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"Dickson, David"
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The moments of the time of ruin in Sparre Andersen risk models
We derive formulae for the moments of the time of ruin in both ordinary and modified Sparre Andersen risk models without specifying either the inter-claim time distribution or the individual claim amount distribution. We illustrate the application of our results in the special case of exponentially distributed claims, as well as for the following ordinary models: the classical risk model, phase-type(2) risk models, and the Erlang(
$\\mathscr{n}$
) risk model. We also show how the key quantities for modified models can be found.
Journal Article
From Lanzmann’s Circle of Flames to Bodies in Pain: Anglo-American Holocaust Fiction and Representations of the Gas Chamber
This article discusses the apparent desire in Anglo-American Holocaust fiction to form a deeper connection to the horror of the Holocaust by recreating scenes of suffering in the gas chamber. Using Elaine Scarry’s The Body in Pain, Alison Landsberg’s theory of ‘prosthetic memory’ and the concept of ‘feeling-with’ as outlined by Sonia Kruks, it discusses the motives underlying these representations and what an audience stands to learn from these bodily encounters with the Holocaust past. The article begins by discussing texts that explore the notions of temporal and emotional distance and the unreachability of the Holocaust dead, while also reflecting the corresponding impulse to reconnect with the murdered by physicalising them as bodies in pain. It then moves on to works that aim to make the experience of death in the gas chamber literally inhabitable for present-day nonwitnesses. In pursuing this argument, the article focuses on six representative texts: Steven Spielberg’s Schindler’s List (1993), Bryan Singer’s Apt Pupil (1998), Tim Blake Nelson’s The Grey Zone (2001), The Boy in the Striped Pyjamas (2006 and 2008, for the book and film respectively), In Paradise (2014) by Peter Matthiessen and Mick Jackson’s Denial (2016).
Journal Article
Continuing Trends in Popular Holocaust Fiction: Heather Morris and the Corporealization of Women’s Suffering
This article explores the problematic representation of female sufferers in works of fiction relating to the Holocaust. Specifically, I contend that modern fiction fails to engage with the moral and emotional complexity of wartime sexual compromise and instead replaces a cognitive understanding of history with a bodily connection to women’s wartime pain. I do so by focusing on Heather Morris’s two Holocaust-themed texts: The Tattooist of Auschwitz (2018) and Cilka’s Journey (2019). Morris, the article contends, cannot connect to the psychological or moral reality of Cilka’s wartime abuse and so instead focuses on the corporealization of her suffering. Having established the existence of the trend in Morris’s fiction, the article then also addresses Morris’s associated need to morally contextualise Cilka’s actions. In order to maintain her connection with Cilka’s body, I assert, Morris must frame Cilka’s actions using the incompatible morality of the post-war present day. To provide the character with depth would block Morris’s engagement with Cilka’s body as a post-memorial nonwitness. This is profoundly problematic as, rather than informing our understanding of the Holocaust past, Morris merely perpetuates a view of the event that is objectifying, de-humanising and frequently misogynistic.
Journal Article
Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress
Exposure of male mice to early life stress alters the levels of specific sperm miRNAs that promote stress-associated behaviors in their offspring. To begin to evaluate whether similar phenomena occur in men, we searched for sperm miRNA changes that occur in both mice and men exposed to early life stressors that have long-lasting effects. For men, we used the Adverse Childhood Experience (ACE) questionnaire. It reveals the degree of abusive and/or dysfunctional family experiences when young, which increases risks of developing future psychological and physical disorders. For male mice, we used adolescent chronic social instability (CSI) stress, which not only enhances sociability defects for >1 year, but also anxiety and defective sociability in female offspring for multiple generations through the male lineage. Here we found a statistically significant inverse correlation between levels of multiple miRNAs of the miR-449/34 family and ACE scores of Caucasian males. Remarkably, we found members of the same sperm miRNA family are also reduced in mice exposed to CSI stress. Thus, future studies should be designed to directly test whether reduced levels of these miRNAs could be used as unbiased indicators of current and/or early life exposure to severe stress. Moreover, after mating stressed male mice, these sperm miRNA reductions persist in both early embryos through at least the morula stage and in sperm of males derived from them, suggesting these miRNA changes contribute to transmission of stress phenotypes across generations. Since offspring of men exposed to early life trauma have elevated risks for psychological disorders, these findings raise the possibility that a portion of this risk may be derived from epigenetic regulation of these sperm miRNAs.
Journal Article
Validation of a focused echocardiographic training program in first opinion practice
Abstract
Background
The EPIC study defines criteria, including echocardiographic assessments of left atrial to aortic ratio (LA: Ao) and left ventricular internal diameter in diastole normalized for body weight (LVIDdN), for dogs with preclinical myxomatous mitral valve disease (MMVD) likely to benefit from pimobendan therapy. Access to echocardiography by a cardiologist is not universally available.
Hypothesis/Objectives
Completion of a focused echocardiographic training program would result in accurate identification of dogs fulfilling the EPIC criteria by primary care veterinarians (PC).
Participants
Six PCs with no previous echocardiographic experience.
Methods
Prospective diagnostic test accuracy study. After training, each PC evaluated ≤10 dogs that they believed to have preclinical MMVD. The evaluation was repeated by 1 of 3 cardiology diplomates, blinded to the PC's findings. Agreement between clinical assessments and echocardiographic measurements was assessed.
Results
Fifty-seven dogs were evaluated by PCs; 1 dog was withdrawn because of congestive heart failure. The median time between PC and cardiologist evaluation was 0 days (range, 0-8). One incorrect diagnosis of MMVD was made by a PC (this dog had dilated cardiomyopathy [DCM]); preclinical MMVD was confirmed by the cardiologist in 55 dogs. No difference in LA: Ao (P = .96; CV = 6.9%) was detected between PCs and cardiologists. LVIDdN (1.69 cm/kg0.294 (1.26-2.21) vs 1.73 cm/kg0.294 (1.32-2.73); P = .001; CV = 6.5%), was significantly lower when measured by PCs vs cardiologists. PCs and cardiologists agreed regarding assessment of EPIC criteria in 49/56 dogs (Alpha = .761, 95% confidence interval 0.697-0.922).
Conclusions and Clinical Importance
The program effectively trained PCs to accurately assess EPIC criteria in dogs with preclinical MMVD.
Journal Article
Silica sol-gel encapsulation of cyanobacteria: lessons for academic and applied research
Cyanobacteria inhabit nearly every ecosystem on earth, play a vital role in nutrient cycling, and are useful as model organisms for fundamental research in photosynthesis and carbon and nitrogen fixation. In addition, they are important for several established biotechnologies for producing food additives, nutritional and pharmaceutical compounds, and pigments, as well as emerging biotechnologies for biofuels and other products. Encapsulation of living cyanobacteria into a porous silica gel matrix is a recent approach that may dramatically improve the efficiency of certain production processes by retaining the biomass within the reactor and modifying cellular metabolism in helpful ways. Although encapsulation has been explored empirically in the last two decades for a variety of cell types, many challenges remain to achieving optimal encapsulation of cyanobacteria in silica gel. Recent evidence with
Synechocystis
sp. PCC 6803, for example, suggests that several unknown or uncharacterized proteins are dramatically upregulated as a result of encapsulation. Also, additives commonly used to ease stresses of encapsulating living cells, such as glycerol, have detrimental impacts on photosynthesis in cyanobacteria. This mini-review is intended to address the current status of research on silica sol-gel encapsulation of cyanobacteria and research areas that may further the development of this approach for biotechnology applications.
Journal Article
Mpox Tongue Lesions
A man with a history of well-controlled HIV infection presented with an 11-day history of progressive painful tongue lesions and 1-week history of sore throat and fevers. On examination, four ulcers were seen on the tongue.
Journal Article
Ruin problems in Markov-modulated risk models
Chen et al. (2014), studied a discrete semi-Markov risk model that covers existing risk models such as the compound binomial model and the compound Markov binomial model. We consider their model and build numerical algorithms that provide approximations to the probability of ultimate ruin and the probability and severity of ruin in a continuous time two-state Markov-modulated risk model. We then study the finite time ruin probability for a discrete m-state model and show how we can approximate the density of the time of ruin in a continuous time Markov-modulated model with more than two states.
Journal Article
An identity based on the generalised negative binomial distribution with applications in ruin theory
In this study, we show how expressions for the probability of ultimate ruin can be obtained from the probability function of the time of ruin in a particular compound binomial risk model, and from the density of the time of ruin in a particular Sparre Andersen risk model. In each case evaluation of generalised binomial series is required, and the argument of each series has a common form. We evaluate these series by creating an identity based on the generalised negative binomial distribution. We also show how the same ideas apply to the probability function of the number of claims in a particular Sparre Andersen model.
Journal Article