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بروس لي : أسطورة الشرق الخالدة /
أسطورة الشرق الخالدة، التنين الصيني، علامة الووشو، مؤسس الجيت كون دو، معلم الفنون القتالية الأشهر في التاريخ، كلها ألقاب حظي بها الرجل الأشهر في الفنون القتالية في تاريخنا المعاصر \"لي تشن فان\" وهو الاسم الأصلي للتنين الصيني \"بروس لي\". يرتبط اسم بروس لي بالأساطير القتالية التي لا تزال يتناقلها الصغار والشباب المهتمون بفنون القتال، ذلك المصارع ذو الأصول الصينية المولود بالولايات المتحدة. تلك الأساطير التي ارتبطت بمولده ونشأته، وتعلمه فنون رياضتي الووشو والكونغ فو، تأسيسه لرياضة الجيت كون دو \"القبضة المعارضة\". حياته الشخصية، أساليبه القتالية الفريدة، أدواره السينمائية التي حققت أعلى الإيرادات في السينما الأمريكية في ذلك الوقت، مقولاته الشهيرة التي ألهمت الكثيرين، أسرار وفاته الغامضة، كل ذلك من أسرار يكشفها لنا المؤلف الصيني لهذا الكتاب تشنغ جيه الباحث المخضرم في كل ما يتعلق بيروس لي والذي أجرى تحليلا شاملا لكم ضخم من المعلومات الرسمية والموثوقة عن بروس لي، وبدأ منذ عام 2013 في كتابة قصة حياة بروس لي التي نعرض لها في هذا الكتاب والتي تضم الكثير من الوثائق المعلومات التي تنشر للمرة الأولى، ويرى مؤلف هذا الكتاب أن قصة حياة بروس لي التي يعرضها هذا الكتاب ليست محتوى أدبيا أو فكريا : ولكنها أقرب ما تكون إلى الحقيقة. كل هذا وأكثر، حول أسطورة الشرق الخالدة بروس لي. بين دفتي هذا الكتاب.
Book
Signaling Pathways Implicated in Carbon Nanotube-Induced Lung Inflammation
Inflammation is a tissue response to a variety of harmful stimuli, such as pathogens, irritants, and injuries, and can eliminate insults and limit tissue damage. However, dysregulated inflammation is recognized as a cause of many human diseases, exemplified by organ fibrosis and cancer. In this regard, inflammation-promoted fibrosis is commonly observed in human lung diseases, such as idiopathic pulmonary fibrosis and pneumoconiosis. Carbon nanotubes (CNTs) are a type of nanomaterials with unique properties and various industrial and commercial applications. On the other hand, certain forms of CNTs are potent inducers of inflammation and fibrosis in animal lungs. Notably, acute inflammation is a remarkable phenotype elicited by CNTs in the lung during the early acute phase post-exposure; whereas a type 2 immune response is evidently activated and dominates during the late acute and chronic phases, leading to type 2 inflammation and lung fibrosis. Numerous studies demonstrate that these immune responses involve distinct immune cells, various pathologic factors, and specific functions and play crucial roles in the initiation and progression of inflammation and fibrosis in the lung exposed to CNTs. Thus, the mechanistic understanding of the immune responses activated by CNTs has drawn great attention in recent years. This article reviews the major findings on the cell signaling pathways that are activated in immune cells and exert functions in promoting immune responses in CNT-exposed lungs, which would provide new insights into the understanding of CNT-induced lung inflammation and inflammation-driven fibrosis, the application of CNT-induced lung inflammation and fibrosis as a new disease model, and the potential of targeting immune cells as a therapeutic strategy for relevant human lung diseases.
Journal Article
Short-term air quality prediction based on EMD-transformer-BiLSTM
Actual acquired air quality time series data are highly volatile and nonstationary, and accurately predicting nonlinear time series data containing complex noise is an ongoing challenge. This paper proposes an air quality prediction method based on empirical mode decomposition (EMD), a transformer and a bidirectional long short-term memory neural network (BiLSTM), which is good at addressing the ultrashort-term prediction of nonlinear time-series data and shows good performance for application to the air quality dataset of Patna, India (6:00 am on October 3, 2015–0:00 pm on July 1, 2020). The AQI sequence is first decomposed into intrinsic mode functions (IMFs) via EMD and subsequently predicted separately via the improved transformer algorithm based on BiLSTM, where linear prediction is performed for IMFs with simple trends. Finally, the predicted values of each IMF are integrated using BiLSTM to obtain the predicted AQI values. This paper predicts the AQI in Patna with a time window of 5 h, and the RMSE, MAE and MAPE are as low as 5.6853, 2.8230 and 2.23%, respectively. Moreover, the scalability of the proposed model is validated on air quality datasets from several other cities, and the results prove that the proposed hybrid model has high performance and broad application prospects in real-time air quality prediction.
Journal Article
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.
Journal Article
The prevalence of HIV among MSM in China: a large-scale systematic analysis
Background
The prevalence of HIV among men who have sex with men (MSM) has become a significant public health challenge. The aim was to comprehensively estimate the national prevalence of HIV among MSM and its time trends through a large-scale systematic analysis.
Methods
Systematic search of Cochrane Library, PubMed, EMBASE, CNKI, VIP, and Wanfang Data databases without language restriction for studies on the prevalence of HIV among MSM published before Dec.31, 2018. Studies were eligible for inclusion if they were published in the peer-reviewed literature and used validated assessment methods to assess the prevalence of HIV among MSM. Estimates were pooled using random-effects analysis.
Results
Data were extracted from 355 cross-sectional studies (571,328 individuals) covered 59 cities from 30 provinces and municipalities of China. The overall national prevalence of HIV among MSM from 2001 to 2018 was estimated to be 5.7% (95% CI: 5.4–6.1%), with high between-study heterogeneity (
I
2
= 98.0%,
P
< 0.001). Our study showed an increased tendency in the HIV prevalence as time progressed by meta-regression analysis (
I
2
= 95.9%,
P
< 0.0001). HIV prevalence was the highest in those aged 50 years and older with HIV prevalence of 19.3% (95%CI: 13.1-27.4%,
N
= 13). HIV was more prevalent in the illiterate population (16.8%), than in those who had received an education. Although the internet was a major venue for Chinese MSM seeking male sex partners (35.6, 95%CI: 32.3-39.9%,
N
= 101), seeking MSM in bathhouses/saunas had the highest associated prevalence of HIV (13.4, 95%CI: 10.3-17.1%,
N
= 22). The HIV prevalence among MSM varied by location: compared with other regions in China, HIV was highly prevalent among MSM in the southwest (10.7, 95%CI: 9.3-12.2%,
N
= 91). Compared to participants who sometimes or always used condoms, participants who had never used a condom in the past 6 months had a higher risk of HIV infection, with odds ratios of 0.1 (95%CI: 0.08-0.14).
Conclusions
Our analysis provided reliable estimates of China’s HIV burden among MSM, which appears to present an increasing national public health challenge. Effective government responses are needed to address this challenge and include the implementation of HIV prevention.
Journal Article
Analysis of Emotional Stress of Teachers in Japanese Teaching Process Based on EEG Signal Analysis
The construction direction of Japanese teaching evaluation system based on hybrid teaching mode is to give full feedback to teaching process, diversify evaluation subjects and evaluation methods, and obtain comprehensive and objective evaluation results. Compared with most similar studies, more EEG data of teachers’ emotional stress relief and healthy people in Japanese teaching process were collected, and a large number of features were extracted. An experiment of teachers’ emotional stress relief recognition in Japanese teaching process based on EEG signal was designed. The feature selection algorithm was used to screen the EEG feature combinations of teachers’ emotional stress relief and healthy subjects, and the classification experiment was carried out to verify the difference. Finally, this paper uses the feature selection algorithm of tree model and the random forest model classifier to establish the recognition model of teachers’ emotional stress discharge in Japanese teaching process based on EEG signals and achieves the effect of more accurate recognition of teachers’ emotional stress discharge in Japanese teaching process. First, the connotation, value, and influencing factors of teachers’ emotion management ability are logically integrated and systematically expounded. Second, based on emotional psychology, emotional intelligence theory, psychotherapy theory, and management theory, teachers’ emotional management ability is constructed according to the three-dimensional structure theory of intelligence and information processing theory. It is constructed from three dimensions: object dimension (teachers themselves, students, and students), content dimension (positive and negative emotions), and operational dimension (emotional perception, emotional understanding, emotional expression, and emotional regulation).
Journal Article
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
The emergence of a novel avian-origin influenza A virus strain (H7N9) causing severe human disease in China has raised serious concerns. In this report, key clinical and virologic features of this outbreak are presented.
Sporadic human infections with avian influenza A viruses, which usually occur after recent exposure to poultry, have caused a wide spectrum of illness, ranging from conjunctivitis and upper respiratory tract disease to pneumonia and multiorgan failure. Low pathogenic avian influenza A (H7N2, H7N3, H9N2, or H10N7)
1
–
4
virus infections have caused lower respiratory tract illness that is mild (conjunctivitis or uncomplicated influenza-like illness) to moderate in severity. Most human infections with highly pathogenic avian influenza (HPAI) A (H7) viruses have resulted in conjunctivitis (H7N3) or uncomplicated influenza illness, but one case of fatal acute respiratory distress syndrome (ARDS) was reported . . .
Journal Article