Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
8,611
result(s) for
"Davis, Scott"
Sort by:
Gilbert Simondon's Psychic and collective individuation : a critical introduction and guide
A critical commentary on Simondon's Psychic and collective individuation. This book clarifies Simondon's complex terminology and structure through chapter by chapter commentary. It also invites a dialogue with other thinkers/philosophers and places the work in its historical context. It includes a discussion about Simondon's relevance to current ideas about biopolitics and post-Nietzschean ethics.
Book
One Anastomosis Gastric Bypass as Revisional Surgery Following Sleeve Gastrectomy: A Systematic Review and Meta-Analysis
Background
Although sleeve gastrectomy (SG) is the most performed metabolic and bariatric surgery (MBS) worldwide, some patients require conversional procedures due to weight recurrence or late complications. Recently, one-anastomosis gastric bypass (OAGB) gained popularity as a viable option to address those problems. The aim of this meta-analysis is to assess the safety and efficacy of conversional OAGB after primary SG in the management of patients with obesity.
Methods
Cochrane, Embase, PubMed, Scopus, and Web of Science were searched for articles from their inception to February 2023 by two independent reviewers using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) system. The review was registered prospectively with PROSPERO (CRD42023403528).
Results
From 1,117 studies screened, twenty studies met the eligibility criteria, with a total of 1,057 patients with obesity undergoing conversional OAGB after primary SG. The mean age ranged from 28.2 to 49.5 years, and 744 patients (75.2%) were women. At one year after revisional OAGB, the pooled mean percent excess weight loss (%EWL) was 65.2% (95%CI: 56.9, 73.4, I
2
= 97%). The pooled mean %EWL after conversional OAGB was 71.1% (95%CI: 62.2, 80.0, I
2
= 90%) at two years and 71.6% (95%CI: 61.0, 82.2, I
2
= 50%) at five years. Additionally, resolution rates of diabetes and hypertension were 65.4% (95%CI: 0.522, 0.785, I
2
= 65%) and 58.9% (95%CI: 0.415, 0.762, I
2
= 89%), respectively.
Conclusions
Our meta-analysis demonstrated OAGB as an effective conversional procedure after primary SG in terms of weight loss and obesity-associated medical problems for selected patients. Despite the promising results, further randomized controlled studies with larger sample sizes and more extended follow-up periods are necessary to determine if the OAGB is the best conversional surgery after SG.
Graphical Abstract
Journal Article
The allure of the archives
Arlette Farge's 'Le Goût de l'archive' is widely regarded as a historiographical classic. While combining through two-hundred-year-old judicial records from the Archives of the Bastille, historian Farge was struck by the extraordinary intimate portrayal they provided of the lives of the poor in pre-Revolutionary France, especially women. She was seduced by the sensuality of old manuscripts and by the revelatory power of voices otherwise lost. In this book, she conveys the exhilaration of uncovering hidden secrets and the thrill of venturing into previously unknown dimensions of the past.
Book
Bariatric surgery and left ventricular assist device in patients with heart failure: A systematic review and meta-analysis
The role of metabolic and bariatric surgery (MBS), in synergy with left ventricular assist device (LVAD) implantation, in the scope of end-stage heart failure management for patients with severe obesity is not well elucidated.
We conducted a meta-analysis using Cochrane, Embase, PubMed, and Scopus databases to include articles from their inception to November 2022.
A total of 271 patients who underwent MBS during or after the LVAD implantation were included from eleven separate studies. After surgery, 67.4% of patients were listed on the heart transplant waitlist with 32.5% undergoing a successful transplant. We reported a mean listing time of 13.8 months. Finally, the pooled postoperative complication rate, 30-day readmission rate, and one-year mortality rate were 47.6%, 23.6% and 10.2% respectively.
MBS and LVAD is a safe and effective approach to bridge patients with severe obesity and end-stage heart failure for definitive heart transplantation.
[Display omitted]
•MBS is safe in patients with obesity and heart failure with an implanted LVAD.•MBS leads to considerable and sustained weight loss in patients with LVAD.•MBS successfully shortens time spent on the heart transplant waiting list.•The majority of patients attain eligibility for heart transplant after MBS.•MBS for patients with LVADs is an effective bridging therapy before transplantation.
Journal Article
Everyone deserves a great manager : the 6 critical practices for leading a team
\"From the organizational experts at FranklinCovey, an essential guide to becoming the great manager every team deserves\"-- Provided by publisher.
BOOK
Conditioning-induced expression of novel glucose transporters in canine skeletal muscle homogenate
Athletic conditioning can increase the capacity for insulin-stimulated skeletal muscle glucose uptake through increased sarcolemmal expression of GLUT4 and potentially additional novel glucose transporters. We used a canine model that has previously demonstrated conditioning-induced increases in basal, insulin- and contraction-stimulated glucose uptake to identify whether expression of glucose transporters other than GLUT4 was upregulated by athletic conditioning. Skeletal muscle biopsies were obtained from 12 adult Alaskan Husky racing sled dogs before and after a full season of conditioning and racing, and homogenates from those biopsies were assayed for expression of GLUT1, GLUT3, GLUT4, GLUT6, GLUT8, and GLUT12 using western blots. Athletic conditioning resulted in a 1.31 ± 0.70 fold increase in GLUT1 (p <0.0001), 1.80 ± 1.99 fold increase in GLUT4 (p = 0.005), and 2.46 ± 2.39 fold increase in GLUT12 (p = 0.002). The increased expression of GLUT1 helps explain the previous findings of conditioning-induced increases in basal glucose clearance in this model, and the increase in GLUT12 provides an alternative mechanism for insulin- and contraction-mediated glucose uptake and likely contributes to the substantial conditioning-induced increases in insulin sensitivity in highly trained athletic dogs. Furthermore, these results suggest that athletic dogs can serve as a valuable resource for the study of alternative glucose transport mechanisms in higher mammals.
Journal Article
President Batman
\"When the Ultra-Humanite wants to score big, he goes straight to the top- he's after the President! But Batman and Green Arrow have a daring rescue plan\"--Page opposite title page.
Book
A Quality Improvement Innovation for Reproductive Health Planning in the Time of COVID
ObjectivesTo see if an outreach approach with telehealth is feasible and acceptable to patients to talk about their reproductive health; and as a secondary outcome, capture data on time spent on the visit and what kind of information was discussed.MethodsA registry was created from three family physicians’ panels of all adult patients with anticipated ability to become pregnant ages 18–45 who had not had a documented reproductive health discussion in the previous 6 months. Using that registry, outreach was performed to schedule a telehealth visit to discuss their reproductive health with their primary care provider. The visit was standardized using the One Key Question approach. For patients who agreed to participate in the research, the patient completed a survey about their experience. The provider also completed a survey on the time spent and the issues addressed.ResultsTwo hundred and six patients were called. Ninety patients (44%) could not be reached. Of the remaining patients, 34 scheduled either a telehealth or in-person visit and 7 also agreed to participate in the survey. New information was uncovered in the visit in 86% of participants. The most common need uncovered during the visit was unrelated medical needs (71%), followed by preconception health education/advice (43%) and contraception needs/counseling (29%). Most participants found the telehealth visit valuable.ConclusionsAn outreach methodology can uncover unmet health needs, both reproductive and otherwise. We found that people who had the visit often needed something, but a majority of patients declined the visit saying that they did not think they needed it. It is possible that patients are not aware of the value of reproductive health discussions, and therefore clinicians need to take every opportunity to have these discussions whenever possible, whether through outreach or inreach (during already scheduled visits).SignificanceWhat is already known on this subject? Many patients still do not receive recommended reproductive health visits, which can increase their risk of unintended pregnancies with potential negative outcomes.What this study adds? Telehealth visits are one way that primary care providers can meet patients’ needs for reproductive health discussions and uncover unmet needs. Providers need to take every opportunity they can to make sure patients receive needed discussions about their reproductive health.
Journal Article
Garfield. Unreality TV
Sucked into an ultimate 3-D television, Garfield and Odie are sent on a reality-bending adventure.
Book
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and recruitment of tumour-associated macrophages.
Using anti-tumour macrophages in breast cancer
Tumour-associated macrophages often benefit tumours, but previous efforts to either deplete or stimulate them have had some anti-tumour effects. Anthony Letai and colleagues suggest that using drugs to modify their phenotype could be even more successful. They show that a class IIa histone deacetylase inhibitor, TMP195, induces anti-tumour immunity in a mouse model of breast cancer. Treatment is associated with altered differentiation and recruitment of tumour-associated macrophages, and acts synergistically with chemotherapy and T-cell checkpoint blockade.
Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages often have net pro-tumour effects
1
, but their embedded location and their untapped potential provide impetus to discover strategies to turn them against tumours. Strategies that deplete (anti-CSF-1 antibodies and CSF-1R inhibition)
2
,
3
or stimulate (agonistic anti-CD40 or inhibitory anti-CD47 antibodies)
4
,
5
tumour-associated macrophages have had some success. We hypothesized that pharmacologic modulation of macrophage phenotype could produce an anti-tumour effect. We previously reported that a first-in-class selective class IIa histone deacetylase (HDAC) inhibitor, TMP195, influenced human monocyte responses to the colony-stimulating factors CSF-1 and CSF-2
in vitro
6
. Here, we utilize a macrophage-dependent autochthonous mouse model of breast cancer to demonstrate that
in vivo
TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours. Furthermore, combining TMP195 with chemotherapy regimens or T-cell checkpoint blockade in this model significantly enhances the durability of tumour reduction. These data introduce class IIa HDAC inhibition as a means to harness the anti-tumour potential of macrophages to enhance cancer therapy.
Journal Article