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115 result(s) for "Davison, Claire"
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ChatGPT Promises and Challenges in Education: Computational and Ethical Perspectives
This paper investigates the integration of ChatGPT into educational environments, focusing on its potential to enhance personalized learning and the ethical concerns it raises. Through a systematic literature review, interest analysis, and case studies, the research scrutinizes the application of ChatGPT in diverse educational contexts, evaluating its impact on teaching and learning practices. The key findings reveal that ChatGPT can significantly enrich education by offering dynamic, personalized learning experiences and real-time feedback, thereby boosting teaching efficiency and learner engagement. However, the study also highlights significant challenges, such as biases in AI algorithms that may distort educational content and the inability of AI to replicate the emotional and interpersonal dynamics of traditional teacher–student interactions. The paper acknowledges the fast-paced evolution of AI technologies, which may render some findings obsolete, underscoring the need for ongoing research to adapt educational strategies accordingly. This study provides a balanced analysis of the opportunities and challenges of ChatGPT in education, emphasizing ethical considerations and offering strategic insights for the responsible integration of AI technologies. These insights are valuable for educators, policymakers, and researchers involved in the digital transformation of education.
ETHICore: Ethical Compliance and Oversight Framework for Digital Forensic Readiness
How can organisations be forensically ready? As organisations are bound to be criticised in the digitally developing world, they must ensure that they are forensically ready. The readiness of digital forensics ensures compliance in an organisation’s legal, regulatory, and operational structure. Several digital forensic investigative methods and duties are based on specific technological designs. The present study is the first to address the core principles of digital forensic studies, namely, reconnaissance, reliability, and relevance. It reassesses the investigative duties and establishes eight separate positions and their obligations in a digital forensics’ investigation. A systematic literature review revealed a gap in the form of a missing comprehensive direction for establishing a digital forensic framework for ethical purposes. Digital forensic readiness refers to the ability of a business to collect and respond to digital evidence related to security incidents at low levels of cost and interruption to existing business operations. This study established a digital forensic framework through a systematic literature review to ensure that organisations are forensically ready to conduct an efficient forensic investigation and to cover ethical aspects. Furthermore, this study conducted a focus group evaluation through focus group discussions to provide insights into the framework. Lastly, a roadmap was provided for integrating the system seamlessly into zero-knowledge data collection technologies.
Ford Madox Ford's Cosmopolis
Ford Madox Ford's Cosmopolis explores and celebrates Ford's internationalism, underlining his lifelong commitment to an international, transmedial approach to the arts. It brings to life his commitment to cosmopolitanism living, and thinking, and his vibrant intellectual networks spiralling around Paris.
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling
Vertebrate skeletal muscles comprise distinct fiber types that differ in their morphology, contractile function, mitochondrial content and metabolic properties. Recent studies identified the transcriptional coactivator PGC-1α as a key mediator of the physiological stimuli that modulate fiber-type plasticity in postembryonic development 1 . Although myoblasts become fated to differentiate into distinct kinds of fibers early in development, the identities of regulatory proteins that determine embryonic fiber-type specification are still obscure. Here we show that the gene u-boot ( ubo ), a mutation in which disrupts the induction of embryonic slow-twitch fibers 2 , encodes the zebrafish homolog of Blimp-1, a SET domain–containing transcription factor that promotes the terminal differentiation of B lymphocytes in mammals 3 . Expression of ubo is induced by Hedgehog (Hh) signaling in prospective slow muscle precursors, and its activity alone is sufficient to direct slow-twitch fiber–specific development by naive myoblasts. Our data provide the first molecular insight into the mechanism by which a specific group of muscle precursors is driven along a distinct pathway of fiber-type differentiation in response to positional cues in the vertebrate embryo.
Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster
Insulin/insulin-like growth factor signalling (IIS), acting primarily through the PI3-kinase (PI3K)/AKT kinase signalling cassette, plays key evolutionarily conserved regulatory roles in nutrient homeostasis, growth, ageing and longevity. The dysfunction of this pathway has been linked to several age-related human diseases including cancer, Type 2 diabetes and neurodegenerative disorders. However, it remains unclear whether minor defects in IIS can independently induce the age-dependent functional decline in cells that accompany some of these diseases or whether IIS alters the sensitivity to other aberrant signalling. We identified a novel hypomorphic allele of PI3K's direct antagonist, Phosphatase and tensin homologue on chromosome 10 (Pten), in the fruit fly, Drosophila melanogaster. Adults carrying combinations of this allele, Pten5, combined with strong loss-of-function Pten mutations exhibit subtle or no increase in mass, but are highly susceptible to a wide range of stresses. They also exhibit dramatic upregulation of the oxidative stress response gene, GstD1, and a progressive loss of motor function that ultimately leads to defects in climbing and flight ability. The latter phenotype is associated with mitochondrial disruption in indirect flight muscles, although overall muscle structure appears to be maintained. We show that the phenotype is partially rescued by muscle-specific expression of the Bcl-2 homologue Buffy, which in flies, maintains mitochondrial integrity, modulates energy homeostasis and suppresses cell death. The flightless phenotype is also suppressed by mutations in downstream IIS signalling components, including those in the mechanistic Target of Rapamycin Complex 1 (mTORC1) pathway, suggesting that elevated IIS is responsible for functional decline in flight muscle. Our data demonstrate that IIS levels must be precisely regulated by Pten in adults to maintain the function of the highly metabolically active indirect flight muscles, offering a new system to study the in vivo roles of IIS in the maintenance of mitochondrial integrity and adult ageing.
Ford Madox Ford's cosmopolis: psycho-geography, flanerie and the cultures of Paris
The controversial British writer Ford Madox Ford (1873-1939) is increasingly recognized as a major presence in early twentieth-century literature. This series of International Ford Madox Ford Studies was founded to reflect the recent resurgence of interest in him. Each volume is based upon a particular theme, issue, or work; and relates aspects of Ford's writing, life, and contacts, to broader concerns of his time. Ford is best-known for his fiction, especially The Good Soldier, long considered a modernist masterpiece; and Parade's End, which Anthony Burgess described as 'the finest novel about the First World War', Samuel Hynes has called 'the greatest war novel ever written by an Englishman', and which was adapted by Tom Stoppard for the acclaimed 2012 BBC/HBO television series, starring Benedict Cumberbatch and Rebecca Hall. The twelve essays in this volume, Ford Madox Ford's Cosmopolis, focus directly on the internationalism so important to Ford, and bring out three main ideas. First, his lifelong commitment to an international vision of literature and culture. Second, 'Cosmopolis' also refers to Ford's experiences of the particular cosmopolitan cities he lived in: London, Paris, New York. Third, the idea that his lifelong experience of Paris in particular informed and shaped his writing. Ford's Cosmopolis is thus not only an ideal city or state open to such cosmopolitan exchange. It is also a mode of writing which invents forms and styles to render the experience of such hybridity, diversity, fluidity, and tolerance. Contributors are: Alexandra Becquet, Helen Chambers, Martina Ciceri, Laurence Davies, Claire Davison, Annalisa Federici, Georges Létissier, Caroline Patey, Andrea Rummel, Max Saunders, Rob Spence, Martin Stannard, George Wickes, Joseph Wiesenfarth.