Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
11
result(s) for
"Dayan, Nava"
Sort by:
Handbook of Formulating Dermal Applications
The conceptualization and formulation of skin care products intended for topical use is a multifaceted and evolving area of science. Formulators must account for myriad skin types, emerging opportunities for product development as well as a very temperamental retail market.
Originally published as \"Apply Topically\" in 2013 (now out of print), this reissued detailed and comprehensive handbook offers a practical approach to the formulation chemist's day-to-day endeavors by:
* Addressing the innumerable challenges facing the chemist both in design and at the bench, such as formulating with/for specific properties; formulation, processing and production techniques; sensory and elegancy; stability and preservation; color cosmetics; sunscreens;
* Offering valuable guidance to troubleshooting issues regarding ingredient selection and interaction, regulatory concerns that must be addressed early in development, and the extrapolation of preservative systems, fragrances, stability and texture aids;
* Exploring the advantages and limitations of raw materials;
* Addressing scale-up and pilot production process and concerns;
* Testing and Measurements Methods.
The 22 chapters written by industry experts such as Roger L. McMullen, Paul Thau, Hemi Nae, Ada Polla, Howard Epstein, Joseph Albanese, Mark Chandler, Steve Herman, Gary Kelm, Patricia Aikens, and Sam Shefer, along with many others, give the reader and user the ultimate handbook on topical product development.
eBook
Skin Microbiome Handbook
The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects.
In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells.
The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.
eBook
Adipogenic Effect of Magnolol in Primary Human Pre‐Adipocytes With Potential Skin Health and Volumizing Effect
Background Aging is associated with fat atrophy and fibrosis with loss of adipocyte differentiation from preadipocytes. New approaches to this loss involve agents that can renew the proliferative and differentiative capacities of preadipocytes with the aim of creating new healthy adipose tissue that secrete adipokines that positively impact on skin health. Material & Methods We investigated the effect of Magnolol (ML), a naturally derived compound, on human primary pre‐adipocyte viability and proliferation as well as adipogenic gene expression and increase in lipid production. Cell proliferation was assessed using fluorescent signaling, and adipocyte differentiation was monitored by following morphological and microscopic changes. RNA purification and real‐time PCR were undertaken to examine gene expression changes, and Oil red O staining was used to confirm adipose cell transformation. Adipokine expression, in particular adiponectin quantification, was also undertaken. Results Magnolol, at a relatively low concentration, demonstrated clear adipogenic activity: with a significant increase in preadipocyte proliferation after 48 h and a significant accumulation of adipocytes as demonstrated by oil red staining. Increased gene expression of PLN1 and FABP4 and a significant increase in adiponectin protein expression was demonstrated. Conclusion Magnolol stimulates preadipocyte proliferation and conversion to adipokine‐producing adipocytes. This has the potential for a positive skin health and volumizing effect if used in a topical formulation.
Journal Article
Is There a Connection Between Sun Exposure, Microbiome and Skin Cancer?
This chapter is written merely as a theoretical thinking exercise. My path in research of the skin microbiome began more than a decade ago when investigating skin barrier and innate immunity and capturing the skin barrier not merely as a physical barrier but also as a biological entity. This research resulted in a book that I edited in collaboration with Prof. Phil Wertz and was published by Wiley and Sons in 2012. From inception, it was clear to me that our understanding of the microbiome is incomplete and that a meta‐analysis approach to connecting elements is essential. Observations in two dimensions connecting the microbiome community and behavior to one module at a time will not assist us in navigating the maze of its complexity since a key aspect of the effect of biota on the human body biology is its function. Most of the current research on the skin microbiome is focused on its mapping and identification while only a fraction is aimed at understanding its means of communication with human cells. Moreover, the acknowledgment that human cell effectors influence the microbiome as well is only beginning to settle in. While working on the innate immunity and microbiome projects, separately, I studied the effect of visible light on skin. This is a part of the sun spectrum that is only partially investigated and to a less extent when compared to our knowledge about UVB and UVA exposure wavelengths. I designed and executed an experiment to explore the impact of this light on various skin biomarkers and cascades and the particular effect of light on chromophores in skin cells [1, 2].
Book Chapter
Neural representations of kinematic laws of motion: Evidence for action-perception coupling
Behavioral and modeling studies have established that curved and drawing human hand movements obey the 2/3 power law, which dictates a strong coupling between movement curvature and velocity. Human motion perception seems to reflect this constraint. The functional MRI study reported here demonstrates that the brain's response to this law of motion is much stronger and more widespread than to other types of motion. Compliance with this law is reflected in the activation of a large network of brain areas subserving motor production, visual motion processing, and action observation functions. Hence, these results strongly support the notion of similar neural coding for motion perception and production. These findings suggest that cortical motion representations are optimally tuned to the kinematic and geometrical invariants characterizing biological actions.
Journal Article
On the Use of the Time Axis for Ecological Separation: Diel Rhythms as an Evolutionary Constraint
Although the time axis may well be significant for ecological separation among competitors and between predators and their prey, the evolution of temporal partitioning may be severely constrained. Research at the interface between biological rhythms, animal physiology, and ecological-evolutionary selective forces may provide valuable insight into the evolution of activity patterns and of temporal partitioning.
Journal Article
Efforts at Rubella Elimination in the United States: The Impact of Hemispheric Rubella Control
We examined rubella vaccination trends, rubella surveillance, and disease patterns for the Americas, Mexico, and the United States, to evaluate the impact of hemispheric rubella control on rubella elimination in the United States during 1997–2004. In 1997, 130,375 rubella cases were reported in the Americas, with 38,042 reported in Mexico. Over the next 7 years, a rubella control initiative resulted in the administration of ∼110 million rubella-containing vaccine doses in Latin America, with 77.7 million doses administered within Mexico. By 2004, the number of reported rubella cases had declined to 3103 in the Americas and 698 in Mexico. Concurrently, the number of rubella cases in the United States fell from 817 during 1997–1999 to <25 cases/year from 2001 onward, with loss of seasonality and geographic clustering, despite no change in vaccination rates. Implementation of rubella control strategies in the Americas, particularly in Mexico, appears to have facilitated rubella elimination in the United States.
Journal Article
Desert Dust Outbreaks over Mediterranean Basin: A Modeling, Observational, and Synoptic Analysis Approach
Dust intrusions from African desert regions have an impact on the Mediterranean Basin (MB), as they cause an anomalous increase of aerosol concentrations in the tropospheric column and often an increase of particulate matter at the ground level. To estimate the Saharan dust contribution to PM10, a significant dust intrusion event that occurred in June 2006 is investigated, joining numerical simulations and specific measurements. As a first step, a synoptic analysis of this episode is performed. Such analysis, based only on meteorological and aerosol optical thickness observations, does not allow the assessment of exhaustive informations. In fact, it is not possible to distinguish dust outbreaks transported above the boundary layer without any impact at the ground level from those causing deposition. The approach proposed in this work applies an ad hoc model chain to describe emission, transport and deposition dynamics. Furthermore, physical and chemical analyses (PIXE analysis and ion chromatography) were used to measure the concentration of all soil-related elements to quantify the contribution of dust particles to PM10. The comparison between simulation results and in-situ measurements show a satisfying agreement, and supports the effectiveness of the model chain to estimate the Saharan dust contribution at ground level.
Journal Article
Seasonal Thermogenic Acclimation of Diurnally and Nocturnally Active Desert Spiny Mice
Diurnally active golden spiny mice (Acomys russatus) and nocturnal common spiny mice (Acomys cahirinus) coexist in hot rocky deserts of Israel. Diurnal and nocturnal activities expose these species to different climatic conditions. Nonshivering thermogenesis (NST) capacity of individuals of both species immediately upon removal from the field exhibited seasonal changes, with no significant interspecific difference. Colony‐reared mice of either species transferred in the laboratory from long to short photoperiod increased NST capacity, though to a lesser extent than observed in the seasonal acclimatization. The underlying biochemical mechanisms of short photoperiod acclimation differed between the species. In both Cytochrome‐c oxidase (Cox) activity was higher in short as compared to long photoperiod. In short‐photoperiod‐acclimatedA. cahirinusuncoupling protein (UCP) content in brown adipose tissue (BAT) was significantly higher than in long photoperiod, while inA. russatusthere was no significant change. InA. russatusthere was a significant increase in lipoprotein lipase (LPL) activity in BAT in short‐photoperiod‐acclimated individuals, while inA. cahirinusLPL activity was high under both acclimations. The low LPL activity in brown adipose tissue of desert‐adaptedA. russatusmay facilitate lipid uptake in white adipose tissue, an advantage in desert conditions where food is scarce and irregularly distributed in space and time.
Journal Article