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Background Enhancing the pooling of basic medical insurance plays a vital role in strengthening the resilience to risk and co-payment capacity of medical insurance funds. In China, there is a concerted effort to shift from municipal to provincial pooling of medical insurance. While existing research suggests that provincial pooling of basic health insurance affects the health of participants, the findings are not yet consistent, and there is limited research on the specific pathways of impact between the two. Therefore, this study aims to explore the influence of provincial pooling of basic medical insurance on participants' health and analyze the mediating role of medical cost burden and medical service utilization. Methods Using data from the 2012–2018 China Labor Dynamics Survey (CLDS), this study focuses on a sample of urban workers enrolled in basic medical insurance. After excluding samples with missing information, a total of 5,684 participants were included in the analysis. The effects of the provincial pooling policy of basic medical insurance on participants' medical cost burden, medical service utilization, and health were analyzed using double difference modeling. Furthermore, structural equation modeling was employed to explore the mediating paths between provincial pooling and health. Results The findings reveal that provincial pooling of basic medical insurance significantly impacts participants' medical cost burden, medical service utilization, and health. Specifically, provincial pooling helps reduce the participants' medical cost burden (β = -0.1205; P  < 0.001), improves the level of medical institutions visited (β = 1.7962; P  < 0.001), and promotes health improvement (β = 1.8370; P  < 0.001). The mediating effect analysis demonstrates that the direct effect of provincial pooling on health is 1.073 ( P  < 0.001), with a mediating effect of medical cost burden between provincial pooling and health measuring 0.129 ( P  < 0.001). Heterogeneity analysis indicates that provincial pooling is more effective in reducing the burden of medical costs for low-income (β = -0.2273; P  < 0.001) and high-age participants (β = -0.2710; P  < 0.001), and it also helps increase the burden of medical costs for low-income (β = 4.0875; P  < 0.001) and high-age participants (β = 1.9010; P  < 0.001) based on provider ranking. Moreover, it is found that provincial pooling is more beneficial in improving the health of high-income (β = 1.7984; P  < 0.001) and middle- and high-age enrollees (β = 1.9220; P  < 0.001; β = 0.5900; P  < 0.001). Further analysis reveals that the provincial unified income and expenditure mode has a more positive effect than the provincial risk adjustment fund mode in reducing the medical expense burden of the insured (-0.2053 < -0.0775), improving the grade of medical institutions (1.8552 > 0.8878), and enhancing the health level (2.8406 > 0.6812). Conclusion The study concludes that provincial pooling of basic medical insurance has a direct positive impact on participants' health and indirectly promotes health improvement by reducing the burden of medical costs. The effects of provincial pooling on participants' medical cost burden, medical service utilization, and health vary based on income and age. Additionally, the provincial-level unified collection and payment model proves to be more advantageous in optimizing the functioning of health insurance funds through the \"law of large numbers\" principle.

The Interdecadal Pacific Oscillation (IPO) is a 40–60 year quasi-oscillation seen mostly in the Pacific basin, but its impacts on surface temperature (T) and precipitation (P) have been found over Australia, the Southwest U.S. and other regions. Here, a global analysis of IPO’s impacts on T and P and its modulation of ENSO’s influence on T and P over the globe is performed using observational and reanalysis data and model simulations. Since 1920, there are two warm (1924–1944 and 1977–1998) and two cold (1945–1976 and 1999–present) IPO phases, whose change is associated with abrupt shifts in North Pacific sea level pressure (SLP) and contrasting anomaly patterns in T and P and atmospheric circulation over the eastern and western Pacific. The IPO explains more than half of the interdecadal variations in T and P over many regions, such as northeastern Australia, western Canada and northern India. Significant correlations between the IPO and local P are observed over eastern Australia, southern Africa and the Southwest U.S. The IPO also modulates ENSO’s influence on local T and P over most of these regions. T over northern India is positively correlated with Niño3.4 ENSO index during cold IPO phases but the correlation turns negative or insignificant during IPO warm phases. Over northeastern Australia, the T versus ENSO and P versus ENSO correlations are stronger during the IPO cold phases than during the warm phases. The P versus ENSO correlation over southern Africa tends to be negative during IPO warm phases but becomes weaker or insignificant during IPO cold phases. The IPO-induced P anomalies can be explained by the associated anomaly circulation, which is characterized by a high SLP center and anti-cyclonic flows over the North Pacific, and negative SLP anomalies and increased wind convergence over the Indonesia and western Pacific region during IPO cold phases. These observed influences of the IPO on regional T and P are generally reproduced by an atmospheric model forced by observed sea surface temperatures.

SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.

For nickel-based catalysts, in-situ formed nickel oxyhydroxide has been generally believed as the origin for anodic biomass electro-oxidations. However, rationally understanding the catalytic mechanism still remains challenging. In this work, we demonstrate that NiMn hydroxide as the anodic catalyst can enable methanol-to-formate electro-oxidation reaction (MOR) with a low cell-potential of 1.33/1.41 V at 10/100 mA cm −2 , a Faradaic efficiency of nearly 100% and good durability in alkaline media, remarkably outperforming NiFe hydroxide. Based on a combined experimental and computational study, we propose a cyclic pathway that consists of reversible redox transitions of Ni II -(OH) 2 /Ni III -OOH and a concomitant MOR. More importantly, it is proved that the Ni III -OOH provides combined active sites including Ni III and nearby electrophilic oxygen species, which work in a cooperative manner to promote either spontaneous or non-spontaneous MOR process. Such a bifunctional mechanism can well account for not only the highly selective formate formation but also the transient presence of Ni III -OOH. The different catalytic activities of NiMn and NiFe hydroxides can be attributed to their different oxidation behaviors. Thus, our work provides a clear and rational understanding of the overall MOR mechanism on nickel-based hydroxides, which is beneficial for advanced catalyst design. Understanding the active sites is essential for advanced catalyst design. Here, the authors report a bifunctional mechanism for the methanol electrooxidation reaction using NiMn hydroxide with Ni III and oxygen active sites which work in a cooperative manner to promote either spontaneous or non-spontaneous methanol oxidation.

Disruption of the alveolar barrier can trigger acute lung injury. This study elucidated the association of methyltransferase‐like 3 (METTL3) with Streptococcus pneumoniae (SP)‐induced apoptosis and inflammatory injury of alveolar epithelial cells (AECs). AECs were cultured and then infected with SP. Furthermore, the expression of METTL3, interleukin (IL)‐10, IL‐6, tumor necrosis factor‐alpha (TNF‐α), monocyte chemoattractant protein‐1 (MCP‐1), long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1), mucin 19 (MUC19), N6‐methyladenosine (m6A), and NEAT1 after m6A modification were detected by qRT‐PCR, Western blot, and enzyme‐linked immunosorbent, m6A quantification, and methylated RNA immunoprecipitation‐qPCR analyses, respectively. Moreover, the subcellular localization of NEAT1 was analyzed by nuclear/cytosol fractionation assay, and the binding between NEAT1 and CCCTC‐binding factor (CTCF) was also analyzed. The results of this investigation revealed that SP‐induced apoptosis and inflammatory injury in AECs and upregulated METTL3 expression. In addition, the downregulation of METTL3 alleviated apoptosis and inflammatory injury in AECs. METTL3‐mediated m6A modification increased NEAT1 and promoted its binding with CTCF to facilitate MUC19 transcription. NEAT1 or MUC19 overexpression disrupted their protective role of silencing METTL3 in AECs, thereby increasing apoptosis and inflammatory injury. In conclusion, this is the first study to suggest that METTL3 aggravates SP‐induced cell damage via the NEAT1/CTCF/MUC19 axis.

Two studies are presented that investigate the effect of linguistic cues on Mandarin speakers' comprehension of transitive constructions. Study 1 investigated Mandarin-speaking 2- to 4-year-olds' and adults' comprehension of the SVO (Subject-verb-object) construction, ba-construction (SbaOV), and subjectless ba-construction ((S)baOV) with novel verbs using the forced choice pointing paradigm (FCPP). Study 2 investigated another group of participants with similar ages' comprehension of the SVO construction, the ba-construction, the long and short passive constructions with novel verbs and FCPP. Although these constructions have differing cue strengths, participants in the same age groups comprehended these construction types equally well. The results suggest that children as young as two attended to the case markers of ba and bei, allowing them to employ abstract syntactic representations in comprehending Mandarin transitive constructions. The findings demonstrate that children are sensitive early on to the structural information encoded in the constructions.

Inflammatory bowel disease (IBD) is a notable health problem and may considerably affect the quality of human life. Previously, the protective roles of tryptanthrin (TRYP) against dextran sulfate sodium (DSS) induced colitis has been proved, but the concrete mechanism remained elusive. It has been suggested that TRYP could diminish the weight loss and improve the health conditions of mice with DSS induced colitis. Hematoxylin and eosin staining revealed that TRYP could improve the histopathological structure of the colon tissue. Two signaling pathways (TNF-α/NF-κBp65 and IL-6/STAT3) were investigated using immunochemistry and western blot. The detected concentrations of the two cytokines TNF-α and IL-6 showed that their levels decreased after TRYP treatment of the colitis. The protein expression level of NF-κBp65 in cytoplasm increased after TRYP treatment of the induced colitis. However, the protein level of NF-κBp65 in the nucleus decreased after administration of TRYP. The expression level of IκBα, the inhibitory protein of NF-κBp65, was tested and the results suggested that TRYP could inhibit the degradation of IκBα. The phosphorylation level of STAT3 was inhibited by TRYP and the expression level of STAT3 and p-STAT3 decreased after administration of TRYP. We conclude that TRYP improves the health condition of mice with DSS induced colitis by regulating the TNF-α/NF-κBp65 and IL-6/STAT3 signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3.

Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. Several types of stem cells have been used to study liver diseases; mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure.

Visual-inertial odometry (VIO) is known to suffer from drifting and can only provide local coordinates. In this paper, we propose a tightly coupled GNSS-VIO system based on point-line features for robust and drift-free state estimation. Feature-based methods are not robust in complex areas such as weak or repeated textures. To deal with this problem, line features with more environmental structure information can be extracted. In addition, to eliminate the accumulated drift of VIO, we tightly fused the GNSS measurement with visual and inertial information. The GNSS pseudorange measurements are real-time and unambiguous but experience large errors. The GNSS carrier phase measurements can achieve centimeter-level positioning accuracy, but the solution to the whole-cycle ambiguity is complex and time-consuming, which degrades the real-time performance of a state estimator. To combine the advantages of the two measurements, we use the carrier phase smoothed pseudorange instead of pseudorange to perform state estimation. Furthermore, the existence of the GNSS receiver and IMU also makes the extrinsic parameter calibration crucial. Our proposed system can calibrate the extrinsic translation parameter between the GNSS receiver and IMU in real-time. Finally, we show that the states represented in the ECEF frame are fully observable, and the tightly coupled GNSS-VIO state estimator is consistent. We conducted experiments on public datasets. The experimental results demonstrate that the positioning precision of our system is improved and the system is robust and real-time.

It is difficult to recover drones for small ships (such as destroyers). Therefore, it is necessary to design a new carrier-borne UAV recovery platform, achieving the purpose of rapid recovery of offshore UAV. This paper presents a fast unfolding and folding inflatable structure for small ship UAV offshore recovery. This paper analyze some static response of the UAV recovery platform. Firstly, parking positions of UAV on the runway surface is a factor. Secondly, runway surface materials is also a factor. Thirdly, airbag’s internal pressure also affects static response of the platform. It is find that static responses such as deformation and stress more sensitive to the runway surface material and the position of UAV, and the transverse deformation is sensitive to the runway surface material, but not to the internal pressure of the airbag.