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"Davis, P"
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Treating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option
The buprenorphine receptor binding profile is unique in that it binds to all three major opioid receptors (mu, kappa, delta), and also binds to the orphan-like receptor, the receptor for orphanin FQ/nociceptin, with lower affinity. Within the mu receptor group, buprenorphine analgesia in rodents is dependent on the recently discovered arylepoxamide receptor target in brain, which involves a truncated 6-transmembrane mu receptor gene protein, distinguishing itself from morphine and most other mu opioids. Although originally designed as an analgesic, buprenorphine has mainly been used for opioid maintenance therapy and only now is increasingly recognized as an effective analgesic with an improved therapeutic index relative to certain potent opioids. Albeit a second-, third-, or fourth-line analgesic, buprenorphine is a reasonable choice in certain clinical situations. Transdermal patches and buccal film formulations are now commercially available as analgesics. This review discusses buprenorphine pharmacodynamics and pharmacokinetics, use in certain populations, and provides a synopsis of systematic reviews and randomized analgesic trials. We briefly discuss postoperative management in patients receiving buprenorphine maintenance therapy, opioid equivalence to buprenorphine, rotations to buprenorphine from other opioids, and clinical relevance of buprenorphine-related QTc interval changes.
Journal Article
Dynamical Backaction Magnomechanics
Dynamical backaction resulting from radiation pressure forces in optomechanical systems has proven to be a versatile tool for manipulating mechanical vibrations. Notably, dynamical backaction has resulted in the cooling of a mechanical resonator to its ground state, driving phonon lasing, the generation of entangled states, and observation of the optical-spring effect. In certain magnetic materials, mechanical vibrations can interact with magnetic excitations (magnons) via the magnetostrictive interaction, resulting in an analogous magnon-induced dynamical backaction. In this article, we directly observe the impact of magnon-induced dynamical backaction on a spherical magnetic sample’s mechanical vibrations. Moreover, dynamical backaction effects play a crucial role in many recent theoretical proposals; thus, our work provides the foundation for future experimental work pursuing many of these theoretical proposals.
Journal Article
Distorted mirrors : Americans and their relations with Russia and China in the twentieth century
\"Drawing on memoirs, archives, and interviews, Davis and Trani trace American prejudice toward Russia and China by focusing on the views of influential writers and politicians over the course of the twentieth century, showing where American images originated and how they evolved\"--Provided by publisher.
Book
Dysregulation of brain and choroid plexus cell types in severe COVID-19
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of COVID-19 can suffer neurological symptoms
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–
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. However, an unbiased understanding of the cellular and molecular processes that are affected in the brains of patients with COVID-19 is missing. Here we profile 65,309 single-nucleus transcriptomes from 30 frontal cortex and choroid plexus samples across 14 control individuals (including 1 patient with terminal influenza) and 8 patients with COVID-19. Although our systematic analysis yields no molecular traces of SARS-CoV-2 in the brain, we observe broad cellular perturbations indicating that barrier cells of the choroid plexus sense and relay peripheral inflammation into the brain and show that peripheral T cells infiltrate the parenchyma. We discover microglia and astrocyte subpopulations associated with COVID-19 that share features with pathological cell states that have previously been reported in human neurodegenerative disease
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. Synaptic signalling of upper-layer excitatory neurons—which are evolutionarily expanded in humans
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and linked to cognitive function
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—is preferentially affected in COVID-19. Across cell types, perturbations associated with COVID-19 overlap with those found in chronic brain disorders and reside in genetic variants associated with cognition, schizophrenia and depression. Our findings and public dataset provide a molecular framework to understand current observations of COVID-19-related neurological disease, and any such disease that may emerge at a later date.
Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.
Journal Article
Heterogeneous melting near the Thwaites Glacier grounding line
Thwaites Glacier represents 15% of the ice discharge from the West Antarctic Ice Sheet and influences a wider catchment
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–
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. Because it is grounded below sea level
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,
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, Thwaites Glacier is thought to be susceptible to runaway retreat triggered at the grounding line (GL) at which the glacier reaches the ocean
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,
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. Recent ice-flow acceleration
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,
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and retreat of the ice front
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–
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and GL
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,
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indicate that ice loss will continue. The relative impacts of mechanisms underlying recent retreat are however uncertain. Here we show sustained GL retreat from at least 2011 to 2020 and resolve mechanisms of ice-shelf melt at the submetre scale. Our conclusions are based on observations of the Thwaites Eastern Ice Shelf (TEIS) from an underwater vehicle, extending from the GL to 3 km oceanward and from the ice–ocean interface to the sea floor. These observations show a rough ice base above a sea floor sloping upward towards the GL and an ocean cavity in which the warmest water exceeds 2 °C above freezing. Data closest to the ice base show that enhanced melting occurs along sloped surfaces that initiate near the GL and evolve into steep-sided terraces. This pronounced melting along steep ice faces, including in crevasses, produces stratification that suppresses melt along flat interfaces. These data imply that slope-dependent melting sculpts the ice base and acts as an important response to ocean warming.
Thwaites Eastern Ice Shelf observations from a new underwater vehicle show that high melt rates occur where ice is sharply sloped at the ocean interface, with lower melt where the ice is comparatively flat.
Journal Article
Baltimore revisited : stories of inequality and resistance in a U.S. city
\"Nicknamed both \"Mobtown\" and \"Charm City\" and located on the border of the North and South, Baltimore is a city of contradictions. From media depictions in The Wire to the real-life trial of police officers for the murder of Freddie Gray, Baltimore has become a quintessential example of a struggling American city. Yet the truth about Baltimore is far more complicated--and more fascinating.
To help untangle these apparent paradoxes, the editors of Baltimore Revisited have assembled a collection of over thirty experts from inside and outside academia. Together, they reveal that Baltimore has been ground zero for a slew of neoliberal policies, a place where inequality has increased as corporate interests have eagerly privatized public goods and services to maximize profits. But they also uncover how community members resist and reveal a long tradition of Baltimoreans who have fought for social justice.
The essays in this collection take readers on a tour through the city's diverse neighborhoods, from the Lumbee Indian community in East Baltimore to the crusade for environmental justice in South Baltimore. Baltimore Revisited examines the city's past, reflects upon the city's present, and envisions the city's future\"-- Provided by publisher.
To help untangle these apparent paradoxes, the editors of Baltimore Revisited have assembled a collection of over thirty experts from inside and outside academia. Together, they reveal that Baltimore has been ground zero for a slew of neoliberal policies, a place where inequality has increased as corporate interests have eagerly privatized public goods and services to maximize profits. But they also uncover how community members resist and reveal a long tradition of Baltimoreans who have fought for social justice.
The essays in this collection take readers on a tour through the city's diverse neighborhoods, from the Lumbee Indian community in East Baltimore to the crusade for environmental justice in South Baltimore. Baltimore Revisited examines the city's past, reflects upon the city's present, and envisions the city's future\"-- Provided by publisher.
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