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Engineering the interaction between light and matter is an important goal in the emerging field of quantum opto-electronics. Thanks to the use of cavity quantum electrodynamics architectures, one can envision a fully hybrid multiplexing of quantum conductors. Here we use such an architecture to couple two quantum dot circuits. Our quantum dots are separated by 200 times their own size, with no direct tunnel and electrostatic couplings between them. We demonstrate their interaction, mediated by the cavity photons. This could be used to scale up quantum bit architectures based on quantum dot circuits or simulate on-chip phonon-mediated interactions between strongly correlated electrons. Controlling the interaction between distant quantum dots is important if they are to be used in quantum information devices. Delbecq et al . place two quantum dot circuits in a microwave cavity and show that they interact via cavity photons, even though they are separated by 200 times their own size.