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"Demuth, Patricia"
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Diagnostic Studies for the Aged: What are the Dangers?
Fluid imbalance is probably the most significant danger to the aged when they undergo diagnostic studies. Know what to look for in your clients and what to do to help them.
Journal Article
Who is Bill Gates?
\"Bill Gates, born in Seattle, Washington, in 1955, is an American business magnate, investor, philanthropist, and author. In this Who Was...? biography, children will learn of Gates' childhood passion for computer technology, which led him to revolutionize personal computers. Through the success of his now-world-famous software company, Microsoft, Bill Gates became one of the wealthiest philanthropists in history.This fascinating story of a child technology genius is sure to captivate any audience!\"-- Provided by publisher.
Book
من هو بيل غيتس ؟
تناول الكتاب حيث حضر رجال الأعمال إلى شركة صغيرة تدعى \"مايكروسوفت\" في عام 1980، بغرض مقابلة رئيس الشركة وهو \"بيل جيتس\". كانوا يرتدون بذلات تحتها قمصان بيضاء اللون، تزينها أربطة العنق، ويحملون في أيديهم حقائب جلدية، وبدت على مظهرهم الأهمية، وقد كانوا كذلك بالفعل، إذ كانوا المديرين التنفيذيين لشركة آي بي إم، وقد كانت شركة آي بي إم حينذاك هي كبرى شركات تصنيع أجهزة الكمبيوتر في العالم، وعندما وصل إليهم شاب صغير سألوه عن مكان مكتب \"بيل جيتس\"، فذهب بهم الشاب إلى المكتب، وحينما وصلوا إليه، جلس هذا الشاب الصغير على المكتب ! فقد كان هو \"بيل جيتس\" رئيس شركة مايكروسوفت ! وفي ذلك الحين كان عمر \"بيل جيتس\" أربعة وعشرين عامًا فقط، بل بدا شكله أصغر من سنه الحقيقية.
BOOK
Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis
Gremlin-1 has been implicated in liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) via inhibition of bone morphogenetic protein (BMP) signalling and has thereby been identified as a potential therapeutic target. Using rat in vivo and human in vitro and ex vivo model systems of MASH fibrosis, we show that neutralisation of Gremlin-1 activity with monoclonal therapeutic antibodies does not reduce liver inflammation or liver fibrosis. Still, Gremlin-1 was upregulated in human and rat MASH fibrosis, but expression was restricted to a small subpopulation of COL3A1/THY1 + myofibroblasts. Lentiviral overexpression of Gremlin-1 in LX-2 cells and primary hepatic stellate cells led to changes in BMP-related gene expression, which did not translate to increased fibrogenesis. Furthermore, we show that Gremlin-1 binds to heparin with high affinity, which prevents Gremlin-1 from entering systemic circulation, prohibiting Gremlin-1-mediated organ crosstalk. Overall, our findings suggest a redundant role for Gremlin-1 in the pathogenesis of liver fibrosis, which is unamenable to therapeutic targeting.
Journal Article
What was Pearl Harbor?
An introduction to the pivotal moment in U.S. history that propelled the country into World War II.
Book
Clinical Validation of Artificial Intelligence–Augmented Pathology Diagnosis Demonstrates Significant Gains in Diagnostic Accuracy in Prostate Cancer Detection
Prostate cancer diagnosis rests on accurate assessment of tissue by a pathologist. The application of artificial intelligence (AI) to digitized whole slide images (WSIs) can aid pathologists in cancer diagnosis, but robust, diverse evidence in a simulated clinical setting is lacking.
To compare the diagnostic accuracy of pathologists reading WSIs of prostatic biopsy specimens with and without AI assistance.
Eighteen pathologists, 2 of whom were genitourinary subspecialists, evaluated 610 prostate needle core biopsy WSIs prepared at 218 institutions, with the option for deferral. Two evaluations were performed sequentially for each WSI: initially without assistance, and immediately thereafter aided by Paige Prostate (PaPr), a deep learning-based system that provides a WSI-level binary classification of suspicious for cancer or benign and pinpoints the location that has the greatest probability of harboring cancer on suspicious WSIs. Pathologists' changes in sensitivity and specificity between the assisted and unassisted modalities were assessed, together with the impact of PaPr output on the assisted reads.
Using PaPr, pathologists improved their sensitivity and specificity across all histologic grades and tumor sizes. Accuracy gains on both benign and cancerous WSIs could be attributed to PaPr, which correctly classified 100% of the WSIs showing corrected diagnoses in the PaPr-assisted phase.
This study demonstrates the effectiveness and safety of an AI tool for pathologists in simulated diagnostic practice, bridging the gap between computational pathology research and its clinical application, and resulted in the first US Food and Drug Administration authorization of an AI system in pathology.
Journal Article
Snakes
An introduction to an animal that's been with us since the time of the dinosaurs--the snake.
Book
Sentence-Position Effects on Children’s Perception and Production of English Third Person Singular –s
Purpose: Two-year-olds produce third person singular \"-s\" more accurately on verbs in sentence-final position as compared with verbs in sentence-medial position. This study was designed to determine whether these sentence-position effects can be explained by perceptual factors. Method: For this purpose, the authors compared 22- and 27-month-olds' perception and elicited production of third person singular \"-s\" in sentence-medial versus-final position. The authors assessed perception by measuring looking/listening times to a 1-screen display of a cartoon paired with a grammatical versus an ungrammatical sentence (e.g., \"She eats now\" vs. \"She eat now\"). Results: Children at both ages demonstrated sensitivity to the presence/absence of this inflectional morpheme in sentence-final, but not sentence-medial, position. Children were also more accurate at producing third person singular \"-s\" sentence finally, and production accuracy was predicted by vocabulary measures as well as by performance on the perception task. Conclusions: These results indicate that children's more accurate production of third person singular \"-s\" in sentence-final position cannot be explained by articulatory factors alone but that perceptual factors play an important role in accounting for early patterns of production. The findings also indicate that perception and production of inflectional morphemes may be more closely related than previously thought.
Journal Article