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La présente étude porte une attention particulière à l'analyse écolinguistique qui examine comment la langue est influencée par l'écosystème dans lequel elle évolue. Dans \"Un monde sans rivage\" d'Hélène Gaudy, nous nous intéressons aux qualités intrinsèques de l'eau sous ses trois états (solide, liquide et gazeux) et à ses dimensions poétiques et métaphoriques. Le récit est inspiré d'une tentative tragique des trois explorateurs pour survoler le Pôle Nord en 1897, mais ils sont perdus sans retour. En 1930, les vestiges, les corps et les photographies ont été révélés par une fonte exceptionnelle des glaces. Gaudy imagine cette aventure et compose son roman d'une inépuisable richesse écologique en s'appuyant sur les photos retrouvées de cette expédition tout en comblant les lacunes par des hypothèses imaginaires et poétiques. Par les photographies et leur capacité à préserver les souvenirs, Gaudy transforme ces hommes oubliés en personnages vivants. Tout au long du roman, Gaudy utilise \"l'eau\" sous toutes ses formes, dans le but de créer des métaphores puissantes en développant son thème écologique ; la confrontation des forces destructrices de la nature polaire à la vie intérieure de l'homme. En effet, \"l'eau\" semble un facteur naturel d'exploration esthétique et existentielle, dépassant sa fonction physique pour symboliser l'étrangeté et la fragilité de l'existence humaine dans cet environnement polaire. Ainsi, \"l'eau\" est le témoin de l'échec de ce voyage et de la survie des trois personnages.

Background Cyberbullying presents a significant challenge for adolescents, leading to severe psychological and social consequences. This study explores the relationships between cyberbullying, self-control, and moral identity among Egyptian school students, considering gender and socioeconomic factors from a nursing perspective. Methods A cross-sectional, descriptive correlational study was conducted among 304 preparatory and secondary school students aged 12–20 years in Egypt. Data were collected through a validated online questionnaire incorporating standardized tools to assess cyberbullying involvement, self-control, and moral identity. Statistical analyses included correlation and regression to examine the relationships between study variables. Ethical approval was secured, and informed consent was obtained from participants and legal guardians. Results Findings revealed that 78.6% of students had low cyberbullying involvement, 58.6% exhibited moderate self-control, and 78.6% demonstrated high moral identity. Self-control showed a significant negative correlation with cyberbullying ( r = -0.32, p  < 0.001) and emerged as a strong predictor of lower cyberbullying engagement (β = -0.287, p  < 0.001). Although moral identity did not directly predict cyberbullying, gender moderated its influence (β = -0.221, p  = 0.006). Socioeconomic status did not significantly mediate the relationships among self-control, moral identity, and cyberbullying. Conclusion Self-control serves as a critical protective factor against cyberbullying among adolescents, while moral identity’s role appears to be gender dependent. These findings emphasize the necessity of targeted interventions in school health programs to enhance self-regulation and ethical awareness among students. Psychiatric and school nurses should integrate cyberbullying prevention strategies into educational initiatives, reinforcing self-control development and ethical reasoning. Future research should further explore psychological and social determinants of cyberbullying and evaluate the effectiveness of nursing-led interventions in adolescent populations. Clinical trial number Not applicable.

Background The clinical longevity of pit and fissure sealants is closely related to their physical and chemical properties. To address the moisture sensitivity of hydrophobic pit and fissure sealants, hydrophilic types were introduced; however, their performance is not yet fully understood. Objectives The present study was carried out to compare and evaluate microleakage, penetration depth, and fluoride release of three different pit and fissure sealants. Methods Thirty extracted permanent upper first premolars were randomly distributed to three groups: Embrace WetBond, Denuseal, and Helioseal F Plus, each with or without bonding application ( n  = 5). Microleakage and penetration depth were evaluated using dye penetration, stereomicroscope examination, and image analysis software. Fluoride release was measured over four weeks using the SPANDS colorimetric method. SPSS version 27.0 was used for statistical analysis, and significance was set at P  < 0.05. Results Bonding application did not significantly reduce microleakage or improve penetration depth for any of the tested materials ( p  > 0.05). Helioseal F Plus demonstrated significantly lower microleakage and greater penetration under both bonded and non-bonded conditions compared with Denuseal ( p  < 0.05). Embrace WetBond showed higher microleakage and lower penetration depth than Helioseal F Plus. All tested pit and fissure sealants exhibited a pronounced initial fluoride release followed by a significant decline over time ( p  < 0.001). Embrace WetBond consistently gave the highest fluoride values among the three materials from Week 1 onward ( p  < 0.05). Conclusion Helioseal F Plus demonstrated superior sealing ability with minimal microleakage and satisfactory penetration. Embrace WetBond exhibited enhanced fluoride release patterns.

The current study aims to evaluate the levels of miR-34a, RASSF1A, and E-cadherin in relation to the levels of isoform B of progesterone receptor (PRB) in endometrioid carcinoma (EC) and atypical hyperplasia (AEH) and their association with clinicopathological parameters. 105 cases (35 EC, 35 AEH, and 35 control) were involved in this study. Cases of AEH received treatment, and other samples were obtained after 6 months to assess the response. E-cadherin and PRB were assessed by immunohistochemistry (IHC), RASSFA methylation by MSP-PCR, and its serum level by ELISA and miR-34a via quantitative PCR. The expressions of miR-34a, RASSF1A, E-cadherin, and PRB differ among the studied groups; all were higher in normal compared with AEH and EC, with a statistically significant difference. The higher PRB expression and decreased miR-34a and RASSF1A expression were associated with resistance to hormonal therapy in AEH. High PRB in EC is associated with lower RASSFA1, E-cadherin, and miR-34a. Decreased expressions of RASSF1A, miR-34a, and E-cadherin had a significant connection to advanced stages. Expression of PRB and miR-34a and serum levels of RASSF1A predict response to treatment in cases of AEH. High PRB and low E-cadherin expression are associated with progressive disease in EC.

Introduction Diabetes mellitus (DM) is a main, highly prevalent, and challenging public health issue. Suboptimal self-care for type II diabetes can lead to poor glycemic control, complications, and even death. Objective This study investigated the incidence of distress and its link with self-care habits of patients with diabetes type II. Methods A correlational, cross-sectional design with a convenient sample of 200 patients was used to conduct this study. Three questionnaires were administered: (A) the demographic and medical data questionnaire; (B) diabetes self-care activities in brief; and (C) the diabetes distress scale in Arabic language. Results The patients’ mean age was 51.78 ± 11.34; 80% of patients practiced lower levels of diabetes self-care, and 37% of them had a high level of diabetes distress. Self-care is associated with diabetes distress (R = −0.152, p-value = .032). Conclusion Self-care activities can help in the early detection and management of diabetes distress. Sustained self-care education is promising to minimize diabetes distress. The potential advantages of association between diabetes distress and self-care can offer self-care programs that enhance diabetes distress management.

Hexaflumuron (HEX) insecticide is widely used in agriculture practices to fight crop insects. The toxicological effect of HEX on Nile tilapia (Oreochromis niloticus) was investigated in this study. Two hundred and forty fish (35.50 ± 1.45 g) were divided into six groups in four replicates (40 fish/group; 10 fish/replicate) and were exposed to six distinct HEX concentrations (0, 2, 4, 6, 8, and 10 mg L−1) for 96-h. The 96-h lethal concentration 50 (96-h LC50) of HEX was calculated to be 7.19 mg L−1. The fish exhibited reduced surface and middle swimming, aggressiveness, and tail-spreading behaviors with increasing bottom swimming and resting patterns after HEX exposure. HEX exposure resulted in body bleeding and fin rot. The erythrogram (red blood cell count, hemoglobin, and packed cell volume %) was significantly reduced with increased mean corpuscular volume by HEX exposure. HEX exposure decreased the white blood cells (WBCs) and differential WBC counts. Acute HEX exposure raised 8-hydroxy-2-deoxyguanosine level while lowering brain acetylcholine esterase activity. HEX exposure caused hepato-renal dysfunction and increased stress-related parameters (glucose and cortisol). Exposure to HEX reduced the immune responses (lysozyme, nitric oxide, immunoglobulin M, and complement 3). A substantial decrease in the antioxidant variables (reduced glutathione content and catalase) with increasing the malondialdehyde was noted by HEX exposure. Moreover, histopathological changes resulted from HEX exposure in the gills, liver, kidney, and spleen. These results indicate that HEX exposure induced behavioral changes, hepato-renal dysfunction, and immune-antioxidant disruption, indicating a possible physiological disruption in O. niloticus.

Contrary to other inflammatory skin disorders like psoriasis or atopic dermatitis, vitiligo does not present with distinct inflammatory symptoms that can be easily evaluated by clinical examination. Identification of a putative biomarker to inform early and accurate treatment responses could be of considerable value. This study aims to validate levels of serum soluble CD27 (sCD27) and macrophage Migration Inhibitory Factor (MIF) as biomarkers of vitiligo to improve the quality of disease management. This cross-sectional study was conducted on 32 vitiligo patients, stratified into two subgroups of 22 active and 10 stable vitiligo patients; the stable group containing 1 segmental and 9 non-segmental presentations, and 32 matched healthy individuals as the control group. Of the 32 patients in the study, 21 were female and 11 were male with a median age of 30 years. The measurements of the study parameters of sCD27 and MIF in the serum were carried out through blood sampling and followed up for three months at one-month intervals for stable vitiligo cases. Mean serum levels of sCD27 and MIF were significantly higher in vitiligo patients than in the control group. A positive correlation was observed in active vitiligo cases between both serum MIF and sCD27 levels and the spreading item of Vitiligo European Task Force (VETF) score as an indicator of disease activity. Serum sCD27 and MIF levels in vitiligo patients were observed to be higher than that of controls with greater correlation found for sCD27 with disease activity.

Rheumatoid arthritis (RA) is a common systemic inflammatory disease. Collagen triple helix repeat containing-1 (CTHRC1) is a unique gene product able to reduce collagen deposition. The present study aimed to assess CTHRC1 level in RA patients and to uncover its relation to clinical, laboratory and radiological findings. The study included 60 adult RA patients. In addition, there were 60 control subjects who included patients with osteoarthritis (n = 20) and reactive arthritis (n = 20) and healthy controls (n = 20). Serum CTHRC1 levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA). Disease activity was calculated using the Disease Activity Score (DAS28-CRP). Radiological damage was evaluated using the Simple Erosion Narrowing Score (SENS). There was significantly higher serum CTHRC1 levels in RA patients when compared to OA, ReA and control groups [median (IQR): 4.66 (1.68-11.7) versus 1.88 (1.14-2.94), 1.55 (0.98-3.15) and 1.14 (0.85-1.3) mg/dL, respectively, p < 0.001]. There was significantly higher CTHRC1 levels in patients with higher disease activity [median (IQR): 2.23 (1.4-4.73) versus 6.55 (4.66-12.0) mg/dL, p = 0.004]. Patients with higher SENS had significantly higher CTHRC1 [median (IQR): 1.99 (1.4-4.66) versus 9.75 (4.39-12.63) mg/dL, p < 0.001] and DAS28 [median (IQR): 4.25 (2.9-5.2) versus 5.4 (4.65-5.8), p = 0.01]. Serum CTHRC1 levels are related to disease severity and radiological affection in RA patients.

Problem statement Vascular Access (VA) in hemodialysis (HD) patients is vital for treatment efficiency and is influenced by Egypt’s healthcare system and socioeconomic factors. It is a complex issue, shaped by both challenges and opportunities within the nation’s healthcare infrastructure. Aim To examine trends in VA use and associated characteristics in patients on HD based on data from a nationwide survey in Egypt. Methods This cross-sectional study targeted patients on maintenance hemodialysis across Egypt, using stratified cluster sampling from 11 representative governorates. Medical personnel collected data using a structured electronic Google Form questionnaire, which gathered data on patient demographics, clinical details, VA creation and complications, and healthcare access. Results The study included 3,582 chronic HD patients. Data were collected over a one-year period from May 2023 to May 2024. An arteriovenous fistula (AVF) was the initial VA for 669 patients (18.7%), while a temporary catheter was used as the initial access in 2,861 patients (79.9%). AVF thrombosis was the primary cause of AVF failure, occurring in 69.7% of cases. Pre-HD VA creation was associated with substantially better fistula maturation, fewer VA numbers, and lower VA-related complications. Conclusion Significant regional and sociodemographic variations in VA practices were observed across Egypt. The findings revealed persistent reliance on temporary catheters at HD initiation, with encouraging but limited progress in pre-HD AVF planning. These trends underscore the need for early referral strategies and targeted interventions to optimize vascular access outcomes nationwide.

Hypothyroidism, marked by low thyroid hormone production, often requires lifelong hormone replacement, which may not fully normalize function. This study compared three thyroid transplant. Fifty mature male albino rats were segregated into three cohorts: control, thyroidectomy-only, and thyroidectomy with transplantation. The transplant group had three intervention subgroups: (1) thyroid allografts alone, (2) allografts with MSCs co-transplantation, (3) engineered thyroid cell sheets. Blood samples were collected at baseline, one week pre-thyroidectomy, one week post-thyroidectomy/pre-transplant, and weekly for four weeks post-transplant for biochemical analysis. Thyroid tissues were harvested at the study endpoint for comparative histological and molecular analyses. Pre-thyroidectomy hormone levels showed no significant differences between groups one week before the thyroidectomy procedure. However, after thyroidectomy, the average serum free T3 and free T4 concentrations were meaningfully diminished, whereas the average serum TSH level was considerably elevated in the follow-up measurements. Conversely, the thyroid allograft-MSCs conjugates demonstrated superior therapeutic effects, with enhanced thyroid hormone production and improved histological structure. In contrast, the tissue-engineered thyroid cell sheets showed a more transient therapeutic effect, likely due to the regenerative capacity and differentiation of MSCs in the thyroid tissue. These findings suggest that stem cells are crucial for both tissue-engineered thyroid cell sheets and thyroid allografts for synthesizing thyroid tissue, which may be more promising approaches for treating hypothyroidism, offering potential alternatives to traditional hormone replacement therapy thyroid allograft alone, allograft-mesenchymal stem cells (MSCs) conjugates, and tissue-engineered thyroid cell sheets to assess their effects on restoring thyroid function and structure post-thyroidectomy.