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A unique feature of gas xenon electroluminescent time projection chambers (GXeEL TPCs) in ββ0ν searches is their ability to reconstruct event topology, in particular to distinguish “single-electron” from “double-electron” tracks, the latter being the signature of a ββ0ν decay near the decay endpoint Qββ . Together with excellent energy resolution and the t 0 provided by primary scintillation, this topological information is key to suppressing backgrounds. Preserving EL, however, requires operation in pure xenon (with helium as the only benign additive), where electron diffusion is large. Consequently, reconstructed track fidelity is limited by diffusion and intrinsic EL blurring. We propose augmenting the detector with the ability to image not only the electron track but also the corresponding mirror ion track. Introducing trace amounts of NH3 ( ∼ 100 ppb) converts primary xenon ions into ammonium ions, NH4+ , via a fast two-step ion–molecule process involving charge transfer followed by proton transfer, while leaving EL unaffected. Electrons drift rapidly to the anode, producing the standard EL image, whereas NH4+ ions drift slowly toward the cathode, allowing time to determine the event energy and barycenter. For events in the region of interest, an ion sensor near the cathode at the projected barycenter captures the ions. Laser interrogation of the sensor’s molecular layer then reveals an ion-track image with sub-millimeter diffusion and no EL-induced smearing. Combined electron–ion imaging strengthens topological discrimination, improving background rejection by about an order of magnitude and significantly extending the discovery potential of GXeEL TPCs for very long ββ0ν lifetimes.

A bstract The NEXT experiment aims at the sensitive search of the neutrinoless double beta decay in 136 Xe, using high-pressure gas electroluminescent time projection chambers. The NEXT-White detector is the first radiopure demonstrator of this technology, operated in the Laboratorio Subterráneo de Canfranc. Achieving an energy resolution of 1% FWHM at 2.6 MeV and further background rejection by means of the topology of the reconstructed tracks, NEXT-White has been exploited beyond its original goals in order to perform a neu- trinoless double beta decay search. The analysis considers the combination of 271.6 days of 136 Xe-enriched data and 208.9 days of 136 Xe-depleted data. A detailed background modeling and measurement has been developed, ensuring the time stability of the radiogenic and cosmogenic contributions across both data samples. Limits to the neutrinoless mode are obtained in two alternative analyses: a background-model-dependent approach and a novel direct background-subtraction technique, offering results with small dependence on the background model assumptions. With a fiducial mass of only 3.50 ± 0.01 kg of 136 Xe-enriched xenon, 90% C.L. lower limits to the neutrinoless double beta decay are found in the T 1 / 2 0 ν > 5 . 5 × 10 23 − 1 . 3 × 10 24 yr range, depending on the method. The presented techniques stand as a proof-of-concept for the searches to be implemented with larger NEXT detectors.

A unique feature of gas xenon electroluminescent time projection chambers (GXeEL TPCs) in β β 0 ν searches is their ability to reconstruct event topology, in particular to distinguish “single-electron” from “double-electron” tracks, the latter being the signature of a β β 0 ν decay near the decay endpoint Q β β . Together with excellent energy resolution and the t 0 provided by primary scintillation, this topological information is key to suppressing backgrounds. Preserving EL, however, requires operation in pure xenon (with helium as the only benign additive), where electron diffusion is large. Consequently, reconstructed track fidelity is limited by diffusion and intrinsic EL blurring. We propose augmenting the detector with the ability to image not only the electron track but also the corresponding mirror ion track. Introducing trace amounts of NH 3 ( ∼ 100 ppb) converts primary xenon ions into ammonium ions, NH 4 + , via a fast two-step ion–molecule process involving charge transfer followed by proton transfer, while leaving EL unaffected. Electrons drift rapidly to the anode, producing the standard EL image, whereas NH 4 + ions drift slowly toward the cathode, allowing time to determine the event energy and barycenter. For events in the region of interest, an ion sensor near the cathode at the projected barycenter captures the ions. Laser interrogation of the sensor’s molecular layer then reveals an ion-track image with sub-millimeter diffusion and no EL-induced smearing. Combined electron–ion imaging strengthens topological discrimination, improving background rejection by about an order of magnitude and significantly extending the discovery potential of GXeEL TPCs for very long β β 0 ν lifetimes.

Abstract Candida albicans is one of the most important opportunistic pathogenic fungi. Weakening of the defense mechanisms of the host, and the ability of the microorganism to adapt to the environment prevailing in the host tissues, turn the fungus from a rather harmless saprophyte into an aggressive pathogen. The disease, candidiasis, ranges from light superficial infections to deep processes that endanger the life of the patient. In the establishment of the pathogenic process, the cell wall of C. albicans (as in other pathogenic fungi) plays an important role. It is the outer structure that protects the fungus from the host defense mechanisms and initiates the direct contact with the host cells by adhering to their surface. The wall also contains important antigens and other compounds that affect the homeostatic equilibrium of the host in favor of the parasite. In this review, we discuss our present knowledge of the structure of the cell wall of C. albicans, the synthesis of its different components, and the mechanisms involved in their organization to give rise to a coherent composite. Furthermore, special emphasis has been placed on two further aspects: how the composition and structure of C. albicans cell wall compare with those from other fungi, and establishing the role of some specific wall components in pathogenesis. From the data presented here, it becomes clear that the composition, structure and synthesis of the cell wall of C. albicans display both subtle and important differences with the wall of different saprophytic fungi, and that some of these differences are of utmost importance for its pathogenic behavior.

We investigate the performance of Opticks , a NVIDIA OptiX API 7.5 GPU-accelerated photon propagation tool compared with a single-threaded Geant4 simulation. We compare the simulations using an improved model of the NEXT-CRAB-0 gaseous time projection chamber. Performance results suggest that Opticks improves simulation speeds by between 58.47 ± 0.02 and 181.39 ± 0.28 times relative to a CPU-only Geant4 simulation and these results vary between different types of GPU and CPU. A detailed comparison shows that the number of detected photons, along with their times and wavelengths, are in good agreement between Opticks and Geant4 .

The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such large cohorts, we describe here a novel sequential strategy that combines pooling of DNA and bootstrapping ( pb GWAS) in order to significantly increase the statistical power and exponentially reduce expenses. We applied this method to a very homogeneous sample of patients belonging to a unique and clinically well-characterized multigenerational pedigree with one of the most severe forms of early onset AD, carrying the PSEN1 p.Glu280Ala mutation (often referred to as E280A mutation), which originated as a consequence of a founder effect. In this cohort, we identified novel loci genome-wide significantly associated as modifiers of the age of onset of AD ( CD44 , rs187116, P =1.29 × 10 −12 ; NPHP1 , rs10173717, P =1.74 × 10 −12 ; CADPS2 , rs3757536, P =1.54 × 10 −10 ; GREM2 , rs12129547, P =1.69 × 10 −13 , among others) as well as other loci known to be associated with AD. Regions identified by pb GWAS were confirmed by subsequent individual genotyping. The pb GWAS methodology and the genes it targeted could provide important insights in determining the genetic causes of AD and other complex conditions.

Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift direction using the relative timing of prompt scintillation and delayed charge collection signals, allowing for reconstruction of an absolute position in the drift direction. In this paper, alternate methods for assigning event drift distance via quantification of electron diffusion in a pure high pressure xenon gas time projection chamber are explored. Data from the NEXT-White detector demonstrate the ability to achieve good position assignment accuracy for both high- and low-energy events. Using point-like energy deposits from 83 m Kr calibration electron captures ( E ∼ 45  keV), the position of origin of low-energy events is determined to 2 cm precision with bias < 1 mm. A convolutional neural network approach is then used to quantify diffusion for longer tracks ( E ≥ 1.5  MeV), from radiogenic electrons, yielding a precision of 3 cm on the event barycenter. The precision achieved with these methods indicates the feasibility energy calibrations of better than 1% FWHM at Q β β in pure xenon, as well as the potential for event fiducialization in large future detectors using an alternate method that does not rely on primary scintillation.

Aerial images of the high summits of the Spanish Central Range reveal significant changes in vegetation over the period 1957 to 1991. These changes include the replacement of high‐mountain grassland communities dominated by Festuca aragonensis, typical of the Cryoro‐Mediterranean belt, by shrub patches of Juniperus communis ssp. alpina and Cytisus oromediterraneus from lower altitudes (Oro‐Mediterranean belt). Climatic data indicate a shift towards warmer conditions in this mountainous region since the 1940s, with the shift being particularly marked from 1960. Changes include significantly higher minimum and maximum temperatures, fewer days with snow cover and a redistribution of monthly rainfall. Total yearly precipitation showed no significant variation. There were no marked changes in land use during the time frame considered, although there were minor changes in grazing species in the 19th century. It is hypothesized that the advance of woody species into higher altitudes is probably related to climate change, which could have acted in conjunction with discrete variations in landscape management. The pronounced changes observed in the plant communities of the area reflect the susceptibility of high‐mountain Mediterranean species to environmental change.

Issue Title: ROSES (Risk of Susidence due to Evaporite Solution) Conference - European Commission's 4th Framework Programme of Research And Technological Development In the valley of the Ebro River to the southeast of the city of Zaragoza (NE Spain), the dissolution of evaporite sediments (gypsum, halite and Na-sulphates) which underlie alluvial deposits gives rise to numerous sinkholes. These sinkholes are a potential hazard to human safety, particularly where they develop in a catastrophic way. Even slow-developing sinkholes are problematic, as they damage urban and agricultural infrastructure, necessitating costly repairs and vigilant maintenance. To assist in developing avoidance strategies for these hazards, the factors controlling sinkhole occurrence have been assessed using geomorphological maps produced from aerial photographs for 1956 and 1981. Important controls on sinkhole development are found to include underlying geological structure (manifest in preferred orientations of sinkholes on the azimuths N130-150E and N30-40E), and the presence of glauberite in the groundwater flow path, which apparently promotes accelerated gypsum dissolution. Perhaps surprisingly, alluvium thickness does not appear to significantly correlate with the density of sinkholes on the floodplain in this area. The maps for 1956 and 1981 reveal that both human activity and natural processes can serve to obscure the true density of sinkhole development. For instance, a large number of sinkholes which were conspicuous in 1956 have since been back-filled by farmers. In the most fluvially active zone of the Ebro valley (the meander belt), the relatively low density of sinkholes compared with adjoining zones suggests that subsidence is being masked by morpho-sedimentary dynamic processes (aggradation and erosion). Careful geomorphological mapping for different time periods yields a much more accurate impression of the frequency of sinkhole development than would be gained from surveying currently visible sinkholes in the area of interest.[PUBLICATION ABSTRACT]