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The present study examined whether spatial processing in the unimpaired cognitive system is influenced by attentional load during multitasking. More specifically, it tested the hypothesis that high attentional load would induce spatial processing asymmetries in the form of a rightward attentional bias. We conducted two separate experiments on healthy adults (n = 101 and n = 98) by using web-based data collections. We capitalized on a condition of perceptual uncertainty to investigate the presence of these spatial asymmetries which cannot be easily detected under regular perceptual conditions. More specifically, we employed a primary audiovisual integration task, which involved presenting stimuli capable of eliciting the sound-induced flash illusion (i.e., task-relevant flashes accompanied by an incongruent number of sounds) on either the left or right side of the screen. This task enabled us to investigate audiovisual integration, but also indirectly provided an opportunity to sensitively explore spatial processing within a highly complex context. In Experiment 1, attentional load was increased by presenting stimuli to be retained before the audiovisual integration task (i.e., “offline” attentional load manipulation). Differently, in Experiment 2, attentional load was increased by having participants to perform visual discrimination during the audiovisual integration task (i.e., “online” attentional load manipulation). Attentional load was increased in a different way within each experiment to test the idea that more demanding tasks, albeit of different nature, would have similarly modulated performance. In both experiments, we replicated the increase of sound-induced flash illusion under high attentional load, which challenges the notion of an early and pre-attentive onset of the illusion. However, this effect was identical for left- and right-sided flashes, which speaks against the existence of load-induced spatial processing asymmetries in the unimpaired cognitive system. Given that both experiments yielded similar results, quantitative aspects of attentional engagement rather than the nature of the attentional resources involved seem to play a critical role.

Background Anismus or non-relaxing puborectalis muscle (PRM), detectable with anal/vaginal ultrasound (US), is a cause of obstructed defecation (OD) and may be treated with biofeedback (BFB). Many patients with anismus are anxious and/or depressed. The aim of this prospective study was to evaluate the outcome of the novel procedure psycho-echo-BFB in patients with anismus and psychological disorders. Methods Patients presenting at our unit with anismus and psychological disorders between January 2009 and December 2013, and not responding to conventional conservative treatment, were enrolled in the study. All underwent four sessions of psycho-echo-BFB, carried out by two psychologists and a coloproctologist, consisting of guided imagery, relaxation techniques and anal/vaginal US-assisted BFB. A validated score for OD was used, and PRM relaxation on straining measured before and after the treatment. PRM relaxation was also measured in a control group of 7 patients with normal bowel habits. Results Ten patients (8 females, median age 47 years, range 26–72 years) underwent psycho-echo-BFB. The OD score, evaluated prior to and at a median of 25 months (range 1–52 months) after the treatment, improved in 7 out of 10 patients, from 13.5 ± 1.2 to 9.6 ± 2.2 (mean ± standard error of the mean (SEM)), p  = 0.06. At the end of the last session, PRM relaxed on straining in all cases, from 0 to 7.1 ± 1.1 mm, i.e., physiological values, not statistically different from those of controls (6.6 ± 1.5 mm). Two patients reported were cured, 3 improved and 5, all of whom had undergone prior anorectal surgery, unchanged. No side effects were reported. Conclusions Psycho-echo-BFB is safe and inexpensive and allows all patients with anismus to relax PRM on straining. Previous anorectal surgery may be a negative predictor.

Porous solids such as zeolites and metal-organic frameworks are useful in molecular separation and in catalysis, but their solid nature can impose limitations. For example, liquid solvents, rather than porous solids, are the most mature technology for post-combustion capture of carbon dioxide because liquid circulation systems are more easily retrofitted to existing plants. Solid porous adsorbents offer major benefits, such as lower energy penalties in adsorption-desorption cycles, but they are difficult to implement in conventional flow processes. Materials that combine the properties of fluidity and permanent porosity could therefore offer technological advantages, but permanent porosity is not associated with conventional liquids. Here we report free-flowing liquids whose bulk properties are determined by their permanent porosity. To achieve this, we designed cage molecules that provide a well-defined pore space and that are highly soluble in solvents whose molecules are too large to enter the pores. The concentration of unoccupied cages can thus be around 500 times greater than in other molecular solutions that contain cavities, resulting in a marked change in bulk properties, such as an eightfold increase in the solubility of methane gas. Our results provide the basis for development of a new class of functional porous materials for chemical processes, and we present a one-step, multigram scale-up route for highly soluble 'scrambled' porous cages prepared from a mixture of commercially available reagents. The unifying design principle for these materials is the avoidance of functional groups that can penetrate into the molecular cage cavities.

In the present paper, we compare the predictions of two well known mechanisms considered able to solve the cusp/core problem (a. supernova feedback; b. baryonic clumps-DM interaction) by comparing their theoretical predictions to recent observations of the inner slopes of galaxies with masses ranging from dSphs to normal spirals. We compare the α - V rot and the α - M ∗ relationships, predicted by the two models with high resolution data coming from Adams et al. (Astrophys. J. 789, 63, 2014 ), Simon et al. (Astrophys. J. 621, 757, 2005 ), LITTLE THINGS (Oh et al. in Astron. J. 149, 180, 2015 ), THINGS dwarves (Oh et al. in Astron. J. 141, 193, 2011a ; Oh et al. in Astron. J. 142, 224, 2011b ), THINGS spirals (Oh et al. in Astron. J. 149, 180, 2015 ), Sculptor, Fornax and the Milky Way. The comparison of the theoretical predictions with the complete set of data shows that the two models perform similarly, while when we restrict the analysis to a smaller subsample of higher quality, we show that the method presented in this paper (baryonic clumps-DM interaction) performs better than the one based on supernova feedback. We also show that, contrarily to the first model prediction, dSphs of small mass could have cored profiles. This means that observations of cored inner profiles in dSphs having a stellar mass < 10 6 M ⊙ not necessarily imply problems for the Λ CDM model.

Classical novae are cataclysmic binary star systems in which the matter of a companion star is accreted on a white dwarf 1 , 2 . Accumulation of hydrogen in a layer eventually causes a thermonuclear explosion on the surface of the white dwarf 3 , brightening the white dwarf to ~10 5 solar luminosities and triggering ejection of the accumulated matter. Novae provide the extreme conditions required to accelerate particles, electrons or protons, to high energies. Here we present the detection of gamma rays by the MAGIC telescopes from the 2021 outburst of RS Ophiuchi, a recurrent nova with a red giant companion, which allowed us to accurately characterize the emission from a nova in the 60 GeV to 250 GeV energy range. The theoretical interpretation of the combined Fermi LAT and MAGIC data suggests that protons are accelerated to hundreds of gigaelectronvolts in the nova shock. Such protons should create bubbles of enhanced cosmic ray density, of the order of 10 pc, from the recurrent novae. Detection of the 2021 outburst of the nova RS Oph in very-high-energy gamma rays by the MAGIC telescopes is reported. Investigation of the gamma-ray emission provides evidence for acceleration of protons within the nova shock, which then propagate outwards to create bubbles of enhanced cosmic ray density.

Objective: To determine the success rate of percutaneous first stage of sacral neuromodulation (SNM) and the efficacy and safety of permanent SNM for incomplete spinal cord lesion (SCL) patients suffering from chronic neurogenic non-obstructive urinary retention (N-NOR). Method: From January 2003 to December 2012, 85 individuals underwent the percutaneous first stage of SNM. Subsequently, only responders who reached a concomitant reduction by at least 50% of volume per catheterization and in the number of catheterizations per day comparing their 7-day voiding diaries at baseline underwent permanent SNM. Final follow-up was conducted by April 2013. Results: Thirty-six individuals responded to percutaneous first stage of SNM. Post-surgery urodynamics documented all patients experiencing first sensation of bladder filling. A statistically significant increase in Qmax ml per sec and decrease in post-voiding residual urine per ml were documented. ( P <0.01). First sensation of bladder filling at baseline represented a statistically significant parameter for the success of the first stage SNM ( P <0.05). Eleven out of 34 patients at follow-ups were ‘inconstant responders’ because they returned to similar baseline voiding symptoms, but responded again with an implant on the controlateral S3 sacral root. Two failed twice and responded once again after an S4 sacral root implant. All but one failure occurred more than 3 years after the previous implant. Other drawbacks were resolved telemetrically. Conclusions: Research is needed to increase the success rate of the first stage SNM on incomplete SCL patients with N-NOR. Permanent SNM is highly efficacious in the medium follow-up.

The Pierre Auger Observatory, which is the largest air-shower experiment in the world, offers unprecedented exposure to neutral particles at the highest energies. Since the start of data collection more than 18 years ago, various searches for ultra-high-energy (UHE, E≳1017eV) photons have been performed, either for a diffuse flux of UHE photons, for point sources of UHE photons or for UHE photons associated with transient events such as gravitational wave events. In the present paper, we summarize these searches and review the current results obtained using the wealth of data collected by the Pierre Auger Observatory.

IntroductionRecently, a 3D phase-contrast technique called 4DFlow has been implemented at MRA in order to quantify blood velocity through the cardiovascular system.1 Due to the curvature and caliber of the cerebral arteries, 4DFlow acquisition and its post-processing has been clinically underdeveloped to pathologies such as aneurysms.2AimTo standardize the 4DFlow acquisition and its post-processing at healthy (HT) and aneurysmal patients (AN).MethodsThis retrospective study was approved by the IRB. Eight subjects (5 HC and 3 AN) were studied in a 1.5T Ingenia Philips scanner. The aneurysms analyzed had amaximum radiusbetween 19 and 2,6 mm, aneck/dome ratiobetween 3,4 and 1.1 were studied within three days prior to embolization. In addition to a standard high-resolution MRA, 4DFlow was acquired with a cubic resolution of 2 mm and 25 temporal phases (in a cardiac cycle). Post-processing was done with an in-house Python routine using finite elements and molecular dynamics algorithms.ResultsIn the vascular regions without pathology, flow, vortex, energy loss and wall shear stress (WSS) analyses were consistent with laminar flow. In aneurysms, turbulent flow (vortex) and pressure heterogeneity along the lesion (WSS) were demonstrated.ConclusionBoth the proposed changes to the standard 4DFlow acquisition (flip angle, sense, temporal/spatial resolutions, phases) and the designed post-processing allow to obtain expected hydrodynamic behaviors in the blood flow at the studied regions.ReferencesDyverfeldt, P., Bissell, M., Barker, A. J., et al. 4D flow cardiovascular magnetic resonance consensus statement. Journal of Cardiovascular Magnetic Resonance 2015;17(1), 1–19.Dunås, T., Holmgren, M., Wåhlin, A., Malm, J., & Eklund, A. (2019). Accuracy of Blood Flow Assessment in Cerebral Arteries with 4D Flow MRI: Evaluation with Three SegmentationDo you have any conflict of interest to declare?: No

Urinary disorders are uncommon in the initial phases of multiple sclerosis, but increase in frequency as the disease progresses, with a negative impact on quality of life. The goal of this study was to propose a protocol for the diagnosis and treatment of urinary disorders in multiple sclerosis, based on data from the scientific literature and the experience of Italian clinical centres. In particular, the following clinical aspects were considered: what to do with patients with asymptomatic multiple sclerosis; what to do with symptomatic patients; how and when to perform a second-level diagnostic evaluation; and how to treat urinary disorders. A diagnostic–therapeutic algorithm is proposed, that can be applied in Italian clinical centres.