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"Ellis, James"
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Ideology in America
\"Public opinion in the United States contains a paradox. The American public is symbolically conservative: it cherishes the symbols of conservatism and is more likely to identify as conservative than as liberal. Yet at the same time, it is operationally liberal, wanting government to do and spend more to solve a variety of social problems. This book focuses on understanding this contradiction. It argues that both facets of public opinion are real and lasting, not artifacts of the survey context or isolated to particular points in time. By exploring the ideological attitudes of the American public as a whole, and the seemingly conflicted choices of individual citizens, it explains the foundations of this paradox. The keys to understanding this large-scale contradiction, and to thinking about its consequences, are found in Americans' attitudes with respect to religion and culture and in the frames in which elite actors describe policy issues\"-- Provided by publisher.
Book
Seasonal variation of pollen collected by honey bees (Apis mellifera) in developed areas across four regions in the United States
For honey bees (Apis mellifera), colony maintenance and growth are highly dependent on worker foragers obtaining sufficient resources from flowering plants year round. Despite the importance of floral diversity for proper bee nutrition, urban development has drastically altered resource availability and diversity for these important pollinators. Therefore, understanding the floral resources foraged by bees in urbanized areas is key to identifying and promoting plants that enhance colony health in those environments. In this study, we identified the pollen foraged by bees in four developed areas of the U.S., and explored whether there were spatial or temporal differences in the types of floral sources of pollen used by honey bees in these landscapes. To do this, pollen was collected every month for up to one year from colonies located in developed (urban and suburban) sites in California, Texas, Florida, and Michigan, except during months of pollen dearth or winter. Homogenized pollen samples were acetolyzed and identified microscopically to the lowest taxonomic level possible. Once identified, each pollen type was classified into a frequency category based on its overall relative abundance. Species richness and diversity indices were also calculated and compared across states and seasons. We identified up to 64 pollen types belonging to 39 plant families in one season (California). Species richness was highest in CA and lowest in TX, and was highest during spring in every state. In particular, \"predominant\" and \"secondary\" pollen types belonged to the families Arecaceae, Sapindaceae, Anacardiaceae, Apiaceae, Asteraceae, Brassicaceae, Fabaceae, Fagaceae, Lythraceae, Myrtaceae, Rhamnaceae, Rosaceae, Rutaceae, Saliaceae, and Ulmaceae. This study will help broaden our understanding of honey bee foraging ecology and nutrition in urban environments, and will help promote the use of plants that serve the dual purpose of providing aesthetic value and nutritious forage for honey bee colonies placed in developed landscapes.
Journal Article
Invisible
On leave from her FBI researcher career, Emmy Dockery tries to convince her boyfriend that hundreds of unsolved cases are linked to a single perpetrator.
Book
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
Astrocytes have essential functions in brain homeostasis that are established late in differentiation, but the mechanisms underlying the functional maturation of astrocytes are not well understood. Here we identify extensive transcriptional changes that occur during murine astrocyte maturation in vivo that are accompanied by chromatin remodelling at enhancer elements. Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. Forced expression of these factors in vitro induces distinct sets of mature astrocyte-specific transcripts. Culturing astrocytes in a three-dimensional matrix containing FGF2 induces expression of
Rorb
,
Dbx2
and
Lhx2
and improves astrocyte maturity based on transcriptional and chromatin profiles. Therefore, extrinsic signals orchestrate the expression of multiple intrinsic regulators, which in turn induce in a modular manner the transcriptional and chromatin changes underlying astrocyte maturation.
Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and identify transcription factors regulating maturation of cultured astrocytes.
Journal Article
The murder house
No. 7 Ocean Drive is a gorgeous, multimillion-dollar beachfront estate in the Hamptons, where money and privilege know no bounds. But its beautiful gothic exterior hides a horrific past: it was the scene of a series of depraved killings that have never been solved. Neglected, empty, and rumored to be cursed, it's known as the Murder House, and locals keep their distance. Detective Jenna Murphy used to consider herself a local, but she hasn't been back since she was a girl. Trying to escape her troubled past and rehabilitate a career on the rocks, the former New York City cop hardly expects her lush and wealthy surroundings to be a hotbed of grisly depravity. But when a Hollywood power broker and his mistress are found dead in the abandoned Murder House, the gruesome crime scene rivals anything Jenna experienced in Manhattan. And what at first seems like an open and shut case turns out to have as many shocking secrets as the Murder House itself, as Jenna quickly realizes that the mansion's history is much darker than even the town's most salacious gossips could have imagined. As more bodies surface, and the secret that Jenna has tried desperately to escape closes in on her, she must risk her own life to expose the truth -- before the Murder House claims another victim.
Book
Integrated Pest Management Control of Varroa destructor (Acari: Varroidae), the Most Damaging Pest of (Apis mellifera L. (Hymenoptera: Apidae)) Colonies
Varroa destructor is among the greatest biological threats to western honey bee (Apis mellifera L.) health worldwide. Beekeepers routinely use chemical treatments to control this parasite, though overuse and mismanagement of these treatments have led to widespread resistance in Varroa populations. Integrated Pest Management (IPM) is an ecologically based, sustainable approach to pest management that relies on a combination of control tactics that minimize environmental impacts. Herein, we provide an in-depth review of the components of IPM in a Varroa control context. These include determining economic thresholds for the mite, identification of and monitoring for Varroa, prevention strategies, and risk conscious treatments. Furthermore, we provide a detailed review of cultural, mechanical, biological, and chemical control strategies, both longstanding and emerging, used against Varroa globally. For each control type, we describe all available treatments, their efficacies against Varroa as described in the primary scientific literature, and the obstacles to their adoption. Unfortunately, reliable IPM protocols do not exist for Varroa due to the complex biology of the mite and strong reliance on chemical control by beekeepers. To encourage beekeeper adoption, a successful IPM approach to Varroa control in managed colonies must be an improvement over conventional control methods and include cost-effective treatments that can be employed readily by beekeepers. It is our intention to provide the most thorough review of Varroa control options available, ultimately framing our discussion within the context of IPM. We hope this article is a call-to-arms against the most damaging pest managed honey bee colonies face worldwide.
Journal Article
Guilty wives
Abbie Elliot and her best friends arrive by helicopter in Monte Carlo and enter the most luxurious hotel they have ever been to. They have four days to live a fantasy life and Abbie quickly finds more pleasure and release than she has ever experienced. But then, one day she and her friends are arrested for a heinous crime and their fantasy vacation becomes a fight for survival.
BOOK
Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma
The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-κB transcription factor pathway associates with advanced disease stages and shorter survival in patients with CRC. NF-κB has been shown to drive tumor-promoting inflammation, cancer cell survival, and intestinal epithelial cell (IEC) dedifferentiation in mouse models of CRC. However, whether NF-κB affects the metabolic adaptations that fuel aggressive disease in patients with CRC is unknown. Here, we identified carboxylesterase 1 (CES1) as an essential NF-κB-regulated lipase linking obesity-associated inflammation with fat metabolism and adaptation to energy stress in aggressive CRC. CES1 promoted CRC cell survival via cell-autonomous mechanisms that fuel fatty acid oxidation (FAO) and prevent the toxic build-up of triacylglycerols. We found that elevated CES1 expression correlated with worse outcomes in overweight patients with CRC. Accordingly, NF-κB drove CES1 expression in CRC consensus molecular subtype 4 (CMS4), which is associated with obesity, stemness, and inflammation. CES1 was also upregulated by gene amplifications of its transcriptional regulator HNF4A in CMS2 tumors, reinforcing its clinical relevance as a driver of CRC. This subtype-based distribution and unfavorable prognostic correlation distinguished CES1 from other intracellular triacylglycerol lipases and suggest CES1 could provide a route to treat aggressive CRC.
Journal Article
Mistress
\"Ben isn't like most people. Unable to control his racing thoughts, he's a man consumed by his obsessions: movies, motorcycles, presidential trivia-and Diana Hotchkiss, a beautiful woman Ben knows he can never have. When Diana is found dead outside her apartment, Ben's infatuation drives him on a hunt to find out what happened to the love of his life. Ben soon discovers that the woman he pined for was hiding a shocking double life. And now someone is out to stop Ben from uncovering the truth about Diana's illicit affairs\"--from publiser's web site.
Book
Characterizing the Impact of Commercial Pollen Substitute Diets on the Level of Nosema spp. in Honey Bees (Apis mellifera L.)
Western honey bee (Apis mellifera L.) populations face declines commonly attributed to pesticide, pathogen, and parasite stress. One way beekeepers combat these stressors is by providing supplemental protein diets to honey bee colonies to ensure adequate colony nutrition. However Nosema spp., a microsporidian parasite of the honey bee, is thought to be associated closely with a colony's nutritional intake, thus possibly negating any benefit the bees otherwise would have received from a nutritional supplement. Through three objectives, we examined how adult bees' consumption of wildflower pollen or commercial pollen substitute diets affected Nosema levels in the bees' midguts. For our first objective, we investigated how method of inoculation with Nosema affects infection levels in inoculated bees. Bees were infected with spores of Nosema four days after emergence. On day 15, bees were collected from the cages and Nosema spores were quantified. We found that inoculation through the pollen diet resulted in the highest Nosema levels in inoculated bees. In our second and third objectives, we provided the test diets to caged, newly emerged bees for a period of 15 days. Bees consuming pollen and a sucrose solution had more Nosema in their midguts than did bees consuming the sucrose solution alone (control). The overall volume of diet consumed by the bees did not correlate with the level of Nosema in their midguts. The level of Nosema was higher in bees fed certain commercial pollen substitute diets than in bees fed wildflower pollen. Our study illustrates how providing nutritional supplements to adult honey bees can impact the intensity of Nosema in their midguts.
Journal Article