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Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events.

Previous neutron scattering experiments on single crystal of Sendust alloy (73.5 at. % Fe, 17 at. % Al, and 9.5 at. % of Si) revealed extremely high spin wave damping at room temperature. The aim of present studies was to test if the spin wave damping originates from lattice disorder or comes from mutual spin waves interactions or other excitations that would be temperature dependent. The spin wave dispersion relation and damping were studied in temperature range from 8 to 295 K. No regular changes of both spin wave damping and stiffness constant (which characterises dispersion relation) with temperature were found. Thus, within this temperature range, spin waves interactions with dynamical excitations of all kinds must be negligible, and their damping is most likely produced by lattice disorder alone. It is of interest to note that the inelastic background intensity below the spin wave peaks increases with temperature and for energy transfers higher than 30 meV this increase is larger than that of spin-wave peak intensity.

This article focuses on the analytic modeling of responses of cells in the body to ionizing radiation. The related mechanisms are consecutively taken into account and discussed. A model of the dose- and time-dependent adaptive response is considered for 2 exposure categories: acute and protracted. In case of the latter exposure, we demonstrate that the response plateaus are expected under the modelling assumptions made. The expected total number of cancer cells as a function of time turns out to be perfectly described by the Gompertz function. The transition from a collection of cancer cells into a tumor is discussed at length. Special emphasis is put on the fact that characterizing the growth of a tumor (ie, the increasing mass and volume), the use of differential equations cannot properly capture the key dynamics—formation of the tumor must exhibit properties of the phase transition, including self-organization and even self-organized criticality. As an example, a manageable percolation-type phase transition approach is used to address this problem. Nevertheless, general theory of tumor emergence is difficult to work out mathematically because experimental observations are limited to the relatively large tumors. Hence, determination of the conditions around the critical point is uncertain.

We present a review of our theoretical calculations about magnon transport in quasi-one-dimensional (1D) magnonic circuits constituted by waveguides coupled to side resonators. Phenomena such as the existence of band gaps, rejective and selective transmissions and Fano resonances will be discussed as well as the applications of these structures in filtering and demultiplexing devices. The calculations are performed based on two types of models and in the frame of the Green's function method. First, the continuum long-wavelength Heisenberg model is studied in 1D monomode waveguide containing symmetric and asymmetric loops or coupled with grafted stubs. Then, we use the discrete dipole approximation in structures composed of a chain of nanometric magnetic clusters coupled to finite clusters on its vicinity. All such circuits exhibit a variety of interference effects in their transport properties which should have important consequences for designing integrated devices such as microwave filters.

Three statistical methods: Bayesian, randomized data binning and Maximum Entropy Method (MEM) are described and applied in the analysis of US radon data taken from the US registry. Two confounding factors—elevation of inhabited dwellings, and UVB (ultra-violet B) radiation exposure—were considered to be most correlated with the frequency of lung cancer occurrence. MEM was found to be particularly useful in extracting meaningful results from epidemiology data containing such confounding factors. In model testing, MEM proved to be more effective than the least-squares method (even via Bayesian analysis) or multi-parameter analysis, routinely applied in epidemiology. Our analysis of the available residential radon epidemiology data consistently demonstrates that the relative number of lung cancers decreases with increasing radon concentrations up to about 200 Bq/m3, also decreasing with increasing altitude at which inhabitants live. Correlation between UVB intensity and lung cancer has also been demonstrated.

Results of X-ray, neutron, magnetization and Mössbauer measurements on polycrystalline samples of Fe3−xCrxAl0.5Si0.5 (x 0, 0.125, 0.250, 0.375 and 0.5) alloys are presented. The alloys crystallize in the structure of DO3 type, and their unit cell volumes are practically independent of the chromium concentration. X-ray and neutron diffraction confirmed the phase homogeneity of all the samples. Neutron and Mossbauer measurements disclosed that Cr atoms occupy preferentially B-sites, while D sites are almost entirely occupied by Al and Si. The total magnetisation as well as the site and individual magnetic moments μFe(A,C), μFe(B) and μCr(B,D) have been found to be linearly dependent on the chromium concentration.

The Bc+/- to J/psi pi+/- and Bc+/- to J/psi pi+/- pi+/- pi-/+ decay modes are studied in proton-proton collisions at a center-of-mass energy of 7 TeV with the CMS detector at the LHC. The kinematic region investigated requires Bc+/- mesons with transverse momentum pt > 15 GeV and rapidity abs(y) < 1.6. The data sample corresponds to an integrated luminosity of 5.1 inverse femtobarns. The ratio of the branching fractions B(Bc+/- to J/psi pi+/- pi+/- pi-/+)/B(Bc+/- to J/psi pi+/-) is measured to be 2.55 +/- 0.80 (stat) +/- 0.33 (syst) +0.04/-0.01 (tau[Bc+]). The ratio of the production cross sections times branching fractions (sigma(Bc+) B(Bc+ to J/psi pi+))/ (sigma(B+) B(B+ to J/psi K+)) is determined to be [0.48 +/- 0.05 (stat) +/- 0.03 (syst) +/- 0.05 (tau_(B)c)]%

The normalised differential top quark-antiquark production cross section is measured as a function of the jet multiplicity in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC with the CMS detector. The measurement is performed in both the dilepton and lepton+jets decay channels using data corresponding to an integrated luminosity of 5.0 inverse femtobarns. Using a procedure to associate jets to decay products of the top quarks, the differential cross section of the t t-bar production is determined as a function of the additional jet multiplicity in the lepton+jets channel. Furthermore, the fraction of events with no additional jets is measured in the dilepton channel, as a function of the threshold on the jet transverse momentum. The measurements are compared with predictions from perturbative quantum chromodynamics and no significant deviations are observed.

The purely electroweak (EW) cross section for the production of two jets in association with a Z boson, in proton-proton collisions at sqrt(s) = 8 TeV, is measured using data recorded by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of 19.7 inverse femtobarns. The electroweak cross section for the lljj final state (with l = e or mu and j representing the quarks produced in the hard interaction) in the kinematic region defined by M[ll] > 50 GeV, M[jj] > 120 GeV, transverse momentum pt[j] > 25 GeV, and pseudorapidity abs(eta[j]) < 5, is found to be sigma[EW](lljj) = 174 +/- 15 (stat) +/- 40 (syst) fb, in agreement with the standard model prediction. The associated jet activity of the selected events is studied, in particular in a signal-enriched region of phase space, and the measurements are found to be in agreement with QCD predictions.