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Abstract A total of 467 sows were used to evaluate the effect of feeding duration of increased lysine (Lys) and metabolizable energy (ME) prior to farrowing on sow and litter performance, piglet survival, and colostrum quality. Sows were blocked by body weight (BW) and parity category on day 106 of gestation and allotted to one of three dietary regimens starting on day 107 of gestation: 1) Control: 2.0 kg/d gestation feed (12.5 g standardized ileal digestible [SID] Lys and 6.5 Mcal ME) until day 113 of gestation, then 2.7 kg/d lactation feed (28 g SID Lys and 9.4 Mcal ME) until parturition; 2) 2.0 kg/d gestation feed (12.5 g SID Lys and 6.5 Mcal ME) until day 113 of gestation, then 3.8 kg/d lactation feed (40 g SID Lys and 13.3 Mcal ME) until parturition; or 3) 3.8 kg/d lactation feed (40 g SID Lys and 13.3 Mcal ME) until parturition. Data were analyzed for treatment within parity effects using the GLIMMIX procedure of SAS. Increasing the duration of feeding additional Lys and ME increased (P < 0.05) sow weight gain from day 106 to 113. Sow backfat gain from day 106 to 113 of gestation increased (P < 0.05) in gilts and sows fed 3.8 kg/d of the lactation diet starting on day 107 vs. the control regimen. Average total born and born alive piglet birth weight (BiWt) were greater (P < 0.05) in gilts fed 3.8 kg/d lactation diet starting on day 107 or 113 vs. control, with no evidence (P > 0.05) for the difference in piglet BiWt in sows or weaning weight in gilts and sows. Piglet mortality after cross-fostering to weaning was decreased (P < 0.05) in sows fed 3.8 kg/d lactation diet starting on day 113 vs. control or increased lactation diet starting on day 107 but not in gilts. Litter gain from cross-foster to weaning was decreased (P < 0.05) in gilts fed 3.8 kg/d lactation diet starting on day 107 compared with control, with no evidence for difference in sows. Colostrum immunoglobulin G was increased (P < 0.05) in gilts and sows fed 3.8 kg/d of the lactation diet starting on day 113 compared with control. There was no evidence that dietary regimen influenced (P > 0.05) piglet colostrum intake or colostrum yield. There was also no evidence for difference (P > 0.05) among regimens in wean-to-estrus interval, subsequent farrowing rate, or subsequent litter characteristics. In conclusion, feeding increased Lys and ME prior to farrowing increased BW and backfat. Feeding increased Lys and ME when gilts were moved into the farrowing room increased BiWt, but reduced litter growth to weaning, with little evidence that sow performance was influenced in this study.

Feed additives have shown benefits throughout the literature in improving grow–finish pigs’ growth performance and carcass characteristics. However, the results have not been well summarized. Therefore, this review summarizes the available research (402 articles) on 14 feed additive categories fed to grow–finish pigs. The categories were acidifiers, betaine, Cr, conjugated linoleic acids, Cu, direct-fed microbials, carbohydrases, proteases, phytases, multi-enzymes, essential oils, L-carnitine, yeasts, and Zn. Qualified articles were collected and selected based on inclusion and exclusion criteria from online databases. The percentage difference for each response variable between the treatment and control group was calculated and summarized. Most results were positive for each feed additive; however, the magnitude of improvement varied, and most were not statistically significant. For ADG, DFM, Cu, L-carnitine, and multi-enzymes showed relatively large positive effects (>2.1% improvement) across a reasonable number of articles. Acidifiers, betaine, CLA, multi-enzymes, DFM, L-carnitine, and yeasts showed relatively large positive effects (>2.5% improvement) on improving G:F. Moreover, except for betaine, Cr, CLA, and L-carnitine, most feed additives showed little and non-significant effects on BF thickness (<1.7% improvement). This review provides a descriptive analysis for commonly used feed additives in the hope of better understanding feed additives’ effects on grow–finish pigs.

Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance. This experiment was conducted to determine the effect of feeding fumonisin-contaminated corn on growth performance and sphinganine (SA) to sphingosine (SO) ratios of 9 to 28 kg pigs. A total of 350 pigs, were used with 5 pigs/pen and 14 pens/treatment. Dietary treatments contained fumonisin-contaminated corn (50 mg/kg of fumonisin B1 + B2) blended with low fumonisin corn (10 mg/kg of fumonisin B1 + B2) to provide dietary fumonisin concentrations of 7.2, 14.7, 21.9, 32.7, and 35.1 mg/kg. From day 0 to 28, increasing fumonisin concentration decreased (linear, p < 0.001) average daily gain, average daily feed intake (linear, p = 0.055), and gain:feed ratio (linear, p = 0.016). Although these response criteria tested linear, the greatest reduction in performance was in pigs fed with 32.7 and 35.1 mg/kg of fumonisin (B1 + B2). Increasing fumonisin concentration increased the serum SA:SO ratio (linear, p < 0.001) on day 14 and 28. In summary, for 9 to 28 kg nursery pigs, increasing fumonisin linearly decreased average daily gain and gain:feed ratio. However, despite the linear response, diets containing up to 21.9 mg/kg of fumonisin did not have as dramatic a decrease in growth performance as those fed more than 32.7 mg/kg. Further research is warranted to determine the effect of fumonisin concentrations between 21.9 and 32.7 mg/kg.

Postweaning mortality is extremely complex with a multitude of noninfectious and infectious contributing factors. In the current review, our objective is to describe the current state of knowledge regarding infectious causes of postweaning mortality, focusing on estimates of frequency and magnitude of effect where available. While infectious mortality is often categorized by physiologic body system affected, we believe the complex multifactorial nature is better understood by an alternative stratification dependent on intervention type. This category method subjectively combines disease pathogenesis knowledge, epidemiology, and economic consequences. These intervention categories included depopulation of affected cohorts of animals, elimination protocols using knowledge of immunity and epidemiology, or less aggressive interventions. The most aggressive approach to control infectious etiologies is through herd depopulation and repopulation. Historically, these protocols were successful for Actinobacillus pleuropneumoniae and swine dysentery among others. Additionally, this aggressive measure likely would be used to minimize disease spread if either a foreign animal disease was introduced or pseudorabies virus was reintroduced into domestic swine populations. Elimination practices have been successful for Mycoplasma hyopneumoniae, porcine reproductive and respiratory syndrome virus, coronaviruses, including transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine deltacoronavirus, swine influenza virus, nondysentery Brachyspira spp., and others. Porcine circovirus type 2 can have a significant impact on morbidity and mortality; however, it is often adequately controlled through immunization. Many other infectious etiologies present in swine production have not elicited these aggressive control measures. This may be because less aggressive control measures, such as vaccination, management, and therapeutics, are effective, their impact on mortality or productivity is not great enough to warrant, or there is inadequate understanding to employ control procedures efficaciously and efficiently. Since there are many infectious agents and noninfectious contributors, emphasis should continue to be placed on those infectious agents with the greatest impact to minimize postweaning mortality.

Postweaning mortality is a complex causal matrix involving animal, environment, and infectious etiologic factors. Despite advances in swine productivity such as total pigs born, growth rate, feed intake, and efficiency, there have been modest to no improvements in postweaning mortality rates over the last several years. Industry averages for postweaning mortality range from four to eight percent for each the nursery, grow-finish, or wean-finish stages. Retrospective mortality causal analyses of individual databases have been performed. However, little information derived from meta-analysis, systematic review, or comprehensive literature reviews are available. In order to develop and evaluate strategies to comprehensively manage and reduce postweaning mortality, addressing the complexity and range of impact that factors have on mortality is necessary to identify and prioritize such contributing factors. Our objective is to describe the current state of knowledge regarding non-infectious causes of postweaning mortality, focusing on estimates of frequency and magnitude of effect where available. Postweaning mortality can be generalized into non-infectious and infectious causes, with non-infectious factors further classified into anatomic abnormalities, toxicity, animal factors, facility factors, nutritional inadequacies, season, and management factors. Important non-infectious factors that have been identified through review of literature include birth weight, pre-weaning management, weaning age and weight, and season. Additionally, reasons for mortality with a low incidence but a high magnitude include abdominal organ torsion/volvulus, sodium ion or ionophore toxicosis, or dietary imbalance due to feed formulation or manufacture error. Many interactive effects are present between and among infectious and non-infectious factors, but an important trend is the impact that non-infectious factors have on the incidence, severity, and resolution of infectious disease. Strategies to reduce postweaning mortality must consider the dynamic, complex state that forms the causal web. Control of postweaning mortality through understanding of the complexity, evaluation of mortality reduction strategies through rigorous scientific evaluation, and implementation remains an area of opportunity for continued growth and development in the global swine industry.

A total of 727 mixed parity (µ = 3.8) sows were used to evaluate the effects of timing and size of meals before farrowing on sow and litter performance. Upon entry to the farrowing house (day 113), sows were blocked by weight within parity and allotted to one of three three feeding management strategies until farrowing: (1) 2.7 kg lactation diet (1.15% standardized ileal digestible lysine and 2,153 kcal/kg net energy) once daily at 0700 hours; (2) four daily meals of 0.67 kg (0100, 0700, 1300, and 1900 hours); (3) ad libitum lactation diet and encouraged to consume feed at 0100, 0700, 1300, and 1900 hours. After farrowing, all sows were provided lactation diets fed on an ad libitum basis until weaning. Data were analyzed for treatment effects within parity category in a mixed model with block as a random effect. Feeding sows ad libitum before farrowing tended to reduce sow body weight (BW) loss (P = 0.077) and reduce backfat (BF) loss (P = 0.003) from entry into the farrowing house until weaning compared with sows fed four daily meals, with sows fed once daily intermediate. Litter gain from 24 h to weaning tended to be greater (P = 0.073) in sows fed on an ad libitum basis or four times daily prior to farrowing compared with sows fed one meal. Piglet weaning weight increased (P = 0.050) in sows fed on an ad libitum basis before farrowing, compared with those fed one meal, with those fed four times daily intermediate. There was no evidence for difference in farrowing duration, stillborn rate, colostrum yield, or 24 h piglet survival regardless of treatment. However, from 24 h after farrowing to weaning, sows fed one daily meal prior to farrowing had an increased (P = 0.012) percentage of fall-behind pigs compared with sows fed on an ad libitum basis, and increased (P = 0.027) preweaning mortality compared with sows fed four daily meals, resulting in reduced (P = 0.006) weaned percentage compared with sows fed four daily meals. There was no evidence for difference (P > 0.10) in subsequent reproductive performance regardless of treatment. In conclusion, when sows were fed on an ad libitum basis from 2 to 3 d, before farrowing there was an observed improvement in sow BW and BF maintenance during lactation, and piglet weaning weight during lactation. Increased frequency of meals prior to farrowing improved the survival of pigs to weaning compared with sows fed a single meal prior to farrowing.

Background Two experiments were conducted to determine the effects of increasing amounts of soybean meal (SBM) in swine diets and estimate the energy value of SBM. Methods A total of 2233 pigs (PIC 337 × 1050, Hendersonville, TN) and 3796 pigs (PIC 359 × C40), initially 11.0 kg and 17.6 kg body weight (BW), were used in Exp. 1 and 2, respectively. In Exp. 1, pigs were placed in 92 pens each containing 20 to 27 pigs. In Exp. 2, pigs were placed in 84 pens each containing 37 to 43 pigs. Treatments were assigned in a randomized complete block design with BW as the blocking factor. Dietary treatments consisted of 21%, 27%, 33%, or 39% SBM in Exp. 1 and 17.5%, 22%, 26.5%, 31%, 35.5%, or 40% SBM in Exp. 2, obtained by changing the inclusion rate of feed-grade amino acids and corn grain. For Exp. 1, representative samples of corn grain, SBM, and distillers dried grains with solubles were analyzed for total AA content prior to diet formulation. For Exp. 2, diets were formulated using NRC (2012) nutrient loadings. Treatment diets were fed for 21 and 22 d (Exp. 1 and 2) and there were 23 replicates in Exp. 1 and 14 replicates in Exp. 2. Pigs were weighed and feed disappearance measured weekly to calculate average daily gain (ADG), average daily feed intake (ADFI), gain-to-feed ratio (G:F), and caloric efficiency (CE). Data were analyzed with block as a random effect and treatment as a fixed effect, and contrasts were constructed to test the linear and quadratic effects of increasing SBM. Results In Exp. 1, there was a tendency (linear, P  = 0.092) for a decrease in ADFI as SBM increased. There was a tendency ( P  = 0.090) for a quadratic response for ADG, with a decrease in ADG observed with 39% SBM inclusion. Pigs fed diets with increasing SBM had a tendency (quadratic, P  = 0.069) for an increase in G:F up to 33% SBM and an improvement (linear, P  = 0.001; quadratic, P  = 0.063) in CE with increasing SBM. Using CE to estimate the energy of SBM relative to corn, a value of 105.4% of corn energy or 2816 kcal/kg NE was determined using all data points. When removing the CE value of the 39% SBM treatment due to the quadratic tendency, SBM was estimated to have 121.1% of corn energy or 3236 kcal/kg NE. In Exp. 2, there was a decrease (linear, P  = 0.001) in ADFI. Pigs fed increasing SBM had a tendency (linear, P  = 0.065) for reduced ADG but an improvement (linear, P  = 0.001) in G:F and CE as SBM increased. The energy value of SBM was estimated as 124.7% of corn energy or 3332 kcal/kg NE. Conclusions The results suggest that feeding increasing levels of SBM improves G:F and CE. The energy value of SBM was estimated to be between 105% and 125% of corn, which is much greater than the NRC (2012) would indicate.

This meta-analysis aims to understand the changes in pig body weight (BW) variation from birth to market and develop prediction equations for coefficient of variation (CV) and standard deviation (SD) as a function of BW. Standard deviation is the measure of dispersion of a set of values from the mean and CV is the SD expressed as a percentage of the mean. Data collected from 16 papers and data sets yielded 117,268 individually weighed pigs with sample size ranging from 120 to 4108 pigs. Polynomial regression analysis was conducted separately for each variation measurement. The resulting prediction equations (CV (%) = 20.04 − 0.135 × (BW) + 0.00043 × (BW)2, R2 = 0.79; SD = 0.41 + 0.150 × (BW) − 0.00041 × (BW)2, R2 = 0.95) suggest that there is a quadratic decreasing relationship between the CV of a population and BW, the slope gets smaller as mean BW increases from birth to market. A quadratic increasing relationship is observed for SD, with slope being smaller as mean BW of pigs increases from birth to market. These prediction equations can be used by swine producers to estimate expected CV and SD of BW among a population of pigs.

Abstract AbstractUnderstanding the relationship between sow and piglet characteristics that are associated with stillborn rate and preweaning mortality is beneficial as litter size continues to increase. Two experiments were previously conducted to evaluate prefarrowing nutrition regimens on sow and litter characteristics. These two datasets (experiments 1 and 2) were then used to identify sow and piglet characteristics associated with stillborn rate and piglet survival to weaning. A total of 1,201 sows that gave birth to 19,168 pigs comprised the dataset. The following characteristics were used in multivariate logistic regression analysis for traits associated with stillborn rate or survival to weaning: parity, litter weight, mean piglet birth weight, sow backfat, and BW at day 113 of gestation, gestation length, farrowing duration, litter size, piglet birth order, farrowing assistance, pig to teat ratio, colostrum intake, and colostrum yield. Sows within each experiment (herd) were categorized into quartiles for each of the independent variables to quantify the relationship to stillborn rate or survival to weaning. Increased stillborn rate was associated (P < 0.01) with heavier litter weights, lighter piglet birth weights, and larger litters in both experiments. In experiment 1, increased stillborn rate was associated (P < 0.01) with longer farrowing duration. Increased stillborn rate was associated with sows with less backfat depth at day 113, older parity, or increased farrowing assistance in experiment 2. In both experiments, pigs born later in the birth order had an increased (P < 0.01) risk of being stillborn. In both experiments, heavier piglet birth weight, greater colostrum intake, and lower total born were associated (P < 0.01) with increased survival to weaning. In experiment 2, pigs born in the first 75% of the litter, or in a litter with lower pig to teat ratio were associated (P < 0.01) with increased survival to weaning. Although the stillborn rate was similar between experiments (6.5% vs. 6.6%), differences in the traits associated with stillborn rate between studies indicate that some associated traits may be herd dependent. However, improving piglet birth weight, placing an emphasis on assisting pigs born later in the birth order and increasing colostrum intake will increase piglet survival from birth to weaning.

Abstract An experiment was conducted to evaluate the effect of dietary medium-chain fatty acid (MCFA) addition on nursery pig growth performance, fecal microbial composition, and mitigation of porcine epidemic diarrhea virus (PEDV) following storage. A total of 360 pigs (DNA 400 × 200, Columbus, NE; initially 6.7 ± 0.07 kg) were randomized to pens (5 pigs per pen) on the day of weaning (approximately 20 d of age), allowed a 6-d acclimation, blocked by BW, and randomized to dietary treatment (9 pens per treatment). All MCFA (Sigma–Aldrich, St. Louis, MO) were guaranteed ≥98% purity, including hexanoic (C6:0), octanoic (C8:0), and decanoic (C10:0) acids. Treatment diets were formulated in 2 phases (7 to 11 and 11 to 23 kg BW) and formulated to meet or exceed NRC requirement estimates. Treatments (n = 8) were a dose response including 0%, 0.25%, 0.5%, 1.0%, and 1.5% added MCFA blend (1:1:1 ratio C6:0, C8:0, and C10:0), as well as treatments with individual additions of 0.5% C6:0, C8:0, or C10:0. Fecal samples were collected from pigs fed control and 1.5% MCFA blend diets on days 0 and 14 and analyzed using 16s rDNA sequencing. Following feed manufacture, feed was stored in bags at barn temperature and humidity for 40 d before laboratory inoculation with PEDV. Subsamples of retained feed were inoculated with PEDV to achieve a titer of 104 TCID50/g and separate sample bottles were analyzed on 0 and 3 d post-inoculation (dpi). Overall, ADG and ADFI were increased (linear, P ≤ 0.010) and feed efficiency (G:F) improved (linear, P = 0.004) with increasing MCFA blend. Pigs fed 0.5% C8:0 had greater (P = 0.038) ADG compared with pigs fed the control diet, and G:F was improved (P ≤ 0.024) when pigs were fed 0.5% C6:0, 0.5% C8:0, or 0.5% C10:0 compared with control. An inclusion level × day interaction was observed (quadratic, P = 0.023), where PEDV Ct values increased (quadratic, P = 0.001) on 0 dpi with increasing levels of MCFA blend inclusion and also increased on 3 dpi (linear, P < 0.001). Fecal microbial diversity and composition were similar between control and 1.5% MCFA blend. In summary, the use of MCFA in nursery pig diets improves growth performance, provides residual mitigation activity against PEDV, and does not significantly alter fecal microbial composition.