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Built in 2004, the Skynet robotic telescope network originally consisted of six 0.4 m telescopes located at the Cerro-Tololo Inter-American Observatory in the Chilean Andes. The network was designed to carry out simultaneous multi-wavelength observations of gamma-ray bursts (GRBs) when they are only tens of seconds old. To date, the network has been expanded to ≈20 telescopes, including a 20 m radio telescope, that span four continents and five countries. The Campaign Manager (CM) is a new observing mode that has been developed for Skynet. Available to all Skynet observers, the CM semi-autonomously and indefinitely scales and schedules exposures on the observer’s behalf while allowing for modification to scaling parameters in real time. The CM is useful for follow up to various transient phenomena including gravitational-wave events, GRB localizations, young supernovae, and eventually, sufficiently bright Argus Optical Array and Large Synoptic Survey Telescope events.

The most powerful and energetic explosions in the known universe – gamma-ray bursts (GRBs) – are thought to originate from the collapse of massive stars or the merger of compact objects. Often marking the birth of a black hole, GRBs produce broadband emission via synchrotron radiation as the resulting ultra-relativistic jet interacts with the surrounding medium. This emission, known as the afterglow, carries rich information about the nature of the burst and its environment. To better understand these cataclysmic events and the environments that surround them, we developed a Python-based modeling and inference framework, AMPy, capable of modeling afterglows in arbitrary and smoothly varying power-law density profiles, extending beyond the standard assumption of either a constant-density interstellar medium (k = 0) or an idealized stellar wind profile (k = 2). This dissertation presents detailed results from modeling 15 events with AMPy which reveal a wide diversity of environmental structures, including steep “superwinds”, shallow “subwinds,” stratified media with smooth transitions between regimes, and cavity-like regions consistent with effective density gradients of k < 0. The recovered stratified and cavity-like profiles are consistent with evolving progenitor winds, shocked regions, termination shocks, or the presence of shells ejected prior to the burst. These findings also reveal that radiative cooling plays a significant role in many events, that synchrotron self-absorption can influence modeling even when unobserved, and that calibration systematics and unaccounted-for statistical uncertainties (“slop”) must be incorporated to avoid biased fits, underestimated uncertainties, and consequently overstated conclusions. AMPy handles all of this self-consistently and efficiently. These results demonstrate that GRB afterglow environments are far more diverse than has been traditionally assumed for the past three decades and that oversimplified models likely misrepresent the physical nature of these explosions.

Built in 2004, the Skynet robotic telescope network originally consisted of six 0.4 m telescopes located at the Cerro-Tololo Inter-American Observatory in the Chilean Andes. The network was designed to carry out simultaneous multi-wavelength observations of gamma-ray bursts (GRBs) when they are only tens of seconds old. To date, the network has been expanded to ≈20 telescopes, including a 20 m radio telescope, that span four continents and five countries. The Campaign Manager (CM) is a new observing mode that has been developed for Skynet. Available to all Skynet observers, the CM semi-autonomously and indefinitely scales and schedules exposures on the observer’s behalf while allowing for modification to scaling parameters in real time. The CM is useful for follow up to various transient phenomena including gravitational-wave events, GRB localizations, young supernovae, and eventually, sufficiently bright Argus Optical Array and Large Synoptic Survey Telescope events.

Built in 2004, the Skynet robotic telescope network originally consisted of six 0.4 m telescopes located at the Cerro-Tololo Inter-American Observatory in the Chilean Andes. The network was designed to carry out simultaneous multi-wavelength observations of gamma-ray bursts (GRBs) when they are only tens of seconds old. To date, the network has been expanded to ~20 telescopes, including a 20 m radio telescope, that span four continents and five countries. The Campaign Manager (CM) is a new observing mode that has been developed for Skynet. Available to all Skynet observers, the CM semi-autonomously and indefinitely scales and schedules exposures on the observer's behalf while allowing for modification to scaling parameters in real time. The CM is useful for follow up to various transient phenomena including gravitational-wave events, GRB localizations, young supernovae, and eventually, sufficiently bright Argus Optical Array and Large Synoptic Survey Telescope events.

We present top-down constraints on global monthly N2O emissions for 2011 from a multi-inversion approach and an ensemble of surface observations. The inversions employ the GEOS-Chem adjoint and an array of aggregation strategies to test how well current observations can constrain the spatial distribution of global N2O emissions. The strategies include (1) a standard 4D-Var inversion at native model resolution (4∘×5∘), (2) an inversion for six continental and three ocean regions, and (3) a fast 4D-Var inversion based on a novel dimension reduction technique employing randomized singular value decomposition (SVD). The optimized global flux ranges from 15.9 TgNyr-1 (SVD-based inversion) to 17.5–17.7 TgNyr-1 (continental-scale, standard 4D-Var inversions), with the former better capturing the extratropicalN2O background measured during the HIAPER Pole-to-Pole Observations (HIPPO) airborne campaigns. We find that the tropics provide a greater contribution to the global N2O flux than is predicted by the prior bottom-up inventories, likely due to underestimated agricultural and oceanic emissions. We infer an overestimate of natural soil emissions in the extratropics and find that predicted emissions are seasonally biased in northern midlatitudes. Here, optimized fluxes exhibit a springtime peak consistent with the timing of spring fertilizer and manure application, soil thawing, and elevated soil moisture. Finally, the inversions reveal a major emission underestimate in the US Corn Belt in the bottom-up inventory used here. We extensively test the impact of initial conditions on the analysis and recommend formally optimizing the initial N2O distribution to avoid biasing the inferred fluxes. We find that the SVD-based approach provides a powerful framework for deriving emission information from N2O observations: by defining the optimal resolution of the solution based on the information content of the inversion, it provides spatial information that is lost when aggregating to political or geographic regions, while also providing more temporal information than a standard 4D-Var inversion.

Valvular heart disease, particularly aortic valve (AV) calcification, remains a significant issue, with AV replacement surgeries among the most common procedures. Current surgical options include mechanical heart valves (MHVs) and bioprosthetic valves, each with inherent limitations. MHVs offer long-term durability but require lifelong anticoagulation therapy, while bioprosthetic valves provide superior hemodynamics but lack durability. The MHV’s non-physiological flow patterns through the hinges and spikes in regional backflow velocity (RBV) during closure may contribute to the need for anticoagulation. This study evaluates two emerging MHVs, the iValve and Triflo, alongside established prosthetic valves. The iValve, featuring a novel bileaflet design, and the Triflo, a trileaflet valve, aim to overcome current MHV limitations. In vitro testing used a pulse duplicator system to assess projected open area (POA), volumetric flow rate, regurgitant volumes, and trans-AV pressure relative to mean pressure (pressure ratio). POA and volumetric flow rates were used to calculate flow velocity and RBV. Results indicate that the iValve and Triflo achieved comparable pressure ratios and significantly lower mean and peak RBV values than traditional MHVs like the SJM and On-X. This suggests improved flow dynamics and reduced shear stress on blood components, potentially minimizing anticoagulation requirements. The iValve prototypes showed regurgitant volumes comparable to conventional MHVs, while the Triflo performed similarly to the control valve. These findings underscore the potential of next-generation MHVs to combine durability, hemodynamic performance, and reduced thrombogenic risk closer to the native valve.

Nitrous oxide (N2O) is a long-lived potent greenhouse gas and stratospheric ozone-depleting substance that has been accumulating in the atmosphere since the preindustrial period. The mole fraction of atmospheric N2O has increased by nearly 25 % from 270 ppb (parts per billion) in 1750 to 336 ppb in 2022, with the fastest annual growth rate since 1980 of more than 1.3 ppb yr−1 in both 2020 and 2021. According to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR6), the relative contribution of N2O to the total enhanced effective radiative forcing of greenhouse gases was 6.4 % for 1750–2022. As a core component of our global greenhouse gas assessments coordinated by the Global Carbon Project (GCP), our global N2O budget incorporates both natural and anthropogenic sources and sinks and accounts for the interactions between nitrogen additions and the biogeochemical processes that control N2O emissions. We use bottom-up (BU: inventory, statistical extrapolation of flux measurements, and process-based land and ocean modeling) and top-down (TD: atmospheric measurement-based inversion) approaches. We provide a comprehensive quantification of global N2O sources and sinks in 21 natural and anthropogenic categories in 18 regions between 1980 and 2020. We estimate that total annual anthropogenic N2O emissions have increased 40 % (or 1.9 Tg N yr−1) in the past 4 decades (1980–2020). Direct agricultural emissions in 2020 (3.9 Tg N yr−1, best estimate) represent the large majority of anthropogenic emissions, followed by other direct anthropogenic sources, including fossil fuel and industry, waste and wastewater, and biomass burning (2.1 Tg N yr−1), and indirect anthropogenic sources (1.3 Tg N yr−1) . For the year 2020, our best estimate of total BU emissions for natural and anthropogenic sources was 18.5 (lower–upper bounds: 10.6–27.0) Tg N yr−1, close to our TD estimate of 17.0 (16.6–17.4) Tg N yr−1. For the 2010–2019 period, the annual BU decadal-average emissions for both natural and anthropogenic sources were 18.2 (10.6–25.9) Tg N yr−1 and TD emissions were 17.4 (15.8–19.20) Tg N yr−1. The once top emitter Europe has reduced its emissions by 31 % since the 1980s, while those of emerging economies have grown, making China the top emitter since the 2010s. The observed atmospheric N2O concentrations in recent years have exceeded projected levels under all scenarios in the Coupled Model Intercomparison Project Phase 6 (CMIP6), underscoring the importance of reducing anthropogenic N2O emissions. To evaluate mitigation efforts and contribute to the Global Stocktake of the United Nations Framework Convention on Climate Change, we propose the establishment of a global network for monitoring and modeling N2O from the surface through to the stratosphere. The data presented in this work can be downloaded from https://doi.org/10.18160/RQ8P-2Z4R (Tian et al., 2023).

We present top-down constraints on global monthly N2O emissions for 2011 from a multi-inversion approach and an ensemble of surface observations. The inversions employ the GEOS-Chem adjoint and an array of aggregation strategies to test how well current observations can constrain the spatial distribution of global N2O emissions. The strategies include (1) a standard 4D-Var inversion at native model resolution (4° × 5°), (2) an inversion for six continental and three ocean regions, and (3) a fast 4D-Var inversion based on a novel dimension reduction technique employing randomized singular value decomposition (SVD). The optimized global flux ranges from 15.9 Tg N yr−1 (SVD-based inversion) to 17.5–17.7 Tg N yr−1 (continental-scale, standard 4D-Var inversions), with the former better capturing the extratropical N2O background measured during the HIAPER Pole-to-Pole Observations (HIPPO) airborne campaigns. We find that the tropics provide a greater contribution to the global N2O flux than is predicted by the prior bottom-up inventories, likely due to underestimated agricultural and oceanic emissions. We infer an overestimate of natural soil emissions in the extratropics and find that predicted emissions are seasonally biased in northern midlatitudes. Here, optimized fluxes exhibit a springtime peak consistent with the timing of spring fertilizer and manure application, soil thawing, and elevated soil moisture. Finally, the inversions reveal a major emission underestimate in the US Corn Belt in the bottom-up inventory used here. We extensively test the impact of initial conditions on the analysis and recommend formally optimizing the initial N2O distribution to avoid biasing the inferred fluxes. We find that the SVD-based approach provides a powerful framework for deriving emission information from N2O observations: by defining the optimal resolution of the solution based on the information content of the inversion, it provides spatial information that is lost when aggregating to political or geographic regions, while also providing more temporal information than a standard 4D-Var inversion.

Nitrous oxide (N2O) is a long-lived potent greenhouse gas and stratospheric ozone-depleting substance that has been accumulating in the atmosphere since the preindustrial period. The mole fraction of atmospheric N2O has increased by nearly 25 % from 270 ppb (parts per billion) in 1750 to 336 ppb in 2022, with the fastest annual growth rate since 1980 of more than 1.3 ppb yr−1 in both 2020 and 2021. According to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR6), the relative contribution of N2O to the total enhanced effective radiative forcing of greenhouse gases was 6.4 % for 1750–2022. As a core component of our global greenhouse gas assessments coordinated by the Global Carbon Project (GCP), our global N2O budget incorporates both natural and anthropogenic sources and sinks and accounts for the interactions between nitrogen additions and the biogeochemical processes that control N2O emissions. We use bottom-up (BU: inventory, statistical extrapolation of flux measurements, and process-based land and ocean modeling) and top-down (TD: atmospheric measurement-based inversion) approaches. We provide a comprehensive quantification of global N2O sources and sinks in 21 natural and anthropogenic categories in 18 regions between 1980 and 2020. We estimate that total annual anthropogenic N2O emissions have increased 40 % (or 1.9 Tg N yr−1) in the past 4 decades (1980–2020). Direct agricultural emissions in 2020 (3.9 Tg N yr−1, best estimate) represent the large majority of anthropogenic emissions, followed by other direct anthropogenic sources, including fossil fuel and industry, waste and wastewater, and biomass burning (2.1 Tg N yr−1), and indirect anthropogenic sources (1.3 Tg N yr−1) . For the year 2020, our best estimate of total BU emissions for natural and anthropogenic sources was 18.5 (lower–upper bounds: 10.6–27.0) Tg N yr−1, close to our TD estimate of 17.0 (16.6–17.4) Tg N yr−1. For the 2010–2019 period, the annual BU decadal-average emissions for both natural and anthropogenic sources were 18.2 (10.6–25.9) Tg N yr−1 and TD emissions were 17.4 (15.8–19.20) Tg N yr−1. The once top emitter Europe has reduced its emissions by 31 % since the 1980s, while those of emerging economies have grown, making China the top emitter since the 2010s. The observed atmospheric N2O concentrations in recent years have exceeded projected levels under all scenarios in the Coupled Model Intercomparison Project Phase 6 (CMIP6), underscoring the importance of reducing anthropogenic N2O emissions. To evaluate mitigation efforts and contribute to the Global Stocktake of the United Nations Framework Convention on Climate Change, we propose the establishment of a global network for monitoring and modeling N2O from the surface through to the stratosphere. The data presented in this work can be downloaded from https://doi.org/10.18160/RQ8P-2Z4R (Tian et al., 2023).

Nitrous oxide (N2O) is a long-lived potent greenhouse gas and stratospheric ozone-depleting substance that has been accumulating in the atmosphere since the preindustrial period. The mole fraction of atmospheric N2O has increased by nearly 25 % from 270 ppb (parts per billion) in 1750 to 336 ppb in 2022, with the fastest annual growth rate since 1980 of more than 1.3 ppb yr−1 in both 2020 and 2021. According to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR6), the relative contribution of N2O to the total enhanced effective radiative forcing of greenhouse gases was 6.4 % for 1750–2022. As a core component of our global greenhouse gas assessments coordinated by the Global Carbon Project (GCP), our global N2O budget incorporates both natural and anthropogenic sources and sinks and accounts for the interactions between nitrogen additions and the biogeochemical processes that control N2O emissions. We use bottom-up (BU: inventory, statistical extrapolation of flux measurements, and process-based land and ocean modeling) and top-down (TD: atmospheric measurement-based inversion) approaches. We provide a comprehensive quantification of global N2O sources and sinks in 21 natural and anthropogenic categories in 18 regions between 1980 and 2020. We estimate that total annual anthropogenic N2O emissions have increased 40 % (or 1.9 Tg N yr−1) in the past 4 decades (1980–2020). Direct agricultural emissions in 2020 (3.9 Tg N yr−1, best estimate) represent the large majority of anthropogenic emissions, followed by other direct anthropogenic sources, including fossil fuel and industry, waste and wastewater, and biomass burning (2.1 Tg N yr−1), and indirect anthropogenic sources (1.3 Tg N yr−1) . For the year 2020, our best estimate of total BU emissions for natural and anthropogenic sources was 18.5 (lower–upper bounds: 10.6–27.0) Tg N yr−1, close to our TD estimate of 17.0 (16.6–17.4) Tg N yr−1. For the 2010–2019 period, the annual BU decadal-average emissions for both natural and anthropogenic sources were 18.2 (10.6–25.9) Tg N yr−1 and TD emissions were 17.4 (15.8–19.20) Tg N yr−1. The once top emitter Europe has reduced its emissions by 31 % since the 1980s, while those of emerging economies have grown, making China the top emitter since the 2010s. The observed atmospheric N2O concentrations in recent years have exceeded projected levels under all scenarios in the Coupled Model Intercomparison Project Phase 6 (CMIP6), underscoring the importance of reducing anthropogenic N2O emissions. To evaluate mitigation efforts and contribute to the Global Stocktake of the United Nations Framework Convention on Climate Change, we propose the establishment of a global network for monitoring and modeling N2O from the surface through to the stratosphere. The data presented in this work can be downloaded from https://doi.org/10.18160/RQ8P-2Z4R (Tian et al., 2023).