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This study quantifies the viscous interaction between propeller tip vortices and a turbulent boundary layer developing over a semi-elliptic leading-edge plate, located downstream. The experimental wind-tunnel set-up is designed to be representative of the tractor–propeller–wing configuration. Using stereoscopic particle image velocimetry and static wall-pressure measurements, the near-wall flow topology is resolved over the plate, semi-immersed in the propeller slipstream. The results show that the interaction exhibits high spatio-temporal coherence and is dominated by a coupling between primary and secondary vortical structures. Two distinct interaction regions are identified relative to the tip-vortex core: on the inboard side, towards the slipstream interior, the boundary-layer flow experiences strong velocity gradient transitions and amplified near-wall vorticity. The flow on the outboard side, moving out of the slipstream, exhibits wall-parallel velocity deficits and vorticity lift-up consistent with unsteady vortex-induced separation mechanisms. Spanwise velocity induced by the wall-normal component of the primary vortex connects these two regions, with the secondary vortex structure identified as enhancing boundary-layer lift-up on the outboard side. Although no local flow reversal occurs under the tested conditions, localised shear amplification and vorticity roll-up indicative of separation-like behaviour were observed. These findings advance the understanding of viscous slipstream–boundary-layer interaction and its implications for tractor–propeller–wing integration.

Lifelogging is a form of personal data collection which seeks to capture the totality of one’s experience through intelligent technology and sensors. Yet despite notable advancement in such technologies, there remain persistent challenges to developing interactive systems to analyse the types of large-scale personal collections often generated by lifelogging. In response to this, we present the Lifelog Application Design (LAD) model which is intended to address these challenges and support the design of more novel interactive systems that may target a broader range of application use cases. The model is deliberately structured to remain impartial to the specific personal data, technology platform, or application criterion, to provide maximum utility across the domain. We demonstrate this utility by exploring two case studies and a retrospective analysis of VRLE, a real-world application prototype developed to examine the potential of large-scale personal data retrieval in virtual reality. This work is based on the accumulation of insights garnered from involvement in a number of collaborative lifelogging projects over the past decade. It is our goal to encourage future researchers to utilise the LAD model to support the design and development of their own application prototypes and further solidify the model’s contribution to the domain as a whole.

This paper presents findings of the eleventh Video Browser Showdown competition, where sixteen teams competed in known-item and ad-hoc search tasks. Many of the teams utilized state-of-the-art video retrieval approaches that demonstrated high effectiveness in challenging search scenarios. In this paper, a broad survey of all utilized approaches is presented in connection with an analysis of the performance of participating teams. Specifically, both high-level performance indicators are presented with overall statistics as well as in-depth analysis of the performance of selected tools implementing result set logging. The analysis reveals evidence that the CLIP model represents a versatile tool for cross-modal video retrieval when combined with interactive search capabilities. Furthermore, the analysis investigates the effect of different users and text query properties on the performance in search tasks. Last but not least, lessons learned from search task preparation are presented, and a new direction for ad-hoc search based tasks at Video Browser Showdown is introduced.

The objective of this thesis is to investigate the various methods of antenna gain characterization and to determine which would work best in the anechoic chamber maintained by the Electrical Engineering Department at the University of Nevada, Reno (UNR). As the antenna becomes more prevalent in today's society, so does the need to accurately characterize it. With the advent of cellular phones, pagers, wireless internet services, and many other applications, the number of antennas in use has seen great growth. High frequency antennas are of particular interest due to the greater bandwidth available in those frequencies. The anechoic chamber located on the UNR campus has some limitations due to its size and construction that make it preferable to measure antennas with operating frequencies higher than approximately 600MHz. Conveniently, many modern antennas need to operate well above this frequency. Cell phones, for example, usually operate between 800 and 1000 MHz. Several different methods are available to characterize an antenna [1,2], all of which, are based on the Friis' Transmission Formula. Although these methods are well known and well documented, they lack the clarity that would enable a technician to make the measurements. Three of these methods will be implemented and their advantages and disadvantages determined. A procedure will then be established that will enable a technician to perform the measurements rather than the engineer.

Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter’s ability to induce endoplasmic reticulum stress response. Increased tumour cell phagocytosis subsequently enhances antigen cross-presentation and activation of cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING) in APCs, resulting in more efficient T cell priming. This bridging of innate and adaptive responses inhibits glioma growth, but also activates immune checkpoint. Sequential administration of an anti-PD1 antibody overcomes this potential adaptive resistance. Together, these findings reveal a dynamic relationship between innate and adaptive immune regulation in tumours and support further investigation of phagocytosis modulation as a strategy to enhance cancer immunotherapy responses. Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses.

Three-dimensional heterostructures are usually created either by assembling two-dimensional building blocks into hierarchical architectures or using stepwise chemical processes that sequentially deposit individual monolayers. Both approaches suffer from a number of issues, including lack of suitable precursors, limited reproducibility, and poor scalability of the preparation protocols. Therefore, development of alternative methods that enable preparation of heterostructured materials is desired. We create heterostructures with incommensurate arrangements of well-defined building blocks using a synthetic approach that comprises mechanical disassembly and simultaneous reordering of layered transition-metal dichalcogenides, MX 2 , and non-layered monochalcogenides, REX, where M = Ta, Nb, RE = Sm, La, and X = S, Se. We show that the discovered solid-state processes are rooted in stochastic mechanochemical transformations directed by electronic interaction between chemically and structurally dissimilar solids toward atomic-scale ordering, and offer an alternative to conventional heterostructuring. Details of composition–structure–properties relationships in the studied materials are also highlighted. 3D heterostructures offer properties that are inaccessible in bulk single-phase solids, but synthetic approaches are limited. The authors use mechanochemical reshuffling of binary precursors and subsequent annealing to design structurally aligned misfit heterostructures with well-defined atomic arrangements.

The primary means of disseminating sport and exercise science research is currently through journal articles. However, not all studies, especially those with null findings, make it to formal publication. This publication bias towards positive findings may contribute to questionable research practices. Preregistration is a solution to prevent the publication of distorted evidence resulting from this system. This process asks authors to register their hypotheses and methods before data collection on a publicly available repository or by submitting a Registered Report. In the Registered Report format, authors submit a stage 1 manuscript to a participating journal that includes an introduction, methods, and any pilot data indicating the exploratory or confirmatory nature of the study. After a stage 1 peer review, the manuscript can then be offered in-principle acceptance, rejected, or sent back for revisions to improve the quality of the study. If accepted, the project is guaranteed publication, assuming the authors follow the data collection and analysis protocol. After data collection, authors re-submit a stage 2 manuscript that includes the results and discussion, and the study is evaluated on clarity and conformity with the planned analysis. In its final form, Registered Reports appear almost identical to a typical publication, but give readers confidence that the hypotheses and main analyses are less susceptible to bias from questionable research practices. From this perspective, we argue that inclusion of Registered Reports by researchers and journals will improve the transparency, replicability, and trust in sport and exercise science research. The preprint version of this work is available on SportR χ iv: https://osf.io/preprints/sportrxiv/fxe7a/ .

Age‐related skeletal muscle atrophy, known as sarcopenia, is characterized by loss of muscle mass, strength, endurance, and oxidative capacity. Although exercise has been shown to mitigate sarcopenia, the underlying governing mechanisms are poorly understood. Mitochondrial dysfunction is implicated in aging and sarcopenia; however, few studies explore how mitochondrial structure contributes to this dysfunction. In this study, we sought to understand how aging impacts mitochondrial three‐dimensional (3D) structure and its regulators in skeletal muscle. We hypothesized that aging leads to remodeling of mitochondrial 3D architecture permissive to dysfunction and is ameliorated by exercise. Using serial block‐face scanning electron microscopy (SBF‐SEM) and Amira software, mitochondrial 3D reconstructions from patient biopsies were generated and analyzed. Across five human cohorts, we correlate differences in magnetic resonance imaging, mitochondria 3D structure, exercise parameters, and plasma immune markers between young (under 50 years) and old (over 50 years) individuals. We found that mitochondria are less spherical and more complex, indicating age‐related declines in contact site capacity. Additionally, aged samples showed a larger volume phenotype in both female and male humans, indicating potential mitochondrial swelling. Concomitantly, muscle area, exercise capacity, and mitochondrial dynamic proteins showed age‐related losses. Exercise stimulation restored mitofusin 2 (MFN2), one such of these mitochondrial dynamic proteins, which we show is required for the integrity of mitochondrial structure. Furthermore, we show that this pathway is evolutionarily conserved, as Marf, the MFN2 ortholog in Drosophila, knockdown alters mitochondrial morphology and leads to the downregulation of genes regulating mitochondrial processes. Our results define age‐related structural changes in mitochondria and further suggest that exercise may mitigate age‐related structural decline through modulation of mitofusin 2. Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age‐related sarcopenia, a condition characterized by muscle mass loss. Through the creation of three‐dimensional models of mitochondria from quadriceps muscle tissue taken from old and young humans, a loss in mitochondrial complexity was observed to occur during aging. A decrease in the expression of mitochondrial fusion protein mitofusin 2 (MFN‐2) in older populations may drive these mitochondrial structural changes. A Drosophila model with the MFN‐2 ortholog knocked down demonstrated a loss of mitochondrial complexity and lower quality cristae, which parallel changes in mitochondria observed in older humans. The use of an in vitro cell exercise model showed that the mechanism by which exercise counteracts the effects of sarcopenia, age‐related disease may be due to increased expression of MFN‐2 during exercise.

The presence of fish within navigation locks can introduce an environmental challenge for construction crews when maintenance is required. This study examined the effectiveness of a dual-deterrent fish herding technique using electricity and acoustic stimuli to reduce the abundance of fish within a navigation lock before a scheduled dewatering for maintenance. Fixed-location multi-beam imaging sonar was used to evaluate fish per minute (FPM) detections near the lock entrance before, during, and after the herding effort. Standardized mobile side-scan sonar surveys were also conducted before and after the herding to examine fish presence throughout the entire lock. Collectively, a 73% reduction in fish targets detected by side-scan sonar and a 43% reduction in FPM detected by imaging sonar were observed following the herding technique. Post-fish herding, an 88% reduction in FPM > 400 mm and a 35% reduction in FPM < 400 mm were observed. Fish abundance within the lock chamber was reduced and did not result in construction delays, which was problematic and costly during previous dewatering events. Because data from this study are limited to a single lock dewatering and fish clearing event, caution is warranted with the extrapolation of these results. However, the applied methods show promise and may inform future fish clearing efforts to aid lock maintenance.

ObjectiveThis study investigated the policies of cardiac and cardiovascular system journals concerning clinical trial registration and guideline adoption to understand how frequently journals use these mechanisms to improve transparency, trial reporting and overall study quality.MethodsWe selected the top 20 (by impact factor) journals cited in the subcategory ‘Cardiac and Cardiovascular Systems’ of the Expanded Science Citation Index of the 2014 Journal Citation Reports to extract journal policies concerning the 17 guidelines we identified. In addition, trial and systematic review registration adherence statements were extracted. 300 randomised controlled trials published in 2016 in the top 20 journals were searched for clinical trial registry numbers and CONSORT diagrams.ResultsOf the 19 cardiac and cardiovascular system journals included in our analysis, eight journals (42%) did not require or recommend trial or review registration. Seven (37%) did not recommend or require a single guideline within their instructions to authors. Consolidated Standards for Reporting Trials guidelines (10/19, 53%) were recommended or required most often. Of the trials surveyed, 122/285 (42.8%) published a CONSORT diagram in their manuscript, while 236/292 (80.8%) published a trial registry number.DiscussionCardiac and cardiovascular system journals infrequently require, recommend or enforce the use of reporting guidelines. Furthermore, too few require or enforce the use of clinical trial registration. Cardiology journal editors should consider guideline adoption due to their potential to limit bias and increase transparency.