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Objective: To understand the cardioprotective effect of Moringa oleifera (MO) seed powder using isoproterenol induced cardiotoxicity in albino rats of wistar strain. Materials and Methods: Hydroalcoholic extract of MO (HAMO) seeds was prepared by soxhlet method and used for the study. After phytochemical analysis, the extract was evaluated for in vivo study. Six rats were grouped. Group 1 as vehicle, group 2 as disease control, group 3 as standard, group 4 and 5 as low and high dose of hydroalcoholic extract of MO (200mg/kg, 400mg/kg) respectively. ECG parameters, cardiac markers and oxidative stress were assessed. Results: 4% yield was obtained. ST segment elevation and increased heart rate by Isoproterenol was treated by hydroalcoholic extract of MO seeds. CK-MB, LDH levels were also restored in treatment groups as compared to disease control. The endogenous antioxidant enzymes catalase and GSH activity increased in treatment groups whereas lipid peroxidation was decreased significantly. The HAMO (400mg/kg) showed better cardioprotective activity as equivalent to Terminalia arjuna tablets which was used as standard. In histology findings, HAMO (400mg/kg) showed decrease in necrosis as compared to disease control. Conclusion: The HAMO (400mg/kg) has proven to attenuate cardiotoxicity induced by Isoproterenol, confirmed by ECG, cardiac markers and histopathological findings.