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"Du, M."
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Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
Objective:
Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary polyphenol capable of preventing obesity and related complications in humans and animal models, on brown-like adipocyte formation in inguinal WAT (iWAT).
Methods:
CD1 female mice (5-month old) were fed a high-fat diet with/without 0.1% resveratrol. In addition, primary stromal vascular cells separated from iWAT were subjected to resveratrol treatment. Markers of brown-like (beige) adipogenesis were measured and the involvement of AMP-activated protein kinase (AMPK) α1 was assessed using conditional knockout.
Results:
Resveratrol significantly increased mRNA and/or protein expression of brown adipocyte markers, including uncoupling protein 1 (UCP1), PR domain-containing 16, cell death-inducing DFFA-like effector A, elongation of very long-chain fatty acids protein 3, peroxisome proliferator-activated receptor-γ coactivator 1α, cytochrome
c
and pyruvate dehydrogenase, in differentiated iWAT stromal vascular cells (SVCs), suggesting that resveratrol induced brown-like adipocyte formation
in vitro
. Concomitantly, resveratrol markedly enhanced AMPKα1 phosphorylation and differentiated SVC oxygen consumption. Such changes were absent in cells lacking AMPKα1, showing that AMPKα1 is a critical mediator of resveratrol action. Resveratrol also induced beige adipogenesis
in vivo
along with the appearance of multiocular adipocytes, increased UCP1 expression and enhanced fatty acid oxidation.
Conclusions:
Resveratrol induces brown-like adipocyte formation in iWAT via AMPKα1 activation and suggest that its beneficial antiobesity effects may be partly due to the browning of WAT and, as a consequence, increased oxygen consumption.
Journal Article
Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals
In the livestock industry, subcutaneous and visceral fat pads are considered as wastes, while intramuscular fat or marbling fat is essential for improving flavor and palatability of meat. Thus, strategies for optimizing fat deposition are needed. Intramuscular adipocytes provide sites for lipid deposition and marbling formation. In the present article, we addressed the origin and markers of intramuscular adipocyte progenitors - fibro-adipogenic progenitors (FAPs), as well as the latest progresses in mechanisms regulating the proliferation and differentiation of intramuscular FAPs. Finally, by targeting intramuscular FAPs, possible nutritional manipulations to improve marbling fat deposition are discussed. Despite recent progresses, the properties and regulation of intramuscular FAPs in livestock remain poorly understood and deserve further investigation.
Journal Article
The Cambridge companion to Catullus
\"Catullus is one of the most popular poets to survive from classical antiquity. Above all others he seems to speak to modern readers with a modern voice. The distinguished contributors to this Companion discuss the principal subjects which drew Catullus' affection and disgust, above all his famous affair with the woman he calls 'Lesbia', and situate him in the social, historical and intellectual context of firstcentury BC Rome. One of the so-called 'new poets', Catullus had a profound effect on subsequent Latin poetry, and this is explored especially for the Augustan age and the late first century AD. A significant part of the volume is concerned with Catullus' survival into the modern world. There are discussions both of the manuscript tradition and of the interpretative scholarship which has been devoted to his poetry, as well as his reception by renaissance and later poets. Students in particular will appreciate this book\"-- Provided by publisher.
BOOK
KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype
To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent inactivating mutations in Kruppel-like factor 2 (
KLF2
), a gene whose deficiency was previously shown to cause splenic marginal zone hyperplasia in mice.
KLF2
mutation was found in 40 (42%) of 96 SMZLs, but rarely in other B-cell lymphomas. The majority of
KLF2
mutations were frameshift indels or nonsense changes, with missense mutations clustered in the C-terminal zinc finger domains. Functional assays showed that these mutations inactivated the ability of KLF2 to suppress NF-κB activation by TLR, BCR, BAFFR and TNFR signalling. Further extensive investigations revealed common and distinct genetic changes between SMZL with and without
KLF2
mutation.
IGHV1-2
rearrangement and 7q deletion were primarily seen in SMZL with
KLF2
mutation, while
MYD88
and
TP53
mutations were nearly exclusively found in those without
KLF2
mutation.
NOTCH2
,
TRAF3
,
TNFAIP3
and
CARD11
mutations were observed in SMZL both with and without
KLF2
mutation. Taken together,
KLF2
mutation is the most common genetic change in SMZL and identifies a subset with a distinct genotype characterised by multi-genetic changes. These different genetic changes may deregulate various signalling pathways and generate cooperative oncogenic properties, thereby contributing to lymphomagenesis.
Journal Article
على مرتفعات اليأس
جاء هذا الكتاب في سبعين فقرة إضافة لمقدمة سيوران، ضمنها صاحب \"دموع وقديسين\" مختلف أفكاره حول الوجود والأخلاق والقيم الإنسانية متأثرا في ذلك خاصة بنيتشه، وتتناول بؤس العالم وعبثيته وعدم قدرة الإنسان المعاصر على فهم هذه العبثية وهو ما أدى إلى تفشي حالات الاكتئاب والمالنخوليا والتوترات العصبية ولقد فشلت الفلسفة وعلم النفس في فهم هذه التحولات في الإنسان وظلت مجرد مقولات متعالية وبالتالي هو يدعو الإنسان المعاصر إلى التعامل مع تحولات حالته النفسية بتحولات وعيه بالزمن وذلك من خلال القبض على الأبدية في لحظة وهي ما يسميها باتاي الديمومة.
BOOK
Vertebral fracture severity assessment on anteroposterior radiographs with a new semi-quantitative technique
Summary
We developed a new tool to assess the severity of osteoporotic vertebral fracture using radiographs of the spine. Our technique can be used in patient care by helping to stratify patients with osteoporotic vertebral fractures into appropriate treatment pathways. It can also be used for research purposes.
Purpose
The aim of our study was to propose a semi-quantitative (SQ) grading scheme for osteoporotic vertebral fracture (OVF) on anteroposterior (AP) radiographs.
Methods
On AP radiographs, the vertebrae are divided into right and left halves, which are graded (A) vertical rectangle, (B) square, (C) traverse rectangle, and (D) trapezoid; whole vertebrae are graded (E) transverse band or (F) bow-tie. Type A and B were compared with normal and Genant SQ grade 1 OVF, Type C and D with grade 2 OVF, and Type E and F with grade 3 OVF. Spine AP radiographs and lateral radiographs of 50 females were assessed by AP radiographs SQ grading. After training, an experienced board-certified radiologist and a radiology trainee assessed the 50 AP radiographs.
Results
The height-to-width ratio of the half vertebrae varied 1.32–1.48. On lateral radiographs, 84 vertebrae of the 50 patients had OVFs (38 grade 1, 24 grade 2, and 22 grade 3). On AP radiographs, the radiologist correctly assigned 84.2%, 91.7%, and 77.2% and the trainee correctly assigned 68.4%, 79.2%, and 81.8% of grade 1, 2, and 3 OVFs, respectively. Compared with lateral radiographs, the radiologist had a weighted Kappa of 0.944 including normal vertebrae and 0.883 not including normal vertebrae, while the corresponding Kappa values for the trainee were 0.891 and 0.830, respectively.
Conclusion
We propose a new semi-quantitative grading system for vertebral fracture severity assessment on AP spine radiographs.
Journal Article
Printed textiles : British and American cottons and linens 1700-1850
\"A fully revised reissue, updated and enhanced with new color photography, of an influential work on American textiles and their British antecedents, regarded as a classic text on both sides of the Atlantic. Printed Textiles was first published by Viking for the Winterthur Museum in 1970. A history of the cotton and linen textiles printed in Britain and America between 1700 and 1850, discussing their design, methods of manufacture, use, and means of trade. Building on research that has come to light since 1970 and utilizing the technical and scientific expertise of the conservators and scientists at Winterthur, and adding pieces acquired by the museum since 1970, Senior Curator of Textiles Linda Eaton presents a thorough and sweeping study enriched by the diverse approaches to material culture today. The book, illustrated with 600 photographs, offers a full appreciation of the beautiful fabrics that are an intimate part of the Winterthur Museum Collection\"-- Provided by publisher.
Book
Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is characterized by rapid loss of vital capacity, disability, and death. There are no effective treatments. Although this study failed to meets its primary end point, the data show therapeutic efficacy at a cost of substantial GI toxicity.
Idiopathic pulmonary fibrosis is a debilitating disease characterized by destruction of the gas-exchanging regions of the lung.
1
Its pathogenesis is thought to involve aberrant wound healing mediated by multiple signaling pathways, resulting in progressive lung injury and scarring.
1
Symptoms, including cough and dyspnea, limit physical activity and reduce the patient's quality of life and independence.
2
The course of the disease is difficult to predict, but it generally involves progressive deterioration, with a median survival time of 2.5 to 3.5 years after diagnosis.
3
Unpredictable acute exacerbations occur in some patients and are often fatal.
3
,
4
BIBF 1120 is a potent intracellular . . .
Journal Article