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Carbon emission trading and green certificate trading mechanisms constitute the cornerstone of low-carbon transitions in integrated energy systems (IESs). However, independent operation of these mechanisms creates coordination barriers that limit their synergistic emission reduction and economic potential. To address this problem, this paper propose a novel low-carbon cooperative operation model based on a green certificate and carbon emission trading mechanism. First, to maximize the environmental value benefits of the system, a dual-market linkage mechanism is constructed, which is mediated by the carbon reduction attributes of green certificates. Second, a multi-operator cooperative alliance is established based on cooperative game theory, and the Shapley value method is employed to rationally allocate cooperative surplus, thereby enhancing the multi-energy complementarity of the IES. Case analysis indicates that under this strategy, the system’s carbon emissions intensity decreased by 30%, while the alliance’s overall operating revenue increased by 22.6%, achieving low-carbon economic operation of IES.

Cestrum nocturnum is a plant that blooms and emits fragrance at night but the mechanism behind its fragrance release remains poorly understood. Here, the floral substances and differential regulatory genes in the petals of C. nocturnum at night were explored by HS-SPME-GC/MS and transcriptome sequencing. Benzaldehyde, phenyl acetaldehyde and benzyl acetate were identified as the main floral scent substances involved in the phenylpropanoid biosynthesis pathway of C. nocturnum . The DEGs in this pathway, PALs , PAAS , PARs , 4CLs , CFATs , BEAT , EGSs and BAMT , showed high expression levels during flowering. Additionally, these genes may play an important role in the formation of a regulatory network for floral scent substance synthesis. DEGs in day/night alternates and plant hormone signalling pathways also had important functions in flowering and fragrance release. These included CO , FT and genes related to the promotion of phytohormone (GA, ABA, IAA, BR) biosynthetic and signal transduction, which showed high expression levels during flowering. These results provide a theoretical reference for the expression levels of differentially expressed functional genes in the flowering and fragrance release of C. nocturnum and lay a foundation for further research on night-blooming aromatic flowers.

Abstract Background: As an essential part of health services, rehabilitation is of great significance to improve the health and quality of life of the whole population. Accelerating aging calls for a significant expansion of rehabilitation services in China, but rehabilitation needs remain unclear. We conducted the study to explore the rehabilitation needs in China and project the trend of rehabilitation needs from 2020 to 2034. Methods: The data of health conditions that might potentially benefit from rehabilitation were obtained from Global Burden of Disease (GBD) study. Estimated annual percentage changes (EAPCs) were calculated to quantify the trends of the age-standardized rates. Projections of rehabilitation needs were made until 2034 using Bayesian age–period–cohort analysis (BAPC). Results: Approximately 460 million persons (33.3% of the total population) need rehabilitation in China, contributing to 63 million years lived with disabilities (YLDs) in 2019. The number of prevalent cases that need rehabilitation increased from around 268 (95% uncertainty interval [UI]: 257–282) million in 1990 to almost 460 (95% UI: 443–479) million in 2019, representing an increase of 71.3%. The highest contribution to the need for rehabilitation was musculoskeletal disorders with about 322 (95% UI: 302–343) million persons in seven aggregate disease and injury categories, and hearing loss with over 95 (95% UI: 84–107) million people among 25 health conditions. Based on the projection results, there will be almost 636 million people (45% of the total population) needing rehabilitation services in China by 2034, representing an increase of 38.3%. The rehabilitation needs of neoplasms, cardiovascular diseases, and neurological disorders are expected to increase significantly from 2019 to 2034, with increases of 102.3%, 88.8% and 73.2%, respectively. Conclusions: The need for rehabilitation in China substantially increased over the last 30 years. It is predicted that over two in five people will require rehabilitation by 2034, thus suggesting the need to develop rehabilitation services that meet individuals’ rehabilitation needs.

As a unique woody oil crop in China, Camellia oleifera Abel. germplasm resources show significant genetic diversity in Ya’an City. This study measured 60 phenotypic traits (32 quantitative, 28 qualitative) of 302 accessions to analyze phenotypic variation, establish a classification system, and screen high-yield, high-oil germplasms. The phenotypic diversity index for fruit (H’ = 1.36–1.44) was significantly higher than for leaf (H’ = 1.31) and flower (H’ < 1), indicating genetic diversity concentrated in reproductive traits, suggesting potential genetic variability in these traits. Fruit quantitative traits (e.g., single fruit weight CV = 35.37%, fresh seed weight CV = 38.93%) showed high genetic dispersion. Principal component analysis confirmed the fruit factor and economic factor as main phenotypic differentiation drivers. Quantitative traits were classified morphologically, and correlation analysis integrated them into 13 key indicators classified using LSD and range methods. Finally, TOPSIS evaluation selected 10 excellent germplasms like TQ122 and TQ49, with fruit weight, fresh seed yield, and kernel oil content significantly exceeding the population average. This study provides data for C. oleifera DUS test guidelines and proposes a multi-trait breeding strategy, supporting high-yield variety selection and germplasm resource protection.

With the escalating demand for advanced and eco-friendly processing technologies in mining engineering, the potential applications of microwave heating technology in the treatment of cement tailings backfill (CTB) are expanding significantly. This research comprehensively investigates the mechanisms through which microwave irradiation duration and power influence the mechanical properties of CTB with varying concentrations and cement-to-sand ratios. The aim is to reveal the influencing patterns through experimental methods, providing scientific evidence for optimizing CTB treatment processes. This paper conducted microwave heating tests, uniaxial compression tests, and SEM-EDS tests on CTB. The research results indicate that heating time and power significantly enhance the early strength of CTB, with a more pronounced effect on CTB with higher concentrations and higher cement–sand ratios. When the heating time is 7 min and the heating power is 340 W, the cement hydration reaction is maximally promoted, thereby increasing the density and strength growth rate of CTB. However, excessively long heating time or overly high heating power may cause microcracks or thermal stress concentration within the CTB, adversely affecting the strength growth rate of CTB. Optimal thermal exposure duration and microwave power settings facilitate the activation of cementitious materials and the nucleation of calcium-silicate-hydrate (C-S-H) phases, thereby accelerating the compressive strength evolution of cemented tailings backfill (CTB). The outcomes of this research offer valuable insights into the deployment of microwave heating methodologies in underground mine backfilling, which are pivotal for augmenting the economic viability and environmental sustainability of mining operations.

Prior to being released, the top coal of a fully mechanized caving face typically experiences the effects of mining-induced pressure and disturbances from the hydraulic support’s canopy. To investigate the promoting effect of canopy disturbances in the support-controlled area on the damage of top coal during fully mechanized top-coal caving mining, block instability theory and discrete block numerical simulation methods were employed. The instability modes during the initial support and cyclic disturbance stages were analyzed. The fracture evolution and displacement distribution curves were studied for coal bodies with strengths of 3.1 MPa, 15.0 MPa, and 29.5 MPa under the mining influence and support strengths of 0.5 MPa, 1.0 MPa, and 1.5 MPa during the initial support and cyclic disturbance processes. The results showed that during the initial support stage, the instability of the block-structured coal body exhibited four modes as follows: inter-block breakage, inter-block delamination, intra-block fracture expansion, and inter-block sliding. During the cyclic disturbance stage, the coal body instability showed three modes as follows: inter-block sliding, intra-block fracture expansion, and inter-block rotation. The disturbance from the support had little impact on the fragmentation of both low-strength and high-strength coal bodies. However, small support forces combined with multiple cycles of disturbance had an enhancing effect on the instability of medium-strength block-structured top coal.

Exogenous biostimulants (EB) are crucial for reducing abiotic stress in plants. It is currently unclear how EB such as melatonin (MT), betaine (BA), and salicylic acid (SA) regulate the stress in Camellia oleifera seedlings under alkali stress (XP). This study demonstrates the moderating effect of SA (0.5, 1, and 2 mmol/L), BA (0.2, 0.4, and 0.8 g/L), and MT (200, 400, and 800 μmol/L) on the relative chlorophyll content, photosynthetic parameters, chlorophyll fluorescence parameters, osmoregulatory substances, and antioxidant enzymes in C. oleifera seedlings under XP. The results showed that spraying different types and different concentrations of EB under alkali stress had a certain alleviating effect on the phenotype of C. oleifera seedlings. Whether 7 or 15 days after the application of EB, the relative chlorophyll content (SPAD) and the degree of yellowish-green in the control group were different from those in the other 10 treatment groups, but the difference in brightness was not significant. As far as the malondialdehyde (MDA) content is concerned, the SA2, BA3, MT2, and MT3 treatment groups can significantly reduce the MDA content on the 7th day of EB application. The electrolytic leakage (EL) is also significantly reduced by MT2 and MT3. It was found that treatment groups SA3 and MT2 could improve the photosynthetic parameters of C. oleifera seedlings to different degrees on the 7th day of EB application. On the 15th day of EB application, treatment groups SA1, SA3, BA1, and BA2 all increased the photosynthetic rate of C. oleifera compared to the XP treatment group, but other treatments did not increase. At the same time, the results showed that the fluorescence parameters of the seedlings showed different degrees of improvement under different EB spraying conditions. Under alkali stress, soluble proteins (SP) and soluble sugars (SS) increased in the XP group, but it was found that the SA3, BA3, and MT2 treatment groups could reduce the content of osmoregulatory substances both on the 7th and 15th days of EB application. In terms of proline (Pro) content, BA1, BA2, and MT2 treatment groups could reduce Pro content on the 7th and 15th days of EB spraying, respectively. As for the antioxidant enzymes, the SA2, BA3, MT2, and MT3 treatment groups could basically increase the activity of antioxidant enzymes and further reduce oxidative damage on the 7th day of application of EB. According to the comprehensive results of the membership function, whether on the 7th or 15th day of EB spraying, the MT2 treatment group has the best overall mitigation effect of the three EB applications, ranking in the top three. This study will help to improve the scientific understanding of C. oleifera’s alkali resistance and interaction with EB while filling the knowledge gap on the physiological response to oleofylline stress.

Background Intestinal microbiota transplantation (IMT) has been recognized as an effective treatment for recurrent Clostridium difficile infection (rCDI) and a novel treatment option for other diseases. However, the safety of IMT in patients has not been established. Aims This systematic review and meta-analysis was conducted to assess the safety of IMT. Methods We systematically reviewed all randomized controlled trials (RCTs) of IMT studies published up to 28 February 2021 using databases including PubMed, EMBASE and the Cochrane Library. Studies were excluded if they did not report adverse events (AEs). Two authors independently extracted the data. The relative risk (RR) of serious adverse events (SAEs) and common adverse events (CAEs) were estimated separately, as were predefined subgroups. Publication bias was evaluated by a funnel plot and Egger’s regression test. Results Among 978 reports, 99 full‐text articles were screened, and 20 articles were included for meta-analysis, involving 1132 patients (603 in the IMT group and 529 in the control group). We found no significant difference in the incidence of SAEs between the IMT group and the control group (RR = 1.36, 95% CI 0.56–3.31, P  = 0.50). Of these 20 studies, 7 described the number of patients with CAEs, involving 360 patients (195 in the IMT group and 166 in the control group). An analysis of the eight studies revealed that the incidence of CAEs was also not significantly increased in the IMT group compared with the control group (RR = 1.06, 95% CI  0.91–1.23, P  = 0.43). Subgroup analysis showed that the incidence of CAEs was significantly different between subgroups of delivery methods ( P (CAE)  = 0.04), and the incidence of IMT-related SAEs and CAEs was not significantly different in the other predefined subgroups. Conclusion Currently, IMT is widely used in many diseases, but its associated AEs should not be ignored. To improve the safety of IMT, patients' conditions should be fully evaluated before IMT, appropriate transplantation methods should be selected, each operative step of faecal bacteria transplantation should be strictly controlled, AE management mechanisms should be improved, and a close follow-up system should be established.

BackgroundChildren and adolescents diagnosed with major depressive disorder (MDD) often grapple with significant non-suicidal self-injury (NSSI), linked to interpersonal challenges, insecure attachment, and internet addiction. This study explores these relationships in children and adolescents using network analysis, drawing data from seven hospitals in China.ResultsThe study included 162 youths with depressive disorder and 102 healthy controls from seven hospitals. The MDD + NSSI group exhibited severe internet addiction, heightened depressive symptoms, and insecure attachment. Network analysis identified central symptoms (compulsive use) and key bridge symptoms (tolerance symptoms) in the networks related to depressive symptoms, internet addiction, and attachments. These findings suggest potential targets for intervention among children and adolescents at risk for or suffering from depression.ConclusionsThis study sheds light on the intricate relationship between NSSI, attachment issues, and internet addiction in Chinese adolescents with MDD. The network analysis pinpointed central and key bridge symptoms, offering valuable insights for targeted interventions in children and adolescents at risk for or experiencing depression and associated challenges.

[...]with the same filtering criteria as WBCs, 15 CRC-specifically hypermethylated CpG sites with average methylation levels less than 0.1 in 8,629 tissue samples from 28 other cancer types in the TCGA dataset were retained, and no CRC-specific hypomethylated CpG sites met the criteria and were retained. Currently, mSEPT9 is the only blood assay in the clinical setting for CRC screening, but its clinical usefulness is limited by its low sensitivity in early-stage CRC.4 Moreover, mSEPT9 is not a CRC-specific marker because of overlapping aberrant methylation across multiple cancers.5,6 Recent evidence suggests that the use of tissue-specific methylation signatures will allow for tracing tissue of origin in cfDNA.7,8 In marker discovery, we eliminated the possible confounding interference of cfDNA released by other cancer tissues or WBCs on the detection of ctDNA methylation levels in CRC. [...]our inhouse validation study suggested that such CRC-specific methylation patterns could be detected in tissues and cfDNA but not in WBCs. [...]we collected a small subset of cfDNA samples from patients with AA and other non-CRC diseases, suggesting that our arrays need to be further optimized and validated in studies including more participants in the future. [...]we identified a panel of CRC-specific methylation patterns by pan-cancer analysis and developed three cfDNA multiplex ddPCR assays.