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The application of inverse dynamics for the improvement of flying qualities is considered. It is shown that the use of the inverse dynamics in the control loop suppresses the dynamics of the aircraft considerably, leaving only the dynamics of the integral in almost the entire frequency range. The inverse dynamics however could not help in case of atmospheric disturbances or modeling uncertainties. A new scheme using a reference model and its inverse was presented to counter these effects. The results of the mathematical modeling showed that the inverse dynamics allow to improve the tracking performances and all other parameters of the pilot-aircraft system compared to the controller synthesized with feedback gains only. These results were confirmed using ground based simulation. These simulations showed that the use of the inverse dynamics based technique allowed to decrease the variance of error up to 60% during a tracking compensation task. The simulations also showed to that the addition of the reference model and its inverse proved to be able to reduce or suppress atmospheric turbulence, couplings between different control channels and effects of modeling uncertainties, while improving the tracking accuracy and decreasing the pilot workload, thus enhancing the flying qualities of the helicopter.

There are analyzed the results of experimental investigations of the feel system characteristics (inceptor's stiffness, side and central sticks, force and displacement sensing control type of inceptor) on pilot-aircraft system. The modification of the pilot structural model is considered. The mathematical modeling of pilot-aircraft system allowed to get close results to the experiments and to develop the criterion for flying qualities providing the potentiality to predict the influence of the feel system characteristics.

The two ways for the improvement of flying qualities are considered: the predictive display (PD) and the predictive display integrated with the flight control system (FCS). The both ways allow to transforming the controlled element dynamics in the crossover frequency range, to improve the accuracy of tracking and to suppress the effect of time delay in the vehicle response too. The technique for optimization of the predictive law is applied to the landing task. The results of the mathematical modeling and experimental investigations carried out for this task are considered in the paper.

The structure and physicochemical properties of palladium catalysts used in liquid-phase hydrogenation processes were studied with the use of adsorption, calorimetric, thermogravimetry, and temperature-programmed reduction techniques. The specific surface areas and average sizes and volume of pores of the adsorbents were determined. The palladium on activated carbon catalysts was found to possess a complex porous structure, whereas palladium on combined alumina and coal carrier catalysts is an adsorbent with a nonporous structure. The concentration of the applied metal and the nature of a support have a significant impact on the physicochemical properties of palladium catalysts.

Acid-base properties of active sites of supported palladium catalysts and individual substrates are studied with the use of potentiometry and pK spectroscopy. The nature and composition of the substrate, as well as the method of production of the supported catalyst, are shown to affect the character of hydrogen adsorption. Spectra of certain supported catalysts are considered.

For the implementation of a closed nuclear fuel cycle it is necessary to carry out a series of experimental studies to justify the choice of technology. In addition, the operation of the radiochemical plant is impossible without high-quality automatic control systems. In the technologies of spent nuclear fuel reprocessing, the method of continuous evaporation is often used for a solution conditioning. Therefore, the effective continuous technological process will depend on the operation of the evaporation equipment. Its essential difference from similar devices is a small size. In this paper the method of mathematic simulation is applied for the investigation of one-effect evaporator with an external heating chamber. Detailed modelling is quite difficult because the phase equilibrium dynamics of the evaporation process is not described. Moreover, there is a relationship with the other process units. The results proved that the study subject is a MIMO plant, nonlinear over separate control channels and not selfbalancing. Adequacy was tested using the experimental data obtained at the laboratory evaporation unit.

The theory of a uniform thermophoretic motion of a volatile high-viscosity sphere with the phase transition of one component of a moderately rarefied binary gas mixture on its surface has been constructed on the basis of the hydrodynamic method in the regime with slip. The relative influence of the evaporation coefficient and the boundary temperature jumps on the distributions of the velocities, temperatures, and concentrations of the volatile component and the thermophoresis rate has been analyzed. Allowance has been made for the thermodiffusion terms, Stefan effects, and the heat due to the convective transfer of the substance of the condensed phase. The formula obtained has wider limits of application than the existing results. The conclusions of the traditional theories are successfully generalized to the cases of weak and moderately strong processes of diffusion evaporation of a single high-viscosity droplet that moves in a nonuniformly heated binary mixture of gases.[PUBLICATION ABSTRACT]

(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]

Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes and are directly associated with many pathologies, including neurodegenerative diseases. The disulfide-linked dimeric structure of these receptors is unique among RTKs. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions. In this work, using high-resolution NMR spectroscopy supported by atomistic computer modeling, conformational variability of the transmembrane domains and their interactions with surrounding lipids were found to differ significantly between representatives of the subfamily. Therefore, we suggest that the heterogeneous and highly dynamic membrane environment should be taken into account in the observed diversity of the structural/dynamic organization and mechanisms of activation of InsR, IGF1R, and IRR receptors. This membrane-mediated control of receptor signaling offers an attractive prospect for the development of new targeted therapies for diseases associated with dysfunction of insulin subfamily receptors.

Artificial biomaterials can significantly increase the rate of tissue regeneration. However, implantation of scaffolds leads not only to accelerated tissue healing but also to an immune response of the organism, which results in the degradation of the biomaterial. The synergy of the immune response and scaffold degradation processes largely determines the efficiency of tissue regeneration. Still, methods suitable for fast, accurate and non-invasive characterization of the degradation degree of biomaterial are highly demandable. Here we show the possibility of monitoring the degradation of decellularized bovine pericardium scaffolds under conditions mimicking the immune response and oxidation processes using multiphoton tomography combined with fluorescence lifetime imaging (MPT-FLIM). We found that the fluorescence lifetimes of genipin-induced cross-links in collagen and oxidation products of collagen are prominent markers of oxidative degradation of scaffolds. This was verified in model experiments, where the oxidation was induced with hypochlorous acid or by exposure to activated neutrophils. The fluorescence decay parameters also correlated with the changes of micromechanical properties of the scaffolds as assessed using atomic force microscopy (AFM). Our results suggest that FLIM can be used for quantitative assessments of the properties and degradation of the scaffolds essential for the wound healing processes in vivo.