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The correlation between living environments and individual lifestyles significantly influences behavior within interior spaces. As people interact with their surroundings, their behavior adapts to the design, layout, and ambiance of their homes. However, this connection remains elusive for many new Egyptian generations. They grapple with expressing their personal identities while simultaneously respecting regional cultural norms. In response to this challenge, our study delves into the impact of regional interior design on the quality of life (QOL) of Egyptian youth residing in Greater Cairo a vibrant, multicultural area. Our primary objective centers around enh with regional nature and identity. To achieve this, we conducted a comprehensive cross sectional survey spanning the years 2023 to 2024. During this period, we engaged participants in exploring their interest in regional identity, interior styles, and lifestyle choices. The findings were illuminating: despite a prevailing preference for practical modern or contemporary design, there exists a significant gap in awareness regarding the pivotal role interior design plays in shaping lifestyle. In light of these insights, we advocate for increased awareness of regional identity. By promoting its integration into interior design practices, we can enhance well-being and foster a stronger sense of community service. Our recommendations emphasize education and cultural awareness, particularly in the context of environmental and community-related aspects. Through these efforts, we aspire to create living spaces that not only reflect individual preferences but also contribute positively to the overall fabric of our multicultural society.

Interior design significantly shapes our built environment, influencing human well-being and resource utilization (Smith, 2019). In response to this critical role, the study introduces an innovative analytical framework for assessing the efficiency and effectiveness of interior spaces. The used approach integrates quantitative metrics with a deep understanding of space anatomy, emphasizing how design decisions impact decision quality (Brown, 2020). Through rigorous analytical study, we seek to enhance decision-making processes. By dissecting space anatomy, we uncover insights that empower designers to make informed choices, ultimately improving the overall quality of interior design projects, and quantifying the efficiency of interior design spaces using an arithmetic approach. By evaluating the relationship between outputs and inputs, we aim to optimize resource utilization while minimizing waste, leveraging network measurement concepts, and exploring intricate relationships among diverse design elements and project activities (Garcia, 2018), using (Quantitative Assessment, Space Anatomy Impact, and Network Measurement). The research findings contribute significantly to elevating decision-making processes within sustainable interior design, fostering environmentally conscious choices.

The intersection of technology and sustainability presents an opportunity to redefine the field of hospitality and interior design. Technologies such as automated lighting, heating, and cooling systems adjust to occupancy patterns, ensuring comfort while conserving energy, and intelligent systems enhance operational efficiencies, aligning with sustainability goals (Ben Youssef & Zeqiri, 2022). This paper employs a descriptive- analytical methodology to explore innovative technological approaches that facilitate sustainable interior design for serviced apartments. By examining case studies and emerging trends, the research highlights how integrated technologies, such as smart energy systems and eco-friendly materials, can transform spaces into models of sustainability. The findings indicate that a holistic incorporation of technology within the design process not only meets the demands of eco-conscious travelers but also enhances the overall guest experience. Smart energy systems, for instance, optimize energy consumption, reduce operational costs and minimize environmental impact. Eco-friendly materials, on the other hand, contribute to healthier indoor environments and promote sustainable resource use (Rashdan & Ashour, 2024). Furthermore, the research underscores the importance of user-centric design in creating sustainable interiors. By leveraging data analytics and user feedback, designers can tailor spaces to meet the specific needs and preferences of the guests, thereby improving satisfaction and loyalty. This approach supports environmental sustainability and drives economic benefits for hospitality providers.

Exercise is a simple, safe, and affordable solution that can be easily taught to men with chronic illnesses to improve their psychological burden and sexual health. Since the role of exercise in ameliorating the psychological burden associated with erectile dysfunction (ED) in hepatitis C (HC) men was not explored, this research aimed to explore this role. This HC study was a randomized-controlled exercise-rehabilitation trial. Recruitment of HC men with ED was conducted from El-Sahel Teaching Hospital, Cairo, Egypt. Men ( = 46) were randomly assigned to a 12-week walking-exercise group (WEG, = 23 HC men with ED received a 1-hour treadmill walking 3 times weekly) or a control group ( = 23 HC men with ED, who did not change their daily physical activity during the research period). Besides Beck's Depression Inventory (BDI), Arabic Version of the Five-Item Version International Index of Erectile Function (IIEF-5), Profile of Mood States Questionnaire (POMSQ), and Ten-Statement Rosenberg self-esteem scale (TSRSE), HC participants' liver enzymes, alanine transaminase (ALT), and aspartate transaminase (AST) were assessed. Significant improvements of POMSQ, BDI, AST, IIEF-5, ALT, and TSRSE within the WEG only were seen. No significant changes occurred in the control group's parameters. Exercise (walking) is a good modality to improve liver enzymes, ED, and ED-associated psychological burden (depression, low self-esteem, and mood disturbances) in HC men with ED.

SARS-CoV-2 infection has been recorded in 230 countries to date. Obesity has a negative impact on one's quality of life and is one of the main causes of mortality globally. Obesity affects the immune system, making the host more susceptible to infectious infections. Also, obesity commonly provokes the severity of respiratory diseases so the correlation of rs7799039 Polymorphism in corpulent patients with COVID-19 infection was clearly investigated in the current study. A total of 232 patients were recruited, 116 patients were obese with COVID-19 infection, and 116 patients were non obese COVID-19. Fasting blood glucose test (FBG), hemoglobin A1C (HbA1C), complete blood count (CBC), international normalized ratio (INR), urea, alanine transaminase (ALT), aspartate aminotransferase (AST), D dimer and C-reactive protein (CRP) were estimated. C.T. scan was performed for each patient, and C.T. severity score was calculated. Genotyping for the rs7799039 SNPs was performed by TaqMan (Applied Biosystems Step One Real-time PCR). Regarding polymorphism, all individuals of non-obese groups significantly had the homozygous allele GG (100%), whereas only 56% of obese groups had GG alleles (P = 0.001). The severity scores significantly (P = 0.001) varied regarding polymorphism regarding Rs7799039, where the largest proportion of those with Grade IV had the homozygous allele AA (57.1%). There was a correlation between the gene allelic discrimination and COVID-19 CT brutality in obese patients. The A allele was considered a risk factor for severity in COVID-19 patients while the G allele contributes to decreasing that risk.

The available pharmacotherapies (immunosuppressant therapies) for systemic sclerosis (SSc) are not curative, especially in cases with non-lethal but challenging manifestations or complications of the disease. Fatigue, anxiety, depression, an over-activated hypothalamic-pituitary- adrenal axis (stress axis), and low sleeping quality are the common SSc-induced non-lethal manifestations that need close management. Diaphragmatic breathing tele-exercise (DBTE), as a standalone deep breathing retraining and tele-interventional technique, has not been utilized in the rehabilitation context of non-lethal complications in women with SSc. This online interventional study aimed to explore the efficacy of DBTE in controlling depression, cardiovascular autonomic functions, stress, sleep, and anxiety in women with SSc. This randomized controlled tele-interventional trial recruited 40 non-obese women with SSc (aged > 18 years old) from an Egyptian teaching hospital. Women were randomly assigned to the DBTE group ( = 20) or non-DBTE group ( = 20). The DBTE group underwent 12-week 20-minute morning and evening DBTE sessions (sessions were supervised daily through the Zoom video conference program). The non-DBTE group served as a waitlist control group. The outcomes of this study were diastolic blood pressure (BPD), serum cortisol, the total score of the Hamilton Anxiety Rating Scale (HARS-TS), systolic blood pressure (BPS), the general score of the Pittsburgh Sleep Quality Index (PSQI-GS), pulse rate (PR), the eight-item Patient Health Questionnaire (EI-PHQ ), respiratory rate (RR), and the Visual Analogue Scale of fatigue (VAS-F). In the DBTE group, there were significantly lowered values of PSQI-GS, HARS-TS, EI-PHQ , serum cortisol, VAS-F, and cardiovascular/respiratory autonomic functions (BPS, BPD, RR, and PR). In the non-DBTE group, no significant changes were observed for any variables. It can be concluded from this tele-interventional trial that the 12-week application of DBTE may reduce cortisol, EI-PHQ , PSQI-GS, HARS-TS, BPS, BPD, RR, PR, and VAS-F in women with SSc.

Previously unknown chalcones such as β ’-chalcanone- α , β -diols and a β -hydroxydihydrochalcone, named pulincisone A-F as well as known chalcone analogs 3,4,2’,4’,6’,7,8-heptahydroxy-7(8)-dihydrochalcone ( 7 ) and 4,2’,6’-trihydroxy-4’-methoxydihydrochalcone ( 8 ) were isolated from Pulicaria incisa (Lam.) DC. and assayed for cancer preventative activity. Structures were identified by spectroscopic methods, including HRESIMS, 1D and 2D NMR experiments. Pulincisone A and B, are epimers, at stereocenter C-8. A structural revision resulted in pulicisone A ( 1 ) and D ( 4 ) replacing pulichalconoids B and C, that were previously reported from the same species. Isolated chalcones were assessed for chemopreventive potential as inducers of NAD(P)H: quinone oxidoreductase 1 (NQO1). Compounds 2 , 3 , 5 , and 6 induced NQO1, using a Prochaska assay. NQO1 protein expression was detected by Western blotting analysis. Compound 6 among four active compounds had the highest potency as NQO1 inducers. Molecular docking analysis of the NQO1 Keap1 Kelch domain suggests Nrf2-dependent induction. These data indicate that pulincisone F ( 6 ) is a promising bioactive antioxidant (NQO1-inducer) with superior docking scores with the Keap1-Nrf2 complex compared to the reference NQO1 inducer sulforaphane (− 8.26 versus − 5.08 kcal mol - , respectively).

Cervical cancer, the third most common cancer worldwide, is primarily caused by human papillomavirus (HPV) infection. This study aimed to develop natural extracts from the seeds of L. using the hydrodistillation method to evaluate their anticancer effects against HeLa cells. The phytochemical composition of seeds' essential oil was identified using gas chromatography mass spectrometry, and their cytotoxicity on proliferation, apoptosis, cell cycle phases, migration, and colony formation of HeLa cancer cell lines was examined. Moreover, the effects of essential oil on the protein expression levels related to apoptosis, cell cycle regulation, and migration in the treated HeLa cells were examined. The essential oil's phytochemical composition was analyzed using gas chromatography-mass spectrometry (GC-MS), revealing benzyl isothiocyanate as the dominant compound (99.49%). Results demonstrated that the essential oil had a high cytotoxic effect, with an IC value of 16.78 µg/mL in the MTT assay. Apoptosis analysis indicated a significant increase in early and late apoptotic HeLa cells (23.45%). Flow cytometry revealed a G2/M phase arrest, which impeded cell division. The oil also exhibited a stronger inhibition of cancer cell migration (38.7%) than methotrexate (45.9%). Additionally, the clonogenic assay revealed a drastic reduction in colony formation (0.004% surviving fraction, 0.25% plating efficiency). ELISA results showed a profound effect on apoptosis-related proteins, reducing BCL-2, MMP-2, and CDK1/cyclin B1 expression, supported by molecular docking studies comparing its efficacy to methotrexate (-5.52, -6.29, and -5.75 vs -5.49, -5.44, and 5.18 kcal mol , respectively). The findings suggest that seed essential oil may serve as a potential anticancer treatment for cervical cancer; however, further studies are required for validation in animal models.

The treatment options for mycosis fungoides (MF) have been expanding but unfortunately many of the currently used treatment modalities are unavailable in Egypt and other African/Arab countries. In addition, there is a lack of consensus on the treatment of hypopigmented MF (HMF), which is a frequently encountered variant in our population. We aimed to develop regional treatment guidelines based on the international guidelines but modified to encompass the restricted treatment availability and our institutional experience. Special attention was also given to studies conducted on patients with skin phototype (III-IV). Treatment algorithm was formulated at Ain-Shams cutaneous lymphoma clinic through the collaboration of dermatologists, haematologists, and oncologists. Level of evidence is specified for each treatment option. For HMF, phototherapy is recommended as a first line treatment, while low-dose methotrexate is considered a second line. For early classical MF, we recommend Psoralen-ultraviolet A (PUVA), which is a well-tolerated treatment option in dark phenotype. Addition of either retinoic acid receptor (RAR) agonist and/or methotrexate is recommended as a second line. Total skin electron beam (TSEB) is considered a third-line option. For advanced stage, PUVA plus RAR agonist and/or methotrexate is recommended as first line, TSEB or monochemotherapy is considered a second line option. Polychemotherapy is regarded as a final option. All patients with complete response (CR) enter a maintenance and follow-up schedule. We suggest a practical algorithm for the treatment of MF for patients with dark phenotype living in countries with limited resources.

Four nonionic surfactants were prepared from the reaction of propylene oxide with oleic acid, linoleic acid, and the free fatty acid mixture from hydrolysis of jatropha oil. The chemical structures of the prepared surfactants were confirmed using IR and NMR spectroscopy. The surface activities of the prepared surfactants were dependent on the polypropylene oxide chain length and also on the nature of the alkyl chains. The nonionic surfactants were evaluated at different concentrations as corrosion inhibitors against the corrosion of Al 6061 aluminum in 2 M HCl solution. The corrosion inhibition tendencies of the surfactants were completely dependent on the fatty acid ratio in the jatropha oil and also on the polypropylene oxide chain length. The corrosion inhibition efficiencies of the surfactants were correlated to their chemical structure and their surface activities.