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"Dong, Hui"
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حكمة ماو تسي دونغ
يناقش هذا الكتاب عناصر حكمة الزعيم ماو في عشرة جوانب، وذلك من الحياة الفردية إلى المجتمع الوطني، ومن بناء الذات وبناء الأسرة إلى حكم البلاد والعالم، تلك الحكمة التي جعلت منه شخصية صينية عالمية أسطورية، ما زالت تعيش في وجدان شعبه، وتحمل ذكراه في قلب كل صيني شعورا بالفخر والاحترام، ينقسم الكتاب إلى مقدمة وعشرة أبواب، ومقدمة لطريق نجاح ماو تسي دونغ وتستكشف طريق نجاح الزعيم ماو، وترى أن الأهم من تعداد الإنجازات التي حققها، هو كيفية تحقيقه كل هذه الإنجازات بنجاح كبير. يتناول الكتاب حكمة ماو تسي دونغ الحياتية والثورية والسياسية والقيادية وكذلك حكمته العسكرية وحكمته في الشؤون الخارجية والاقتصاد والرأي العام ووحكمته في بناء الحزب الشيوعي الصيني وحكم البلاد.
Book
Activation of silent biosynthetic gene clusters using transcription factor decoys
Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases (kb) in multiple streptomycetes, and characterization of a novel oxazole family compound produced by a 98-kb biosynthetic gene cluster. Owing to its simplicity and ease of use, this strategy can be scaled up readily for discovery of natural products in streptomycetes.
Transcription factor decoys, DNA molecules designed to mimic regulatory DNAs and prevent repressors binding to their DNA targets, are used to achieve de-repression of silent biosynthetic gene clusters, resulting in production of new natural products.
Journal Article
فهم الصين : السجلات الكاملة للدورة الثانية من المؤتمر الدولي \فهم الصين\
الوقوف على كافة مجريات وتطورات الواقع الصيني فيما يتعلق بسياسات الحزب الشيوعي الصيني بوجه عام، والأوضاع الاقتصادية بالصين على الصعيدين المحلي والدولي، ليس بالأمر الهين على الباحثين والأكاديميين بل والمهتمين بالشأن الصيني عموما، لذا فإن هذا الكتاب \"فهم الصين\" يعد محطة مهمة في قراءة وفهم حاضر الصين ومستقبلها القريب والبعيد على حد سواء، حيث يكتسب هذا الكتاب خصوصيته وأهميته، من كونه يتألف من عدة أوراق بحثية وكلمات لأهم القادة السياسيين الصينيين والدوليين كل من منطلق موقعه السياسي، والذين ألقوا كلماتهم على هامش أهم حدث سياسي يحدث في الصين كل خمس سنوات، وهو اجتماع اللجنة المركزية للحزب الشيوعي الصيني في دورته الثامنة عشرة. ويتناول هذا الكتاب عددا من المحاور الأساسية فيما يتعلق بالسياسة الخارجية للصين، ودورها الاقتصادي إقليميا وعالميا، منها : استراتيجية التنمية الاقتصادية وتعزيز التنمية المنسقة في إطار الخطة الخمسية الثالثة عشرة للصين، وتحسين الحوكمة العالمية وبناء مجتمع المصالح المشتركة على نحو شامل وكذلك المشاركة الفعالة في الحوكمة الاقتصادية العالمية والسعي لتحقيق تنمية سلمية مشتركة، وإدارة الفضاء السيبراني في الصين، بالإضافة إلى استراتيجية الدفاع الوطني الصينية، وتعزيز حماية البيئة الإيكولوجية وبناء مجتمع رغد الحياة بشكل شامل، بالإضافة إلى تحليل وعرض لمستقبل مبادرة \"الحزام والطريق\" في ظل النظام العالمي الجديد.
Book
Mental Health and Psychosocial Problems of Medical Health Workers during the COVID-19 Epidemic in China
Objective: We explored whether medical health workers had more psychosocial problems than nonmedical health workers during the COVID-19 outbreak. Methods: An online survey was run from February 19 to March 6, 2020; a total of 2,182 Chinese subjects participated. Mental health variables were assessed via the Insomnia Severity Index (ISI), the Symptom Check List-revised (SCL-90-R), and the Patient Health Questionnaire-4 (PHQ-4), which included a 2-item anxiety scale and a 2-item depression scale (PHQ-2). Results: Compared with nonmedical health workers (n = 1,255), medical health workers (n = 927) had a higher prevalence of insomnia (38.4 vs. 30.5%, p < 0.01), anxiety (13.0 vs. 8.5%, p < 0.01), depression (12.2 vs. 9.5%; p< 0.04), somatization (1.6 vs. 0.4%; p < 0.01), and obsessive-compulsive symptoms (5.3 vs. 2.2%; p < 0.01). They also had higher total scores of ISI, GAD-2, PHQ-2, and SCL-90-R obsessive-compulsive symptoms (p ≤ 0.01). Among medical health workers, having organic disease was an independent factor for insomnia, anxiety, depression, somatization, and obsessive-compulsive symptoms (p < 0.05 or 0.01). Living in rural areas, being female, and being at risk of contact with COVID-19 patients were the most common risk factors for insomnia, anxiety, obsessive-compulsive symptoms, and depression (p < 0.01 or 0.05). Among nonmedical health workers, having organic disease was a risk factor for insomnia, depression, and obsessive-compulsive symptoms (p < 0.01 or 0.05). Conclusions: During the COVID-19 outbreak, medical health workers had psychosocial problems and risk factors for developing them. They were in need of attention and recovery programs.
Journal Article
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes. Accumulation of these chemicals has adverse effects on human health, including inflammation in multiple organs, yet how PFAS are sensed by host cells, and how tissue inflammation eventually incurs, is still unclear. Here, we show that the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1β secretion and pyroptosis. Mechanistically, PFOS activates the AIM2 inflammasome in a process involving mitochondrial DNA release through the Ca
2+
-PKC-NF-κB/JNK-BAX/BAK axis. Accordingly,
Aim2
−/
−
mice have reduced PFOS-induced inflammation, as well as tissue damage in the lungs, livers, and kidneys in both their basic condition and in an asthmatic exacerbation model. Our results thus suggest a function of AIM2 in PFOS-mediated tissue inflammation, and identify AIM2 as a major pattern recognition receptor in response to the environmental organic pollutants.
The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.
Journal Article
Island and Page curve for one-sided asymptotically flat black hole
A
bstract
Great breakthrough in solving black hole information paradox took place when semiclassical island rule for entanglement entropy of Hawking radiation was proposed in recent years. Up to now, most papers which discussed island rule of asymptotic flat black hole with
D
≥ 4 focus on eternal black hole. In this paper, we take one more step further by discussing island of “in” vacuum state which describes one-sided asymptotically flat black hole formed by gravitational collapse in
D
≥ 4. We find that island
I
emerges at late time and saves entropy bound. And boundary of island
∂I
depends on the position of cutoff surface. When cutoff surface is far from horizon,
∂I
is inside and near horizon. When cutoff surface is set to be near horizon,
∂I
is outside and near horizon. This is different from the case of eternal black hole in which
∂I
is always outside horizon no matter cutoff surface is far from or near horizon. We will see that different states will manifestly affect
S
ent
in island formula when cutoff surface is far from horizon and thus have different result for Page time.
Journal Article
Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting
Asthma, a heterogeneous chronic respiratory disorder affecting millions globally, is driven by complex interactions between genetic susceptibility, environmental triggers, and dysregulated immunity. Emerging evidence positions ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, as a pivotal mechanism. This review introduces the “Ferroptosis-Immune-Metabolic Axis” as an integrative framework for asthma pathogenesis. We detail how environmental insults (e.g., allergens, pollutants) initiate ferroptosis in airway epithelial cells, leading to the release of damage-associated molecular patterns (DAMPs) and lipid peroxidation products (e.g., 4-HNE). These molecules activate and recruit immune cells (M1 macrophages, neutrophils, Th17 cells), which in turn exacerbate oxidative stress and iron dysregulation, creating a self-amplifying cycle. Metabolic reprogramming, including enhanced polyunsaturated fatty acid (PUFA) synthesis and glycolytic flux, provides the essential substrates and energy to sustain this vicious cycle. We dissect endotype-specific manifestations: IL-33-driven epithelial ferroptosis in eosinophilic asthma and ALOX15-mediated lipid peroxidation coupled with hepcidin-induced iron retention in neutrophilic asthma. Therapeutically, we highlight novel strategies such as inhaled GPX4 mRNA nanocarriers and ALOX15 inhibitors, underscoring the potential of targeting this axis for precision medicine in refractory asthma.
Journal Article
The gut-lung axis in COPD: immunomodulatory roles of gut microbiota and novel therapeutic strategies
Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and systemic inflammation, with accumulating evidence implicating gut microbiota dysbiosis as a key modulator of disease pathogenesis via the gut-lung axis. This review synthesizes current knowledge on the bidirectional communication between the gut and lungs, highlighting how microbial metabolites—particularly short-chain fatty acids (SCFAs), tryptophan derivatives, and bile acids—regulate pulmonary immunity through G-protein-coupled receptors, histone deacetylase inhibition, and aryl hydrocarbon receptor signaling. Dysbiosis-driven disruptions in these pathways exacerbate neutrophilic inflammation, impair regulatory T-cell function, and sustain TLR4/NF-κB activation, amplifying lung tissue damage and remodeling. Therapeutic strategies targeting the gut-lung axis show promise in restoring microbial homeostasis and mitigating COPD progression. Probiotics (e.g., Lactobacillus and Bifidobacterium ), prebiotics (e.g., inulin), and dietary interventions (e.g., high-fiber diets) enhance SCFA production, strengthen epithelial barriers, and suppress pro-inflammatory cytokines. Advanced approaches, including fecal microbiota transplantation, nanotechnology-enabled metabolite delivery (e.g., dendrimer-complexed indole-3-acetic acid), and traditional Chinese medicine (TCM) formulations (e.g., the postbiotic formulation Qipian), demonstrate efficacy in preclinical and clinical studies by synchronizing gut-lung microbiota and inhibiting inflammatory pathways. Despite these advances, challenges remain in translating findings to clinical practice, including methodological heterogeneity, antibiotic and corticosteroid confounding, and inter-individual microbiota variability. Future research must integrate multi-omics technologies, validate biomarkers (e.g., Bacteroidales/ Lactobacillus ratio, SCFA levels), and develop personalized interventions to bridge the bench-to-bedside gap. Harnessing the gut-lung axis offers transformative potential for COPD management, shifting the paradigm from symptomatic treatment to disease-modifying strategies rooted in microbiome immunology.
Journal Article
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats
1
–
4
. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans
5
–
7
. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
Characterization of full-length genome sequences from patients infected with a new coronavirus (2019-nCoV) shows that the sequences are nearly identical and indicates that the virus is related to a bat coronavirus.
Journal Article