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Root exudates are carriers for the transfer of material, energy and information between plant roots and soils. Plants encountering environmental stresses such as heavy metal pollution adapt to the environment by producing and secreting root exudates. In this study, laboratory soil culture experiment and pot experiment with Sedum plumbizincicola were used to study the effects of single and combined application of three root exudates, citric acid, glycine, and fructose, on the Cd-activation and phytoremediation of Cd-contaminated paddy soil. Results from the soil culture experiment showed that for the single application of root exudates, all three root exudates significantly activated the Cd in soil as presented by the increased content of diethylenetriamine pentaacetic acid extracted Cd (DTPA-Cd). In Particular, citric acid (SC) at a relatively low concentration (2 mmol/kg) exhibited the best Cd activation efficiency by increasing DTPA-Cd in the soil by 66.12%. For the combined application of root exudates, citric acid in combination with glycine (SC + G, 1:3) had the best activation effect on the Cd in the soil. In the phytoremediation pot experiment, both the single application of citric acid at a low concentrate (1 mmol/kg) and the combined application of citric acid and glycine (1:1) significantly reduced the total Cd and DTPA-Cd in the soil and increased the biomass and the content of Cd in S. plumbizincicola ; thus, the phytoremediation efficiency of Cd-contaminated soil increased by 42.33% and 35.61%. The results from this study suggest that citric acid plays a crucial role in Cd activation and phytoremediation with single or combined applications with glycine. However, the mechanisms under the synergetic interaction between citric acid and glycine require further investigation.

Complement functions as an important host defense system and complement C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role of other complement components in tuberculosis. Complement gene expression in peripheral blood mononuclear cells of tuberculosis patients and controls were determined using whole genome transcriptional microarray assays. The mRNA and protein levels of three C1q components, C1qA, C1qB, and C1qC, were further validated by qRT-PCR and enzyme-linked immunosorbent assay, respectively. The percentages of C1q expression in CD14 positive cells were determined by flow cytometry. Finally, C1qC protein level was quantified in the pleural fluid of tuberculosis and non-tuberculosis pleurisy. C1q expression increases significantly in the peripheral blood of patients with active tuberculosis compared to healthy controls and individuals with latent TB infection. The percentage of C1q-expressing CD14 positive cells is significantly increased in active TB patients. C1q expression in the peripheral blood correlates with sputum smear positivity in tuberculosis patients and is reduced after anti-tuberculosis chemotherapy. Notably, receiver operating characteristic analysis showed that C1qC mRNA levels in peripheral blood efficiently discriminate active from latent tuberculosis infection and healthy controls. Additionally, C1qC protein level in pleural effusion shows improved power in discriminating tuberculosis from non-tuberculosis pleurisy when compared to other inflammatory markers, such as IL-6 and TNF-α. C1q expression correlates with active disease in human tuberculosis. C1q could be a potential diagnostic marker to discriminate active tuberculosis from latent tuberculosis infection as well as tuberculosis pleurisy from non-tuberculosis pleurisy.

Due to the extraordinary mechanical properties of ultra-high-performance concrete (UHPC), the shear stirrups in UHPC beams could potentially be eliminated. This study aimed to determine the effect of beam height and steel fiber volume content on the shear behavior of non-stirrup UHPC beams under a larger shear span–depth ratio (up to 2.8). Eight beams were designed and fabricated including six non-stirrup UHPC beams and two comparing stirrup-reinforced normal concrete (NC) beams. The experimental results demonstrated that the steel fiber volume content could be a crucial factor affecting the ductility, cracking strength, and shear capacity of non-stirrup UHPC beams and altering their failure modes. Additionally, the height of the beam had a considerable effect on its shear resistance. French standard formulae were more accurate for the UHPC beams with larger shear span–depth ratios, PCI-2021 formulae greatly overestimated the shear capacity of UHPC beams with larger shear span–depth ratios, and Xu’s formulae were more accurate for the steel fiber-reinforced UHPC beams with larger shear span–depth ratios. In summary, French standard formulae were the most suitable formulae for predicting the shear capacity of UHPC beams in this paper.

The formation of many hydrothermal gold deposits is closely related to iron-rich rocks. The host rocks of the Madiyi Formation of the Mid- to Late Neoproterozoic Banxi Group for the Woxi Au (-Sb-W) deposit, which is located in western Hunan Province of the western Jiangnan Orogen, South China, is rich in hematite, which provides a good example for studying the relationship between the formation of gold deposit and iron-rich rocks. Field investigation and petrographic observation on the unaltered, weakly altered and strongly altered rocks demonstrate that the bleaching is caused by a combination of carbonatization, sulfidation and sericitization. Mass balance calculation suggests that, during decolourization there is no change in TFe 2 O 3 , while FeO is gained and Fe 2 O 3 is lost. Geochemical modeling found that Au was mainly present as AuHS(aq) and Au(HS) 2 − , and that the water-rock interactions decreased the sulfur fugacity which destroyed the stability of such aqueous complexes. Combined with the locally occurred native gold in quartz veins, it is concluded that the major gold precipitation mechanisms are sulfidation and fluid boiling. Based on previous geochronological and geochemical research further gold mineralization is proposed to be generated by deep sourced magmatic or metamorphic fluid migrated upward along the Woxi fault, and the iron-rich Madiyi Formation is the idea chemical trap for gold deposition. The decrease of sulfur contents caused by fluid-rock interactions and fluid boiling are the major mechanisms for gold mineralization.

The shear stirrups and bend-up reinforcement in ultra-high-performance concrete (UHPC) beams could potentially be excluded due to the superior mechanical properties of UHPC. This paper reports the new findings of an experimental research into the factors that influence the shear behavior of non-stirrup UHPC beams. Fourteen beams were tested in shear, comprising twelve non-stirrup UHPC beams and two normal concrete (NC) beams reinforced with stirrups. The test variables included the steel fiber volume content (2.0%, 1.5%, and 0%), the shear span-to-effective-depth ratio (1.2, 1.8, 2.0, and 3.1), beam width (150 mm and 200 mm), and beam height (300 mm, 350 mm, and 400 mm). The results demonstrated that the steel fiber volume content had a significant influence on the shear behavior of the non-stirrup UHPC beams. The failure modes of the beams without steel fibers were typically brittle, whereas those reinforced with steel fibers exhibited ductile failure. The shear resistance of the beams could be significantly enhanced by the addition of steel fibers in the concrete mix. Furthermore, the post-cracking load-bearing performance of the beams could also be markedly improved by the addition of steel fibers. In addition, the shear span-to-effective-depth ratio had a considerable impact on the failure mode and the ultimate shear strength of the tested beams. The contribution of steel fibers to the shear capacity of the UHPC beams was observed to increase as the shear span-to-effective-depth ratio increased. The French standard formulae tended to overestimate the contribution of steel fibers, and the calculation results were found to be more accurate for UHPC beams with a moderate shear span-to-effective-depth ratio (around 2.0). Moreover, the French standard formulae demonstrated greater accuracy at a larger beam height for calculating the contribution of UHPC matrix.

Background Chronic inflammatory disorders in peritoneal dialysis (PD) contribute to the adverse clinical outcome. Systemic immune inflammation index (SII) is the novel and convenient measurement that is positively associated with various diseases. However, scarce is known regarding the association between SII with all-cause mortality among PD patients. Methods In this multi-center retrospective cohort study, 1,677 incident patients with PD were enrolled. Eligible patients were stratified into groups based on SII level: tertile 1(< 456.76), tertile 2(456.76 to 819.03), and tertile 3(> 819.03). The primary endpoint was the all-cause mortality. Both Cox regression analysis and competing risk models were used to examine the association between SII and all-cause mortality. Subgroup analysis was performed to assess the influence of the SII tertiles on all-cause mortality in different subgroups. Results During the follow-up period of 30.5 ± 20.0 months, 26.0% (437/1,677) patients died, of whom the SII tertile 3 group accounted for 39.1% (171/437) of the deaths. Patients in the SII tertile 3 group had a higher all-cause mortality rate than patients in the SII tertile 1 and 2 groups (log-rank = 13.037, P  < 0.001). The SII tertile 3 group was significantly associated with 80% greater risk (95% confidence interval:1.13 to 2.85; P  = 0.013) compared with the SII tertile 1 group in multivariable Cox regression analysis. The competing risk model also indicated that the relationship between SII tertiles and all-cause mortality remains (subdistribution hazard ratio: 1.86; 95% confidence interval: 1.15 to 2.02, P  = 0.011). Furthermore, the relationship between the log-transformed SII and all-cause mortality in patients with PD was nearly linear ( P  = 0.124). Conclusion A close relationship was observed between the SII and all-cause mortality in patients undergoing PD, suggesting that more attention should be paid to the SII, which is a convenient and effective measurement in clinical practice.

The glucose-to-lymphocyte ratio (GLR), a glucose metabolism and systemic inflammatory response parameter, is associated with an adverse prognosis for various diseases. However, the association between serum GLR and prognosis in patients undergoing peritoneal dialysis (PD) is poorly understood. In this multi-center cohort study, 3236 PD patients were consecutively enrolled between 1 January 2009 and 31 December 2018. Patients were divided into four groups according to the quartiles of baseline GLR levels (Q1: GLR ≤ 2.91, Q2:2.91 < GLR ≤ 3.91, Q3:3.91 < GLR < 5.59 and Q4: GLR ≥ 5.59). The primary endpoint was all-cause and cardiovascular disease (CVD) related mortality. The correlation between GLR and mortality was examined using Kaplan-Meier and multivariable Cox proportional analyses. During the follow-up period of 45.93 ± 29.01 months, 25.53% (826/3236) patients died, of whom 31% (254/826) were in Q4 (GLR ≥ 5.59). Multivariable analysis revealed that GLR was significantly associated with all-cause mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .019) and CVD mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .04). Compared with the Q1 (GLR ≤ 2.91), placement in Q4 was associated with an increased risk of all-cause mortality (adjusted HR: 1.26, 95% CI: 1.02 ∼ 1.56, p = .03) and CVD mortality (adjusted HR 1.76; CI 1.31 ∼ 2.38, p < .001). A nonlinear relationship was found between GLR and all-cause or CVD mortality in patients undergoing PD (p = .032). A higher serum GLR level is an independent prognostic factor for all-cause and CVD mortality in patients undergoing PD, suggesting that more attention should be paid to GLR.

Background Although peritoneal dialysis (PD) is an efficient therapy for renal replacement, the long-term survival rate of patients undergoing PD remains low. The platelet-to-albumin ratio (PAR), recently identified as a parameter of inflammatory and nutritional status, is associated with an adverse prognosis for various diseases. However, the association between the serum PAR and prognosis of patients undergoing PD is poorly understood. This study aimed to evaluate whether the PAR is a reliable predictor of cardiovascular disease (CVD) and all-cause mortality in patients undergoing PD. Methods This multicenter cohort study enrolled patients undergoing PD from January 1, 2009, to September 30, 2018. The patients were divided into four groups according to the quartiles of their baseline PAR. The primary endpoint was all-cause and CVD-related mortality. Cox proportional hazard models were used to determine the association between the PAR and all-cause or CVD-related mortality. The receiver operating characteristic (ROC) curve was utilized to compare the performance among PAR and other inflammatory indicators. C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were applied to examine the incremental prognostic value of PAR compared with baseline model for predicting all-cause and CVD mortality. Results A total of 2825 patients were included. During the follow-up period of 47.5 ± 28.3 months, 747 (26.4%) mortality cases were observed, of which 415 (55.6%) were CVD-related. Compared with the Q1 (PAR < 4.43), placement in Q4 (PAR > 7.27) was associated with an increased risk of all-cause mortality and CVD mortality ( p  < 0.001). The adjusted restricted cubic spline analysis indicated that the relationship of the PAR with all-cause and cardiovascular mortality was linear (p for nonlinearity = 0.289 and 0.422, respectively). No positive correlations were shown in the interaction tests. PAR exhibited superior predictive value for mortality compared to other inflammatory indicators, with a respective AUC value of 0.611 ( P  < 0.001) for all-cause mortality and 0.609 ( P  < 0.001) for cardiovascular mortality. According to the C-statistic, continuous NRI and IDI, the addition of PAR to the baseline model yielded a moderate but significant improvement in outcome prediction. Conclusions The PAR is an independent prognostic factor associated with all-cause and cardiovascular mortality in patients undergoing PD.

In this paper, a bending test of a precast ultra-high-performance concrete (UHPC) diaphragm slab was carried out. The test revealed that the flexural failure process of specimens under the action of a positive bending moment can be divided into three stages: the elastic, crack-propagation, and yield stages. The first stiffness reduction of the structure was caused by cracks at the bottom of the diaphragm slab, while the second stiffness drop resulted from the yielding of the bottom longitudinal rebars. During the loading process, the ultimate bearing capacity was 3.75 times higher than the design load value (150 kN vs. 40 kN). Additionally, a nonlinear finite element model was established using Abaqus software validated by the test and exploiting parameter analysis. Based on this model, the initial crack stress of the actual slab was determined to be 5.12 MPa. Parameter analysis indicated that the shear strength of the diaphragm slab was stronger than the flexural strength, and the diaphragm slab’s bearing capacity could be improved by increasing the ratio of bottom longitudinal reinforcement. This research confirmed that the new UHPC diaphragm slab used in Guangzhou Smart City is safe, and it also helped the design of similar UHPC slabs for utility tunnels.

Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function. In this review, we will review the relevant roles that oral-gut microbial homeostasis plays in the pathogenesis of oral mucosal diseases and provide evidence for dysregulation of microbial homeostasis in patients with oral mucosal diseases, and explore specific probiotic strains by regulating oral and intestinal axis microbial homeostasis and host immune and inflammatory responses, in order to provide new ideas for the clinical treatment of oral mucosal diseases.