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result(s) for
"Denton, Terry"
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Killer koalas from outer space and lots of other very bad stuff that will make your brain explode!
A collection of ridiculous stories featuring zombie kittens, rocket-stealing ants, and, of course, killer koalas from outer space.
Book
Six practical tips for over-anxious parents
1. Relax. Childhood is not a competition or a race. Slow down and smell the Play-Doh. 2. Help your child find a balance between screen time, reading time and outside...
Newspaper Article
The 26-story treehouse
Andy and Terry, introduced in \"The 13-Story Treehouse\", have expanded their incredible arboreal residence by adding several exciting features, including a robot-controlled ice-cream parlor, a mud-fighting arena, an ATM (Automatic Tattoo Machine), and the Maze of Doom. Their publisher, Mr. Bignose, is demanding their next book, so the friends attempt to tell stories about how they met and how they first built their treehouse. They also have to cope with a tank of sick, underwear-eating sharks and a pack of invading buccaneers.
Book
What body part is that?
Provides a humorous explanation of where the superlative parts of the body are, what they look like, and their functions.
Book
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development.
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta.
Journal Article
The 52-story treehouse
Andy and Terry's incredible, ever-expanding treehouse has 13 new stories, including a watermelon-smashing level, a wave machine, a life-size snakes and ladders game (with real ladders and real snakes!), a rocket-powered carrot-launcher, a Ninja Snail Training Academy and a high-tech detective agency with all the latest high-tech detective technology, which is lucky because they have a BIG mystery to solve - where is Mr Big Nose??? Well, what are you waiting for? Come on up!
Book
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death
Malaria is a life-threatening disease caused by different species of the protozoan parasite
Plasmodium
, with
P. falciparum
being the deadliest. Increasing parasitic resistance to existing antimalarials makes the necessity of novel avenues to treat this disease an urgent priority. The enzymes responsible for the synthesis of phosphatidylcholine and phosphatidylethanolamine are attractive drug targets to treat malaria as their selective inhibition leads to an arrest of the parasite’s growth and cures malaria in a mouse model. We present here a detailed study that reveals a mode of action for two
P. falciparum
choline kinase inhibitors both
in vitro
and
in vivo
. The compounds present distinct binding modes to the choline/ethanolamine-binding site of
P. falciparum
choline kinase, reflecting different types of inhibition. Strikingly, these compounds primarily inhibit the ethanolamine kinase activity of the
P. falciparum
choline kinase, leading to a severe decrease in the phosphatidylethanolamine levels within
P. falciparum,
which explains the resulting growth phenotype and the parasites death. These studies provide an understanding of the mode of action, and act as a springboard for continued antimalarial development efforts selectively targeting
P. falciparum
choline kinase.
Journal Article
The 13-storey treehouse
Andy and Terry live in the WORLD'S BEST treehouse! It's got a giant catapult, a secret underground laboratory, a tank of man-eating sharks and a marshmallow machine that follows you around and shoots marshmallows into your mouth whenever you're hungry! Just watch out for the sea monkeys, and the monkeys pretending to be sea monkeys, and the giant mutant mermaid sea monster ... Oh, and, whatever you do, don't get trapped in a burp-gas-filled bubble ...! Andy Griffiths and Terry Denton's fantastically funny The 13-Storey Treehouse is told through a combination of text and cartoon-style illustrations.
Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Journal Article