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"Du, Jie"
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تحديث الاقتصاد الصيني
في كتابه \"تحديث الاقتصاد الصيني\" يتناول تشياو جنغ عملية الإصلاح الاقتصادي في الصين خلال ثلاثة عقود تم فيها وصف التطور السريع لاقتصاد الصين ب\"المعجزة الاقتصادية\"، ولكنه وصف غير دقيق -بتعبير المؤلف- وبمعنى أكثر دقة، يعتبر التطور السريع لاقتصاد الصين مجرد عملية انتعاش اقتصادي. إنها عملية مواكبة لاقتصادات الأسواق في المناطق المتقدمة.
Book
Spatiotemporal pattern of greenhouse gas emissions in China’s wastewater sector and pathways towards carbon neutrality
Greenhouse gas (GHG) emissions from the wastewater sector are a major contributor to the overall GHG emissions of all countries, however, there is currently a lack of global, national-scale, detailed spatiotemporal emission data. In this study we elaborated dynamic plant-resolved emission factor values based on the case-specific operating parameters of each municipal wastewater treatment plant (WWTP) and the associated sewers and sludge disposal utilities in China, contrasting with previous estimations that typically focused on WWTP operation without differentiating their spatiotemporal discrepancies. We demonstrate here that China’s municipal wastewater industry generated 53.0 MtCO2e in total GHG emissions in 2019, with the northern and southern areas exhibiting noticeably higher GHG intensities. Due to improved wastewater treatment, the national average wastewater GHG intensity grew by 17.2% between 2009 and 2019, although it is anticipated that the intensity will begin to fall starting in 2020 at rates dependent on the chosen treatment methods. A net-zero emission by the entire sector may be achieved as early as 2044 with continually increasing decarbonized energy and a progressive shift to resource-oriented operations, compared with just a 23.7% decrease by 2050 under the baseline scenario. Joint efforts at the scientific, economic and policy level will be required to make this happen. This study may serve as a roadmap for developing carbon-neutral wastewater management policies and technologies in China and the rest of the globe.Based on case-specific operating parameters of each municipal wastewater treatment plant and the associated sewers and sludge disposal utilities, this study presents a detailed analysis of the current carbon footprint of the wastewater sector in China and scenarios for reducing future emissions.
Journal Article
Hierarchical multi‐agent reinforcement learning for multi‐aircraft close‐range air combat
The close‐range autonomous air combat has gained significant attention from researchers involved in applications related to artificial intelligence (AI). A majority of the previous studies on autonomous air combat were focused on one‐on‐one air combat scenarios, however, the modern air combat is mostly conducted in formations. With regard to the aforementioned factors, a novel hierarchical maneuvering control architecture is introduced that is applied to the multi‐aircraft close‐range air combat scenario, which can handle air combat scenarios with variable‐size formation. Subsequently, three air combat sub‐tasks are designed, and recurrent soft actor‐critic (RSAC) algorithm combined with competitive self‐play (SP) is incorporated to learn the sub‐strategies. A novel hierarchical multi‐agent reinforcement learning (HMARL) algorithm is proposed to obtain the high‐level strategy for target and sub‐strategy selection. The training performance of the training algorithm of sub‐strategies and high‐level strategy in different air combat scenarios is evaluated. The obtained strategies are analyzed and it is found that the formations exhibit effective cooperative behavior in symmetric and asymmetric scenarios. Finally, the ideas of engineering implementation of the maneuvering control architecture are given. The study provides a solution for future multi‐aircraft autonomous air combat.
Aiming at the problem of maneuvering control in homogeneous multi‐aircraft close‐range air combat, a hierarchical maneuvering control architecture is proposed, which allows for multi‐aircraft close‐range air combat in formations of varying numbers of aircraft, which has good performance, symmetry and outputs smooth control commands. We also present some ideas for the engineering realization.
Journal Article
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance. Ferroptosis is a form of regulated cell death, induced by an iron-dependent accumulation of lipid peroxides during chemotherapy. However, whether the Wnt/beta-catenin signaling directly controls resistance to cell death, remains unclear. Here, we show that the activation of the Wnt/beta-catenin signaling attenuates cellular lipid ROS production and subsequently inhibits ferroptosis in GC cells. The beta-catenin/TCF4 transcription complex directly binds to the promoter region of GPX4 and induces its expression, resulting in the suppression of ferroptotic cell death. Concordantly, TCF4 deficiency promotes cisplatin-induced ferroptosis in vitro and in vivo. Thus, we demonstrate that the aberrant activation of the Wnt/beta-catenin signaling confers ferroptosis resistance and suggests a potential therapeutic strategy to enhance chemo-sensitivity for advanced GC patients.
Journal Article
The Role of Water Content of Deep Eutectic Solvent Ethaline in the Anodic Process of Gold Electrode
Traditional coupling of ligands for gold wet etching makes large-scale applications problematic. Deep eutectic solvents (DESs) are a new class of environment-friendly solvents, which could possibly overcome the shortcomings. In this work, the effect of water content on the Au anodic process in DES ethaline was investigated by combining linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). Meanwhile, we employed atomic force microscopy (AFM) to image the evolution of the surface morphology of the Au electrode during its dissolution and passivation process. The obtained AFM data help to explain the observations about the effect of water content on the Au anodic process from the microscopic perspective. High water contents make the occurrence of anodic dissolution of gold at higher potential, but enhances the rate of the electron transfer and gold dissolution. AFM results reveal the occurrence of massive exfoliation, which confirms that the gold dissolution reaction is more violent in ethaline with higher water contents. In addition, AFM results illustrate that the passive film and its average roughness could be tailored by changing the water content of ethaline.
Journal Article
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis
Pyroptosis is a form of inflammatory cell death that could be driven by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation following myocardial infarction (MI). Emerging evidence suggests the therapeutic potential for ameliorating MI-induced myocardial damages by targeting NLRP3 and pyroptosis. In this study, we investigated the myocardial protection effect of a novel anthraquinone compound (4,5-dihydroxy-7-methyl-9,10-anthraquinone-2-ethyl succinate) named Kanglexin (KLX) in vivo and in vitro. Male C57BL/6 mice were pre-treated either with KLX (20, 40 mg· kg
−1
per day, intragastric gavage) or vehicle for 7 consecutive days prior to ligation of coronary artery to induce permanent MI. KLX administration dose-dependently reduced myocardial infarct size and lactate dehydrogenase release and improved cardiac function as compared to vehicle-treated mice 24 h after MI. We found that MI triggered NLRP3 inflammasome activation leading to conversion of interleukin-1β (IL-1β) and IL-18 into their active mature forms in the heart, which could expand the infarct size and drive cardiac dysfunction. We also showed that MI induced pyroptosis, as evidenced by increased DNA fragmentation, mitochondrial swelling, and cell membrane rupture, as well as increased levels of pyroptosis-related proteins, including gasdermin D, N-terminal GSDMD, and cleaved caspase-1. All these detrimental alterations were prevented by KLX. In hypoxia- or lipopolysaccharide (LPS)-treated neonatal mouse ventricular cardiomyocytes, we showed that KLX (10 μM) decreased the elevated levels of terminal deoxynucleotidyl transferase dUTP nick end labeling- and propidium iodide-positive cells, and pyroptosis-related proteins. We conclude that KLX prevents MI-induced cardiac damages and cardiac dysfunction at least partly through attenuating NLRP3 and subsequent cardiomyocyte pyroptosis, and it is worthy of more rigorous investigations for its potential for alleviating ischemic heart disease.
Journal Article
Prevalence and factors associated with fertility desire among people living with HIV: A systematic review and meta-analysis
The fertility desire of people living with HIV (PLHIV) has been rising in the past decade. However, there are many studies among which the association remains controversial between the fertility desire of HIV-infected persons and antiretroviral therapy (ART), sex, marital status, and educational level.
We performed a literature search of these meta-analyses in PubMed, the Cochrane Library, Web of Science and ScienceDirect in November 2019. We also reviewed references of eligible studies to complement the search. We used pooled odds ratios (ORs) and 95% confidence intervals (CIs) with a random-effects model and a fixed-effects model to estimate the association between fertility desire among PLHIV and ART, sex, age, marital status, educational level, and number of children. Subgroups with I square values (I2) and sensitivity analyses were performed to assess the heterogeneity and the stability of the overall ORs, respectively. We evaluated publication bias using Egger's test and a visual inspection of the symmetry in funnel plots.
In these meta-analyses 50 articles were included with 22,367 subjects. The pooled prevalence of fertility desire among PLHIV was estimated to be 42.04%. The pooled analyses showed that the fertility desire of PLHIV is associated with ART (OR = 1.11, 95% CI:1.00-1.23, P = 0.043), sex (OR = 1.51, 95% CI:1.10-2.09), age (OR = 2.65, 95% CI:2.24-3.14), marital status (OR = 1.34, 95% CI:1.08-1.66), educational level (OR = 0.85, 95% CI:0.73-1.00, P = 0.047) and the number of children (OR = 3.99, 95% CI:3.06-5.20). PLHIV who are on ART, are male, are younger than 30, are married/cohabiting, have received a secondary education or above, and are childless have a higher prevalence of fertility desire. The two factors of age and the number of children, in particular demonstrated a strong significant association with fertility desire. We found moderate heterogeneity in the meta-analyses of age and educational level and high heterogeneity in the meta-analyses of sex, marital status and number of children. Publication bias was detected in the meta-analyses of the association of fertility with sex and educational level.
This study demonstrates that the prevalence of fertility desire among HIV-infected people is 42.04%, and the fertility desire among PLHIV is associated with ART experience, sex, age, marital status, the number of children, and educational level. Since a majority of PLHIV are of reproductive age, it is necessary to support PLHIV in terms of their needs regarding reproductive decision-making. Through counseling and reproductive health care, further measures to prevent the horizontal and vertical transmission of HIV should be taken.
Journal Article
Multi-geohazards susceptibility mapping based on machine learning—a case study in Jiuzhaigou, China
Jiuzhaigou, located in the transitional area between the Qinghai–Tibet Plateau and the Sichuan Basin, is highly prone to geological hazards (e.g., rock fall, landslide, and debris flow). High-performance-based hazard prediction models, therefore, are urgently required to prevent related hazards and manage potential emergencies. Current researches mainly focus on susceptibility of single hazard but ignore that different types of geological hazards might occur simultaneously under a complex environment. Here, we firstly built a multi-geohazard inventory from 2000 to 2015 based on a geographical information system and used satellite data in Google earth and then chose twelve conditioning factors and three machine learning methods—random forest, support vector machine, and extreme gradient boosting (XGBoost)—to generate rock fall, landslide, and debris flow susceptibility maps. The results show that debris flow models presented the best prediction capabilities [area under the receiver operating characteristic curve (AUC 0.95)], followed by rock fall (AUC 0.94) and landslide (AUC 0.85). Additionally, XGBoost outperformed the other two methods with the highest AUC of 0.93. All three methods with AUC values larger than 0.84 suggest that these models have fairly good performance to assess geological hazards susceptibility. Finally, evolution index was constructed based on a joint probability of these three hazard models to predict the evolution tendency of 35 unstable slopes in Jiuzhaigou. The results show that these unstable slopes are likely to evolve into debris flows with a probability of 46%, followed by landslides (43%) and rock falls (29%). Higher susceptibility areas for geohazards were mainly located in the southeast and middle of Jiuzhaigou, implying geohazards prevention and mitigation measures should be taken there in near future.
Journal Article
Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs in tumor tissues, and reduce the toxic effects of chemotherapy drugs on normal cells. Hence, great stability was obtained in the biological solution. Moreover, we designed an effective nanoparticle system for the doxorubicin (DOX) delivery targeting the oral squamous cell carcinoma (OSCC) by mediating the HN-1 (TSPLNIHNGQKL) through hydrogen and π–π bonds. DOX@NGO-PEG-HN-1 showed significantly higher cellular uptakes and cytotoxicity in OSCC cells (CAL-27 and SCC-25), compared to free DOX. Moreover, HN-1 showed considerable tumor-targeting and competition inhibition phenomenon. As we expected, the nanocarrier showed pH-responsive drug release. In total, our study represented a good technique to construct OSCC-targeted delivery of nanoparticles and improve the anticancer medicines’ efficiency.
Journal Article
Music Therapy and Music Intervention for NSCLC Patients Undergoing PET with Fear of Cancer Recurrence
Background: Cancer and psychiatric symptoms are associated. Fear of cancer recurrence (FCR) is the most common psychological problem for cancer survivors. Pharmacological interventions can help, but also have major drawbacks. Music therapy and music interventions have been shown to be a safe and practical complementary treatment. Objective: This randomized, controlled trial aimed to investigate the effects of music therapy and music intervention in attenuating non-small cell lung cancer (NSCLC) patients’ anxiety related to FCR. Methods: NSCLC patients with FCR were randomly allocated to a music therapy and intervention group (G1) and Control group (G2). Patients’ anxiety was measured using the State-Trait Anxiety Inventory scores and heart rates. Primary outcome measure were PET scans. Secondary measures were salivary cortisol, salivary α-amylase levels and heart rate. Findings: Patients in G1 showed higher glucose metabolism of 18F-FDG in the superior frontal gyrus, anterior cingulate, superior temporal gyrus, and parahippocampal gyrus, compared to those in G2 (all P < .001). Heart rates and salivary α-amylase area under the curve (AUC) and relative variation (VAR) in G1 were significantly lower than those in G2 (all P < .05). State-Trait Anxiety Inventory scores and cortisol AUC in G1 were significantly lower than those in G2 (all P < .05). Conclusions: Music therapy and interventions can reduce anxiety and endocrinological responses and change glucose metabolism of 18F-FDG in fear-related brain regions.
Trial registration: Registered retrospectively, ISRCTN Registry, www.isrctn.com, ISRCTN23276302
Clinical Implications: Cancer treatment centers and physical examination centers should consider providing music therapy and intervention to the appropriate patients as a routine component of a comprehensive clinical care during medical examinations.
Journal Article