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The past decade has seen increased international recognition of the importance of the services provided by natural ecosystems. It is unclear however whether such international awareness will lead to improved environmental management in many regions. We explore this issue by examining the specific case of fish migration and dams on the Mekong river. We determine that dams on the Mekong mainstem and major tributaries will have a major impact on the basin's fisheries and the people who depend upon them for food and income. We find no evidence that current moves towards dam construction will stop, and consider two scenarios for the future of the fisheries and other ecosystems of the basin. We conclude that major investment is required in innovative technology to reduce the loss of ecosystem services, and alternative livelihood strategies to cope with the losses that do occur.

We compared the effects of water resource development on migratory fish in two North American rivers using a descriptive approach based on four high-level indicators: (1) trends in abundance of Pacific salmon, (2) reliance on artificial production to maintain fisheries, (3) proportion of adult salmon that are wild- versus hatchery-origin, and (4) number of salmon populations needing federal protection to avoid extinction. The two rivers had similar biological and physical features but radically different levels of water resource development: the Fraser River has few dams and all are located in tributaries, whereas the Columbia River has more than 130 large mainstem and tributary dams. Not surprisingly, we found substantial effects of development on salmon in the Columbia River. We related the results to potential effects on migratory fish in the Mekong River where nearly 200 mainstem and tributary dams are installed, under construction, or planned and could have profound effects on its 135 migratory fish species. Impacts will vary with dam location due to differential fish production within the basin, with overall effects likely being greatest from 11 proposed mainstem dams. Minimizing impacts will require decades to design specialized fish passage facilities, dam operations, and artificial production, and is complicated by the Mekong's high diversity and productivity. Prompt action is needed by governments and fisheries managers to plan Mekong water resource development wisely to prevent impacts to the world's most productive inland fisheries, and food security and employment opportunities for millions of people in the region.

Based on the book of the same name by Clover (2004), the film moves through the value chain from up-market sushi restaurants in London, to global supermarket chains, and down through fish markets to industrial fishing vessels on the seas. With 90-95% of the catch destined for local domestic markets, the fish supply crisis here will also have far more profound consequences than the omission of bluefin tuna from the sushi bars of Tokyo or Paris, or North Sea cod from supermarket shelves in London or Oslo.

Alzheimer's Disease is a chronic progressive neurodegenerative disorder that impairs the cerebral lymphatic system and compartmental fluid exchange leading to a decline in cognitive function. Due to the lack of disease modifying medications, non-pharmacological Cranial Osteopathic Manipulation (COM) is evolving as a potential minimally invasive treatment choice. In this work, the effect of quantified COM treatment, using a nanosensor glove, on 3-month-old (Yg) and 18-month-old transgenic (Tg) rat model of Alzheimer's Disease were studied using the Morris Water Maze (MWM), Western Blots, and Proteomics and Transcriptomics assays. The results revealed that COM had minimal to no significant difference in the behavioral and biochemical parameters in the Yg rats, suggesting COM treatment was harmless. While COM exhibited no significant differences in Tg rat MWM escape latency, navigation to the platform was significantly different on testing days 5 and 6, with p-values of signed initial heading error were 0.014 and 0.034 respectively. This indicates a difference in learning and spatial working memory. A proteomic assay on Tg rat hippocampus identified 51 significantly differentially expressed proteins with 34 associated with neurological disorders, while transcriptome remained indifferent. In this study, for the first time we have established a technique to quantify the force applied during COM treatment on an animal model of AD, offering a more objective approach for evaluating the effect of such treatments. Our results indicate that a quantifiable COM can be applied to rodents and to study the resulting behavioral and biochemical phenotypes.Competing Interest StatementI have read the journal's policy and the authors of this manuscript have the following competing interests: BMC is founder and CEO of Clab LLC

According to Sousa's daughter, Helen Sousa Abert, the producer and writer of the screen play for the movie, Lamar Trotti had lunch with her and her sister, Jane Priscilla Sousa in Port Washington, New York, in November of 1951. Director Abert further stated, \"Considerable negotiations with interested producers regarding this might be necessary ... requiring authorization from the Corporation to her to negotiate in its behalf in connection with its interest in the musical compositions and autobiography of Commander Sousa, in book form, entitled Marching Along.\" [...]complicating the process of making the movie, the March King's wife, Jane, who served as president of the Sousa Corporation, died on March 11,1944, requiring a reorganization of the board of directors. At a special board meeting held on May 26, 1944, the resolution adopted January 29,1942 was revisited and re-affirmed that Helen Abert be authorized to negotiate with, \"moving picture producers and companies,\" to make a film about the March King.