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"Dennis, Joe"
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Inferno : warzones!
\"Spinning out of the universe-shattering events of Secret Wars comes a new twist on the X-Men classic that's a whole hell of a lot hotter than you remember. Five years ago a band of demons rose up out of the fiery depths and turned Manhattan into Hell on Earth. The X-Men fought to vanquish the demon horde and... the X-Men failed. Welcome back to the Inferno. On this the fifth anniversary of Manhattan's fall, Colossus is leading a small band of mutants back into the Inferno. He doesn't know what they'll find on the other side of those flames but he knows for certain... They're not coming back without his sister.\" -- Provided by publisher.
BOOK
CanRisk-GP protocol: A feasibility study of incorporating proactive multifactorial breast cancer risk assessment into general practice
CanRisk is a risk assessment tool that implements the BOADICEA multifactorial breast cancer risk model. The BOADICEA model is recommended for use by the National Institute for Health and Care Excellence (NICE) in English, Welsh, and Northern Irish secondary/tertiary care to identify women who may be at moderate or high risk of developing breast cancer. BOADICEA combines information on cancer family history, demographic, lifestyle, hormonal risk factors and mammographic density with polygenic scores (PGS). Offering risk assessment using CanRisk in general practice has the potential to identify more women at moderate or high risk of developing breast cancer and improve their management and the appropriateness of referrals to secondary/tertiary care.
In this feasibility study we plan to invite women aged 40-49 years from 5-8 practices across Cambridgeshire and Peterborough in England, UK to complete a breast cancer risk assessment using CanRisk via a newly developed public-facing version of the CanRisk tool and provide saliva samples for PGS. The study team will provide a risk report back to both the participants and their GP, with those women at above-population level risk advised to make an appointment with their GP to be referred to the clinical genetics service and subsequently managed in line with current NICE guidelines. This study will provide evidence on (1) whether offering cancer risk assessment including PGS in general practice is feasible and acceptable to women and healthcare professionals; (2) whether this approach can identify women at above-population level risk of breast cancer who would otherwise not have been identified and so not had access to risk-reducing options; and (3) the costs associated with implementing proactive multifactorial breast cancer risk assessment in women under 50 within general practice.
This study is listed on the ISRCTN registry. The registration number is ISRCTN17376192.
Journal Article
Absolute Green Lantern/Green Arrow
\"This stunning Absolute Edition of Green Lantern/Green Arrow collect the early 1970s, featuring classic team-ups written by Dennis O'Neil with art by Neal Adams! In these stories, Green Lantern Hal Jordan continued his usual cosmic-spanning adventures, as he used his amazing Power Ring to police Sector 2814 against universe-threatening menaces. Meanwhile, on Earth, Oliver Queen, the archer known as Green Arrow, was confronting menaces of a different kind: racism, poverty, drugs, and other social ills! This Absolute Edition will include additional script and character development pages as well as character sketches\"-- Provided by publisher.
Book
Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
Background
Latin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have found an inverse relationship between the individual proportion of Native American ancestry and BC risk. Here, we use ancestry-informative markers to rule out potential confounding of this relationship, estimating the confounder-free effect of Native American ancestry on BC risk.
Methods and study population
We used the informativeness for assignment measure to select robust instrumental variables for the individual proportion of Native American ancestry. We then conducted separate Mendelian randomization (MR) analyses based on 1401 Colombian women, most of them from the central Andean regions of Cundinamarca and Huila, and 1366 Mexican women from Mexico City, Monterrey and Veracruz, supplemented by sensitivity and stratified analyses.
Results
The proportion of Colombian Native American ancestry showed a putatively causal protective effect on BC risk (inverse variance-weighted odds ratio [OR] = 0.974 per 1% increase in ancestry proportion, 95% confidence interval [CI] 0.970–0.978,
p
= 3.1 × 10
–40
). The corresponding OR for Mexican Native American ancestry was 0.988 (95% CI 0.987–0.990,
p
= 1.4 × 10
–44
). Stratified analyses revealed a stronger association between Native American ancestry and familial BC (Colombian women: OR = 0.958, 95% CI 0.952–0.964; Mexican women: OR = 0.973, 95% CI 0.969–0.978), and stronger protective effects on oestrogen receptor (ER)-positive BC than on ER-negative and triple-negative BC.
Conclusions
The present results point to an unconfounded protective effect of Native American ancestry on BC risk in both Colombian and Mexican women which appears to be stronger for familial and ER-positive BC. These findings provide a rationale for personalised prevention programmes that take genetic ancestry into account, as well as for future admixture mapping studies.
Journal Article
Avengers arena : the complete collection
\"Trapped on an isolated island, sixteen superhuman teens -- including members of the Runaways and Avengers Academy -- are given a chilling ultimatum by their demented captor. And only one of them will make it out alive! Thus begins a primal battle that tests each combatant's skills, stamina, and morals. Welcome to Arcade's Murderworld -- where secrets are plenty, alliances are fleeting, and the key to victory might be rewriting the rules of the game\"--Page [4] of cover.
Book
Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study
Background
Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in an increased burden of cardiovascular disease in breast cancer survivors. Risk stratification may help address this clinical dilemma. This study is the first to assess the association between a coronary artery disease-specific polygenic risk score and incident coronary artery events in female breast cancer survivors.
Methods
We utilized the Studies in Epidemiology and Research in Cancer Heredity prospective cohort involving 12,413 women with breast cancer with genotype information and without a baseline history of cardiovascular disease. Cause-specific hazard ratios for association of the polygenic risk score and incident coronary artery disease (CAD) were obtained using left-truncated Cox regression adjusting for age, genotype array, conventional risk factors such as smoking and body mass index, as well as other sociodemographic, lifestyle, and medical variables.
Results
Over a median follow-up of 10.3 years (IQR: 16.8) years, 750 incident fatal or non-fatal coronary artery events were recorded. A 1 standard deviation higher polygenic risk score was associated with an adjusted hazard ratio of 1.33 (95% CI 1.20, 1.47) for incident CAD.
Conclusions
This study provides evidence that a coronary artery disease-specific polygenic risk score can risk-stratify breast cancer survivors independently of other established cardiovascular risk factors.
Journal Article
Batman by Neal Adams
\"Experience all of Neal Adams' legendary Batman work--covers and stories--in chronological order! Batman by Neal Adams Book One contains Adams' contributions to the Dark Knight's legacy from 1967 through 1969, showing the process of introduction, adaption and innovation that the young artist brought to this legendary crime-fighter! Over the years, only a handful of artists have truly shaped the look of DC Comics' Batman. But since the original creation of the character in the 1930s by Bob Kane and Bill Finger, undoubtedly the most influential individual to take up the mantle of the Bat is Neal Adams. Beginning in the late 1960s and continuing through the 1970s, Adams' reimagining of \"the Batman\" revitalized the Caped Crusader for an entire generation of fans, rescuing him from TV-inspired campiness and returning him to his roots as a shadowy urban vigilante. In Adams' talented hands, Batman matured into \"the Dark Knight\"--a transformation that not only delighted readers and inspired his creative peers, but also planted the seeds for the 21st century's explosive growth of comics and superheroes into every corner of the world's popular culture.\"-- Provided by publisher.
BOOK
Measuring the Non-linear Directed Information Flow in Schizophrenia by Multivariate Transfer Entropy
People living with schizophrenia (SCZ) experience severe brain network deterioration. The brain is constantly fizzling with non-linear causal activities measured by electroencephalogram (EEG) and despite the variety of effective connectivity methods, only few approaches can quantify the direct non-linear causal interactions. To circumvent this problem, we are motivated to quantitatively measure the effective connectivity by multivariate transfer entropy (MTE) which has been demonstrated to be able to capture both linear and non-linear causal relationships effectively. In this work, we propose to construct the EEG effective network by MTE and further compare its performance with the Granger causal analysis (GCA) and Bivariate transfer entropy (BVTE). The simulation results quantitatively show that MTE outperformed GCA and BVTE under varied signal-to-noise conditions, edges recovered, sensitivity, and specificity. Moreover, its applications to the P300 task EEG of healthy controls (HC) and SCZ patients further clearly show the deteriorated network interactions of SCZ, compared to that of the HC. The MTE provides a novel tool to potentially deepen our knowledge of the brain network deterioration of the SCZ.
Journal Article
Batman, the brave and the bold : the Bronze Age
\"The late '60s marked the height of Batmania, when fans of the Batman television series and the comic books couldn't get enough of the Caped Crusader. His appearances on covers meant higher sales, so it was decreed Batman would take up permanent residence in THE BRAVE AND THE BOLD. His courage was never questioned, and he fearlessly teamed up with the most daring partners from across the DC Universe at a time when such crossovers were rare. These groundbreaking stories featured some of Batman's greatest team-ups with such legendary characters as Wonder Woman, the Flash, Deadman, Green Arrow, Green Lantern, the Teen Titans and others, all by some of the foremost comics talent of the Bronze Age--Neal Adams, Jim Aparo, Bob Haney, Dick Giordano and Dennis O'Neil, to name a few.\"-- Provided by publisher.
Book
FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data
Background
Identifying subpopulations within a study and inferring intercontinental ancestry of the samples are important steps in genome wide association studies. Two software packages are widely used in analysis of substructure: Structure and Eigenstrat. Structure assigns each individual to a population by using a Bayesian method with multiple tuning parameters. It requires considerable computational time when dealing with thousands of samples and lacks the ability to create scores that could be used as covariates. Eigenstrat uses a principal component analysis method to model all sources of sampling variation. However, it does not readily provide information directly relevant to ancestral origin; the eigenvectors generated by Eigenstrat are sample specific and thus cannot be generalized to other individuals.
Results
We developed FastPop, an efficient R package that fills the gap between Structure and Eigenstrat. It can: 1, generate PCA scores that identify ancestral origins and can be used for multiple studies; 2, infer ancestry information for data arising from two or more intercontinental origins. We demonstrate the use of FastPop using 2318 SNP markers selected from the genome based on high variability among European, Asian and West African (African) populations. We conducted an analysis of 505 Hapmap samples with European, African or Asian ancestry along with 19661 additional samples of unknown ancestry. The results from FastPop are highly consistent with those obtained by Structure across the 19661 samples we studied. The correlations of the results between FastPop and Structure are 0.99, 0.97 and 0.99 for European, African and Asian ancestry scores, respectively. Compared with Structure, FastPop is more efficient as it finished ancestry inference for 19661 samples in 16 min compared with 21–24 h required by Structure. FastPop also provided scores based on SNP weights so the scores of reference population can be applied to other studies provided the same set of markers are used. We also present application of the method for studying four continental populations (European, Asian, African, and Native American).
Conclusions
We developed an algorithm that can infer ancestries on data involving two or more intercontinental origins. It is efficient for analyzing large datasets. Additionally the PCA derived scores can be applied to multiple data sets to ensure the same ancestry analysis is applied to all studies.
Journal Article