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The present study has been designed to evaluate the effects of acetaminophen on the reproductive parameters and the ameliorative effects of rutin and Mesenchymal stem cells in male rats. The rats were divided into two studies: firstly, twenty young male rats were used as a source of bone marrow-derived MSCs. Secondly, fifty adult male rats were divided into 5 groups: Control group (G1); rats were administrated of AAP (750 mg/kg b.w.) every 72h for 21 days, then left for 30 and 60 days without treatment (G2), rats were administrated of AAP for 21 days then treated with RT (25 mg/kg b.w/d) for 30 and 60 days (G3), rats were administrated of AAP for 21 days then the rats were injected by BM-MSCs (1.5 x 106 cells in 0.5 PBS) in the tail vein for 30 and 60 days (G4), and rats were administrated of AAP for 21 days then the rats were injected by BM-MSCs in the tail vein, then treated with RT for 30 and 60 days (G5). Administration of AAP produced a significant decrease in the mean value of the Te, LH, and FSH levels after 30 and 60 days as compared to the C groups. Whereas rats treated with RT and MSCs showed a significantly high increase in the mean values of these hormone levels after 30 and 60 days compared with the AAP group. In conclusion, this study demonstrated that RT and MSCs when treated in combination, are protected against the AAP-induced decrease in the hormone level of testicular.

The aims of study to determine the cardioprotective effects of rutin and mesenchymal stem cells on acetaminophen induced cardiac enzymatic damage in rats. seventy male rats were divided into two studies. One: twenty young male rats were used as a source of bone marrow-derived MSCs. Two: fifty adult male rats were divided into five groups: G1: control group; G2: rats were given of PARA (750 mg/kg b.w.) every 72h orally for 21 days, then left for 30 and 60 days without any treatment; G3: rats were given of PARA then, administrated of rutin (25mg/kg b.w/d) for 30 and 60 days; G4: rats were given of PARA then, injected by BM-MSCs (1.5x 106 cells in 0.5 PBS) in the tail vein for 30 and 60 days, and G5: rats were given of PARA then, injected by BM-MSCs in the tail vein, and then administrated of rutin orally for 30 and 60 days. Treated by the PARA showed, a significant increased the CK-MB and LDH levels when compared with normal rats at 30 and 60 days. While, the PARA+MSCs+RTN group showed, a significant decrease in the CK-MB and LDH levels as compared with other groups rats at 30 and 60 days. Rats treated with both MSCs and RTN after treated by PARA showed, a markedly improved in cardiac enzymes activity.