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ChatGPT is one of many generative artificial intelligence (AI) tools that has emerged recently, creating controversy in the education community with concerns about its potential to be used for plagiarism and to undermine students' ability to think independently. Recent publications have criticized the use of ChatGPT and other generative AI tools in the classroom, with little focus on the potential benefits. This article focuses on the potential of ChatGPT as an educational tool for statistics and data science. It encourages readers to consider the history of trepidation surrounding introducing new technology in the classroom, such as the calculator. We explore the possibility of leveraging ChatGPT's capabilities in statistics and data science education, providing examples of how ChatGPT can aid in developing course materials and suggestions for how educators can prompt students to interact with ChatGPT responsibly. As educators, we can guide the use of generative AI tools in statistics and data science classrooms so that students and educators can leverage the benefits of this technology.

Letras y Limpias is the first book to explore the literary significance of the figure of the curandera within Mexican American literature. Amanda Ellis traces the significance of the curandera and her evolution across a variety of genres written by leading Mexican American authors, including Américo Paredes, Rudolfo Anaya, Gloria E. Anzaldúa, Manuel Munoz, ire'ne lara silva, and more. Ellis explores the curandera in relationship to decoloniality, bioethics, and the topic of healing while recognizing the limitations and spiritual shortcomings of Western medicine. Ellis argues that our contemporary western health-care system does not know how to fully grapple with illnesses that patients face. Ellis reads the curandera's perennial representation as an ongoing example of decolonial love useful for deconstructing narrow definitions of health and personhood, and for grappling with the effects of neoliberalism and colonialism on the health-care industry. Letras y Limpias draws from Chicana feminist theory to assert the importance of the mindbodyspirit connection. Ellis conveys theoretical insights about the continual reimagining of the figure of the curandera as a watermark across Mexican American literary texts. This literary figure points to the oppressive forces that create susto and reminds us that healing work requires specific attention to colonialism, its legacy, and an intentional choice to carry forward the traditional practices rooted in curanderismo passed on from prior generations. By turning toward the figure of the curandera, readers are better poised to challenge prevailing ideas about health, and imagine ways to confront the ongoing problems that coloniality creates. Letras y Limpias shows how the figure of the curandera offers us ways to heal that have nothing to do with copays or medical professionals refusing care, and everything to do with honoring the beauty and complexity of any, every, and all humans.

Piezoelectric fluoropolymers convert mechanical energy to electricity and are ideal for sustainably providing power to electronic devices. To convert mechanical energy, a net polarization must be induced in the fluoropolymer, which is currently achieved via an energy-intensive electrical poling process. Eliminating this process will enable the low-energy production of efficient energy harvesters. Here, by combining molecular dynamics simulations, piezoresponse force microscopy, and electrodynamic measurements, we reveal a hitherto unseen polarization locking phenomena of poly(vinylidene fluoride– co –trifluoroethylene) (PVDF-TrFE) perpendicular to the basal plane of two-dimensional (2D) Ti 3 C 2 T x MXene nanosheets. This polarization locking, driven by strong electrostatic interactions enabled exceptional energy harvesting performance, with a measured piezoelectric charge coefficient, d 33 , of −52.0 picocoulombs per newton, significantly higher than electrically poled PVDF-TrFE (approximately −38 picocoulombs per newton). This study provides a new fundamental and low-energy input mechanism of poling fluoropolymers, which enables new levels of performance in electromechanical technologies. Fluoropolymers are state-of-the-art flexible piezoelectric materials, yet require massive energy inputs to function. Here, the authors show that the electrostatic field around a 2D material leads to polarization orientation and maximized piezoelectric performance, without external energy input.

Contact electrification and triboelectric charging are areas of intense research. Despite their low ability to accept or donate electrons, polymer insulator based triboelectric nanogenerators have emerged as highly efficient mechanical‐to‐electrical conversion devices. Here, it is reviewed the structure–property–performance of polymer insulators in triboelectric nanogenerators and focus on tools that can be used to directly enhance charge generation, via altering a polymer's mechanical, thermal, chemical, and topographical properties. In addition to the discussion of these fundamental properties, the use of additives to locally manipulate the polymer surface structure is discussed. The link between each property and the underlying charging mechanism is discussed, in the context of both increasing surface charge and predicting the polarity of surface charge, and pathways to engineer triboelectric charging are highlighted. Key questions facing the field surrounding data reporting, the role of water, and synergy between mass, electron, and ion transfer mechanisms are highlighted with aspirational goals of a holistic model for triboelectric charging proposed.

Here, a stable derivative of cellulose, called cellulose carbamate (CC), was produced from Kenaf (Hibiscus cannabinus) core pulp (KCP) and urea with the aid of a hydrothermal method. Further investigation was carried out for the amount of nitrogen yielded in CC as different urea concentrations were applied to react with cellulose. The effect of nitrogen concentration of CC on its solubility in a urea-alkaline system was also studied. Regenerated cellulose products (hydrogels and aerogels) were fabricated through the rapid dissolution of CC in a urea-alkaline system. The morphology of the regenerated cellulose products was viewed under Field emission scanning electron microscope (FESEM). The transformation of allomorphs in regenerated cellulose products was examined by X-ray diffraction (XRD). The transparency of regenerated cellulose products was determined by Ultraviolet-visible (UV-Vis) spectrophotometer. The degree of swelling (DS) of regenerated cellulose products was also evaluated. This investigation provides a simple and efficient procedure of CC determination which is useful in producing regenerated CC products.

Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic constriction injury (CCI)-allodynia, months after morphine ceased. No such effect of opioids on neuropathic pain has previously been reported. Using pharmacologic and genetic approaches, we discovered that the initiation and maintenance of this multimonth prolongation of neuropathic pain was mediated by a previously unidentified mechanism for spinal cord and pain—namely, morphine-induced spinal NOD-like receptor protein 3 (NLRP3) inflammasomes and associated release of interleukin-1β (IL-1β). As spinal dorsal horn microglia expressed this signaling platform, these cells were selectively inhibited in vivo after transfection with a novel Designer Receptor Exclusively Activated by Designer Drugs (DREADD). Multiday treatment with the DREADD-specific ligand clozapine-N-oxide prevented and enduringly reversed morphine-induced persistent sensitization for weeks to months after cessation of clozapine-N-oxide. These data demonstrate both the critical importance of microglia and that maintenance of chronic pain created by early exposure to opioids can be disrupted, resetting pain to normal. These data also provide strong support for the recent “two-hit hypothesis” of microglial priming, leading to exaggerated reactivity after the second challenge, documented here in the context of nerve injury followed by morphine. This study predicts that prolonged pain is an unrealized and clinically concerning consequence of the abundant use of opioids in chronic pain.

Triboelectric nanogenerator (TENG) development is undergoing rapid progress utilizing the state‐of‐the‐art 3D‐printing technologies. Herein a critical analysis of the latest developments in 3D‐printed wearable and implantable TENGs that can be used to energize small portable electronic and biomedical devices is presented. Recent progress in 3D‐printed triboelectric nanogenerator (3DP‐TENG) materials and architectural formations, as well as their performance, is evaluated for powering systems that implement physiological monitoring, multifunctional sensing, electronic energizing, noise canceling, dust filtering, and self‐healing. Furthermore, the review explicitly focuses on the 3D‐printing approaches used to form stable and robust 3DP‐TENGs. In addition, the key challenges to improving the performance of 3DP‐TENGs for optimal energy harvesting are discussed, and a roadmap is given for research and translation to commercial markets in the next decade. Herein the recent developments in triboelectric nanogenerators (TENGs) fabricated using 3D‐printing technologies are highlighted. Material functionalization, device structure formation, optimal energy harvesting, system integration, and translation to commercial market are covered. The approaches needed to overcome the current challenges to developing 3D‐printed TENGs and integrating them into host systems are discussed.

Shortly after we created a face-to-face, student-centered, general education classroom at the University of Kentucky, we were asked to create a similar environment online. In this article, we describe what we did and what we learned in the process. This is not a comparative, controlled study, but an anthology of examples and reflection. Our aim is to share experiences that other instructors might find useful when constructing their online classes.

Fluoropolymers are state-of-the-art flexible piezoelectric materials, yet require massive energy inputs to function. Here, the authors show that the electrostatic field around a 2D material leads to polarization orientation and maximized piezoelectric performance, without external energy input.

Core microRNA (miRNA) sequences exist as populations of variants called isomiRs made up of different lengths and nucleotide compositions. In particular, the short sequences of miRNA make single-base isomiR mismatches very difficult to be discriminated. Non-specific hybridizations often arise when DNA probe-miRNA target hybridization is the primary, or initial, mode of detection. These errors then become exacerbated through subsequent amplification steps. Here, we present the design of DNA probes modified with poly-guanine (PG) tracts that were induced to form G-quadruplexes (G4) for hi-fidelity discrimination of miRNA core target sequence from single-base mismatched isomiRs. We demonstrate that, when compared to unmodified probes, this G4 'gate-keeping' function within the G4-modified probes enables more stringent hybridization of complementary core miRNA target transcripts while limiting non-specific hybridizations. This increased discriminatory power of the G4-modified probes over unmodified probes is maintained even after further reverse transcriptase extension of probe-target hybrids. Enzymatic extension also enhanced the clarity and sensitivity of readouts and allows different isomiRs to be distinguished from one another via the relative positions of the mismatches.