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\"Explores the young star's life, including his childhood in Venezuela growing up under the aegis of the cultish Children of God. Putting him at the center of a new generation of leading men emerging in the early 1990s including Johnny Depp, Keanu Reeves, Brad Pitt, Nicolas Cage, and Leonardo DiCaprio, Edwards traces the Academy Award nominee's meteoric rise, couches him in an examination of the 1990s, and illuminates his lasting legacy on Hollywood and popular culture itself\"--Amazon.com.

Despite their limited spatial extent, freshwater ecosystems host remarkable biodiversity, including one-third of all vertebrate species. This biodiversity is declining dramatically: Globally, wetlands are vanishing three times faster than forests, and freshwater vertebrate populations have fallen more than twice as steeply as terrestrial or marine populations. Threats to freshwater biodiversity are well documented but coordinated action to reverse the decline is lacking. We present an Emergency Recovery Plan to bend the curve of freshwater biodiversity loss. Priority actions include accelerating implementation of environmental flows; improving water quality; protecting and restoring critical habitats; managing the exploitation of freshwater ecosystem resources, especially species and riverine aggregates; preventing and controlling nonnative species invasions; and safeguarding and restoring river connectivity. We recommend adjustments to targets and indicators for the Convention on Biological Diversity and the Sustainable Development Goals and roles for national and international state and nonstate actors.

Draws on extensive research and interviews to provide insight into the optimism and integrity in both the personal life and career of actor Tom Hanks.

Cyclometallated µ-halogeno dimers derived from nitrogen donor ligands (1-phenylpyrazoles, 2-phenylpyridine, and 1-(2′-pyridyl)indole) were treated with unidentate nitrogen and phosphorus donor ligands to give a series of neutral monomeric palladium(II) and platinum(II) complexes. An initial prescreen of the complexes against the mouse lymphoid leukæmia cell line L1210 indicated that the complexes exhibited growth inhibitory activity over a relatively wide concentration range. Two factors that gave rise to increased activity were steric hindrance about the metal centre resulting from hindered ligands such as 2,6-dimethylpyridine, or the presence of a phosphorus donor ligand. Little correlation between palladium and platinum complexes was noted. Four complexes were selected for further in vivo study and, while none of the palladium complexes showed more than marginal activity against P388 leukæmia at doses below toxic levels, one platinum complex with a hindered metal centre did display significant antitumour activity against this model.Key words: cyclometallation, palladium, platinum, cytotoxicity, anticancer.

Marvel Entertainment was a struggling toymaker not even twenty years ago. Today, Marvel Studios is the dominant player both in Hollywood and in global pop culture. But what accounts for its stunning rise? In 'MCU', beloved culture writers Joanna Robinson, Dave Gonzales, and Gavin Edwards draw on more than a hundred interviews with actors, producers, directors, and writers to present the definitive chronicle of Marvel Studios and its sole, ongoing production, the Marvel Cinematic Universe. As they delve into the studio's key moments - from the contentious hiring of Robert Downey Jr. for Iron Man to the negotiations over Disney's acquisition of Marvel to studio head Kevin Feige's embrace of streaming TV - the authors demonstrate that the genius of Marvel was its resurrection and modification of Hollywood's old studio system.

Atmospheric hydroxyl (OH), hydroperoxy (HO^sub 2^), total peroxy (HO^sub 2^ and organic peroxy radicals, RO^sub 2^) mixing ratios and OH reactivity (first order OH loss rate) were measured at a rural site in central Pennsylvania during May and June 2002. OH and HO^sub 2^ mixing ratios were measured with laser induced fluorescence (LIF); HO^sub 2^ + RO^sub 2^ mixing ratios were measured with chemical ionization mass spectrometry (CIMS). The daytime maximum mixing ratios were up to 0.6 parts per trillion by volume (pptv) for OH, 30 pptv for HO^sub 2^, and 45 pptv for HO^sub 2^ + RO^sub 2^. A parameterized RACM (Regional Atmospheric Chemistry Mechanism) box model was used to predict steady state OH, HO^sub 2^ and HO^sub 2^ + RO^sub 2^ concentrations by constraining the model to the measured OH reactivity and previously measured volatile organic compound (VOC) distributions. The averaged model calculations are generally in good agreement with the observations. For OH, the model matched the observations for day and night, with an average observed-to-modeled ratio of 0.80. In previous studies such as PROPHET98, nighttime NO was near 0 pptv and observed nighttime OH was significantly larger than modeled OH. In this study, nighttime observed and modeled OH agree to within measurement and model uncertainties because the main source of the nighttime OH was the reaction HO^sub 2^ + NO [arrow right] OH + NO^sub 2^, with the NO being continually emitted from the surrounding fertilized corn field. The observed-to-modeled ratio for HO^sub 2^ is 1.0 on average, although daytime HO^sub 2^ is underpredicted by a factor of 1.2 and nighttime HO^sub 2^ is over-predicted by a factor of 2. The average measured and modeled HO^sub 2^ + RO^sub 2^ agree well during daytime, but the modeled value is about twice the measured value during nighttime. While measured HO^sub 2^ + RO^sub 2^ values agree with modeled values for NO mixing ratios less than a few parts per billion by volume (ppbv), it increases substantially above the expected value for NO greater than a few ppbv. This observation of the higher-than-expected HO^sub 2^ + RO^sub 2^ with the CIMS technique confirms the observed increase of HO^sub 2^ above expected values at higher NO mixing ratios in HO^sub 2^ measurements with the LIF technique. The maximum instantaneous O^sub 3^ production rate calculated from HO^sub 2^ and RO^sub 2^ reactions with NO was as high as 10-15 ppb h^sup -1^ at midday; the total daily O^sub 3^ production varied from 13 to 113 ppbv d^sup -1^ and was 48 ppbv d^sup -1^ on average during this campaign.[PUBLICATION ABSTRACT]

Reaction of a series of nitrogen donor ligands (1-phenylpyrazoles, 2-phenylpyridine, benzo[h]quinoline, 1-(2′-pyridyl)indole, 1-phenylindazole, and 2-phenylindazole) with palladium(II) and platinum(II) salts gave complexes where ortho-metallation had occurred resulting in bidentate binding to the metal centres through N and C atoms. These cyclometallated products were isolated as µ-chloro dimers. Subsequent treatment of these µ-chloro dimers with chelating diamines such as 1,2-ethanediamine converted them into 14 cationic (1+) complexes. Analogous coordination mixed ligand complexes (charge 2+) were prepared by reaction of dichloro(1,2-ethanediamine-N,N′)palladium(II) with aromatic diamines such as 2-(1′-pyrazolyl)pyridine, 2,2′-bipyridine, and 1,10-phenanthroline. The complexes exhibited growth inhibitory activity against L1210 mouse leukæmia cells in vitro over a wide concentration range; in general, the cyclometallated complexes were more active than the mixed ligand complexes, although one cyclometallated organoplatinum complex was less active than the mixed ligand analogue. Substitution around the periphery of the aromatic ligands also resulted in increased activity. One complex, derived from 1-(2'-pyridyl)indole, was tested in vivo and showed no significant antitumour inhibition against P388 leukæmia at doses below toxic levels. Key words: anticancer, metallointercalator, cyclometallation, palladium, platinum, cytotoxicity.

[1] The opening of Dombey and Son (1848) supports Terry Eagleton's view that with Dickens we have entered a phase of social history in which all the real power seems to have been taken over by material things--money, institutions, commodities, power relations--while human beings themselves, falling under their tyrannical sway, are reduced to the level of coalbuckets and candlesticks.