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Typhoons are hazard that is threatening the Philippines every year. Design and construction of the houses and shelter in Catanduanes changes rapidly incorporating provision against wind speed. The effect of typhoon become the basis in the design of structures and the windows components. The study sought to answer what is the type of house built in Catanduanes, what is typical window system used for houses/building in Catanduanes, what are the protection and provision being implemented to withstand the effect of high winds pressure, and what are the safety practices to counter the effect of high winds of typhoon? Most designs and houses constructed in the late 80's already introduced these provisions that make them easy to install the windows shutter locally termed as \"typhoon guard\". This was also implemented by architects, engineers, and owners as a mandatory inclusion in the building construction and design. The selection criteria for designer and owner include the budget, structural integrity of the window, and aesthetical appearance. Respondents acknowledge that windows must be protected from the force of gusty winds and debris impact and this will also ensure that your entire house or building stays safe and intact. Many respondents agree that it is vital to protect the window from breakage by using materials that can withstand the full force of the wind pressure or employing protection components to keep the window intact and safe. However, most owners of nipa hut and a handful of owners of bungalow houses suffer minor and major damages during super typhoon Rolly, and they have common concerns about their safety and evacuation to safe buildings is the ultimate safety practice to mitigate the risk pose by the typhoon. It is recommended that typical windows systems to be used in homes and buildings must be rigid enough to withstand wind forces. Safety practices to counter the effect of high winds of typhoon includes removal of possible debris and projectile must be practiced. Also, Integrated windows protection design such as windbreaker must be re-integrated into the design of the building and adopt new window design to mitigate typhoon wind forces.

Background Butterflies (Papilionoidea) are perhaps the most charismatic insect lineage, yet phylogenetic relationships among them remain incompletely studied and controversial. This is especially true for skippers (Hesperiidae), one of the most species-rich and poorly studied butterfly families. Methods To infer a robust phylogenomic hypothesis for Hesperiidae, we sequenced nearly 400 loci using Anchored Hybrid Enrichment and sampled all tribes and more than 120 genera of skippers. Molecular datasets were analyzed using maximum-likelihood, parsimony and coalescent multi-species phylogenetic methods. Results All analyses converged on a novel, robust phylogenetic hypothesis for skippers. Different optimality criteria and methodologies recovered almost identical phylogenetic trees with strong nodal support at nearly all nodes and all taxonomic levels. Our results support Coeliadinae as the sister group to the remaining skippers, the monotypic Euschemoninae as the sister group to all other subfamilies but Coeliadinae, and the monophyly of Eudaminae plus Pyrginae. Within Pyrginae, Celaenorrhinini and Tagiadini are sister groups, the Neotropical firetips, Pyrrhopygini, are sister to all other tribes but Celaenorrhinini and Tagiadini. Achlyodini is recovered as the sister group to Carcharodini, and Erynnini as sister group to Pyrgini. Within the grass skippers (Hesperiinae), there is strong support for the monophyly of Aeromachini plus remaining Hesperiinae. The giant skippers ( Agathymus and Megathymus ) once classified as a subfamily, are recovered as monophyletic with strong support, but are deeply nested within Hesperiinae. Conclusions Anchored Hybrid Enrichment sequencing resulted in a large amount of data that built the foundation for a new, robust evolutionary tree of skippers. The newly inferred phylogenetic tree resolves long-standing systematic issues and changes our understanding of the skipper tree of life. These resultsenhance understanding of the evolution of one of the most species-rich butterfly families.

This study investigates the awareness of geological hazards and disaster preparedness among communities in Catanduanes, Philippines. The research employs a descriptive survey method, utilising a validated questionnaire to assess knowledge and awareness across five key areas: basic disaster knowledge, geological hazard understanding, capacity building, preparedness and response, and post-disaster management. The findings reveal a complex landscape of community awareness. While respondents show strong recognition of common disasters like earthquakes and typhoons, there is limited understanding of a broader range of geological hazards. The study identifies significant communication gaps between government agencies and the public, particularly in disseminating disaster-related information. The study also notes a concerning lack of confidence among respondents regarding their disaster preparedness and the government’s readiness to face disasters. Based on these findings, the study recommends enhancing public education and communication strategies, particularly focusing on comprehensive hazard awareness, evacuation protocols and long-term recovery processes. The research underscores the importance of leveraging modern communication platforms and addressing gender disparities in information dissemination to build a more resilient community in Catanduanes.ContributionThis study provides valuable insights for policymakers, educators and disaster management professionals, providing a foundation for targeted interventions to improve geological hazard awareness and disaster preparedness in the region.

Pyomyositis is a skeletal muscle infection mainly found in tropical regions. It commonly affects larger muscles, especially those of the hips. MRI tends to be the gold standard for diagnosis. Staphylococcus aureus remains the predominant causal organism in most cases of pyomyositis. Immunocompromised patients are more likely to be susceptible to this infection.In our case, an immunocompetent 27-year-old male in rural southwest Virginia was found to have a large abscess in his upper arm. Contrast-enhanced CT scan was acquired prior to drainage, leading to the diagnosis of pyomyositis. Empiric treatment with IV vancomycin 1 g q 24 hours and piperacillin/tazobactam 3.375 mg q 8 hours, prompt incision and drainage, and negative pressure wound VAC led to a complete resolution of the infection.

Sulfuric acid anodization is one of the common methods used to improve corrosion resistance of aluminum alloys. Organic acids can be added to the sulfuric acid electrolyte in order to improve the properties of the anodized aluminum produced. In this study, the use of gallic acid as an additive to the sulfuric acid anodization of AA1100 was explored. The effect of varying anodization current density and gallic acid concentration on the properties of anodized aluminum samples was observed using electrochemical impedance spectroscopy, linear polarization, and scanning electron microscopy. It was observed that the corrosion resistance of samples anodized in gallic-sulfuric acid solution at 10 mA·cm−2 is lower than samples anodized in sulfuric acid. It was also observed that higher anodization current density can lead to lower corrosion resistances for aluminum samples anodized in gallic-sulfuric acid solution. However, samples anodized at 5 mA·cm−2 and at a gallic acid concentration of 5 g·L−1 showed better corrosion performance than the samples anodized in sulfuric acid only. This suggests that the use of low amounts of gallic acid as an additive for sulfuric acid anodization can lead to better corrosion resistances for anodized aluminum.

We report a female with infantile onset of systemic lupus erythematosus secondary to C1q deficiency, in whom we identified a novel homozygous mutation in C1qB. The patient developed a progressive encephalopathy associated with spasticity, and suffered several arterial ischaemic strokes. Cerebral imaging demonstrated acquired intracranial calcification and a cerebral vasculopathy reminiscent of moyamoya. This case demonstrates overlap with some features of Aicardi-Goutières syndrome which, like C1q deficiency, is a monogenic cause of inflammation involving dysregulation of the innate immune system and stimulation of a type I interferon response.

Understanding the evolutionary mechanisms governing the uneven distribution of species richness across the tree of life is a great challenge in biology. Scientists have long argued that sexual conflict is a key driver of speciation. This hypothesis, however, has been highly debated in light of empirical evidence. Recent advances in the study of macroevolution make it possible to test this hypothesis with more data and increased accuracy. In the present study, we use phylogenomics combined with four different diversification rate analytical approaches to test whether sexual conflict is a driver of speciation in brush-footed butterflies of the tribe Acraeini. The presence of a sphragis, an external mating plug found in most species among Acraeini, was used as a proxy for sexual conflict. Diversification analyses statistically rejected the hypothesis that sexual conflict is associated with shifts in diversification rates in Acraeini. This result contrasts with earlier studies and suggests that the underlying mechanisms driving diversification are more complex than previously considered. In the case of butterflies, natural history traits acting in concert with abiotic factors possibly play a stronger role in triggering speciation than does sexual conflict.

The establishment of donor-derived haemopoiesis in the recipients of allogeneic bone-marrow transplants (BMT) involves extensive proliferation of haemopoietic stem cells. The biological consequences of this replicative stress are ill defined, but any “ageing” effect would carry the risk of an increased frequency of clonal disorders during later life. We compared blood-cell mean telomere lengths in donor/recipient pairs. Mean telomere length was calculated by in-gel hybridisation to leucocyte DNA from 56 normal individuals aged 0–96 years, and from 14 consecutive BMT recipients (aged 2–14 years) plus their respective donors (aged 2–46 years). Engraftment was confirmed by variable numbers of tandem repeats (VNTR) or gender analysis. On average, blood-cell telomeres of transplant recipients were 0·4 kb (95% CI -0·2 to -0·6) shorter than those of their respective donors. This degree of telomere loss is equivalent to a median of 15 years' (range 0–40) ageing in the healthy controls. The kinetics of haemopoietic engraftment impose replicative stress on the haemopoietic stem cells, resulting in a pronounced ageing effect, which may be sufficient to accelerate the onset of clonal haemopoietic disorders usually associated with later life. Monitoring of haemopoietic status in BMT recipients as time since BMT increases will be important. Assessment of transplant protocols under development in terms of their effects on telomere shortening is also indicated.

Ongoing investigations into causes and cures for human movement disorders are important toward the elucidation of diseases such as Parkinson's disease (PD) and dystonia. The use of animal model systems can provide links to susceptibility factors, as well as therapeutic interventions. In this regard, the nematode roundworm, Caenorhabditis elegans, is ideal for examining age-dependent neurodegenerative disease studies. It is genetically tractable, has a short lifespan, and a well-defined nervous system. Green fluorescent protein is readily visualized in C. elegans because it is a transparent organism, thus the nervous system and factors that alter the viability of neurons can be directly examined in vivo. Through expression of the human PD-associated protein (α-synuclein in the worm dopamine neurons), neurodegeneration is observed in an age-dependent manner. Furthermore, expression of the early-onset dystonia-related protein torsinA increases vulnerability to endoplasmic reticulum (ER) stress in C. elegans, because torsinA is located in the ER. Here we provide an overview of collaborative studies we have conducted that collectively demonstrate the usefulness of the nematode model to discern functional effectors of dopaminergic neurodegeneration and ER stress that translate to mammalian data in the fields of PD and dystonia. Taken together, the application of C. elegans toward the evaluation of genetic modifiers for movement disorders research has predictive value and serves to accelerate the path forward for therapeutic interventions.

Responses to the 1999 Youth Risk Behavior Survey including suicide ideation, attempt, medically treated attempt, and six problem behaviors were analyzed. Youth across the spectrum ideated. Overwhelmingly, the 17% of youth with more than three problem behaviors were the youth who acted; they accounted for 60% of medically treated suicidal acts. Compared to adolescents with zero problem behaviors, the odds of a medically treated suicide attempt were 2.3 times greater among respondents with one, 8.8 with two, 18.3 with three, 30.8 with four, 50.0 with five, and 227.3 with six. A count of problem behaviors offers a reliable way to identify suicide risk.