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"Elliott, David"
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SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions
Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. Here we present SUPPA2, a new method that addresses these challenges, and enables streamlined analysis across multiple conditions taking into account biological variability. Using experimental and simulated data, we show that SUPPA2 achieves higher accuracy compared to other methods, especially at low sequencing depth and short read length. We use SUPPA2 to identify novel Transformer2-regulated exons, novel microexons induced during differentiation of bipolar neurons, and novel intron retention events during erythroblast differentiation.
Journal Article
Art & trousers : tradition and modernity in contemporary Asian art
\"An illustrated collection of more than thirty essays and 640 color images, Art and Trousers moves deftly between regional analysis, portraits of individual artists, and a metaphorical history of trousers. This book presents a panoramic view of modern and contemporary Asian art, varying its focus on the impacts of invention, tradition, exchange, colonization, politics, social development, and gender. David Elliott spotlights the practice of many leading global artists of the early twenty-first century, including Hiroshi Sugimoto, Cai Guo-Qiang, Ai Weiwei, Xu Bing, Rashid Rana, Bharti Kher, Makoto Aida, Chatchai Puipia, and Yeesookyung, among many others. Art and Trousers offers insight into the development of a key curatorial practice for our times, and it will be an essential resource for anyone seeking to understand contemporary art and the way it operates across borders\"--Publisher's website.
BOOK
Has Methodism’s ‘White History’ Determined Its ‘Black Future’? African Traditional Healing and the Methodist Church of Southern Africa
Postcolonial discourses on religion have extensively explored the intersections of race and religion. Particular research within such discourses has been conducted to explore the intersection of Whiteness and Christianity in postcolonial contexts. The Methodist Church of Southern Africa (MCSA) is an example of a postcolonial Christian denomination that seeks to assert itself as ‘authentically African’ whilst having a distinctly colonial, missionary history in Southern Africa. This article explores the enduring intersections of Whiteness and Christianity in the MCSA through analyzing the methodology and theoretical framework of a discussion document produced by the MCSA to explore the relationship between Methodism, ukuthwasa, and African Indigenous Religion. I contend that the MCSA structurally and epistemically, albeit unintentionally, reproduces Whiteness through privileging seemingly universal Methodist methods, theories, and concepts for producing theological knowledge that are colonially produced and continue to underscore the infrastructure of MCSA ecclesiology. The stubborn persistence of colonially inherited epistemologies is particularly evident when we see how a potentially groundbreaking document on ukuthwasa (calling) is subjected to the constraints of the very epistemic traditions it is intended to dislodge. Furthermore, I argue that, through the persistence of this epistemology, the MCSA moves to domesticate and civilize the African Indigenous in Southern Africa.
Journal Article
Voices : the final hours of Joan of Arc
\"David Elliott explores how Joan of Arc changed the course of history and remains a figure of fascination centuries after her extraordinary life and death in a fiery, evocative novel-in-verse\"--Provided by publisher.
BOOK
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E-Cadherin. Here, we summarise the role of FUT8 in various cancers (including lung, liver, colorectal, ovarian, prostate, breast, melanoma, thyroid, and pancreatic), discuss the potential mechanisms involved, and outline opportunities to exploit FUT8 as a critical factor in cancer therapeutics in the future.
Journal Article
Best in show
With clever and cheerful verse, this ode to our canine companions introduces big dogs and small dogs, scruffy dogs and elegant dogs and dogs from around the world, offering a pawsome read-aloud for dog lovers and aspiring pet owners.
CHILDBOOK
Ferrodraco lentoni gen. et sp. nov., a new ornithocheirid pterosaur from the Winton Formation (Cenomanian–lower Turonian) of Queensland, Australia
The Australian pterosaur record is poor by world standards, comprising fewer than 20 fragmentary specimens. Herein, we describe the new genus and species
Ferrodraco lentoni
gen. et sp. nov., based on the most complete pterosaur specimen ever found in Australia, and the first reported from the Winton Formation (Cenomanian–lower Turonian). The presence of premaxillary and mandibular crests, and spike-shaped teeth with subcircular bases, enable
Ferrodraco
to be referred to Anhangueria.
Ferrodraco
can be distinguished from all other anhanguerian pterosaurs based on two dental characters: the first premaxillary and mandibular tooth pairs are small; and the fourth–seventh tooth pairs are smaller than the third and eighth ones.
Ferrodraco
was included in a phylogenetic analysis of Pterosauria and resolved as the sister taxon to
Mythunga camara
(upper Albian Toolebuc Formation, Australia), with that clade occupying the most derived position within Ornithocheiridae.
Ornithocheirus simus
(Albian Cambridge Greensand, England),
Coloborhynchus clavirostris
(Valanginian Hastings Sands, England), and
Tropeognathus mesembrinus
(upper Aptian–lower Albian Romualdo Formation, Brazil) were resolved as successive sister taxa, which suggests that ornithocheirids were cosmopolitan during the Albian–Cenomanian. Furthermore, the stratigraphic age of
Ferrodraco lentoni
(Cenomanian–lower Turonian) implies that anhanguerians might have survived later in Australia than elsewhere.
Journal Article
The Cool Crazy Crickets to the rescue!
The members of the Cool Crazy Crickets club decide to earn some money, but they have differences of opinion about how they should spend it.
Book
Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While the use of marijuana cannabinoids for MS has recently been approved in some countries, the precise mechanism of action leading to attenuate neuroinflammation is not clear. We used experimental autoimmune encephalomyelitis (EAE), a murine model of MS, to explore the anti-inflammatory properties of cannabidiol (CBD), a non-psychoactive cannabinoid. Treatment with CBD caused attenuation of EAE disease paradigms as indicated by a significant reduction in clinical scores of paralysis, decreased T cell infiltration in the central nervous system, and reduced levels of IL-17 and IFNγ. Interestingly, CBD treatment led to a profound increase in myeloid-derived suppressor cells (MDSCs) in EAE mice when compared to the vehicle-treated EAE controls. These MDSCs caused robust inhibition of MOG-induced proliferation of T cells
. Moreover, adoptive transfer of CBD-induced MDSCs ameliorated EAE while MDSC depletion reversed the beneficial effects of CBD treatment, thereby conclusively demonstrating that MDSCs played a crucial role in CBD-mediated attenuation of EAE. Together, these studies demonstrate for the first time that CBD treatment may ameliorate EAE through induction of immunosuppressive MDSCs.
Journal Article