Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,016
result(s) for
"Dogan, Ahmet"
Sort by:
Domes : a journey through European architectural history
This enchanting and important book presents the art of the internationally famous architectural photographer, Ahmet Ertug in his latest folio, capturing the spatial essence of that most defining symbol of architecture, the Dome. The book is a journey through architectural history, from the immense spherical dome of the first-century Roman Pantheon, its oculus open to the sky, to the steel and glass of Norman Foster's Bundestag, Berlin, one of the most visited new architectural structures in the world. Along the way, are the domes of Byzantium including the Hagia Sophia, its dome pierced with lunette windows that make it seemingly float by magic, the mighty domes of the Middle Ages, the Renaissance and the Baroque, each presenting its architect with the greatest of all structural challenges - Brunelleschi's Florence Cathedral, Michelangelo's St Peter's, Sir Christopher Wren's St Pauls' in London, and the iron and glass domes of nineteenth-century France.
BOOK
Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (
n
= 15) are characterized by later initiation in the patient’s life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable.
The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in the patient’s life.
Journal Article
The effect of emotional intelligence training on occupational anxiety among paramedic students: a quasi-experimental study
Background
Paramedic students often face high levels of occupational anxiety due to heavy theoretical and clinical workloads. This anxiety can adversely affect academic performance, clinical competence and the quality of patient care. Emotional intelligence (EI), defined as the ability to recognize and manage emotions while maintaining healthy social relationships, may help reduce such anxiety. This study aimed to determine the relationship between EI and occupational anxiety in paramedic students and to evaluate the effect of a short-term EI training program on reducing occupational anxiety.
Methods
This study employed a single-group quasi-experimental design. The population consisted of students enrolled in the paramedic program, and the sample included 110 paramedic students who participated in both the pre-test and post-test assessments. The intervention involved delivering a structured EI training program to the students. Data were collected using a Demographic Information Form, the Emotional Intelligence Scale, and the Occupational Anxiety Scale. All instruments were administered twice, before and after the training.
Results
The mean EI score of the students increased significantly from 75.12 ± 11.15 before the training to 79.42 ± 12.59 after the training (
p
= 0.002). The mean occupational anxiety score decreased significantly from 59.48 ± 13.57 before the training to 54.60 ± 17.16 after the training (
p
= 0.003). Moreover, a significant negative correlation was found between EI and occupational anxiety (
r
=–0.474,
p
< 0.001). Regression analysis indicated that EI was a significant predictor of occupational anxiety (β=–0.560,
p
< 0.001), explaining 22.4% of the total variance in occupational anxiety scores.
Conclusion
EI training significantly improved paramedic students’ levels of emotional recognition/understanding, facilitation, and regulation, while significantly reducing their occupational anxiety levels. These findings highlight the importance of interventions aimed at enhancing emotional resilience in health education. Structuring training programs to support the development of EI is crucial for effective anxiety management and the prevention of burnout.
Clinical trial number
Not applicable.
Journal Article
Challenges Faced by Medical Rescue Teams During Disaster Response: A Systematic Review Study
This study was conducted to identify the challenges faced by medical rescue teams during the response phase of sudden-onset disasters and provide a comprehensive understanding of these challenges. Peer-reviewed, English-language articles published until January 2023 that described the challenges faced by medical rescue teams during disaster response were searched in the Web of Science, Scopus, Cochrane, PubMed, and Science Direct databases. The articles were assessed using the Mixed Methods Appraisal Tool (MMAT) version 2018, a quality evaluation tool, and a qualitative thematic synthesis approach was adopted. A total of 353 publications were identified, and 18 of these met the inclusion criteria. Of the 18 included studies, 8 were review articles, 4 were special reports, 3 were cross-sectional studies, 1 was a mixed methods study, 1 was a qualitative study, and 1 was a short communication. Through qualitative analysis, the challenges faced by medical rescue teams during disaster response were categorized into 6 factors: organizational, individual, environmental and health, logistical, communication and information, and other factors. These factors are significant in terms of issues such as delayed access to disaster victims, disruptions in response processes, and an increase in morbidity and mortality rates. Therefore, the findings in our study shed light on future research in the field of disasters and offer opportunities to develop a roadmap for improving the conditions of medical rescue teams.
Journal Article
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In this study we interrogate 752 NDMM patients using whole genome sequencing (WGS) to investigate the relationship of copy number (CN) signatures to chromothripsis and show they are highly associated. CN signatures are highly predictive of the presence of chromothripsis (AUC = 0.90) and can be used identify its adverse prognostic impact. The ability of CN signatures to predict the presence of chromothripsis is confirmed in a validation series of WGS comprised of 235 hematological cancers (AUC = 0.97) and an independent series of 34 NDMM (AUC = 0.87). We show that CN signatures can also be derived from whole exome data (WES) and using 677 cases from the same series of NDMM, we are able to predict both the presence of chromothripsis (AUC = 0.82) and its adverse prognostic impact. CN signatures constitute a flexible tool to identify the presence of chromothripsis and is applicable to WES and WGS data.
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data.
Journal Article
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor protein 53 ( TP53 ) mutations are common in JAK2 V617F - mutant, post-MPN AML but not in chronic-phase MPN and lead to clonal dominance of JAK2 V617F /TP53- mutant leukemic cells. Consistent with these data, expression of JAK2 V617F combined with Tp53 loss led to fully penetrant AML in vivo. JAK2 V617F-mutant, Tp53 -deficient AML was characterized by an expanded megakaryocyte erythroid progenitor population that was able to propagate the disease in secondary recipients. In vitro studies revealed that post-MPN AML cells were sensitive to decitabine, the JAK1/2 inhibitor ruxolitinib, or the heat shock protein 90 inhibitor 8-(6-iodobenzo[d][1.3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purine-6-amine (PU-H71). Treatment with ruxolitinib or PU-H71 improved survival of mice engrafted with JAK2 V617F-mutant, Tp53 -deficient AML, demonstrating therapeutic efficacy for these targeted therapies and providing a rationale for testing these therapies in post-MPN AML.
Significance Myeloproliferative neoplasms (MPN) are chronic hematopoietic disorders characterized by clonal proliferation of mature myeloid elements. A subset of MPNs transforms to acute myeloid leukemia (AML). The mechanisms and pathways that contribute to transformation from MPN to AML have not been well delineated. We have characterized the somatic mutational spectrum of post-MPN AML and demonstrate that somatic tumor protein 53 ( TP53 ) mutations are common in JAK2 V617F - mutant, post-MPN AML but not in chronic-phase MPN. We demonstrate that expression of JAK2 V617F combined with Tp53 loss in a murine model leads to fully penetrant AML in vivo . We have characterized this model and used it to test therapeutic strategies. These data reveal novel insights into the pathogenesis of, and potential therapeutic strategies for, leukemic transformation.
Journal Article
Accelerated single cell seeding in relapsed multiple myeloma
Multiple myeloma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites. To characterize this evolutionary process, we interrogated, by whole genome sequencing, 25 samples collected at autopsy from 4 patients with relapsed MM and an additional set of 125 whole exomes collected from 51 patients. Mutational signatures analysis showed how cytotoxic agents introduce hundreds of unique mutations in each surviving cancer cell, detectable by bulk sequencing only in cases of clonal expansion of a single cancer cell bearing the mutational signature. Thus, a unique, single-cell genomic barcode can link chemotherapy exposure to a discrete time window in a patient′s life. We leveraged this concept to show that MM systemic seeding is accelerated at relapse and appears to be driven by the survival and subsequent expansion of a single myeloma cell following treatment with high-dose melphalan therapy and autologous stem cell transplant.
In multiple myeloma, disease progresses via seeding to different anatomic sites and clonal expansion. Here, utilising autopsy material, the authors show that systemic seeding accelerates at relapse following treatment.
Journal Article
Psychological Hardiness and Compassion Satisfaction Among the Turkish Red Crescent: The Case of 2023 Kahramanmaras Earthquake
This study assessed psychological hardiness and compassion satisfaction among the Türk Kızılay (Turkish Red Crescent) personnel and volunteers involved in the 2023 Kahramanmaraş earthquake. Additionally, the relationship between compassion satisfaction and psychological hardiness was also investigated.
This cross-sectional study was conducted between March and July 2023. Participants completed an online survey, which included the Sociodemographic Information Form, Psychological Hardiness Scale, and Compassion Satisfaction Scale. The data was analyzed with SPSS version 25 (IBM Corp., Armonk, New York, USA), using a significance level of 95% and
< 0.05.
The study involved 400 participants, comprising 84 (21%) personnel and 316 (79%) volunteers. Participants exhibited an average psychological hardiness level of 24.56 ± 7.25 and a compassion satisfaction level of 47.40 ± 17.28. A significant positive correlation was observed between compassion satisfaction and psychological hardiness (r = 0.571;
< 0.001). The results of logistics regression have revealed that the level of psychological hardiness is higher in males compared to females (OR = 1.930, CI = 1.115 - 3.340;
< 0.05) and is also higher in those with high compassion satisfaction compared to those with low compassion satisfaction (OR = 1.386, CI = 1.256 - 1.529;
< 0.001).
The findings of this study indicate that individuals involved in disaster response should consider compassion satisfaction as an important tool for enhancing psychological hardiness.
Journal Article
Fabrication of Sea Buckthorn Oil and Caffeic Acid‐Based Polypropylene Composite Fibrous Mats by Electrospinning
Electrospun composite fibrous mats based on chlorinated polypropylene (CPP) incorporating sea buckthorn oil (SBO) and caffeic acid (CA) were developed to obtain multifunctional materials with enhanced biological performance. The primary aim of this study was to investigate the combined effect of SBO and CA on the physicochemical, antioxidant, antibacterial, and release properties of CPP‐based fibers. The incorporation of bioactive components improved surface wettability, as evidenced by a decrease in water contact angle from 135° for neat CPP to 128° for CPP‐SBO‐CA. Antibacterial activity was also enhanced, with CPP‐SBO‐CA achieving 42% reduction against Staphylococcus aureus and 45% against Pseudomonas aeruginosa , outperforming CPP‐SBO. Although the antioxidant activity of the composite mats remained limited (≈14% DPPH inhibition) due to low additive content, measurable improvement was observed compared to neat CPP. Release studies demonstrated that the electrospun fiber structure effectively transformed the rapid release of neat compounds into a controlled, diffusion‐governed process, with CPP‐SBO‐CA showing approximately 55%–60% cumulative release within 6 h. Overall, the results indicate that the synergistic incorporation of SBO and CA into CPP fibers provides a promising strategy for designing bioactive materials with sustained release and improved functional performance for biomedical applications such as wound dressing.
Journal Article