we identified are benign in their contribution to 46,XY DSD. Indeed, only one variant, in the conserved N‐terminal zinc finger of GATA4, was considered pathogenic, with functional analysis confirming differences in its ability to regulate Sox9 and AMH and in protein interaction with ZFPM2. Conclusions Our study helps define the genetic factors contributing to 46,XY DSD and suggests that the majority of variants we identified in GATA4 and ZFPM2/FOG2 are not causative. We identified a number of 46,XY DSD individuals with variants in GATA4 and FOG2. Variant curation and functional analysis revealed the majority of these variants are not likely to be causative.
Journal Article
Source decomposition of eddy-covariance CO2 flux measurements for evaluating a high-resolution urban CO2 emissions inventory
We present the comparison of source-partitioned CO2 flux measurements with a high-resolution urban CO2 emissions inventory (Hestia). Tower-based measurements of CO and 14C are used to partition net CO2 flux measurements into fossil and biogenic components. A flux footprint model is used to quantify spatial variation in flux measurements. We compare the daily cycle and spatial structure of Hestia and eddy-covariance derived fossil fuel CO2 emissions on a seasonal basis. Hestia inventory emissions exceed the eddy-covariance measured emissions by 0.36 µmol m−2 s−1 (3.2%) in the cold season and 0.62 µmol m−2 s−1 (9.1%) in the warm season. The daily cycle of fluxes in both products matches closely, with correlations in the hourly mean fluxes of 0.86 (cold season) and 0.93 (warm season). The spatially averaged fluxes also agree in each season and a persistent spatial pattern in the differences during both seasons that may suggest a bias related to residential heating emissions. In addition, in the cold season, the magnitudes of average daytime biological uptake and nighttime respiration at this flux site are approximately 15% and 27% of the mean fossil fuel CO2 emissions over the same time period, contradicting common assumptions of no significant biological CO2 exchange in northern cities during winter. This work demonstrates the effectiveness of using trace gas ratios to adapt eddy-covariance flux measurements in urban environments for disaggregating anthropogenic CO2 emissions and urban ecosystem fluxes at high spatial and temporal resolution.
Journal Article
فن النفوذ الصامت : حكمة خالدة .. لتتعلم القيادة دون امتلاك سلطة. كونفوشيوس-جلال الدين الرومي-غاندي-بوذا-الطاوية-معلموا ال \زن\ وغيرهم
تقوم ديفيز بعمل بارع في إظهار الصلة بين رؤى القدماء والتفكير الحديث والمتعلقة بمسائل القيادة والممارسة اليومية لها، تتميز قراءتها للحكماء الشرقيين بالحكمة والإنسانية والاستنارة، نشأ عن شرحها الموجز ونظرتها الفاحصة للأساطير والملاحم كتاب سيمنحك الكثير من الأمور التي ستتحدث عنها لسنوات أنه عبارة عن اثني عشر منهاجا حول القيادة في كتاب واحد مليء بالقصص والتقنيات العظيمة.
BOOK
The development and diversity of religious cognition and behavior: Protocol for Wave 1 data collection with children and parents by the Developing Belief Network
The Developing Belief Network is a consortium of researchers studying human development in diverse social-cultural settings, with a focus on the interplay between general cognitive development and culturally specific processes of socialization and cultural transmission in early and middle childhood. The current manuscript describes the study protocol for the network’s first wave of data collection, which aims to explore the development and diversity of religious cognition and behavior. This work is guided by three key research questions: (1) How do children represent and reason about religious and supernatural agents? (2) How do children represent and reason about religion as an aspect of social identity? (3) How are religious and supernatural beliefs transmitted within and between generations? The protocol is designed to address these questions via a set of nine tasks for children between the ages of 4 and 10 years, a comprehensive survey completed by their parents/caregivers, and a task designed to elicit conversations between children and caregivers. This study is being conducted in 39 distinct cultural-religious groups (to date), spanning 17 countries and 13 languages. In this manuscript, we provide detailed descriptions of all elements of this study protocol, give a brief overview of the ways in which this protocol has been adapted for use in diverse religious communities, and present the final, English-language study materials for 6 of the 39 cultural-religious groups who are currently being recruited for this study: Protestant Americans, Catholic Americans, American members of the Church of Jesus Christ of Latter-day Saints, Jewish Americans, Muslim Americans, and religiously unaffiliated Americans.
Journal Article
The influence of near-field fluxes on seasonal carbon dioxide enhancements: results from the Indianapolis Flux Experiment (INFLUX)
BackgroundNetworks of tower-based CO2 mole fraction sensors have been deployed by various groups in and around cities across the world to quantify anthropogenic CO2 emissions from metropolitan areas. A critical aspect in these approaches is the separation of atmospheric signatures from distant sources and sinks (i.e., the background) from local emissions and biogenic fluxes. We examined CO2 enhancements compared to forested and agricultural background towers in Indianapolis, Indiana, USA, as a function of season and compared them to modeled results, as a part of the Indianapolis Flux (INFLUX) project.ResultsAt the INFLUX urban tower sites, daytime growing season enhancement on a monthly timescale was up to 4.3–6.5 ppm, 2.6 times as large as those in the dormant season, on average. The enhancement differed significantly depending on choice of background and time of year, being 2.8 ppm higher in June and 1.8 ppm lower in August using a forested background tower compared to an agricultural background tower. A prediction based on land cover and observed CO2 fluxes showed that differences in phenology and drawdown intensities drove measured differences in enhancements. Forward modelled CO2 enhancements using fossil fuel and biogenic fluxes indicated growing season model-data mismatch of 1.1 ± 1.7 ppm for the agricultural background and 2.1 ± 0.5 ppm for the forested background, corresponding to 25–29% of the modelled CO2 enhancements. The model-data total CO2 mismatch during the dormant season was low, − 0.1 ± 0.5 ppm.ConclusionsBecause growing season biogenic fluxes at the background towers are large, the urban enhancements must be disentangled from the biogenic signal, and growing season increases in CO2 enhancement could be misinterpreted as increased anthropogenic fluxes if the background ecosystem CO2 drawdown is not considered. The magnitude and timing of enhancements depend on the land cover type and net fluxes surrounding each background tower, so a simple box model is not appropriate for interpretation of these data. Quantification of the seasonality and magnitude of the biological fluxes in the study region using high-resolution and detailed biogenic models is necessary for the interpretation of tower-based urban CO2 networks for cities with significant vegetation.
Journal Article
Interactions between Mediterranean Diet Supplemented with Dairy Foods and the Gut Microbiota Influence Cardiovascular Health in an Australian Population
The impact of a Mediterranean diet on the intestinal microbiome has been linked to its health benefits. We aim to evaluate the effects of a Mediterranean diet supplemented with dairy foods on the gut microbiome in Australians at risk of cardiovascular disease. In a randomised controlled cross-over study, 34 adults with a systolic blood pressure ≥120 mmHg and with risk factors for cardiovascular disease were randomly allocated to a Mediterranean diet with 3–4 daily serves of dairy foods (Australian recommended daily intake (RDI) of 1000–1300 mg per day (MedDairy)) or a low-fat (LFD) control diet. Between each 8-week diet, participants underwent an 8-week washout period. Microbiota characteristics of stool samples collected at the start and end of each diet period were determined by 16S rRNA amplicon sequencing. MedDairy-associated effects on bacterial relative abundance were correlated with clinical, anthropometric, and cognitive outcomes. No change in the overall faecal microbial structure or composition was observed with either diet (p > 0.05). The MedDairy diet was associated with changes in the relative abundance of several bacterial taxa, including an increase in Butyricicoccus and a decrease in Colinsella and Veillonella (p < 0.05). Increases in Butyricicoccus relative abundance over 8 weeks were inversely correlated with lower systolic blood pressure (r = −0.38, p = 0.026) and positively correlated with changes in fasting glucose levels (r = 0.39, p = 0.019), specifically for the MedDairy group. No significant associations were observed between the altered taxa and anthropometric or cognitive measures (p > 0.05). Compared to a low-fat control diet, the MedDairy diet resulted in changes in the abundance of specific gut bacteria, which were associated with clinical outcomes in adults at risk of CVD.
Journal Article