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Background This study aimed to assess the anthropometric measures and pubertal growth of children and adolescents with Type 1 diabetes mellitus (T1DM) and to detect risk determinants affecting these measures and their link to glycemic control. Patients and methods Two hundred children and adolescents were assessed using anthropometric measurements. Those with short stature were further evaluated using insulin-like growth factor 1 (IGF-1), bone age, and thyroid profile, while those with delayed puberty were evaluated using sex hormones and pituitary gonadotropins assay. Results We found that 12.5% of our patients were short (height SDS < -2) and IGF-1 was less than -2 SD in 72% of them. Patients with short stature had earlier age of onset of diabetes, longer duration of diabetes, higher HbA1C and urinary albumin/creatinine ratio compared to those with normal stature (p  <  0.05). Additionally, patients with delayed puberty had higher HbA1c and dyslipidemia compared to those with normal puberty (p  <  0.05). The regression analysis revealed that factors associated with short stature were; age at diagnosis, HbA1C > 8.2, and albumin/creatinine ratio > 8 (p  <  0.05). Conclusion Children with uncontrolled T1DM are at risk of short stature and delayed puberty. Diabetes duration and control seem to be independent risk factors for short stature.

Background Knee osteoarthritis (OA) is a debilitating condition that can severely limit an individual's mobility and quality of life. This study evaluated the efficacy of colchicine therapy in promoting cartilage healing in a rat model with monosodium iodoacetate (MIA)-induced knee OA. Histological and biochemical changes as well as semiquantitative radiographic characteristics were used to evaluate this. Methods An experimental knee OA model was induced by MIA in rats. Subsequently, 40 Wistar albino female rats were randomly divided into four groups, each consisting of 10 rats: a negative control group, an osteoarthritic control group, an osteoarthritic reference group treated with meloxicam®, and an osteoarthritic group administered an intraperitoneal injection of colchicine. Body weight and knee diameter measurements were taken weekly. Semiquantitative radiographic imaging and enzyme-linked immunosorbent assay analysis were performed on serum samples to assess the levels of inflammatory cytokine interleukin-1 beta (IL-1β) and the anti-inflammatory cytokine interleukin-10 (IL-10) prior to the conclusion of the trial. Histological examination was conducted using hematoxylin and eosin staining. Results Colchicine significantly reduced the osteoarthritic conditions after six weeks of supplementation. We observed decreased joint diameters in response to treatment in OA animals. Colchicine significantly decreased the IL-1β ( p  = 0.000) and increased the IL-10 ( p  = 0.000) in the serum of osteoarthritic rats in response to treatment in OA rats compared to the OA group with no treatment. Colchicine reduced the osteoarthritic rats' radiographic scores and enhanced the knee joint's histological structure. Conclusion The results indicate that colchicine could be beneficial in the treatment of rats with MIA-induced knee osteoarthritis, as it appears to postpone cartilage deterioration and reduce the activity of inflammatory mediators.