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Pain-o-metry provides biomarkers indicating connections between pain-related conditions and the health of various physiological systems, including the cardiovascular system. In this study, a non-linear data-driven analytical technique was employed to analyze second-by-second hemodynamic responses to recurrent clino-orthostatic challenges in 43 female fibromyalgia patients and 38 healthy women. The primary goal was to elucidate the systemic and systematic interaction of diverse hemodynamic and cardiovascular mechanisms across various timeframes and phases, precisely identifying their collective role as a unified bodily mechanism in managing regular gravity-induced blood redistribution challenges within the context of chronic pain. Findings suggest a connection between chronic disease and the equilibrium between cardiac preload and afterload in blood pressure regulation. Patients exhibit a shift towards afterload due to deficiencies in mechanisms governing initial transient reactions and later steady-state processes related to acutely induced blood redistributions. The imbalance is linked to reduced venous blood return, increasing cardiac strain—particularly in terms of contractility and heart rate—as the body compensates for heightened cardiac afterload and reduced effective blood volume. This makes individuals more susceptible to chronic peripheral tissue and cerebrovascular hypoperfusion, potentially leading to chronic ischemia and inflammation in various tissues and organs. The data-driven analytical technique enables the identification of combinations of gravity-induced hemodynamic and cardiovascular responses within specific timeframes for precise detection. This approach aims to facilitate potential diagnostic and monitoring applications in wearable devices, enhancing the ability to identify at-risk populations for preventive interventions.

Situational or persistent body fluid deficit (i.e., de- or hypo-hydration) is considered a significant health risk factor. Bioimpedance analysis (BIA) has been suggested as an alternative to less reliable subjective and biochemical indicators of hydration status. The present study aimed to compare various BIA models in the prediction of direct measures of body compartments associated with hydration/osmolality. Fish (n = 20) was selected as a biological model for physicochemically measuring proximate body compartments associated with hydration such as water, dissolved proteins, and non-osseous minerals as the references or criterion points. Whole-body and segmental/local impedance measures were used to investigate a pool of BIA models, which were compared by Akaike Information Criterion in their ability to accurately predict the body components. Statistical models showed that ‘volumetric-based’ BIA measures obtained in parallel, such as distance 2 /R p , could be the best approach in predicting percent of body moisture, proteins, and minerals in the whole-body schema. However, serially-obtained BIA measures, such as the ratio of the reactance to resistance and the resistance adjusted for distance between electrodes, were the best fitting in predicting the compartments in the segmental schema. Validity of these results should be confirmed on humans before implementation in practice.

The azimuthal correlation, Δϕ12, of high transverse momentum jets in pp collisions at s=13 TeV is studied by applying PB-TMD distributions to NLO calculations via MCatNLO together with the PB-TMD parton shower. A very good description of the cross section as a function of Δϕ12 is observed. In the back-to-back region of Δϕ12→π, a very good agreement is observed with the PB-TMD Set 2 distributions while significant deviations are obtained with the PB-TMD Set 1 distributions. Set 1 uses the evolution scale while Set 2 uses transverse momentum as an argument in αs, and the above observation therefore confirms the importance of an appropriate soft-gluon coupling in angular ordered parton evolution. The total uncertainties of the predictions are dominated by the scale uncertainties of the matrix element, while the uncertainties coming from the PB-TMDs and the corresponding PB-TMD shower are very small. The Δϕ12 measurements are also compared with predictions using MCatNLO together Pythia8, illustrating the importance of details of the parton shower evolution.

Contrasting findings on the mechanisms of chronic pain and hypertension development render the current conventional evidence of a negative relationship between blood pressure (BP) and pain severity insufficient for developing personalized treatments. In this interdisciplinary study, patients with fibromyalgia (FM) exhibiting clinically normal or elevated BP, alongside healthy participants were assessed. Different pain sensitization responses were evaluated using a dynamic 'slowly repeated evoked pain' (SREP) measure, as well as static pain pressure threshold and tolerance measures. Cardiovascular responses to clino-orthostatic (lying-standing) challenges were also examined as acute re- and de-hydration events, challenging cardiovascular and cerebrovascular homeostasis. These challenges involve compensating effects from various cardiac preload or afterload mechanisms associated with different homeostatic body hydration statuses. Additionally, hair cortisol concentration was considered as a factor with an impact on chronic hydration statuses. Pain windup (SREP) and lower pain threshold in FM patients were found to be related to BP rise during clinostatic (lying) rehydration or orthostatic (standing) dehydration events, respectively. These events were determined by acute systemic vasoconstriction (i.e., cardiac afterload response) overcompensating for clinostatic or orthostatic cardiac preload under-responses (low cardiac output or stroke volume). Lower pain tolerance was associated with tonic blood pressure reduction, determined by permanent hypovolemia (low stroke volume) decompensated by permanent systemic vasodilation. In conclusion, the body hydration status profiles assessed by (re)activity of systemic vascular resistance and effective blood volume-related measures can help predict the risk and intensity of different pain sensitization components in chronic pain syndrome, facilitating a more personalized management approach.

Various approaches are considered in the method of smoothed particle hydrodynamics (SPH) for calculating the volume concentration of gas phase in a liquid during the rarefaction or destruction. A scheme for calculating the concentration of gas phase, consisting of three stages, is proposed. At low concentrations, the calculation is carried out according to the full model, which includes the laws to describing the concentration dynamics. At high concentration the simplified model is used, when the change in concentration is determined by the dynamics of liquid. When the maximum concentration is reached, corresponding to a single particle without neighbors, the rate of concentration growth is fixed and the further development of the process is governed by inertia.

A lack of personalized approaches in non-medication pain management has prevented these alternative forms of treatment from achieving the desired efficacy. One hundred and ten female patients with fibromyalgia syndrome (FMS) and 60 healthy women without chronic pain were assessed for severity of chronic or retrospective occasional pain, respectively, along with alexithymia, depression, anxiety, coping strategies, and personality traits. All analyses were conducted following a ‘resource matching’ hypothesis predicting that to be effective, a behavioral coping mechanism diverting or producing cognitive resources should correspond to particular mechanisms regulating pain severity in the patient. Moderated mediation analysis found that extraverts could effectively cope with chronic pain and avoid the use of medications for pain and mood management by lowering depressive symptoms through the use of distraction mechanism as a habitual (‘out-of-touch-with-reality’) behavior. However, introverts could effectively cope with chronic pain and avoid the use of medications by lowering catastrophizing through the use of distraction mechanism as a situational (‘in-touch-with-reality’) behavior. Thus, personalized behavior management techniques applied according to a mechanism of capturing or diverting the main individual ‘resource’ of the pain experience from its ‘feeding’ to supporting another activity may increase efficacy in the reduction of pain severity along with decreasing the need for pain relief and mood-stabilizing medications.

Recent research on cancer-associated microbial communities led to the accumulation of data on the interplay between bacteria, immune and tumor cells, the pathways of bacterial induction of carcinogenesis, and its meaningfulness for medicine. Microbial communities that have any kind of impact on tumor progression and microorganisms associated with tumors have been defined as oncobiome. Over the last decades, a number of studies were dedicated to Helicobacter pylori and its role in the progression of stomach tumors, so this correlation can be regarded as proven. Involvement of bacteria in the induction of lung cancer has been largely ignored for a long time, though some correlations between this type of cancer and lung microbiome were established. Despite the fact that in the present the microbial impact on lung cancer progression has many confirmations, the underlying mechanisms are poorly understood. Microorganisms can contribute to tumor initiation and progression through production of bacteriotoxins and other proinflammatory factors. The purpose of this review is to organize the available data on lung cancer microbiome and its role in malignant tumor progression.

The necessity of using express analysis methods to control medium condition is substantiated. It has been shown that the method of express control based on the phenomenon of nuclear magnetic resonance is one of the most preferable. It was found that to increase the information about the medium condition state obtained from the recorded NMR signal, it is necessary to use a mathematical model (based on analytical solutions of the Bloch equations). Two approaches are considered that are used to describe the NMR signal in a liquid medium. It is determined that in the classical approach in the system of Bloch equations it is possible to take into account the peculiarities of using radiotechnical methods of signal registration. The direction of the analytical solution of the Bloch equation is proposed. The experimental data are compared with the numerical solution.

In a series of measurements, a comparison is made of nonlinear scattering in suspensions of porous silicon nanoparticles in ethanol and bidistilled water. Scattering has a threshold character in terms of the concentration of nanoparticles and the energy of the initiating laser. With a small difference in the sizes of nanoparticles, a significant difference in the nature of scattering spectra and optimal concentrations of suspensions is observed.

Introduction: Patients with fibromyalgia syndrome (FMS) exhibit higher levels of neuroticism and psychoticism and lower levels of extraversion, which may influence medication use. Objective: The objective of this study was to analyze associations between personality traits (from Eysenck’s model) and medication use in patients with FMS and to explore factors mediating/moderating these relations. Method: Data on personality, medication use, and clinical severity were collected from 94 FMS patients and 56 individuals from a nonclinical population. Results: Patients had higher neuroticism and psychoticism compared to participants from the nonclinical population, with no significant differences observed in extraversion. Neuroticism was positively associated with the use of antidepressants and anxiolytics, as well as with higher levels of anxiety and depression. In contrast, extraversion was negatively associated with the use of antidepressants, anxiolytics, and opioids and with lower anxiety, depression, and the emotional and cognitive dimensions of pain and a reduced prevalence of comorbid emotional disorders. Psychoticism was positively associated with the sensorial, emotional, and cognitive dimensions of pain. Depression and anxiety levels mediated the relationships between neuroticism and extraversion and the use of antidepressants and anxiolytics. Additionally, comorbid depressive disorders moderated the association between neuroticism and antidepressant use. Conclusion: Higher neuroticism and lower extraversion primarily increase the likelihood of using mood‐regulating medications, but not analgesic drugs. Implementing coping strategies aimed at reducing neuroticism and enhancing extraversion may help to reduce medication use in patients with FMS.